Editorial Material
Clinical Neurology
Jacopo C. DiFrancesco, Lorenzo Stanzani
Summary: Cerebral amyloid angiopathy (CAA) is a common neuropathological finding in patients with Alzheimer's disease (AD), characterized by cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS). Both CMBs and CAA are associated with progressive cognitive impairment in AD patients, providing further evidence for the interplay between neurovascular and neurodegenerative processes in AD.
Review
Clinical Neurology
Aristeidis H. Katsanos, Vasileios-Arsenios Lioutas, Andreas Charidimou, Luciana Catanese, Kelvin Kuan Huei Ng, Kanjana Perera, Danielle de Sa Boasquevisque, Guido J. Falcone, Kevin N. Sheth, Jose Rafael Romero, Georgios Tsivgoulis, Eric E. Smith, Mukul Sharma, Magdy H. Selim, Ashkan Shoamanesh
Summary: Although statin use is not associated with the presence of cerebral microbleeds overall, it may increase the risk of lobar microbleeds formation. Further investigation within magnetic resonance imaging ancillary studies of randomized trials is warranted to explore this hypothesis.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Sungyang Jo, E-Nae Cheong, Nayoung Kim, Jungsu S. Oh, Woo Hyun Shim, Hyung-Ji Kim, Sun Ju Lee, Yoojin Lee, Minyoung Oh, Jae Seung Kim, Bum Joon Kim, Jee Hoon Roh, Sang Joon Kim, Jae-Hong Lee
Summary: This study found that microbleeds in cerebral amyloid angiopathy (CAA) can lead to damage in white matter tracts and subsequent cognitive decline, while cortical thickness does not mediate the association between lobar microbleeds and cognition.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Aleksandra Stanisavljevic, Joseph M. Schrader, Xiaoyue Zhu, Jennifer M. Mattar, Ashley Hanks, Feng Xu, Mark Majchrzak, John K. Robinson, William E. Van Nostrand
Summary: Hypertension may cause significant changes in the redistribution of amyloid and the size and distribution of thalamic vessel occlusions in cerebral amyloid angiopathy (CAA).
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Yasuteru Inoue, Yukio Ando, Yohei Misumi, Mitsuharu Ueda
Summary: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid beta (Aβ) in brain vessels, leading to vessel fragility, hemorrhages, and neurological symptoms. The pathogenesis of CAA is not fully understood, but recent advances in mass spectrometric methodology have identified potential key molecules associated with CAA. Understanding the interactions between cerebrovascular Aβ deposits and these molecules may lead to the development of effective CAA therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Isabel Alvarez-Mora, Victor Antonio Blanco-Palmero, Juan Francisco Quesada-Espinosa, Ana Rosa Arteche-Lopez, Sara Llamas-Velasco, Carmen Palma Milla, Jose Miguel Lezana Rosales, Irene Gomez-Manjon, Aurelio Hernandez-Lain, Justino Jimenez Almonacid, Belen Gil-Fournier, Soraya Ramiro-Leon, Marta Gonzalez-Sanchez, Alejandro Octavio Herrero-San Martin, David Andres Perez-Martinez, Estrella Gomez-Tortosa, Eva Carro, Fernando Bartolome, Maria Jose Gomez-Rodriguez, Maria Teresa Sanchez-Calvin, Alberto Villarejo-Galende, Marta Moreno-Garcia
Summary: The SORL1 gene has been strongly implicated in the development of Alzheimer's disease, with a high proportion of patients with candidate variants having SORL1 variants. This study expands the understanding of the clinical manifestations associated with SORL1 gene by reporting detailed clinical and neuroimaging findings of patients with AD and SORL1 mutations. Furthermore, this study presents new insights into the association of SORL1 variants with severe cerebral amyloid angiopathy and provides evidence that SORL1 might contribute to AD development as a risk factor gene rather than a major autosomal dominant gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ashwin Ambi, Aleksandra Stanisavljevic, Tiffany W. Victor, Adam W. Lowery, Judianne Davis, William E. Van Nostrand, Lisa M. Miller
Summary: Removing copper does not effectively decrease copper content in vascular amyloid deposits and may even increase the development of disease pathology in cerebral amyloid angiopathy (CAA).
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
S. Voigt, P. C. de Kruijff, E. A. Koemans, I Rasing, E. S. van Etten, G. M. Terwindt, M. J. P. van Osch, M. A. van Buchem, M. A. A. van Walderveen, M. J. H. Wermer
Summary: Superficially located asymptomatic cerebellar macrobleeds and microbleeds are common in Dutch-type hereditary CAA. Cerebellar microbleeds are already present in the presymptomatic stage and are predominantly superficially located. Despite the high frequency of cerebellar micro and macrobleeds, CAA pathology did not result in symptomatic cerebellar ICH in patients with D-CAA.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Neurosciences
Riccardo Milani, Lucio Aniello Mazzeo, Daniela Vismara, Ilaria Salemi, Emanuele Dainese, Emanuela Maderna, Elisa Pellencin, Marcella Catania, Nicole Campanella, Giuseppe Di Fede, Giorgio Giaccone, Andrea Salmaggi
Summary: Cerebral amyloid angiopathy (CAA) is a small vessel disease that leads to spontaneous intracerebral hemorrhage (ICH) in the elderly and is strongly associated with Alzheimer's disease (AD). Recently, iatrogenic early-onset CAA has been identified in patients who had a history of traumatic brain injury or other cerebral and extra-cerebral lesions that required neurosurgery or other medical procedures. The transmission of A beta seeds from neurosurgical instruments or exposure to cadaveric dura mater is suspected to be involved.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Geriatrics & Gerontology
Hai-ling Wang, Chun-lin Zhang, Yan-mei Qiu, An-qi Chen, Ya-nan Li, Bo Hu
Summary: Cerebral microbleeds (CMBs) are small lesions in the brain's microvessels that are linked to various neurological conditions. The exact pathogenesis and treatment options for CMBs require further investigation and research.
Article
Medicine, General & Internal
Aikaterini Theodorou, Lina Palaiodimou, Georgia Papagiannopoulou, Odysseas Kargiotis, Klearchos Psychogios, Apostolos Safouris, Eleni Bakola, Maria Chondrogianni, Vasiliki Kotsali-Peteinelli, Konstantinos Melanis, Athanasios Tsibonakis, Elissavet Andreadou, Sofia Vasilopoulou, Stefanos Lachanis, Georgios Velonakis, Elias Tzavellas, John S. Tzartos, Konstantinos Voumvourakis, Georgios P. Paraskevas, Georgios Tsivgoulis
Summary: This study aimed to assess the prevalence of baseline characteristics, clinical and radiological findings, and outcomes among patients with cerebral amyloid angiopathy (CAA) in Greece. The results showed that focal neurological deficits, cognitive decline, and transient focal neurological episodes were the most common clinical manifestations, while hemorrhagic lesions were the most prevalent neuroimaging findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Mingxu Xia, Ya Su, Jiayu Fu, Jiajie Xu, Qiong Wang, Feng Gao, Yong Shen, Qiang Dong, Xin Cheng
Summary: This study found that serum MMP-2 levels in the acute phase may serve as a promising biomarker to predict CAA-ICH recurrence and evaluate the risk of cognitive impairment. Additionally, higher levels of MMP-2 were associated with cerebral microbleeds count and MRI burden score.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Endocrinology & Metabolism
Susanne J. van Veluw, Matthew P. Frosch, Ashley A. Scherlek, Daniel Lee, Steven M. Greenberg, Brian J. Bacskai
Summary: This study used in vivo two-photon microscopy to observe aged APP/PS1 mice with mild-to-moderate CAA, finding extravascular fibrin-positive clots at individual rupture sites. Compared to wild-type controls, transgenic mice were more likely to experience spontaneous extravascular leakage, suggesting that CAA does not directly predispose vessels to leak but is influenced by complex flow dynamics.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Slaven Pikija, Janja Pretnar-Oblak, Senta Frol, Branko Malojcic, Thomas Gattringer, Kinga Rak-Frattner, Dimitre Staykov, Andrea Salmaggi, Riccardo Milani, Jozef Magdic, Sarah Iglseder, Eugen Trinka, Theo Kraus, Andreea Toma, Jacopo C. Difrancesco, Payam Tabaee Damavandi, Natalia Fabin, Anna Bersano, Patricia de la Riva Juez, Ines Albajar Gomez, Benedetta Storti, Simon Fandler-Hoefler
Summary: A large international case series of iCAA patients revealed a wide age range for diagnosis and a high prevalence of symptoms following neurosurgical procedures. Dissemination of awareness about this rare condition is crucial for identifying more affected patients.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Ashkan Shoamanesh, Saloua Akoudad, Jayandra J. Himali, Alexa S. Beiser, Charles DeCarli, Sudha Seshadri, M. Arfan Ikram, Jose R. Romero, Meike W. Vernooij
Summary: In community-dwelling older adults, cortical superficial siderosis is associated with cerebral amyloid angiopathy, indicating that individuals with this condition may be at a higher risk for intracerebral hemorrhage and future neurological events.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Geriatrics & Gerontology
Aline Mendes, Francois R. Herrmann, Laurence Genton, Christine Serratrice, Emmanuel Carrera, Maria Isabel Vargas, Gabriel Gold, Christophe E. Graf, Dina Zekry, Max Scheffler
Summary: The incidence of acute stroke in older COVID-19 patients was 4.15%, with common characteristics being altered consciousness/delirium and focal neurological deficits. Risk factors for stroke included smoking, previous stroke history, and low BMI. However, acute stroke did not affect in-hospital mortality or institutionalization rates at discharge.
Article
Nutrition & Dietetics
Aline Mendes, Christine Serratrice, Francois R. Herrmann, Gabriel Gold, Christophe E. Graf, Dina Zekry, Laurence Genton
Summary: Nutritional risk at admission is associated with prolonged length of hospital stay (LOS) but not with mortality in older patients with COVID-19.
CLINICAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Samanta Buchholzer, Frederic Faure, Livia Tcheremissinoff, Francois R. Herrmann, Tommaso Lombardi, Siu-Kwan Ng, Jean-Michel Lopez, Urs Borner, Robert L. Witt, Robert Irvine, Olivier Abboud, Claudio R. Cernea, Shirish Ghan, Takeshi Matsunobu, Zahoor Ahmad, Randall Morton, Aleksandar Anicin, Emad A. Magdy, Rashid Al Abri, Iordanis Konstantinidis, Pasquale Capaccio, Hila Klein, Vincent Vander Poorten, Davide Lombardi, Bernard Lyons, Hussain Al Rand, George Liao, Jeong K. Kim, Sethu Subha, Richard Y. -X. Su, Chin-Hui Su, Franciscus Boselie, Raphael Andre, Jorg D. Seebach, Francis Marchal
Summary: This study aimed to establish and validate a novel questionnaire to document symptoms of xerostomia and sialadenitis, including their impact on quality of life. The validation of the questionnaire was conducted on patients with various salivary pathologies and healthy volunteers. The results showed good internal coherence of the questionnaire items, with the recommended use of the Q10 version for more accurate international use.
Article
Neurosciences
Panteleimon Giannakopoulos, Cristelle Rodriguez, Marie-Louise Montandon, Valentina Garibotto, Sven Haller, Francois R. Herrmann
Summary: This study examines the impact of personality on Alzheimer's disease (AD) and vascular imaging markers. The results show that high levels of conscientiousness and openness are positively associated with AD-signature MRI markers, while higher extraversion levels are associated with an increased number of cortical microbleeds.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Psychiatry
Isabella D'Orta, Francois R. Herrmann, Panteleimon Giannakopoulos
Summary: There are significant sociodemographic and clinical differences between offenders receiving court-ordered treatments and regular prison inmates. In the Swiss penitentiary system, court-ordered treatment patients are less exposed to acculturation issues and have a higher prevalence of personality and psychotic disorders.
ANNALS OF GENERAL PSYCHIATRY
(2022)
Article
Immunology
Laurence Genton, Vladimir Lazarevic, Ozren Stojanovic, Martina Spiljar, Souad Djaafar, Thibaud Koessler, Valerie Dutoit, Nadia Gaia, Julie Mareschal, Andrew James Macpherson, Francois Herrmann, Mirko Trajkovski, Jacques Schrenzel
Summary: In this pilot study, fecal microbiota transplantation (FMT) from pancreatic cancer (PC) patients was associated with a decrease in visceral fat compared to FMT from healthy individuals. Some differences in fecal microbiota between PC and control samples are common to humans and mice, suggesting potential elements involved in metabolic and immune alterations. Additional research is needed to confirm these findings.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Neurosciences
Marcella M. Authiat, Emmanuelle Gruz-Gibelli, Julien Colas, Estelle Bianchi, Marta Garcia-Arauzo, Pascale Marin, Francois R. Herrmann, Armand Savioz
Summary: This study found that DNA double-strand breaks (DSBs) were lower in Alzheimer's disease cells carrying the preseniline-1 (PS1) P117L mutation compared to normal cells. Additionally, the DSBs in mutated cells could not be decreased by treatment with all-trans retinoic acid (RA). Increased expression of BRCA1 and BARD1 proteins in the mutated cells suggests their involvement in reducing DSBs in the pathological situation.
Article
Clinical Neurology
Alessandra Griffa, Giulia Bommarito, Frederic Assal, Maria Giulia Preti, Rachel Goldstein, Stephane Armand, Francois R. Herrmann, Dimitri Van De Ville, Gilles Allali
Summary: This study aimed to assess whether gait, neuropsychological, and multimodal MRI parameters can predict short-term symptom reversal after cerebrospinal fluid tap test in patients with idiopathic normal pressure hydrocephalus (iNPH). The results showed that none of the individual parameters could predict the outcome, but a multivariable approach achieved modest prediction accuracy and could be included in patient-screening procedures. Further exploration of their value in predicting shunting outcome, particularly in relation to gait and white-matter parameters, is needed.
JOURNAL OF NEUROLOGY
(2022)
Article
Psychology, Multidisciplinary
Cristelle Rodriguez, Marie-Louise Montandon, Francois R. Herrmann, Alan J. Pegna, Panteleimon Giannakopoulos
Summary: Previous studies suggest that people automatically take into account others' perspective even when it hinders their own goals. This ability is crucial for understanding others' mental states and social interactions. However, the cognitive and emotional determinants of automatic perspective taking (APT) are still debated. This study examined the performance of 91 healthy adults in an APT task and found that individuals with lower attentional resources and increased impulsivity performed worse in the task and exhibited less responsiveness to egocentric and altercentric interference.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Laurent Levy, Jean-Marie Robine, Gregoire Rey, Raul Fernando Mendez Turrubiates, Marcos Quijal-Zamorano, Hicham Achebak, Joan Ballester, Xavier Rodo, Francois R. Herrmann
Summary: The study found that the transition of daylight saving time can affect the all-cause mortality rate in European countries, with a decrease in mortality in spring and an increase in mortality in fall. Additionally, the DST transition can lead to a change in the weekly mortality pattern.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
Guillaume T. Duval, Anne-Marie Schott, Dolores Sanchez-Rodriguez, Francois R. Herrmann, Cedric Annweiler
Summary: The study suggests that older women born in the summer to early fall months have higher muscle mass and strength.
Article
Dentistry, Oral Surgery & Medicine
Murali Srinivasan, Stephan Duong, Veronique Trombert, Nicole Kalberer, Dina Zekry, Francois R. Herrmann, Joris Delavy, Gabriel Gold, Frauke Muller
Summary: The study aimed to validate a novel screening test for cognitive and functional decline in older patients rehabilitated with complete removable dental prostheses (CRDPs). Edentate old in-patients rehabilitated with CRDPs were included in the study. Participants were requested to remove and reinsert their prostheses in the appropriate jaws, and the results were associated with the participants' MMSE score, FIM, age, and sex. The prosthesis presentation test (PPT) was found to be associated with the FIM and its cognitive sub-sets.
Meeting Abstract
Endocrinology & Metabolism
Melany Hars, Francois Herrmann, Thierry Chevalley, Serge Ferrari, Gabriel Gold, Rene Rizzoli, Patrik Vuilleumier, Andrea Trombetti
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Panteleimon Giannakopoulos, Marie-Louise Montandon, Francois R. Herrmann, Dennis Hedderich, Christian Gaser, Elias Kellner, Cristelle Rodriguez, Sven Haller
Summary: Novel quantitative AI-based volumetric scores provide additional value in predicting subsequent cognitive decline in elderly controls compared to established visual MRI markers.
EUROPEAN RADIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Michalina Radomska, Joao Flores Alves dos Santos, Kerstin Weber, Marc Baertschi, Pierre R. Burkhard, Francois Herrmann, Sanaa Belayachi, Nicolas Favez, Alessandra Canuto
Summary: This study developed a questionnaire called Preoperative Hope and Expectations Questionnaire (PHEQ) to assess cognitive representations of surgery outcomes. The results showed that PHEQ has satisfactory psychometric properties and can be considered as a reliable instrument for research and clinical practice.