microRNA-34a as a Therapeutic Agent against Human Cancer

MicroRNA-34a suppresses the breast cancer stem cell-like characteristics by downregulating Notch1 pathway

(2015) Le Kang et al.   CANCER SCIENCE

LincHOTAIR epigenetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer

(2015) Y-w Liu et al.   Cell Death & Disease

Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness

(2015) Wei Ma et al.   Oncotarget

Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness

(2015) Helge Siemens et al.   Oncotarget

Early Targets of miR-34a in Neuroblastoma

(2014) Pasqualino De Antonellis et al.   MOLECULAR & CELLULAR PROTEOMICS

Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways

(2014) Sachin S. Rathod et al.   FEBS Open Bio

Tumor Suppressor Alterations Cooperate to Drive Aggressive Mesotheliomas with Enriched Cancer Stem Cells via a p53-miR-34a-c-Met Axis

(2013) C. W. Menges et al.   CANCER RESEARCH

A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells

(2013) Pengcheng Bu et al.   Cell Stem Cell

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

(2012) Young-Ho Ahn et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: A review

(2011) Fei Chen et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Genome-wide Characterization ofmiR-34aInduced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis

(2011) Markus Kaller et al.   MOLECULAR & CELLULAR PROTEOMICS

Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice

(2011) Phong Trang et al.   MOLECULAR THERAPY

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

MiR-34a Targeting of Notch Ligand Delta-Like 1 Impairs CD15+/CD133+ Tumor-Propagating Cells and Supports Neural Differentiation in Medulloblastoma

(2011) Pasqualino de Antonellis et al.   PLoS One

Targeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells

(2011) Dara Nalls et al.   PLoS One

Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling

(2011) Ashish Lal et al.   PLoS Genetics

Epigenetic inactivation of the miR-34a in hematological malignancies

(2010) C.S. Chim et al.   CARCINOGENESIS

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

(2010) Dmitri Lodygin et al.   CELL CYCLE

MicroRNA-34a Inhibits Glioblastoma Growth by Targeting Multiple Oncogenes

(2009) Y. Li et al.   CANCER RESEARCH

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells

(2009) Y Saito et al.   ONCOGENE

Epigenetic Silencing of MicroRNA-34b/c and B-Cell Translocation Gene 4 Is Associated with CpG Island Methylation in Colorectal Cancer

(2008) M. Toyota et al.   CANCER RESEARCH

Cancer Epigenetics: Modifications, Screening, and Therapy

(2007) Gal-Yam Einav Nili et al.   Annual Review of Medicine