Article
Chemistry, Applied
Wei Xiong, Shi Hang Xiong, Qi Ling Chen, Ke Gang Linghu, Guan Ding Zhao, John M. T. Chu, Gordon T. C. Wong, Juan Li, Yuan Jia Hu, Yi Tao Wang, Hua Yu
Summary: The study developed a strategy using BC-NP nanoparticles to enhance the oral bioavailability and therapeutic effect of BBR in diabetic kidney disease. The BC-NPs improved the intestinal permeability of BBR by regulating TJs and Pgp-mediated drug efflux, leading to significantly increased oral bioavailability and therapeutic potency of BBR.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Yasmeen Cheema, Yusra Sajid Kiani, Kenneth J. J. Linton, Ishrat Jabeen
Summary: Researchers developed a pharmacophore model based on the cryo-EM structure of ABCB1 to screen for new inhibitors, resulting in the identification of six potential inhibitors with distinct chemistries and favorable properties. The compounds exhibited low nanomolar range inhibitory concentrations and two of them were able to resensitize ABCB1-expressing cells to taxol. This study demonstrates the utility of cryo-electron microscopy in drug identification and design.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Lara Garcia-Varela, Pascalle Mossel, Pablo Aguiar, Daniel A. Vazquez-Matias, Aren van Waarde, Antoon T. M. Willemsen, Anna L. Bartels, Nicola A. Colabufo, Rudi A. J. O. Dierckx, Philip H. Elsinga, Gert Luurtsema
Summary: This study found that small changes in P-gp function caused by low doses of tariquidar could be detected by [F-18]MC225-K-1 values, confirming the high sensitivity of the radiotracer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Medicinal
I-Ting Wu, Chan-Yen Kuo, Ching-Hui Su, Yu-Hsuan Lan, Chin-Chuan Hung
Summary: This study investigated the inhibitory effects of pinostrobin and tectochrysin on P-gp in MDR cancer cells and the underlying mechanisms. The results showed that these compounds were not substrates of P-gp and did not affect its expression, but they noncompetitively inhibited the efflux of rhodamine 123 and doxorubicin through P-gp, leading to the resensitization of MDR cancer cells. Therefore, pinostrobin and tectochrysin are effective P-gp inhibitors and potential candidates for resensitizing MDR cancer cells.
Article
Biochemistry & Molecular Biology
Catia A. Bonito, Ricardo J. Ferreira, Maria-Jose U. Ferreira, Jean-Pierre Gillet, M. Natalia D. S. Cordeiro, Daniel J. V. A. dos Santos
Summary: In this study, the impact of four P-gp mutations on drug-binding and efflux-related signal-transmission mechanism was evaluated. The repacking of the transmembrane helices induced by mutations and ligands indicates P-gp's sensitivity to perturbations in the transmembrane region. Changes in drug-binding were observed as a consequence of transmembrane helices repacking, but were not always correlated with alterations in ligand binding mode and affinity. The changes in drug efflux are mostly related to changes in drug specificity rather than effects on signal-transmission mechanism.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Pharmacology & Pharmacy
Sachin Rathod, Heta Desai, Rahul Patil, Jayant Sarolia
Summary: This article discusses the significance of studying P-glycoprotein in drug delivery and highlights the effective reversal of P-gp inhibition using nonionic surfactants. Nonionic surfactants, being inert, non-toxic, and efficient, show potential as P-gp inhibitors and improve drug absorption and bioavailability through various mechanisms.
Article
Biochemistry & Molecular Biology
Dhanamjai Penta, Priya Mondal, Jagadish Natesh, Syed Musthapa Meeran
Summary: The study demonstrates that diindolylmethane can enhance the efficacy of Centchroman in treating breast cancer by modulating drug efflux transporters, inhibiting cell proliferation, inducing apoptosis, and hindering stemness of cancer cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Aobulikasimu Hasan, Dan Tang, Dilaram Nijat, Hequn Yang, H. A. Aisa
Summary: The study isolated several new diterpenoids from Euphorbia glomerulans, with compound 5 showing high efficacy in reversing multidrug resistance in cancer by inhibiting P-gp transport function. Molecular docking predicted the recognition mechanism of compound 5 and verapamil with P-gp.
BIOORGANIC CHEMISTRY
(2021)
Article
Agronomy
Tan Dai, Zhiwen Wang, Xingkai Cheng, Huige Gao, Li Liang, Pengfei Liu, Xili Liu
Summary: Both fungicide efflux and detoxification metabolism are involved in the resistance mechanisms of Phytophthora capsici to SYP-14288.
PEST MANAGEMENT SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Sachin Rathod, Pratap Bahadur, Sanjay Tiwari
Summary: alpha-Tocopheryl polyethylene glycol succinate (TPGS) is a safe excipient that can enhance drug solubility and dispersion. Its aggregation behavior can be modulated by other amphiphiles and organic additives, allowing for the development of various drug formulations. TPGS improves drug bioavailability by enhancing permeation and reducing levels of P-glycoproteins.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Rasmus Blaaholm Nielsen, Rene Holm, Ils Pijpers, Jan Snoeys, Ulla Gro Nielsen, Carsten Uhd Nielsen
Summary: This study aimed to investigate the potential of the combination of the P-gp inhibitor zosuquidar and the nonionic surfactant polysorbate 20 in potentiating P-gp-mediated efflux inhibition. Cell-based experiments and animal experiments revealed that the combination of these two substances can enhance P-gp inhibition in vitro. However, in vivo experiments showed that coadministration of both substances leads to a decrease in oral etoposide bioavailability.
Article
Biochemistry & Molecular Biology
Ayoub Shiravandi, Mohammad Kazemi Ashtiani, Hamed Daemi
Summary: We developed a method to improve the electrospinnability of chitosan and fabricate uniform nanofibrous mats. The sulfation of chitosan and its mixing with poly(vinyl alcohol) effectively enhanced the solubility and mechanical properties of the chitosan nanofibrous mats. These mats showed successful loading and sustained release of a cationic drug model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Reiko Watanabe, Tsuyoshi Esaki, Rikiya Ohashi, Masataka Kuroda, Hitoshi Kawashima, Hiroshi Komura, Yayoi Natsume-Kitatani, Kenji Mizuguchi
Summary: A computer model was developed to predict the efflux potential of drugs through brain capillary endothelial cells' P-gp, proposing a novel system for evaluating brain-to-plasma concentration ratios of P-gp substrates. Validation with experimental data improved the accuracy of predicting drug penetration across the blood-brain barrier, solely based on chemical structure information, compared to previous studies.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Lara Garcia-Varela, Manuel Rodriguez-Perez, Antia Custodia, Rodrigo Moraga-Amaro, Nicola A. Colabufo, Pablo Aguiar, Tomas Sobrino, Rudi A. J. O. Dierckx, Aren van Waarde, Philip H. Elsinga, Gert Luurtsema
Summary: P-glycoprotein (P-gp) inducer MC111 increases P-gp functionality in the whole brain of rats, potentially offering a treatment option for neurodegenerative diseases.
MOLECULAR PHARMACEUTICS
(2021)
Article
Engineering, Environmental
Thi Hien Nguyen, Thuy Chinh Nguyen, Thi Minh Tu Nguyen, Dinh Hoa Hoang, Do Mai Trang Tran, Dinh Thang Tran, Phuong Thai Hoang, Van Tan Le, Thi Kim Ngan Tran, Hoang Thai
Summary: The study developed microparticles loaded with alpha-mangostin extracted from Vietnamese mangosteen skin using carrageenan and chitosan. The microparticles exhibited improved release ability of alpha-mangostin into solutions, maintained its bioactivities, reduced vero cell toxicity, and showed antibacterial and antioxidant activities. The combination of chitosan and carrageenan in the microparticles enhanced the controlled release of alpha-mangostin.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Engineering, Biomedical
Suleixin Yang, Peng Hua, Chengwei He, Hua Yu, Dan Shao, Zhi Shi, Meiwan Chen, Ka Hong Wong
Summary: In this study, a ferroptosis/apoptosis combinational therapy was achieved by depleting GSH and downregulating GPX4 to disrupt redox homeostasis and amplify ferroptosis-related oxidation effect. ROS-responsive serum-resistant nanoparticles were used to co-deliver shGPX4 and shMTHFD2 plasmids, leading to efficient transfection, lysosomal escape, and induction of ferroptosis and apoptosis in tumor cells.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Yuan He, Chang Liu, Run Han, Yingmin Liang, Judith Choi Wo Mak, Yinghao Zhu, Haifeng Li, Ying Zheng
Summary: Pulmonary delivery is an effective strategy for treating local respiratory diseases. In this study, a lipid-coated genistein nanocrystals formulation was developed to enhance drug concentration in the lungs. The formulation exhibited reduced drug release rate, decreased intracellular uptake and transcellular transport, and impeded macrophages clearance. In vivo studies showed improved lung retention and reduced systemic absorption. This research suggests that the lipid-coated nanocrystals formulation is suitable for enhancing local pulmonary delivery.
CHINESE CHEMICAL LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Ling Wang, Tsukasa Katayama, Chaoyue Wang, Qin Li, Yun Shi, Yuqiang Fang, Fuqiang Huang, Yinghao Zhu, Hai-feng Li, Shintaro Yasui, Xintang Huang, Jianding Yu
Summary: GaFeO3-type oxide materials exhibit coexistence of spontaneous magnetization and ferroelectric polarization properties at room temperature, but the magnetization of single crystals is low. In this study, the magnetization of GaFeO3-type single crystals at room temperature was greatly enhanced by increasing the Fe content and co-doping Sc3+ and Al3+.
Review
Chemistry, Inorganic & Nuclear
Yinghao Zhu, Kaitong Sun, Si Wu, Pengfei Zhou, Ying Fu, Junchao Xia, Hai-Feng Li
Summary: Multiferroics are advanced materials with potential applications that possess both charge polar and magnetic order, making them at the forefront of modern science. Previous studies have shown that the RECrO3 (RE = rare earth) compounds may be another rare candidate system combining ferroelectricity and magnetism. However, there are still unresolved issues causing disputes about whether RECrO3 is multiferroic or not. To address these questions, growing single crystals is a key step to obtain reliable information. This review comprehensively discusses the parent and doped ferroelectric YCrO3 compounds, including their synthesis methods, structural, magnetic, ferroelectric, dielectric, optical, and chemical properties, as well as potential applications. The review also summarizes the general results, consensuses, controversies, future research opportunities, and emerging challenges in the field.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Yinghao Zhu, Pengfei Zhou, Kaitong Sun, Hai-Feng Li
Summary: In-house X-ray powder diffraction was used to study the room-temperature structural evolution of orthochromate RECrO3 (RE = Y, Eu-Lu) single crystals grown by the floating-zone method with a laser-diode furnace. An anomaly in the evolution of lattice parameters was found in the LuCrO3 single crystal, possibly due to the loss of both spin and orbital angular moments of Lu3+ ions leading to the disappearance of magnetostriction effect. The evolution of Bragg (0 2 0), (1 1 2), (2 0 0), and (0 2 1) peaks was monitored, showing regular variations with rare-earth ionic radius indicating changes in lattice constants.
JOURNAL OF SOLID STATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qian Zhao, Kaitong Sun, Yinghao Zhu, Zirui Zhao, Hai-Feng Li
Summary: This study used high-resolution synchrotron X-ray diffraction to investigate the crystallographic information of the YCrO3 compound. The results show that local crystalline distortion is an important factor in the formation of ferroelectric order.
JOURNAL OF APPLIED CRYSTALLOGRAPHY
(2022)
Article
Chemistry, Physical
Pengfei Zhou, Kaitong Sun, Shunping Ji, Zirui Zhao, Ying Fu, Junchao Xia, Si Wu, Yinghao Zhu, Kwun Nam Hui, Hai-Feng Li
Summary: As a typical solid-state electrolyte, Na1+xZr2SixP3-xO12 NASICONs provide a platform for solid-state batteries with higher safety and energy densities. Improving ionic conductivity and reducing interfacial resistance between electrolytes and cathode materials are crucial for higher-efficiency solid-state batteries, which usually require high craftsmanship and high-pressure equipment. This study introduces an effective additive, MgF2, in synthesizing NASICONs, resulting in electrolytes with improved performance and fewer defects.
MATERIALS TODAY ENERGY
(2023)
Article
Polymer Science
Zhe Pan, Minmin Mao, Bin Zhang, Zhongyu Li, Kaixin Song, Hai-Feng Li, Zhu Mao, Dawei Wang
Summary: In this manuscript, bisphenol F epoxy resin (EPF) was fabricated into polymer films using a hot-pressing method. The curing degree of EPF was found to be significantly affected by the ratio of EP monomer/curing agent, resulting in improved breakdown strength and energy storage performance. Specifically, an EPF film with an EP monomer/curing agent ratio of 1:1.5 achieved a high discharged energy density (U-d) of 6.5 J.cm(-3) and efficiency (eta) of 86% under an electric field of 600 MV.m(-1), demonstrating the facile production of high-quality EP films with excellent energy storage performance for pulse power capacitors.
Article
Materials Science, Multidisciplinary
Junchao Xia, Yi Huang, Xiao Xu, Yong Yu, Yan Wang, Kaitong Sun, Dasha Mao, Yitao Jiao, Hai-Feng Li, Jiaqing He
Summary: Fabricating the Sb2Te3(SnTe)(n) compound is an effective way to enhance the thermoelectric performance of SnTe by suppressing the lattice thermal conductivity and optimizing the band structure. The cation-site compensation approach is proposed to manipulate the transport properties in the Sb2Te3(SnTe)(10) alloy, and Mn compensation has the most appealing effect. By finely manipulating electron and phonon transports, the Sb2Te3(SnMn0.08Te)(10) alloy achieves a peak ZT of about 1.3 at 773 K and an average ZT of about 0.78 (300-823 K).
MATERIALS TODAY PHYSICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Pengfei Zhou, Zirui Zhao, Kaitong Sun, Qian Zhao, Fangyuan Xiao, Ying Fu, Hai-Feng Li
Summary: The solid-state battery (SSB) is a promising solution for addressing safety issues in commercial batteries and energy storage systems. However, the development of SSBs is hindered by the low ionic conductivity of solid-state electrolytes. In this study, a cobalt-doping strategy was developed using a machine learning method to improve the ionic conductivity of the NASICON compound. The strategy proved to be successful in enhancing the NASICONs' ionic conductivity and structural performance.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Materials Science, Ceramics
Junchao Xia, Jianmin Yang, Kaitong Sun, Dasha Mao, Xiaoke Wang, Hai-Feng Li, Jiaqing He
Summary: The TE performance of Mg-alloyed SnTe was enhanced by managing lattice defects. Suppression of Sn vacancies led to higher carrier mobility and power factor compared to Bi-doped SnTe. Dense dislocation arrays in Bi-doped SnTe resulted in ultra-low lattice thermal conductivity. The combination of Sn-compensation and Bi-doping achieved high power factor and low lattice thermal conductivity simultaneously.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2023)
Article
Biochemical Research Methods
Ying Ellie Fu, Kaitong Sun, Yinghao Zhu, Hai-Feng Li
Summary: This article presents a protocol for the growth of RECrO3 crystals using a laser-diode floating-zone furnace. The successful growth of large orthochromate single crystals enables the exploration of their properties and potential applications.
Article
Engineering, Biomedical
Yue Quan, Ziyu Huang, Yuxin Wang, Yu Liu, Sen Ding, Qian Zhao, Xiuping Chen, Haifeng Li, Zikang Tang, Bingpu Zhou, Yinning Zhou
Summary: This study investigated the responses of H9c2 cells to ultramicromagnetic micropillar arrays and found that these micropillars significantly enhanced cell proliferation, cytoskeletal rearrangements, and contractility. Additionally, they were able to decrease reactive oxygen species (ROS) levels, preventing F-actin degeneration. These findings have important implications for the regulation and detection of cell behaviors.
MATERIALS TODAY BIO
(2023)
Article
Materials Science, Multidisciplinary
S. Yano, Chin -Wei Wang, Yinghao Zhu, Kaitong Sun, Hai-Feng Li
Summary: We investigated the magnetic phase transitions of ErCrO3 using single-crystal and powder samples. The study found that ErCrO3 exhibits different structural phases at different temperatures, with the F1 (Gy;CzR) phase dominating at low temperatures and the F4 (Gx, Fz) phase being more significant at high temperatures.
Article
Materials Science, Multidisciplinary
Zhenyuan Zeng, Xiaoyan Ma, Si Wu, Hai-Feng Li, Zhen Tao, Xingye Lu, Xiao-hui Chen, Jin-Xiao Mi, Shi-Jie Song, Guang-Han Cao, Guangwei Che, Kuo Li, Gang Li, Huiqian Luo, Zi Yang Meng, Shiliang Li
Summary: This study investigates the magnetic properties of YCu3(OH)(6)Br-2[Br1-x(OH)(x)] and finds that its magnetic ground state is consistent with the proposed candidate ground state in the two-dimensional kagome Heisenberg antiferromagnetic system.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)