期刊
ACTA PHARMACEUTICA SINICA B
卷 5, 期 3, 页码 210-214出版社
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2015.01.012
关键词
Flower buds; Loincera japonica; Caprifoliaceae; Glucosylated caffeoylquinic acid; Coxsackie virus B3
资金
- National Natural Science Foundation of China (NNSFC) [20772156, 30825044]
- Program for Changpang Scholars and Innovative Research Team in University (PCSIRT) [IRT1007]
- National Science and Technology Project of China [2012ZX09301002-002]
Three new glucosylated caffeoylquinic acid isomers (1-3), along with six known compounds, have been isolated from an aqueous extract of the flower buds of Lonicera japonica. Structures of the new compounds were determined by spectroscopic and chemical methods as (-)-4-O-(4-O-beta-D-glucopyranosylcaffeoyl)quinic acid (-)-3-O-(4-O-beta-D-glucopyranosylcaffeoyl)quinic acid (2), and (-)-5-O-(4-O-beta-D-glucopyranosylcaffeoyl)quinic acid (3), respectively. In the preliminary in vitro assays, two known compounds methyl caffeate and 2'-O-methyladenosine showed inhibitory activity against Coxsackie virus B3 with IC50 values of 3.70 mu mol/L and 6.41 mu mol/L and SI values of 7.8 and 12.1, respectively. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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