Article
Acoustics
V Faure-Bardon, J. Fourgeaud, J. Stirnemann, M. Leruez-Ville, Y. Ville
Summary: The study demonstrates the effectiveness of high-dosage maternal oral valacyclovir in reducing fetal infection rates in cases of cytomegalovirus maternal primary infection, confirming the feasibility and benefits of secondary prevention in a clinical setting with established screening policies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Virology
Pauline Sartori, Charles Egloff, Najeh Hcini, Christelle Vauloup Fellous, Claire Perillaud-Dubois, Olivier Picone, Leo Pomar
Summary: Cytomegalovirus infection is a common congenital infection, affecting approximately 1% of global births. Various prevention strategies are available during pregnancy to mitigate the immediate and long-term consequences of this infection, including education, vaccines, screening, prenatal diagnosis, and preventive and curative treatments in utero.
Article
Infectious Diseases
Paola Zelini, Piera d'Angelo, Marica De Cicco, Cristian Achille, Antonella Sarasini, Loretta Fiorina, Daniela Cirasola, Valentina Marazzi, Stefania Piccini, Milena Furione, Alessia Arossa, Giulia Muscettola, Arsenio Spinillo, Daniele Lilleri
Summary: This study investigates the frequency and characteristics of non-primary infection of human cytomegalovirus (HCMV) in pregnant women. The findings suggest that non-primary infection is common during pregnancy, but the risk of congenital infection is low. The study also examines the transmission routes and immune response during pregnancy.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Immunology
Jacob Amir, G. Chodick, Joseph Pardo
Summary: This study evaluates the efficacy of valaciclovir in preventing vertical cytomegalovirus transmission with a revised protocol. The results show that valaciclovir is effective in preventing vertical transmission, especially when initiated earlier.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Bar Zemer Tov, Asnat Walfisch, Naama Schwartz, Hila Meir, Vered Kleitman
Summary: Higher social class, residing in a central district, and higher parity are identified as significant risk factors for CMV seroconversion during pregnancy among army personnel.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Pediatrics
Megan H. Pesch, Mark R. Schleiss
Summary: This article reviews recent developments in the understanding of congenital cytomegalovirus (cCMV), including epidemiology and transmission, diagnostic strategies, newborn screening programs, therapeutics, and vaccine trials. It discusses how this knowledge informs the pathophysiology of cCMV and directs strategies for improving outcomes and quality of life for infected children. The article also provides an update on the epidemiology of cCMV in the United States, evolving understanding of maternal-fetal transmission, enhanced screening approaches, and recognition of neonatal and long-term sequelae. Finally, it reviews the current landscape of pediatric cCMV research and gives recommendations for future investigation.
Article
Obstetrics & Gynecology
Hannah Greye, Thomas Wex, Elina Taneva, Anke Redlich, Serban-Dan Costa, Anke Rissmann
Summary: The aim of this study was to determine the seroprevalence rate for cytomegalovirus (CMV) in pregnant women and the rate of CMV serological testing utilised during pregnancy in a rural region in Germany. The study found that out of 19,511 pregnant women, only 3,800 underwent CMV serological testing, with 2,081 of them testing negative and a seroconversion rate of 0.37-1.42%.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Pediatrics
Fabiola Scaramuzzino, Michela Di Pastena, Sara Chiurchiu, Lorenza Romani, Maia De Luca, Giulia Lucignani, Donato Amodio, Annalisa Seccia, Pasquale Marsella, Teresa Grimaldi Capitello, Daniela Longo, Paolo Palma, Laura Lancella, Stefania Bernardi, Paolo Rossi, Francesca Ippolita Calo Carducci
Summary: This study found that children born to mothers with secondary cytomegalovirus (CMV) infection have similar risks of symptomatic congenital CMV (cCMV) and long-term sequelae as those born to mothers with primary CMV infection. It is important to pay appropriate attention to seropositive mothers in order to prevent reinfection and to detect and possibly treat infected babies.
FRONTIERS IN PEDIATRICS
(2022)
Review
Obstetrics & Gynecology
Karl Wehbe, Lucille Pencole, Martin Lhuaire, Jeanne Sibiude, Laurent Mandelbrot, Isabelle Villena, Olivier Picone
Summary: This systematic review aimed to assess the effectiveness of hygiene measures during pregnancy to prevent toxoplasmosis infection. The findings suggest that hygiene measures are effective primary prevention strategies in reducing toxoplasmosis and avoiding congenital toxoplasmosis and its consequences.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2022)
Article
Infectious Diseases
Rituparna Das, Daniel Blazquez-Gamero, David Bernstein, Soren Gantt, Oliver Bautista, Karen Beck, Anthony Conlon, Daniel I. S. Rosenbloom, Dai Wang, Michael Ritter, Beth Arnold, Paula Annunziato, Kevin L. Russell
Summary: This study evaluated the safety and efficacy of the V160 vaccine in CMV-seronegative women. The results showed that the three-dose V160 vaccine did not reduce the incidence of CMV infection, but it was generally well-tolerated and immunogenic. This study provides insights for the design of future CMV vaccine trials.
LANCET INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Mara J. Dinsmoor, Lida M. Fette, Brenna L. Hughes, Dwight J. Rouse, George R. Saade, Uma M. Reddy, Donna Allard, Gail Mallett, Elizabeth A. Thom, Cynthia Gyamfi-Bannerman, Michael W. Varner, William H. Goodnight, Alan T. N. Tita, Maged M. Costantine, Geeta K. Swamy, Kent D. Heyborne, Edward K. Chien, Suneet P. Chauhan, Yasser Y. El-Sayed, Brian M. Casey, Samuel Parry, Hyagriv N. Simhan, Peter G. Napolitano, George A. Macones
Summary: This study evaluated the sensitivity and specificity of amniocentesis in detecting congenital cytomegalovirus infection. The results suggest that amniocentesis is an accurate predictor of congenital cytomegalovirus infection with high sensitivity and specificity.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Medicine, General & Internal
Iren A. Kopcsone Nemeth, Csaba Nador, Laszlo Szilagyi, Akos Lehotsky, Tamas Haidegger
Summary: The ability of healthcare workers to learn proper hand hygiene is an important factor in reducing hospital infections. This study found that some staff members were able to quickly learn the technique, while others struggled even with more disinfectant. Identifying these individuals helps improve training efforts.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Nawa Schirwani-Hartl, Pilar Palmrich, Christina Haberl, Nicole Perkmann-Nagele, Herbert Kiss, Angelika Berger, Judith Rittenschober-Bohm, Gregor Kasprian, Patric Kienast, Asma Khalil, Julia Binder
Summary: This retrospective analysis investigated the efficacy of administering hyperimmune globulin (HIG) therapy every 2 weeks compared to every 4 weeks in pregnant women with primary cytomegalovirus (CMV) infection. The study found no significant difference in congenital CMV rates or fetal ultrasound and magnetic resonance imaging (MRI) anomalies between the two groups. Larger studies are needed to evaluate the impact of administering HIG every 2 weeks on maternal-fetal transmission rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Suresh B. Boppana, Michiel van Boven, William J. Britt, Soren Gantt, Paul D. Griffiths, Scott D. Grosse, Terri B. Hyde, Tatiana M. Lanzieri, Marisa M. Mussi-Pinhata, Sarah E. Pallas, Swetha G. Pinninti, William D. Rawlinson, Shannon A. Ross, Ann C. T. M. Vossenm, Karen B. Fowler
Summary: Cytomegalovirus is the most common infectious cause of congenital malformation and is a leading cause of sensory neural hearing loss and motor cognitive deficits. The global burden of congenital CMV infection may be underestimated, but there are candidate vaccines in development and licensure is possible within the next five years.
Article
Public, Environmental & Occupational Health
Qiongjie Zhou, Qiaomei Wang, Haiping Shen, Yiping Zhang, Shikun Zhang, Xiaotian Li, Ganesh Acharya
Summary: A substantial proportion of Chinese women planning pregnancy were susceptible to cytomegalovirus before conception, with low to moderate levels of immunoglobulin G seropositivity and significant geographic variation. Regional differences in seropositivity should be considered in the integration of cytomegalovirus antibody testing in preconception screening programs to develop prevention strategies targeting congenital infections.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Obstetrics & Gynecology
Enrico Ferrazzi, Paolo Beretta, Stefano Bianchi, Irene Cetin, Paolo Guarnerio, Anna Locatelli, Anna Maria Marconi, Mario Giuseppe Meroni, Giulia Pavone, Armando Pintucci, Federico Prefumo, Valeria Savasi, Arsenio Spinillo, Beatrice Tassis, Patrizia Vergani, Michele Vignali, Fabio Parazzini, Carlo La Vecchia
Summary: Universal testing for pregnant women during the COVID-19 pandemic is suggested as a useful strategy. During the study period, 3.1% of pregnant women tested positive for SARS-Cov-2, a significantly higher proportion than estimated by health authorities. Among the positive cases, 44.9% had symptoms or reported close contact with positive patients.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Surgery
Paolo Sala, Stefano Bogliolo, Fabio Barra, Alessandra Fazio, Mattia Maramai, Chiara Cassani, Barbara Gardella, Luciana Babilonti, Flavio Giannelli, Serafina Mammoliti, Arsenio Spinillo, Simone Ferrero, Mario Valenzano Menada, Sergio Costantini, Paolo Bruzzi, Pierangelo Marchiole
Summary: This retrospective study demonstrated improved survival outcomes for patients undergoing neoadjuvant chemotherapy followed by radical surgery compared to those undergoing concurrent chemo-radiotherapy. Therefore, our findings support the use of neoadjuvant chemotherapy as an effective alternative to standard therapy before radical surgery.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Emanuela Miceli, Alessandro Vanoli, Catherine Klersy, Gino Roberto Corazza, Antonio Di Sabatino
Summary: Approximately half of potential autoimmune gastritis patients will progress to overt autoimmune gastritis within two years, especially those with concurrent autoimmune disorders.
DIGESTIVE AND LIVER DISEASE
(2022)
Letter
Dermatology
S. M. A. Ahmed, M. Volonte, E. Isoletta, C. Vassallo, C. F. Tomasini, D. Lilleri, P. Zelini, V. Musella, C. Klersy, V. Brazzelli
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Oncology
Emanuele Cereda, Richard Tancredi, Catherine Klersy, Federica Lobascio, Silvia Crotti, Sara Masi, Silvia Cappello, Nicole Stobaus, Maja Tank, Sara Cutti, Luca Arcaini, Elisabetta Bonzano, Sara Colombo, Paolo Pedrazzoli, Kristina Norman, Riccardo Caccialanza
Summary: In cancer patients, muscle weakness is a more powerful predictor of survival than bioelectrical impedance analysis-estimated skeletal muscle mass, and should be considered as an additional key feature of sarcopenia.
Letter
Medicine, General & Internal
F. Calabretta, P. S. Preti, M. Russo, C. Klersy, A. Di Sabatino
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Virginia V. Ferretti, Catherine Klersy, Raffaele Bruno, Sara Cutti, Rossella E. Nappi
Summary: There are differences in the severity and mortality rate of COVID-19 between the sexes, with women having better outcomes. The role of sex steroid hormones and menopause in causing this gender disparity has not been proven. A retrospective analysis in Italy showed that men had higher mortality rates after the age of 65, particularly among those aged over 80.
Article
Nutrition & Dietetics
Francesca Garofoli, Iolanda Mazzucchelli, Micol Angelini, Catherine Klersy, Virginia Valeria Ferretti, Barbara Gardella, Giulia Vittoria Carletti, Arsenio Spinillo, Chryssoula Tzialla, Stefano Ghirardello
Summary: This study investigated the association between perinatal leptin concentrations and growth trajectories of newborns during their first year. The results showed an inverse correlation between leptin levels and maternal plasma and milk. Premature infants seemed to be most affected by leptin, and low leptin levels appeared to hinder their ability to regain a normal body weight within one year.
Article
Medicine, General & Internal
Andrea Demarchi, Giulio Conte, Shih-Ann Chen, Li-Wei Lo, Wei-Tso Chen, Tom De Potter, Peter Geelen, Andrea Sarkozy, Francesco R. Spera, Tobias Reichlin, Laurent Roten, Pascal Defaye, Adrien Carabelli, Serge Boveda, Hamed Bourenane, Lisa Riesinger, Simon Kochhauser, Gala Caixal, Lluis Mont, Daniel Scherr, Martin Manninger, Francesco Pentimalli, Stefano Cornara, Catherine Klersy, Angelo Auricchio
Summary: This study evaluated the efficacy and long-term follow-up of catheter ablation in patients with previous pulmonary lobectomy/pneumonectomy history and atrial fibrillation. The results showed that catheter ablation by radiofrequency or cryoablation is feasible and safe for these patients, with similar efficacy observed in both males and females over a median follow up of 29.7 months.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Giulia Borgonovo, Elen Vettus, Alessandra Greco, Laura Anna Leo, Francesco Fulvio Faletra, Catherine Klersy, Moreno Curti, Mariacarla Valli
Summary: This study aims to investigate early tissue changes related to chemo-induced and radiation-induced cardiotoxicity in breast cancer patients using cardiac imaging and circulating biomarkers. The study will enroll 150 women with stage I-III unilateral breast cancer and collect baseline and follow-up data. The results will provide evidence on the optimal screening imaging for cardiotoxicity.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Biochemistry & Molecular Biology
Paola Zelini, Piera D'Angelo, Emanuele Cereda, Catherine Klersy, Peressini Sabrina, Riccardo Albertini, Giuseppina Grugnetti, Anna Maria Grugnetti, Carlo Marena, Sara Cutti, Daniele Lilleri, Irene Cassaniti, Baldanti Fausto, Riccardo Caccialanza
Summary: The levels of vitamin D are associated with the immune response elicited by the BNT162b2 vaccine, and adequate levels of vitamin D may improve the vaccine's effectiveness.
Article
Cardiac & Cardiovascular Systems
Francesca Romana Gentile, Enrico Baldi, Catherine Klersy, Sebastian Schnaubelt, Maria Luce Caputo, Christian Clodi, Jolie Bruno, Sara Compagnoni, Alessandro Fasolino, Claudio Benvenuti, Hans Domanovits, Roman Burkart, Roberto Primi, Gerhard Ruzicka, Michael Holzer, Angelo Auricchio, Simone Savastano
Summary: A study found that ECG features can predict the 30-day survival rate of patients after out-of-hospital cardiac arrest. Age >62 years, female sex, QRS wider than 120 ms, the presence of a Brugada pattern, and ST-segment elevation in >1 segment were independently associated with 30-day mortality. By dividing the population into three risk classes based on a score, significant differences in survival rates at 30 days were observed.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Francesca Toto, Laura Leo, Catherine Klersy, Tiziano Torre, Thomas Theologou, Alberto Pozzoli, Elena Caporali, Stefanos Demertzis, Enrico Ferrari
Summary: The study evaluated the clinical outcomes and hemodynamic performance of two standard aortic bioprostheses. The results showed that the postoperative outcomes and mid-term follow-up were similar between the Trifecta and Perimount bioprostheses. Although the Trifecta valve showed better hemodynamic performance in the early postoperative period, this advantage did not persist over time. There was no difference in the reoperation rate for structural valve degeneration between the two valves.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Medicine, General & Internal
Andreas Haeberlin, Fabian Noti, Alexander Breitenstein, Angelo Auricchio, Tobias Reichlin, Giulio Conte, Catherine Klersy, Moreno Curti, Etienne Pruvot, Giulia Domenichini, Beat Schaer, Michael Kuehne, Michal Gruszczynski, Haran Burri, Richard Kobza, Christian Grebmer, Francois D. Regoli, Francesco Pelliccia
Summary: This study analyzed the procedural outcomes of transvenous lead extraction (TLE) during device upgrade, and found that TLE is effective and does not pose a disproportionate risk to the upgrade procedure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Enrico Ferrari, Alberto Pozzoli, Catherine Klersy, Francesca Toto, Tiziano Torre, Tiziano Cassina, Giovanni Pedrazzini, Stefanos Demertzis
Summary: This study compared the outcomes of transcatheter aortic valve replacement (TAVR) procedures performed through alternative access routes. The results showed that both transapical and direct transaortic TAVR procedures provided satisfactory clinical results and had similar thirty-day outcomes in high-risk patients with severe aortic valve stenosis and diseased peripheral arteries.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)