期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 184, 期 2, 页码 192-201出版社
WILEY
DOI: 10.1111/bjh.15703
关键词
CD138 plasma cells; Syndecan-1; IgG4-producing plasma cells; Hodgkin's lymphoma; tumour microenvironment
类别
Plasma cells are important prognostic actors in different malignancies. The tumour microenvironmental composition in classic Hodgkin lymphoma (cHL) is a major prognostic key element; however, clinicopathological studies regarding plasma cells in cHL are lacking. The aim of this study was to investigate CD138+ (also termed SDC1+) plasma cell and IgG4 producing (IgG4+) plasma cells infiltration in the microenvironment of cHL. Immunohistochemistry with anti-CD138 and IgG4 antibodies was performed on diagnostic tumour biopsies from 124 patients with cHL, on tissue micro array (TMA). In 120 cases, CD138+ plasma cell-infiltration was associated with the presence of B-symptoms (P = 0.028) and advanced stage, IIB-IVB (P = 0.009). In multivariate analysis, CD138+ plasma cells correlated with eosinophil infiltration (P = 0.013). The subgroup of IgG4+ plasma cells was analysed in 122 cases and only correlated to CD138+ plasma cells (P = 0.004). Patients with high proportion of tumour infiltrating CD138+ plasma cells (defined as >= 10%), had a more inferior event-free survival (P = 0.007) and overall survival (P = 0.004) than patients with a low proportion of infiltrating CD138+ plasma cells (<10%), although significance was not maintained in multivariate analysis. In summary, a high proportion of tumour-associated plasma cells in cHL reflect an important component in the microenvironment of cHL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据