Article
Immunology
Yaya Zhou, Xing Shi, Wei Fu, Fei Xiang, Xinliang He, Bohan Yang, Xiaorong Wang, Wan-Li Ma
Summary: This study revealed the difference in gut microbiota composition between moderate COVID-19 patients with and without fever. Patients with fever showed enrichment of potential pathogens, while those without fever had higher levels of anti-inflammatory and protective bacteria.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Takuo Emoto, Tomohiro Hayashi, Tokiko Tabata, Tomoya Yamashita, Hikaru Watanabe, Tomoya Takahashi, Yasuhiro Gotoh, Kenjiro Kami, Naofumi Yoshida, Yoshihiro Saito, Hidekazu Tanaka, Kensuke Matsumoto, Tetsuya Hayashi, Takuji Yamada, Ken-ichi Hirata
Summary: The study found that in HF patients, the abundance of cntA/B is positively correlated with TMAO levels, mainly derived from the genera Escherichia and Klebsiella. Microbial dysbiosis may be a potential therapeutic target for HF.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Immunology
Li-Juan Lv, Sheng-Hui Li, Ji-Ying Wen, Guang-Yang Wang, Hui Li, Tian-Wen He, Qing-Bo Lv, Man-Chun Xiao, Hong-Li Duan, Min-Chai Chen, Zhou-Ting Yi, Qiu-Long Yan, Ai-Hua Yin
Summary: This study compared the gut microbiome of patients with preeclampsia (PE) and healthy pregnant women. The results showed that the gut microbiota of PE patients had certain enriched species and microbial functions, while the gut microbiome of healthy pregnant women had different enriched species and functions. The diagnostic potential of gut microbial biomarkers for PE was also developed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Haibo Fu, Liangzhi Zhang, Chao Fan, Chuanfa Liu, Wenjing Li, Jiye Li, Xinquan Zhao, Shangang Jia, Yanming Zhang
Summary: Our study revealed that wild yaks and half-blood yaks had higher abundance of the phylum Firmicutes in their gut microbiota, while domestic yaks showed reduced abundance of this bacterial group. Wild yaks displayed higher microbial diversity compared to domestic yaks. Wild yaks harbored microbial pathways crucial for host digestion and growth, while domestic yaks had higher abundance of methane-metabolism-related pathways in their gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Giovanni Forcina, Lucia Perez-Pardal, Julio Carvalheira, Albano Beja-Pereira
Summary: The development of DNA sequencing technology has had a significant impact on research in animal nutrition, health, and breeding. The gut microbiome plays a crucial role in the health and production performance of livestock, but current research has focused on a small number of globally distributed varieties, neglecting local breeds and other microbial components.
Article
Medicine, General & Internal
Yalei Cao, Haojie Wang, Zirun Jin, Jing Hang, Hui Jiang, Huajun Wu, Zhe Zhang
Summary: This study found significant differences in gut microbial diversity between patients with non-obstructive azoospermia (NOA) and control individuals. The study also identified microbial strains that had differential abundance in the two groups. These findings suggest that gut microbiota may play a significant role in the pathogenesis of NOA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Microbiology
Gensheng Liu, Pinghua Li, Liming Hou, Qing Niu, Guang Pu, Binbin Wang, Taoran Du, Sung Woo Kim, Peipei Niu, Qiang Li, Ruihua Huang
Summary: Utilizing high fiber and low-cost crop coproducts can help alleviate competition between people and livestock for crops. Microbial fermentation in the large intestine plays a significant role in the digestion of dietary fibers in pigs. Research on the gut microbiota of pigs with high fiber digestibility revealed potential new types of microorganisms associated with fiber digestion and highlighted specific gene families contributing to cellulose and hemicellulose degradation. Lignin degradation genes were found to be more abundant in pigs with high fiber digestibility, indicating a stronger fiber digestion potential.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Xiangning Bai, Aswathy Narayanan, Piotr Nowak, Shilpa Ray, Ujjwal Neogi, Anders Sonnerborg
Summary: The gut microbiome plays a significant role in HIV-1 immunopathogenesis, with HIV-1-infected individuals on ART showing reduced alpha diversity and increased beta diversity compared to HIV-1-negative controls. Specific species, such as Streptococcus anginosus, Actinomyces odontolyticus, and Rothia mucilaginosa, were enriched in the HIV-1-ART group. The degree of immunodeficiency correlated with gut microbiome composition and metabolic pathways, while microbial shifts were associated with changes in virulome and resistome. Methodological evaluations highlighted the impact of DNA extraction protocols on genomic DNA quantity and quality, as well as the importance of metagenome sequencing depth for recovering microbial genes. Less than 5 million reads per sample were found sufficient for taxonomy profiling in human fecal metagenomic samples.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yan Li, Haiting Sun, Yufen Huang, Anqi Yin, Linjuan Zhang, Jiao Han, Yixuan Lyu, Xiangzhao Xu, Yifang Zhai, Huan Sun, Ping Wang, Jinyang Zhao, Silong Sun, Hailong Dong, Feng Zhu, Qiang Wang, Luis Augusto Rohde, Xuefeng Xie, Xin Sun, Lize Xiong
Summary: Attention-deficit/hyperactivity disorder (ADHD) is a highly heterogeneous psychiatric disorder, and the gut microbial characteristics of patients may be associated with the development and symptomatic presentations of ADHD.
Article
Genetics & Heredity
Florence Thirion, Finn Sellebjerg, Yong Fan, Liwei Lyu, Tue H. Hansen, Nicolas Pons, Florence Levenez, Benoit Quinquis, Evelina Stankevic, Helle B. Sondergaard, Thomas M. Dantoft, Casper S. Poulsen, Sofia K. Forslund, Henrik Vestergaard, Torben Hansen, Susanne Brix, Annette Oturai, Per Soelberg Sorensen, Stanislav D. Ehrlich, Oluf Pedersen
Summary: This study found significant differences in the gut microbiota of patients with multiple sclerosis, which are directly associated with inflammation markers. In treatment-naive cases, the bacterial richness is positively linked to disease activity. However, two symbiotic bacterial species that produce beneficial immune-modulating compounds were found in non-disease-active cases, providing a rationale for testing these bacteria as adjunct therapeutics in future clinical trials.
Article
Microbiology
Mei Luan, Mengtian Niu, Pengju Yang, Dan Han, Yudan Zhang, Weizhe Li, Qiannan He, Yixin Zhao, Binyue Mao, Jianan Chen, Kuanhou Mou, Pan Li
Summary: The gut microbiota compositions and genetic functions of patients with non-segmental vitiligo are different from those of healthy controls. Identified gut microbial markers may be used for earlier diagnosis and treatment targets.
Article
Cell Biology
Qiaoxing Liang, Jing Li, Yanli Zou, Xiao Hu, Xiuli Deng, Bin Zou, Yu Liu, Lai Wei, Lingyi Liang, Xiaofeng Wen
Summary: The study revealed that DED is associated with a dysbiosis of the conjunctival microbiota, characterized by decreased alpha-diversity and increased inter-individual variation. Specific microbial species showed abnormal abundance in DED, with different associations seen in various subtypes of the disease. This suggests potential for personalized treatment approaches based on microbial signatures in DED.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Chi-Hsuan Sung, Rachel Pilla, Chih-Chun Chen, Patricia Eri Ishii, Linda Toresson, Karin Allenspach-Jorn, Albert E. Jergens, Stacie Summers, Kelly S. Swanson, Holger Volk, Teresa Schmidt, Helene Stuebing, Johanna Rieder, Kathrin Busch, Melanie Werner, Anja Lisjak, Frederic P. Gaschen, Sara E. Belchik, M. Katherine Tolbert, Jonathan A. Lidbury, Joerg M. Steiner, Jan S. Suchodolski
Summary: DNA shotgun sequencing is an untargeted approach for identifying changes in relative abundances, while qPCR allows reproducible quantification of specific bacteria. The canine dysbiosis index (DI) assesses the canine fecal microbiota by using a mathematical algorithm based on qPCR results. qPCR-based DI effectively predicts overall microbiota shifts observed by shotgun sequencing in dogs.
Article
Immunology
Jin-Xin Meng, Xin-Yu Wei, Huanping Guo, Yu Chen, Wei Wang, Hong-Li Geng, Xing Yang, Jiang Jiang, Xiao-Xuan Zhang
Summary: In this study, shotgun metagenomics was used to analyze the composition and function of the gut microbiota in mice during acute and chronic Toxoplasma gondii infection. The results showed that T. gondii infection decreased gut bacterial diversity immediately, but increased with the duration of infection. Dysbiosis of gut microbiota was observed in both acute and chronic infection periods. The functional analysis revealed distinct variations in KEGG pathways and CAZy family between infected and healthy mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemical Research Methods
Carlo Ferravante, Domenico Memoli, Domenico Palumbo, Paolo Ciaramella, Antonio Di Loria, Ylenia D'Agostino, Giovanni Nassa, Francesca Rizzo, Roberta Tarallo, Alessandro Weisz, Giorgio Giurato
Summary: HOME-BIO is a comprehensive pipeline for metagenomics data analysis, comprising three independent analytical modules designed for an inclusive analysis of large NGS datasets. It is a powerful and easy-to-use tool that can be run by users with limited computational expertise, allowing in-depth analyses and customization according to specific user needs.
BMC BIOINFORMATICS
(2021)
Article
Pediatrics
Yuanyuan Qi, Peng Shi, Renjie Chen, Yufeng Zhou, Lijuan Liu, Jianguo Hong, Lanfang Cao, Yanming Lu, Xiaoyan Dong, Jing Li, Yu Shi, Min Xia, Bo Ding, Liling Qian, Libo Wang, Wenhao Zhou, Yonghao Gui, Xiaobo Zhang
Summary: Asthma and allergic skin diseases were the most common ADs in outpatient and emergency departments during the study period. Respiratory tract infection was the most common comorbidity of asthma in children. More attention should be paid to the treatment of comorbidities to improve childhood AD outcomes.
Article
Genetics & Heredity
Feifan Xiao, Yulan Lu, Bingbing Wu, Bo Liu, Gang Li, Ping Zhang, Qinhua Zhou, Jinqiao Sun, Huijun Wang, Wenhao Zhou
Summary: NGS has been used to detect SCID patients with DCLRE1C variants, revealing various compound variants and highlighting the importance of not ignoring DCLRE1C gene deletions in these patients.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Yun Cao, Siyuan Jiang, Jianhua Sun, Mingyan Hei, Laishuan Wang, Huayan Zhang, Xiaolu Ma, Hui Wu, Xiaoying Li, Huiqing Sun, Wei Zhou, Yuan Shi, Yanchen Wang, Xinyue Gu, Tongling Yang, Yulan Lu, Lizhong Du, Chao Chen, Shoo K. Lee, Wenhao Zhou
Summary: This cohort study evaluated care practices and outcomes for very preterm infants in Chinese neonatal intensive care units. The findings suggest that survival rates and survival without major morbidity for these infants in China are lower compared to high-income countries, highlighting the need for clinical quality improvement and health services reorganization to enhance outcomes.
Article
Genetics & Heredity
Lin Yang, Zejun Wei, Xiang Chen, Liyuan Hu, Xiaomin Peng, Jin Wang, Chunmei Lu, Yanting Kong, Xinran Dong, Qi Ni, Yulan Lu, Bingbing Wu, Huijun Wang, Katia Meirelles, Xia Tian, Jing Zhang, Fengqi Chang, Liu Liu, Changhua Li, Wesley You, Guoqiang Cheng, Laishuan Wang, Yun Cao, Chao Chen, Ping Fang, Sha Tang, Wenhao Zhou
Summary: The study demonstrates the clinical utility of focused medical exome sequencing in NICU patients, with a diagnostic rate of 12.3% in 2303 sick neonates. Diagnosed patients showed direct impacts on medical management, highlighting the significance of more focused care for NICU cohorts.
Article
Dentistry, Oral Surgery & Medicine
Y. Qiao, W. Gong, B. Li, R. Xu, M. Wang, L. Shen, H. Shi, Y. Li
Summary: The oral microbiota of children with autism spectrum disorder (ASD) can contribute to ASD-like behaviors, differences in microbial community structures, and altered neurosignaling activities in recipient mice.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Neurosciences
Zhuo Li, Gang Lu, Enli Luo, Bin Wu, Zhe Li, Jianwen Guo, Zhangyong Xia, Chunye Zheng, Qiaozhen Su, Yan Zeng, Wai Yee Chan, Xianwei Su, Xinmin Qiu, Xirun Zheng, Qiaodi Cai, Yanjuan Xu, Yingjun Chen, Yuzhen Fan, Weiwei Chen, Zecheng Yu, Xinjie Chen, Chunying Zheng, Mingbang Wang, Wai Sang Poon, Xiaodong Luo
Summary: The study identified significant differences in microbiota composition in the oral cavity and gut between PD patients and healthy controls, with correlations to clinical characteristics and metabolic pathways. Dysbiosis in the oral and gut microbiota may influence PD progression through metabolism and inflammation-related pathways. This suggests potential therapeutic targets for understanding and treating PD.
Article
Pediatrics
Xueli Zhang, Shujuan Zeng, Guoqiang Cheng, Liufang He, Mingqiu Chen, Mingbang Wang, Wenhao Zhou, Huixian Qiu, Zhangxing Wang
Summary: This study found that the diversity of gut microbiota and the relative abundance of probiotic Lactobacillus were significantly decreased in the neonatal jaundice group, while potentially harmful gut bacteria such as Escherichia coli and Staphylococcus were significantly increased. The gut microbiota showed a positive correlation with clinical indicators, suggesting that gut microbiota composition may be a potential biomarker for neonatal jaundice.
Article
Genetics & Heredity
Chunquan Cai, Zhaoqing Yin, Aiping Liu, Hui Wang, Shujuan Zeng, Zhangxing Wang, Huixian Qiu, Shijun Li, Jiaxiu Zhou, Mingbang Wang
Summary: This study systematically assessed gene mutations in immune mediators in patients with ASD and found rare variants associated with ASD, suggesting that these genetic variants may serve as new targets for the clinical genetic assessment of ASD.
Article
Pediatrics
Yingmei Xie, Hui Wang, Bing Hu, Xueli Zhang, Aiping Liu, Chunquan Cai, Shijun Li, Cheng Chen, Zhangxing Wang, Zhaoqing Yin, Mingbang Wang
Summary: Autism spectrum disorder (ASD) affects around 1% of children with no effective blood test or cure. Recent studies have suggested that ASD is a neurological disorder with a strong genetic basis and abnormal formation of dendritic spines. Chromosome microarray (CMA) and whole-exome sequencing (WES) were used to identify new candidate genes for ASD. The study identified a de novo variant in the CTTNBP2 gene, which is associated with dendritic spine formation and provides genetic evidence for ASD spine pathology.
Article
Immunology
Caiyan Zhang, Tingyan Liu, Yixue Wang, Weiming Chen, Jing Liu, Jinhao Tao, Zhengzheng Zhang, Xuemei Zhu, Zhenyu Zhang, Meixiu Ming, Mingbang Wang, Guoping Lu, Gangfeng Yan
Summary: This study used mNGS to characterize the microbiome of BALF in children with severe pneumonia and identified potentially pathogenic microorganisms. The study found that bacterial combined with viral or fungal infections may be present in the BALF of patients with severe pneumonia, and viral or fungal infections are associated with greater disease severity and death.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Neurosciences
Lin Wan, Xiuyu Shi, Huimin Yan, Yan Liang, Xinting Liu, Gang Zhu, Jing Zhang, Jing Wang, Mingbang Wang, Guang Yang
Summary: This study found significant differences in pre-treatment gut microbiota and serum metabolome between children with IESS who responded to ACTH and those who did not. The presence of maleficent Clostridioides and Peptoclostridium_phage_p630P in the gut may be associated with treatment response. This information can guide treatment selection and potential interventions for children with IESS.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
James T. Morton, Dong-Min Jin, Robert H. Mills, Yan Shao, Gibraan Rahman, Daniel McDonald, Qiyun Zhu, Metin Balaban, Yueyu Jiang, Kalen Cantrell, Antonio Gonzalez, Julie Carmel, Linoy Mia Frankiensztajn, Sandra Martin-Brevet, Kirsten Berding, Brittany D. Needham, Maria Fernanda Zurita, Maude David, Olga V. Averina, Alexey S. Kovtun, Antonio Noto, Michele Mussap, Mingbang Wang, Daniel N. Frank, Ellen Li, Wenhao Zhou, Vassilios Fanos, Valery N. Danilenko, Dennis P. Wall, Paul Cardenas, Manuel E. Baldeon, Sebastien Jacquemont, Omry Koren, Evan Elliott, Ramnik J. Xavier, Sarkis K. Mazmanian, Rob Knight, Jack A. Gilbert, Sharon M. Donovan, Trevor D. Lawley, Bob Carpenter, Richard Bonneau, Gaspar Taroncher-Oldenburg
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by diverse cognitive, behavioral, and communication impairments. This study proposes a framework using Bayesian differential ranking algorithm to identify ASD-associated molecular and taxa profiles across various datasets. The findings suggest a functional architecture in the gut-brain axis (GBA) that correlates with ASD phenotypes and involves microbial species in specific genera. Additionally, temporal changes in the microbiome composition were strongly associated with ASD phenotypes.
NATURE NEUROSCIENCE
(2023)
Review
Genetics & Heredity
Yulian Fang, Yaqiong Cui, Zhaoqing Yin, Mengzhu Hou, Pan Guo, Hanjie Wang, Nan Liu, Chunquan Cai, Mingbang Wang
Summary: This study conducted a systematic review and meta-analysis on the association between genetic variants and autism spectrum disorder (ASD) risk. The results revealed significant associations between certain single nucleotide polymorphisms (SNPs) of candidate genes, including CNTNAP2, MTHFR, OXTR, and VDR, and increased ASD risk.
Article
Biochemistry & Molecular Biology
Aiping Liu, Chunquan Cai, Zhangxing Wang, Bin Wang, Juntao He, Yanhong Xie, Honglian Deng, Shaozhi Liu, Shujuan Zeng, Zhaoqing Yin, Mingbang Wang
Summary: The altered urine metal concentrations may serve as important risk factors for ASD, and further research is recommended to explore the mechanisms and clinical treatment measures for such alterations.
Article
Biochemistry & Molecular Biology
Shujuan Zeng, Zhangxing Wang, Peng Zhang, Zhaoqing Yin, Xunbin Huang, Xisheng Tang, Lindong Shi, Kaiping Guo, Ting Liu, Mingbang Wang, Huixian Qiu
Summary: By analyzing the meconium metabolome of neonates, the study found significant differences in gut metabolites between neonates with jaundice and healthy controls. Levels of branched-chain amino acids (BCAAs) were positively correlated with serum bilirubin levels, and these metabolites have the potential to be biomarkers for neonatal jaundice.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)