Article
Biochemistry & Molecular Biology
Fulong Li, Baipeng Chen, Ming Xu, Yang Feng, Yongqiang Deng, Xiaoli Huang, Yi Geng, Ping Ouyang, Defang Chen
Summary: In this study, the pathogenic bacteria Elizabethkingia miricola was isolated from diseased bullfrogs, and transcriptome analysis revealed its role in immune activation and inflammatory response in the frog brain. This study is significant for identifying therapeutic targets and establishing effective measures to prevent and control bullfrog meningitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wenjun Shao, Yue Huang, Lili Wang, Penghui Li, Yan Jia, Jiewen Zhang
Summary: The study found that Fgl2 can alleviate the symptoms and damage of autoimmune myelitis by reducing TLR9 expression, indicating its potential role in the treatment of autoimmune diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yujie Zhou, Songyan Yu, Wenyong Zhang
Summary: Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins that play a central role in the immune system. Recent research has shown that NLRs have significant impacts on gastrointestinal inflammatory diseases and cancers. Understanding the role and molecular mechanism of NLR signaling pathways may lead to the development of new therapeutic strategies for these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
John Le, Yathushigan Kulatheepan, Samithamby Jeyaseelan
Summary: The respiratory system has various innate immune mechanisms to cope with microbial infections and limit tissue damage. Macrophages, neutrophils, dendritic cells, epithelial cells, and endothelial cells play key roles in this immune response. Recognition of invading microorganisms by the myeloid and structural cells of the respiratory system triggers a signaling cascade that leads to the activation of transcription factors, induction of cytokines/chemokines, recruitment of immune cells, and subsequent clearance of microbes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuting Ji, Liya Sun, Yuan Liu, Yanhui Li, Tongxuan Li, Jiameng Gong, Xiali Liu, Huiqiang Ma, Jingying Wang, Bing Chen, Shan-Yu Fung, Hong Yang
Summary: Excessive activation of Toll-like receptor (TLR) signaling pathways and the circulating endotoxin are important in the development of inflammatory diseases. Researchers have constructed three types of hexapeptide-modified nano-hybrids and found that peptide-modified lipid-core nanomicelles show strong TLR inhibitory activities. Mechanistic studies reveal that lipid-core nanomicelles can bind to and scavenge lipophilic TLR ligands, blocking the ligand-receptor interaction and regulating TLR signaling outside the cell. The peptide modification also enables the nanomicelles to modulate endosomal TLR signal transduction inside macrophages. In a mouse model, intratracheal administration of these nanomicelles effectively reduces lung inflammation and injuries. This study provides new strategies for developing therapeutic nanodevices for treating inflammatory diseases.
Article
Agriculture, Dairy & Animal Science
Bingxin Li, Longsheng Hong, Yindan Luo, Bingqi Zhang, Ziyu Yu, Wanyan Li, Nan Cao, Yunmao Huang, Danning Xu, Yugu Li, Yunbo Tian
Summary: LPS is a virulence factor of Gram-negative bacteria and its excessive concentration in geese can induce liver damage and reduce production performance. In this study, transcriptome sequencing analysis identified 727 differentially expressed genes related to LPS-induced liver injury and enrichment analysis showed the involvement of Toll-like receptor, MAPK, NOD-like receptor, FoxO, and PPAR signaling pathways. The TLR7-mediated MAPK signaling pathway played a major role in LPS-induced liver injury in geese.
Article
Cell Biology
Linlin Ying, Hao Wu, Shuaishuai Zhou, Han Lu, Manyi Ding, Bo Wang, Shanshan Wang, Yanjun Mao, Fenglin Xiao, Yao Li
Summary: The experiment aimed to investigate the Toll-like receptor signaling pathway of quercetin regulating avian beta-defensin (AvBD) in the ileum of Arbor Acre (AA) broilers. The results showed that dietary supplementation with quercetin significantly decreased the mortality rate of broilers and had a positive impact on the intestinal microecological balance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoling Peng, Jihong Wang, Zheng Li, Xiaoqian Jia, Anqi Zhang, Jie Ju, Volker Eulenburg, Feng Gao
Summary: This study explores the role of TLR2 in morphine tolerance and its relationship with melatonin and NLRP3 inflammasome. It is found that morphine tolerance is associated with increased TLR2 expression and NLRP3 inflammasome activation in the spinal cord, while melatonin level is down-regulated. Chronic melatonin administration reduces TLR2 expression and NLRP3 inflammasome activation, partially restoring the analgesic effect of morphine. Inhibition of TLR2 and microglia activation attenuates the development of morphine tolerance by restoring spinal melatonin level and suppressing NLRP3 inflammasome signaling.
NEUROCHEMICAL RESEARCH
(2023)
Article
Immunology
Jeremy Kiripolsky, Eileen M. Kasperek, Chengsong Zhu, Quan-Zhen Li, Jia Wang, Guan Yu, Jill M. Kramer
Summary: Primary Sjogren's syndrome, predominantly seen in women, is characterized by exocrine gland dysfunction and serious systemic manifestations. Research suggests that ECM degradation may represent a novel source of chronic B cell activation in the context of pSS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Long-Fei Li, Grace G-L Yue, Ben C-L Chan, Qiang Zeng, Quan-Bin Han, Ping-Chung Leung, Kwok-Pui Fung, Ji-Kai Liu, Clara B-S Lau
Summary: The water-soluble components of edible mushroom Rubinoboletus ballouii were investigated for their immunomodulatory properties. Polysaccharides of Rubinoboletus ballouii were found to promote the maturation of dendritic cells and increase the secretion of certain cytokines. In addition, these polysaccharides showed potential for restoring immune function in immunosuppressed mice.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Applied
Burak Barut, Can Ozgur Yalcin, Yasemin Altun, Didem Akkaya, Elif Nur Barut, Hueseyin Bas, Zekeriya Biyiklioglu
Summary: In this study, compound 3a was synthesized and tested on A549 lung cancer cells. The results showed that 3a significantly reduced cell viability and induced apoptosis when irradiated with red light. The Toll-like receptor signaling pathway and related protein expression were also observed to change. This suggests that 3a can induce A549 cell death in a dose and red-light irradiation time-dependent manner and may be an effective candidate for photodynamic therapy in lung cancer treatment.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rana Al-Sadi, Viszwapriya Dharmaprakash, Prashant Nighot, Shuhong Guo, Meghali Nighot, Toan Do, Thomas Y. Ma
Summary: The probiotic bacteria BB1 causes a strain-specific enhancement of the intestinal TJ barrier through a novel mechanism involving BB1 attachment to the enterocyte TLR-2 receptor complex and activation of p38 kinase pathway. This enhancement is sustained, and BB1 strain designated as BB1 causes a maximal enhancement in TJ barrier function. The mechanism of BB1 enhancement of intestinal TJ barrier is mediated by the p38 kinase pathway, not the NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Walter V. Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T. Grimaldo, Avantika Krishna, Michael J. Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina de la Garza, Marco Ramos-Castaneda, Scott E. Evans, Seyed Javad Moghaddam
Summary: By knocking out TLR2, 4, and 9 genes, we found that TLRs play an important role in the promotion of K-ras-driven lung adenocarcinoma by COPD-like airway inflammation caused by prolonged exposure to pathogenic foreign antigens in airway epithelial cells. Knockout of TLR2, 4, or 9 resulted in reduced tumor burden, angiogenesis, and tumor cell proliferation, accompanied by increased tumor cell apoptosis and reprogramming of the tumor microenvironment to an antitumorigenic state. Knocking out downstream signaling pathways, MyD88/NF-kappa B, in airway epithelial cells further confirmed these findings. Our study expands the understanding of TLR signaling in lung cancer and may contribute to the development of more reliable and effective prevention and treatment modalities for lung cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kiran Shabir, Seley Gharanei, Sophie Orton, Vanlata Patel, Parbata Chauhan, Emmanouil Karteris, Harpal S. Randeva, James E. Brown, Ioannis Kyrou
Summary: Adipose tissue functions as an endocrine organ by secreting various adipokines that regulate metabolism and other physiological processes. The altered secretion of adipokines has been associated with obesity and cardio-metabolic diseases. Asprosin, a recently discovered adipokine, is elevated in cardio-metabolic diseases and has pro-inflammatory effects, at least in part through the TLR4 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ziyuan Zhang, Yaling Hu, Wenyuan Liu, Xiaodong Zhang, Ruihua Wang, Hui Li, Dalin Sun, Jingai Fang
Summary: Based on transcriptomics analysis, this study found that Yishen capsule can reduce microalbuminuria and alleviate pathological changes in DN rats, which may be achieved by regulating the NOD-like receptor signaling pathway.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Evolutionary Biology
Ismail Sahin Gul, Jens Staal, Paco Hulpiau, Evi De Keuckelaere, Kai Kamm, Tom Deroo, Ellen Sanders, Katrien Staes, Yasmine Driege, Yvan Saeys, Rudi Beyaert, Ulrich Technau, Bernd Schierwater, Frans van Roy
GENOME BIOLOGY AND EVOLUTION
(2018)
Article
Multidisciplinary Sciences
Kai Kamm, Hans-Juergen Osigus, Peter F. Stadler, Rob DeSalle, Bernd Schierwater
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Mansi Srivastava, Emina Begovic, Jarrod Chapman, Nicholas H. Putnam, Uffe Hellsten, Takeshi Kawashima, Alan Kuo, Therese Mitros, Asaf Salamov, Meredith L. Carpenter, Ana Y. Signorovitch, Maria A. Moreno, Kai Kamm, Jane Grimwood, Jeremy Schmutz, Harris Shapiro, Igor V. Grigoriev, Leo W. Buss, Bernd Schierwater, Stephen L. Dellaporta, Daniel S. Rokhsar
Article
Multidisciplinary Sciences
Bernd Schierwater, Kai Kamm, Mansi Srivastava, Daniel Rokhsar, Rafael D. Rosengarten, Stephen L. Dellaporta
Article
Biochemistry & Molecular Biology
Frederique Varoqueaux, Elizabeth A. Williams, Susie Grandemange, Luca Truscello, Kai Kamm, Bernd Schierwater, Gaspar Jekely, Dirk Fasshauer
Letter
Biochemistry & Molecular Biology
Hans-Jurgen Osigus, Sarah Rolfes, Rebecca Herzog, Kai Kamm, Bernd Schierwater
Article
Multidisciplinary Sciences
Kai Kamm, Hans-Juergen Osigus, Peter F. Stadler, Rob DeSalle, Bernd Schierwater
SCIENTIFIC REPORTS
(2019)
Article
Evolutionary Biology
Hideyuki Miyazawa, Hans-Juergen Osigus, Sarah Rolfes, Kai Kamm, Bernd Schierwater, Hiroaki Nakano
Summary: Placozoans, the simplest known metazoan animals, are classified into 20 haplotypes belonging to three genera. Their mitochondrial genomes show unique features and variations in size, gene order, and exon-intron boundaries among different clades. Phylogenomic analyses reveal a different tree topology from previous studies, with interesting patterns of small inverted repeats present in all mitochondrial genomes of the Trichoplax and Hoilungia genera.
GENOME BIOLOGY AND EVOLUTION
(2021)
Review
Biochemistry & Molecular Biology
Bernd Schierwater, Hans-Juergen Osigus, Tjard Bergmann, Neil W. Blackstone, Heike Hadrys, Jens Hauslage, Patrick O. Humbert, Kai Kamm, Marc Kvansakul, Kathrin Wysocki, Rob DeSalle
Summary: Trichoplax adhaerens, the placozoan, is a tiny, simply organized organism lacking symmetry, organs, nerve cells, and muscle cells. Its genome is the smallest among metazoans, making it a potential model for understanding the minimal requirements of metazoan animal organization.
Review
Biochemistry & Molecular Biology
Bernd Schierwater, Hans-Jurgen Osigus, Tjard Bergmann, Neil W. Blackstone, Heike Hadrys, Jens Hauslage, Patrick O. Humbert, Kai Kamm, Marc Kvansakul, Kathrin Wysocki, Rob DeSalle
Summary: The placozoan Trichoplax adhaerens serves as a unique animal bridging different research disciplines. It has been a subject of hot evolutionary debates and challenges some fundamental concepts. In part 2, the exceptional genetics of the phylum Placozoa and challenging model system applications of Trichoplax adhaerens are discussed.
Article
Evolutionary Biology
Kai Kamm, Bernd Schierwater
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2007)
Article
Evolutionary Biology
Kai Kamm, Bernd Schierwater
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2006)
Article
Biochemistry & Molecular Biology
Kai Kamm, Bernd Schierwater, Wolfgang Jakob, Stephen L. Dellaporta, David J. Miller
Article
Gastroenterology & Hepatology
K Kamm, S Hoppe, G Breves, B Schröder, M Schemann
NEUROGASTROENTEROLOGY AND MOTILITY
(2004)