Article
Agriculture, Multidisciplinary
Wang Kai, Wu Ping-xian, Chen De-juan, Zhou Jie, Yang Xi-di, Jiang An-an, Ma Ji-deng, Tang Qian-zi, Xioa Wei-hang, Jiang Yan-zhi, Zhu Li, Qiu Xiao-tian, Li Ming-zhou, Li Xue-wei, Tang Guo-qing
Summary: A genome-wide scan was performed to detect selection signatures in the domestication process of Landrace and Yorkshire pigs, revealing that genes associated with basic metabolism, disease resistance, body morphology, and organ control were subject to selection pressure. This study provides new insights into the potential genetic variation of phenotypic diversity in different pig breeds and helps understand the selection effects of modern breeding in these pigs.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Article
Genetics & Heredity
Rui Cao, Jian Feng, Yuejin Xu, Yifei Fang, Wei Zhao, Zhenyang Zhang, Zhe Zhang, Meng Li, Qishan Wang, Yuchun Pan
Summary: This study investigated the genetic differences and introgression between Lulai pigs, Laiwu pigs, and Yorkshires, identifying significantly different genes and genomic regions. The findings reveal the genetic exchanges among these breeds and shed light on the molecular background of synthesized Lulai pig breeds.
Article
Genetics & Heredity
Kai Wang, Pingxian Wu, Dejuan Chen, Jie Zhou, Xidi Yang, Anan Jiang, Weihang Xiao, Xiaotian Qiu, Yangshuang Zeng, Xu Xu, Guoqing Tang
Summary: The study found that genes related to immunity, disease resistance, and metabolism in Chinese domestic pigs underwent strong selection pressure during domestication and evolution, while genes related to appearance, production performance, and reproduction underwent strong artificial selection in commercial pig breeds.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2021)
Article
Multidisciplinary Sciences
Jose Miguel Rodriguez-Lopez, Manuel Lachica, Lucrecia Gonzalez-Valero, Ignacio Fernandez-Figares
Summary: The study measured metabolic responses to glucose infusion in Iberian and Landrace pigs, showing that Iberian pigs had higher levels of insulin, lactate, triglycerides, and urea, while lower levels of glucose, creatinine, and cholesterol compared to Landrace pigs. The results suggest that growing Iberian pigs may exhibit early signs of insulin resistance.
Article
Agronomy
Blazej Nowak, Anna Mucha, Magdalena Moska, Magdalena Zaton-Dobrowolska, Wojciech Kruszynski
Summary: The study analyzed 12 microsatellite markers related to litter size in Polish Large White and Polish Landrace sows, finding significant differences in reproductive traits between the two breeds. The results suggest the need for breed-specific markers for future research.
Article
Agriculture, Dairy & Animal Science
Mahboob Alam, Hyuk-Kee Chang, Seung-Soo Lee, Tae-Jeong Choi
Summary: The study investigated the genetic parameters of production and reproduction traits in Korean Duroc, Landrace, and Yorkshire pigs, revealing moderate to high heritability of production traits and low heritability of reproduction traits. Genetic correlations were found between certain traits, emphasizing the importance of careful breeding plans. The findings suggest potential for further improvement through selective breeding in Korean pig populations.
Article
Genetics & Heredity
Wei Zhang, Mei Zhou, Linqing Liu, Shiguang Su, Lin Dong, Xinxin Meng, Xueting Li, Chonglong Wang
Summary: This study conducted a genome-wide comparison of CNVs between Wannan black pigs and Asian wild boars, identifying selected CNVs related to muscle, reproduction, residual feed intake, and ear size. The findings provide important information for further research on the genetic basis of complex phenotypic traits in Wannan black pigs and offer guidance for their protection and utilization.
Article
Ecology
Peter D. Price, Daniela H. Palmer Droguett, Jessica A. Taylor, Dong Won Kim, Elsie S. Place, Thea F. Rogers, Judith E. Mank, Christopher R. Cooney, Alison E. Wright
Summary: This paper examines the main approaches for studying gene expression evolution, tests their inherent biases and discusses open questions about the evolution of the transcriptome.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Agriculture, Dairy & Animal Science
Artur Gurgul, Igor Jasielczuk, Anna Miksza-Cybulska, Aldona Kawecka, Tomasz Szmatola, Jedrzej Krupinski
Summary: The study found that the genetic structures of the populations of the seven conserved sheep breeds or local populations in Poland are not heavily affected, except for the Swiniarka breed. Each breed has distinct genetic profiles with signs of common origin and admixture, similar to other worldwide sheep populations. The analysis identified loci of the genome with the strongest divergence between the breeds, primarily due to artificial selection, providing a basis for further studies aimed at identifying sources of genetic variation in these sheep breeds.
Article
Genetics & Heredity
Yachun Han, Tao Tan, Zixin Li, Zheng Ma, Ganqiu Lan, Jing Liang, Kui Li, Lijing Bai
Summary: This study analyzed the genetic diversity and selection signatures associated with important economic traits in Huainan (HN) pigs and Yunan (YN) black pigs. The results identified specific genetic regions and potential candidate genes related to these traits, as well as tissue-specific regulatory elements in YN black pigs.
Article
Biotechnology & Applied Microbiology
Kai Wang, Pingxian Wu, Shujie Wang, Xiang Ji, Dong Chen, Weihang Xiao, Yiren Gu, Yangshuang Zeng, Xu Xu, Guoqing Tang
Summary: In this study, DNA methylation differences between the Chinese Qingyu pig and the Landrace pig were explored using reduced representation bisulfite sequencing (RRBS). Six genomic regions were identified as key regions associated with phenotypic differences, and five differentially methylated genes (ADCY1, FUBP3, GRIN2B, KIT, and PIK3R6) were identified as key candidate genes associated with meat characteristics. These findings provide new insights into the epigenetic research of the Chinese Qingyu pig.
Article
Biochemistry & Molecular Biology
Piotr Pawlicki, Anna Galuszka, Laura Pardyak, Ryszard Tuz, Bartosz J. Plachno, Martyna Malopolska, Klaudia Dubniewicz, Ping Yang, Malgorzata Kotula-Balak, Kazimierz Tarasiuk
Summary: The study explores the functional status of Leydig cells after immunocastration, providing important knowledge for the diagnosis and treatment of testis dysfunction caused by hormone imbalances and Leydig cell abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yanyue Li
Summary: This study analyzed the miRNAomes of Landrace and Neijiang pig backfat, identified differentially expressed miRNAs related to lipid metabolism, and suggested a potential biomarker for Neijiang pig breeding.
Article
Clinical Neurology
Sydney E. Sneed, Kelly M. Scheulin, Erin E. Kaiser, Madison M. Fagan, Brian J. Jurgielewicz, Elizabeth S. Waters, Samantha E. Spellicy, Kylee J. Duberstein, Simon R. Platt, Emily W. Baker, Steven L. Stice, Holly A. Kinder, Franklin D. West
Summary: The study found differences in brain anatomy and gait patterns pre-stroke between YC and LR pigs, but highly comparable stroke pathologies post-stroke. These results suggest that different pig breeds may show similar ischemic stroke response and outcomes, allowing findings to be compared across porcine stroke studies using different breeds.
FRONTIERS IN NEUROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Sirous Eydivandi, Mahmoud Amiri Roudbar, Siavash Salek Ardestani, Mehdi Momen, Goutam Sahana
Summary: The study analyzed genetic diversity in 15 sheep breeds, detecting 629 and 256 genes with selection signatures using F-ST and xp-EHH, respectively. Genes like CIDEA, HGATL, and MGST1 affecting economic traits were identified. Sixty shared genes, including four candidates related to adenosine metabolic procedure, were identified as signatures of selection.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Simlat, Agata Ptak, Anita Jaglarz, Agnieszka Szewczyk, Michal Dziurka, Artur Gurgul
Summary: In this study, a new strain of Pantoea vagans, SRS89, was isolated from surface-sterilized stevia seeds and evaluated using various methods. The strain exhibited certain properties, such as yellow color and Gram-negative classification. Genome sequencing and annotation revealed numerous genes involved in transcription, amino acid and carbohydrate metabolism, as well as carotenoid and terpenoid biosynthesis. The strain also showed the ability to synthesize rebaudioside A, a valuable metabolite.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
A. Ludwiczak, J. Skladanowska-Baryza, B. Kuczynska, E. Sell-Kubiak, M. Stanisz, E. Skrzypczak
Summary: Studying rabbit milk and its attributes is crucial for breeding practice to ensure the health and growth of rabbit kits. This study analyzed the physicochemical properties of rabbit milk and investigated the impact of reproductive status on milk yield and attributes. The results showed that milk production increased from the 2nd to the 14th day of lactation, while milk composition varied significantly with lactation day and pregnancy negatively affected milk production and composition, as well as kits growth. The findings highlight the importance of understanding rabbit milk for optimal breeding outcomes.
Article
Biology
Anna Koseniuk, Grzegorz Smolucha, Artur Gurgul, Tomasz Szmatola, Maria Oczkowicz, Anna Radko
Summary: This study used genotyping-by-sequencing to analyze the genetic diversity of Polish wild boars and domestic pigs, identified DNA regions with significant genetic differences between the two subspecies, and determined genes associated with muscle development, pre-weaning mortality stress, and sensory perception.
FOLIA BIOLOGICA-KRAKOW
(2023)
Article
Biochemistry & Molecular Biology
Ewa Tomaszewska, Malgorzata Swiatkiewicz, Siemowit Muszynski, Janine Donaldson, Katarzyna Ropka-Molik, Marcin B. Arciszewski, Maciej Murawski, Tomasz Schwarz, Piotr Dobrowolski, Sylwia Szymanczyk, Slawomir Dresler, Joanna Bonior
Summary: Chronic pancreatitis (CP) is an irreversible and progressive inflammatory disease. This study aimed to investigate the changes in pro-inflammatory cytokines, antioxidant defense system, and selected serum biochemical parameters in a cerulein-induced CP model in pigs. The study found that repetitive cerulein injections not only led to CP and induced inflammation in the intestine, but also impaired the intestinal barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Alicja Wierzbicka, Malgorzata Swiatkiewicz, Miroslaw Tyra, Tomasz Szmatola, Maria Oczkowicz
Summary: This study compared the effects of cholecalciferol and calcidiol on meat quality and muscle tissue transcriptome. The results suggest that increasing the dose of cholecalciferol and using calcidiol in the diet of finishers may improve meat texture parameters, but have no significant effect on muscle tissue transcriptome.
Article
Biochemistry & Molecular Biology
Ewelina Semik-Gurgul, Tomasz Szmato, Artur Gurgul, Klaudia Pawlina-Tyszko, Anna Galuszka, Rafal Pedziwitr, Maciej Witkowski, Tomasz Zabek
Summary: DNA methylation is a key mechanism in regulating gene expression, and aberrant methylation plays an important role in tumor development. In this study, we used RRBS and RNA-Seq to analyze the methylome and transcriptome of horse sarcoids. We identified thousands of differentially methylated sites and differentially expressed genes, suggesting the involvement of aberrant DNA methylation in the deregulation of gene expression in equine sarcoids. Further enrichment analysis revealed the activation of molecular pathways related to tumor progression. These findings provide valuable insights into the epigenetic alterations in equine sarcoids and can be used for future studies on biomarker identification.
Article
Genetics & Heredity
Ewelina Semik-Gurgul, Artur Gurgul, Tomasz Szmatola
Summary: Recent publications have revealed the important role of long non-coding RNAs (lncRNAs) in gene-specific transcription regulation. However, the role of lncRNA in equine sarcoids, a type of skin neoplasia in horses, has not been investigated yet. This study aims to explore the expression of lncRNA in the pathogenesis of equine sarcoids and its regulatory function in bovine papillomavirus-dependent neoplasia of horse dermal tissues. Through RNA sequencing and methylation analysis, differentially expressed lncRNAs and potential methylation disturbances were identified. The findings provide new insights into the involvement of lncRNA in equine sarcoids.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Agriculture, Dairy & Animal Science
Igor Jasielczuk, Tomasz Szmatola, Anna Miksza-Cybulska, Aldona Kawecka, Artur Gurgul
Summary: This study investigated the linkage disequilibrium, historical effective population size, and haplotype block structure in nine Polish conserved sheep breeds. The results showed that the Illumina OvineSNP50 BeadChip assay is only suitable for reliable genomic breeding value estimation in certain breeds.
SMALL RUMINANT RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Artur Gurgul, Igor Jasielczuk, Tomasz Szmatola, Sebastian Sawicki, Ewelina Semik-Gurgul, Boguslawa Dlugosz, Monika Bugno-Poniewierska
Summary: A genotyping strategy based on Nanopore sequencing was developed for simple and cost-efficient genome-wide analysis in horses. The method generated 28,426 highly accurate polymorphisms, which can be improved by increasing sequencing depth.
Article
Agronomy
Karolina Szulc, Ewa Skrzypczak, Marcin Arszylo
Summary: In Poland, pork consumption remains high despite a decline in the pig population. One potential solution to reduce pig production costs is to use sows of hybrid lines. This study aimed to investigate the reproductive performance of CG36 sows in relation to parity and farrowing season. The results showed that the investigated population had high levels of reproduction traits and young age at first farrowing. The number of piglets born alive, number of piglets weaned per litter, and number of piglets weaned per sow per year reached economically advantageous levels. There was no effect of farrowing season on reproduction traits, indicating optimal environmental conditions in the animal housing. The study also found correlations between certain reproduction traits, suggesting the need to control certain factors to reduce age at first farrowing in CG36 sows.
Article
Oncology
Pawel Przybylski, Anna Lewinska, Iwona Rzeszutek, Dominika Bloniarz, Aleksandra Moskal, Gabriela Betlej, Anna Deregowska, Martyna Cybularczyk-Cecotka, Tomasz Szmatola, Grzegorz Litwinienko, Maciej Wnuk
Summary: In this study, three mitochondria-targeted quercetin derivatives were synthesized and tested against six breast cancer cell lines with different mutation and receptor status. The activity of the quercetin derivatives was found to be modulated by the mutation status. One derivative induced apoptosis in breast cancer cells at a concentration of 1 μM. The derivatives also eliminated doxorubicin-induced senescent breast cancer cells and sensitized these cells to apoptosis.
Article
Agriculture, Dairy & Animal Science
Tomasz Szmatola, Artur Gurgul, Igor Jasielczuk, Katarzyna Ropka-Molik
Summary: This study analyzed runs of homozygosity and heterozygosity in a large population of Holstein cattle using medium-density and high-density SNP panels. The results showed that the high-density SNP panel allowed for more precise identification of runs of homozygosity patterns compared to the medium-density panel.
ANNALS OF ANIMAL SCIENCE
(2023)