Apatinib affect VEGF-mediated cell proliferation, migration, invasion via blocking VEGFR2/RAF/MEK/ERK and PI3K/AKT pathways in cholangiocarcinoma cell

Targeting Angiogenesis in Biliary Tract Cancers: An Open Option

(2017) Valeria Simone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progression-free survival of up to 8 months of an advanced intrahepatic cholangiocarcinoma patient treated with apatinib: a case report

(2017) Fu-chao Ma et al.   OncoTargets and Therapy

Insulin-Like Growth Factor-1 and Vascular Endothelial Growth Factor in Malignant and Benign Biliary Obstructions

(2016) Ahmed Abdel-Razik et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Intracellular autocrine VEGF signaling promotes EBDC cell proliferation, which can be inhibited by Apatinib

(2016) Sui Peng et al.   CANCER LETTERS

Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma

(2016) Hong Peng et al.   Oncotarget

VEGFR2 inhibition by RNA interference affects cell proliferation, migration, invasion, and response to radiation in Calu-1 cells

(2015) Y. Liu et al.   Clinical & Translational Oncology

Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors

(2014) Florian Ewald et al.   INVESTIGATIONAL NEW DRUGS

Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo

(2014) DONGSHENG XU et al.   ONCOLOGY REPORTS

Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma

(2013) Sumera Rizvi et al.   GASTROENTEROLOGY

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

(2013) Sampurna Chatterjee et al.   JOURNAL OF CLINICAL INVESTIGATION

Chemotherapy for cholangiocarcinoma: An update

(2013) Natalia Ramírez-Merino   World Journal of Gastrointestinal Oncology

YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivo

(2011) Shu Tian et al.   CANCER SCIENCE

Prognostic Value of Cirrhosis for Intrahepatic Cholangiocarcinoma After Surgical Treatment

(2011) Ya-yong Li et al.   JOURNAL OF GASTROINTESTINAL SURGERY

VEGF is essential for the growth and migration of human hepatocellular carcinoma cells

(2011) Lei Zhang et al.   MOLECULAR BIOLOGY REPORTS

Molecular Targeted Therapy of Biliary Tract Cancer – Results of the First Clinical Studies

(2010) Marcus W. Wiedmann et al.   CURRENT DRUG TARGETS