Effective bioreactor pH control using only sparging gases

Probing lactate metabolism variations in large-scale bioreactors

(2018) Sen Xu et al.   BIOTECHNOLOGY PROGRESS

Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations

(2016) Sen Xu et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-density mammalian cell cultures in stirred-tank bioreactor without external pH control

(2016) Sen Xu et al.   JOURNAL OF BIOTECHNOLOGY

Equipment characterization to mitigate risks during transfers of cell culture manufacturing processes

(2015) Christian Sieblist et al.   CYTOTECHNOLOGY

Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture

(2015) Benjamin Neunstoecklin et al.   JOURNAL OF BIOTECHNOLOGY

Evaluating the impact of high Pluronic®F68 concentrations on antibody producing CHO cell lines

(2014) Tharmala Tharmalingam et al.   BIOTECHNOLOGY AND BIOENGINEERING

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

(2012) Huong Le et al.   JOURNAL OF BIOTECHNOLOGY

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance

(2011) Jincai Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

(2011) Matthew Gagnon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effects of Elevated pCO2 and Osmolality on Growth of CHO Cells and Production of Antibody-Fusion Protein B1: A Case Study

(2005) Marie M. Zhu et al.   BIOTECHNOLOGY PROGRESS