期刊
BIOTECHNOLOGY ADVANCES
卷 37, 期 4, 页码 519-529出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2018.12.004
关键词
Lignocellulose; Cellulose; Fungi; Genetic engineering; Consolidated bioprocessing
资金
- National Natural Science Foundation of China [31700062]
- Young Scholars Program of Shandong University (YSPSDU)
Filamentous fungi, as the main producers of lignocellulolytic enzymes in industry, need to be engineered to improve the economy of large-scale lignocellulose conversion. Investigation of the cellular processes involved in lignocellulolytic enzyme production, as well as optimization of enzyme mixtures for higher hydrolysis efficiency, have provided effective targets for the engineering of lignocellulolytic fungi. Recently, the development of efficient genetic manipulation systems in several lignocellulolytic fungi opens up the possibility of systems engineering of these strains. Here, we review the recent progresses made in the engineering of lignocellulolytic fungi and highlight the research gaps in this area.
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