Article
Chemistry, Analytical
Ke Shi, Na Na, Jin Ouyang
Summary: We developed a label- and enzyme-free single molecule fluorescence counting strategy for detecting HIV DNA fragments. This method showed high sensitivity and selectivity, making it a promising tool for HIV DNA analysis in clinical applications.
Article
Chemistry, Analytical
Qian Bi, Feng Qiu, Ruo Yuan, Yun Xiang
Summary: This study introduces a highly sensitive and non-label electrochemical biosensor for detecting ACP by inhibiting the coordination of metal ion/PPi and amplifying the signal with G-quadruplex/hemin nanowires. This method allows for the selective and sensitive detection of low levels of ACP in diluted serum samples, without the need for enzymes or nanomaterials.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Shereena Joseph, Soumya Rajpal, Debashree Kar, Shital Devinder, Saurabh Pandey, Prashant Mishra, Joby Joseph
Summary: In this study, an optical detection scheme based on guided mode resonance (GMR) was developed for the identification of a specific bacteria. The sensitivity of the sensor was evaluated and a good detection limit was achieved. The developed GMR biosensor is low-cost, easy to handle, and can be transformed into a portable detection modality.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Multidisciplinary
Sara Hassanpour Tamrin, Amir Sanati Nezhad, Arindom Sen
Summary: Exosomes are cell-derived structures containing lipids, proteins, and nucleic acids, playing roles in physiological and pathological processes. Microfluidic technology offers simple, cost-effective, precise, and fast processing for exosome isolation, yet faces challenges hindering their clinical utility.
Review
Chemistry, Analytical
Pandiyaraj Kanagavalli, Chrysanthus Andrew, Murugan Veerapandian, Mani Jayakumar
Summary: This review provides a comprehensive overview of scalable fabrication methods and applications of hybridized graphene nanostructures as label-free electrochemical biosensor platforms, with a focus on the use of electrodeposition and electroless deposition techniques, as well as surface functionalization strategies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Taiji Dong, Bingkun Gao, Bing Yan, Yekun Zhou, Yunkai Wang, Weicheng Wang, Kaichuan Xu, Chunlei Jiang, Zengbo Wang
Summary: In the field of biomedicine, the development of a tapered fiber optic biosensor (TFOB) allows for nondestructive and label-free detection of individual living cells. Through theoretical and simulation analysis, the fiber tip of the TFOB is found to be a highly sensitive sensing element that translates the intensity change of the evanescent field into changes in output power. Experimental results demonstrate the TFOB's ability to detect low-amplitude vibration signals and measure respiratory vibrations of pasta yeast cells.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Dexin Du, Jue Wang, Mingquan Guo, Jiangnan Shu, Wei Nie, Zhiping Bian, Di Yang, Hua Cui
Summary: Label-free electrochemiluminescence (ECL) immunoassays (lf-ECLIA) have become an attractive method for biomarker detection due to their simplicity, speed, and cost-effectiveness. This study investigated the interaction between biomarkers and analytical interfaces constructed using a nanoluminophore and antibody-functionalized gold nanoparticles. The results showed that positively charged biomarkers increased the ECL intensity, while negatively charged biomarkers decreased the ECL intensity. A charge-dependent lf-ECLIA method was established based on the ECL signal changes, which exhibited different responses to positively charged and negatively charged biomarkers.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
B. Chakraborty, A. Das, N. Mandal, N. Samanta, N. Das, C. Roy Chaudhuri
Summary: This study focused on enhancing mass transport of analyte towards sensor surface using an electric field in a graphene-ZnO nanorods heterostructure, aiming to improve the performance of carcinoembryonic antigen detection platform. The system achieved a detection limit of 1 fg/ml in human serum, which is three orders of magnitude lower than existing attempts on PoC devices. The results demonstrate the potential and value of this approach.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Qiming Chen, Chenhui Yao, Cuiyun Yang, Zhanmin Liu, Sibao Wan
Summary: The study developed a new electrochemical assay for rapid and sensitive detection of L. monocytogenes in food, significantly reducing the detection time. The assay showed good sensitivity and reliability in detecting a range of bacterial concentrations and was confirmed by testing artificially contaminated pork samples.
Article
Chemistry, Analytical
Jianmei Yang, Xiaoyan Gan, Xinmei Song, Ruo Yuan, Yun Xiang
Summary: This article describes a label-free and highly sensitive method for detecting NGAL based on aptamer. The method utilizes metal ion-dependent DNAzyme and exonuclease III (Exo III) triggered signal amplification cascades to detect NGAL in diluted human serums. The biosensor shows high selectivity and has the potential to detect various protein biomarkers for disease diagnosis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Mechanics
Jianyu Guo, Guoquan Nie, Jinxi Liu, Lele Zhang
Summary: In this study, the free vibration of a piezoelectric semiconductor (PSC) plate is analyzed, considering the coupling between deformation, polarization, and carriers within the framework of the first-order shear deformation theory. The effects of steady-state carrier density, axial force, external electric voltage, length-to-thickness ratio, and length-to-width ratio on the free vibration characteristics of the PSC plate are discussed through a detailed parametric study.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2022)
Article
Chemistry, Analytical
Kurt Sy, Neil Adrian P. Ondevilla, Hsuan-Yu Fang, Peng-Wen Liu, Pei -Wen Chen, Jin-Seng Lin, Peng-Ting Chen, Hsien-Chang Chang
Summary: Quantification of lactic acid bacteria is important in the probiotic industry. A rapid bacteria quantification platform was developed, utilizing ring-shaped interdigitated electrodes to concentrate bacteria particles via electrokinetic forces. The platform showed high accuracy, low cost, and fast analysis time, making it suitable for rapid bacteria detection and potential commercial use.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Monika Janik, Ewa Brzozowska, Paula Czyszczon, Anna Celebanska, Marcin Koba, Andrzej Gamian, Wojtek J. Bock, Mateusz Smietana
Summary: A highly sensitive device based on a microcavity in-line Mach-Zehnder interferometer induced in an optical fiber has been developed for fast bacteria detection. This device, when combined with specific low-molecular-weight bioreceptors, can efficiently detect bacteria label-free with a detection capability as low as 10 colony-forming units per mL in a sample volume of only hundreds of picoliters. The sensor is one of the most sensitive and lowest-analyte-volume label-free biosensors among fiber optical platforms.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Kenta Nakama, Mohammed Sedki, Ashok Mulchandani
Summary: A novel chemiresistor biosensor using M13 phage-modified reduced graphene oxide was developed for detecting E. coli. The sensor showed a linear and specific response towards E. coli with high selectivity, indicating potential in detecting coliforms.
ANALYTICA CHIMICA ACTA
(2021)
Article
Materials Science, Composites
Yinghong Yu, Xiao Liu, Xiyue Cui, Yishou Wang, Xinlin Qing
Summary: This study developed an innovative multifunctional piezoelectric-fiber hybrid sensor network for comprehensive monitoring of multiple physical quantities during the curing process of thick carbon fiber-reinforced polymer (CFRP) composites. Three different approaches based on non-invasive and integrated piezoelectric lead-zirconate-titanate (PZT) sensor network were effectively developed to track the degree of cure and key steps using guided wave velocity and amplitude. The proposed sensor network demonstrated its effectiveness in in-situ and real-time monitoring of multiple physical quantities during the curing cycle, contributing to the advancement in smart manufacturing and life-cycle structural health monitoring of composites.
COMPOSITES SCIENCE AND TECHNOLOGY
(2023)
Article
Emergency Medicine
Richard J. Hamilton, Mark Ramzy, Jamie Teufel, Glenn Laub, J. Yasha Kresh
PREHOSPITAL EMERGENCY CARE
(2020)
Editorial Material
Education, Scientific Disciplines
Richard J. Hamilton
Article
Chemistry, Multidisciplinary
Kubra Keser, Hamdi Mihciokur, Mehmet Cagri Soylu
Review
Biotechnology & Applied Microbiology
M. Nguyen, S. G. Joshi
Summary: The increasing global prevalence of carbapenem-resistant Acinetobacter baumannii poses a significant threat to public health, highlighting the urgent need for better understanding of this pathogen and the development of novel treatments and control strategies. This review provides an overview of carbapenem, its importance in hospital medicine, and the peculiarities of the bacterial pathogen A. baumannii, including its virulence factors and resistance mechanisms. Various control strategies for combating carbapenem resistance in hospitals and limiting outbreaks are also discussed.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Furkan Soysaldi, Mehmet Cagri Soylu
Summary: The study found that the QCM-D sensor with the ID coating in DNA detection is 6.4 times more sensitive than the uncoated one. Signal quality exceeded the standard, and comparison under atomic force microscopy showed that ID-MPS was more effective.
Article
Chemistry, Multidisciplinary
Mehmet Cagri Soylu, Sukru Taner Azgin
Summary: This study explored a method using sewage sludge and cow dung to produce organic fertilizer, with a unique QCM detection system for low-level detection of E. coli in vermicompost tea. The results showed that sewage sludge could be a valuable liquid organic fertilizer, and the QCM biosensing demonstrated good detection sensitivity and stability for sensitive measurement of E. coli.
Article
Microbiology
Sandhya T. Chakravarthi, Suresh G. Joshi
Summary: As one of the leading causes of dementia, Alzheimer's disease is characterized by progressive cognitive decline. The exact causes of the pathologies, such as beta-amyloid deposits and neurofibrillary tangles, are mostly unknown, but there is accumulating evidence suggesting an association between infectious diseases and Alzheimer's disease. Certain bacterial species, particularly spirochetes and oral microbes, show correlations with AD pathologies.
Article
Chemistry, Multidisciplinary
Kubra Keser, Mehmet Cagri Soylu
Summary: In this study, a simple, fast, sensitive, and relatively low-cost arsenic detection system with an eco-friendly sensor was developed for real-time monitoring of arsenic in the field. The system showed excellent stability and high sensitivity in detecting phenylarsine oxide (PAO) in drinking water, with the potential to detect other heavy metals in water and different biomarkers in human fluids.
Article
Chemistry, Physical
Canan Alper Billur, Gencosman Sahin, Emine Guneri, Buket Saatci, Mehmet Cagri Soylu
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Proceedings Paper
Engineering, Electrical & Electronic
Ahmet Sari, Okan Zafer Batur, Ceyhun Kirimli
2019 16TH INTERNATIONAL CONFERENCE ON SYNTHESIS, MODELING, ANALYSIS AND SIMULATION METHODS AND APPLICATIONS TO CIRCUIT DESIGN (SMACD 2019)
(2019)
Proceedings Paper
Engineering, Biomedical
Mehmet Cagri Soylu, Fatma Betul Kosker, Melis Keskin, Kubra Keser, Kubra Ceran
2018 MEDICAL TECHNOLOGIES NATIONAL CONGRESS (TIPTEKNO)
(2018)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)