Article
Biochemistry & Molecular Biology
Liangcong Hu, Xudong Xie, Hang Xue, Tiantian Wang, Adriana C. Panayi, Ze Lin, Yuan Xiong, Faqi Cao, Chengcheng Yan, Lang Chen, Peng Cheng, Kangkang Zha, Yun Sun, Guodong Liu, Chenyan Yu, Yiqiang Hu, Ranyang Tao, Wu Zhou, Bobin Mi, Guohui Liu
Summary: miR-1224-5p is a key regulator of bone osteogenesis, which is associated with fracture healing and osteoporosis development. By targeting ADCY2 and the Rap1 signaling pathway, miR-1224-5p can slow down osteoclast differentiation and promote osteoblast differentiation. In vivo experiments showed that overexpression of miR-1224-5p can promote fracture healing and ameliorate the progression of osteoporosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Xia Li, Ruisheng Xu, Jun-Xing Ye, Feng-Lai Yuan
Summary: Oral bisphosphonates (BPs) are commonly used for the treatment of osteoporosis. This study found that long-term BP treatment can modulate the expression of specific microRNAs (miRNAs), specifically miR-30a-5p, which is negatively correlated with bone formation. In vitro and in vivo experiments demonstrated that miR-30a-5p inhibits osteoblastic differentiation and bone formation. This research provides important insights into the regulatory mechanisms of long-term BP treatment in postmenopausal osteoporosis.
Article
Biochemistry & Molecular Biology
Gang Wang, Lifu Wan, Lecheng Zhang, Chao Yan, Yuelei Zhang
Summary: This study found that miR-133a plays a role in regulating cell proliferation, osteoblast differentiation, and adipocyte differentiation of BMSCs by targeting FGFR1. BMSC-specific knockdown of miR-133a can attenuate bone loss.
DNA AND CELL BIOLOGY
(2021)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Yan Xie, Jie Zhou, Lijie Tian, Yuan Dong, Hairui Yuan, Endong Zhu, Xiaoxia Li, Baoli Wang
Summary: miR-196b-5p plays a role in various malignancies and has been found to affect bone cells and bone homeostasis by inhibiting osteoblast differentiation and regulating the Wnt/beta-catenin signaling pathway. Inhibition of miR-196b-5p can reduce ovariectomy-induced bone loss.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xuejun Zhao, Zijie Xia, Ziang Wang, Mengsi Zhou, Xuebing Qiu, Cheng Wang, Tian Xu, Qian Fang, Zhenping Ming, Huifen Dong
Summary: This study reveals that the downregulation of miR-182-5p contributes to the alleviation of liver fibrosis caused by Schistosoma japonicum infection. Knockdown of miR-182-5p leads to increased expression of immunosuppressive protein TTP, which destabilizes inflammatory factor mRNA and attenuates liver fibrosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Zhihao Chen, Ying Huai, Gaoyang Chen, Shuyu Liu, Yan Zhang, Dijie Li, Fan Zhao, Xiaofeng Chen, Wenjing Mao, Xuehao Wang, Chong Yin, Chaofei Yang, Xia Xu, Kang Ru, Xiaoni Deng, Lifang Hu, Yu Li, Songlin Peng, Ge Zhang, Xiao Lin, Airong Qian
Summary: It was found that the level of miR-138-5p was negatively correlated with bone mineral density and osteogenic markers in patients with senile osteoporosis. High levels of miR-138-5p aggravated the decrease in aged osteoblast differentiation and led to bone loss. MiR-138-5p was shown to regulate aged osteoblast differentiation by targeting MACF1. Therapeutic inhibition of miR-138-5p counteracted the decrease in bone formation and aging-related bone loss.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Chenyue Li, Hongxuan Lie, Weifeng Sun
Summary: This study investigates the role of miRNA in regulating ANG and BDNF in oxygen-induced retinopathy mouse model and human retinal microvascular endothelial cells. The findings show that overexpression of miR-182-5p can significantly suppress the expression of ANG and BDNF in HRECs cells, and knockdown of ANG and BDNF by miR-182-5p transfection can improve cell functions.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Yen-Zung Wu, Hsuan-Ti Huang, Tsung-Lin Cheng, Yen-Mou Lu, Sung-Yen Lin, Cheng-Jung Ho, Tien-Ching Lee, Chia-Hao Hsu, Peng-Ju Huang, Han Hsiang Huang, Jhong-You Li, Yu-De Su, Shih-Chieh Chen, Lin Kang, Chung-Hwan Chen
Summary: miRNAs play crucial roles in osteoporosis, and analyzing human blood samples can help identify miRNAs with diagnostic value and therapeutic potential. Further studies are needed to validate their clinical application value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiang-jun Chen, Sha Liu, Dong-mei Han, De-zhi Han, Wei-jing Sun, Xiao-chun Zhao, Jun-qing Liang, Li Yu
Summary: Melanoma is a major skin malignancy with unclear molecular drivers for progression and prognosis. FUT8-AS1 has been identified as a lncRNA related to melanoma prognosis, and its downregulation is associated with aggressive clinical factors. Functionally, FUT8-AS1 suppresses melanoma cell proliferation, migration, and invasion by regulating the NF90/miR-145-5p/NRAS/MAPK signaling axis, highlighting its potential as a therapeutic target for melanoma treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Ziyi Wang, Xinghua Ge, Yan Wang, Yunjie Liang, Huifang Shi, Tao Zhao
Summary: miR-361-5p is highly expressed in PMOP patients and OP rats, and has a good diagnostic effect on PMOP. Dex treatment can increase the expressions of miR-361-5p, VEGFA, and BMD related indexes in OP rats. Additionally, Dex can promote osteogenesis-angiogenesis in BMSCs and decrease apoptosis after coculture with HUVECs.
Article
Oncology
Wei He, Hongyan Jin, Qian Liu, Quanxin Sun
Summary: In this study, it was found that the upregulation of miR-182-5p and downregulation of BNIP3 led to increased radioresistance in NPC cells. BNIP3 was identified as a target of miR-182-5p, and miR-182-5p reversed the inhibitory effect of BNIP3 in 5-8F-R cells. Cellular experiments showed that the upregulation of BNIP3 inhibited cell proliferation, viability, invasion, and migration, while promoting apoptosis in 5-8F-R cells, but these effects were attenuated by the simultaneous upregulation of miR-182-5p.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Orthopedics
Yejian Huang, Minggao Tao, Shixian Yan, Xueming He
Summary: Background studies have shown that long non-coding RNA (lncRNA) affects bone cell differentiation and formation. However, the relationship between lncRNA HAGLR and postmenopausal osteoporosis (PMOP) remains uncertain.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell & Tissue Engineering
Gang Wang, Fengbin Wang, Lecheng Zhang, Chao Yan, Yuelei Zhang
Summary: miR-133a is strongly associated with GIO and similar disorders induced by glucocorticoids in MSCs. Silencing miR-133a resulted in positive effects on GC-treated MSCs and on bone loss in GIO animal models. Moreover, the FGFR1-MAPK/ERK signaling may be involved in the protective effect of miR-133a silencing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Irena Abramovic, Borna Vrhovec, Lucija Skara, Alen Vrtaric, Nora Nikolac Gabaj, Tomislav Kulis, Goran Stimac, Dejan Ljiljak, Boris Ruzic, Zeljko Kastelan, Bozo Kruslin, Floriana Bulic-Jakus, Monika Ulamec, Ana Katusic-Bojanac, Nino Sincic
Summary: Prostate cancer is the most commonly diagnosed neoplasm among men, often resembling benign prostate hyperplasia, necessitating the need for biomarkers with higher differential value. Epigenetic biomarkers in liquid biopsies, especially miRNA, show promise in addressing this challenge. MiR-182-5p and miR-375-3p in blood plasma demonstrate higher performance than PSA in discriminating between PCa and BPH. Further investigation into seminal plasma as a potential source for PCa biomarkers is warranted.