Article
Medicine, Research & Experimental
Chen Yu, Hua Dong, Qingchen Wang, Junzhe Bai, Yan-Ni Li, Juan-Juan Zhao, Jia-Zhu Li
Summary: Danshensu has protective effects against cisplatin-induced nephrotoxicity by improving kidney damage, attenuating abnormal renal function indicators and oxidative stress, activating Nrf2/HO-1, and inhibiting the NF-kappa B pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Muhammad Umar Ijaz, Hussain Ahmed, Asma Ashraf, Sidra Aziz, K. A. Al-Ghanim, Mumtaz Akhtar, M. Nadeem Riaz, Shahid Mahboob
Summary: The study shows that VIT can effectively alleviate cisplatin-induced renal damage in male albino rats by reducing biochemical, inflammatory, and histopathological impairments.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Qisheng Lin, Shu Li, Haijiao Jin, Hong Cai, Xuying Zhu, Yuanting Yang, Jingkui Wu, Chaojun Qi, Xinghua Shao, Jialin Li, Kaiqi Zhang, Wenyan Zhou, Minfang Zhang, Jiayi Cheng, Leyi Gu, Shan Mou, Zhaohui Ni
Summary: This study investigated the mechanism by which mitophagy protects against ferroptosis in cisplatin-induced acute kidney injury. The results showed aggravated iron accumulation, lipid peroxidation, and ferroptosis in mice lacking BNIP3, Pink1, or Park2. Additionally, the synthetic antioxidant ferroptosis inhibitor, Ferrstatin-1, rescued the effects of mitophagy inhibition.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Blessy George, John T. Szilagyi, Melanie S. Joy, Lauren M. Aleksunes
Summary: This study investigates the time-dependent expression and excretion of the protein calbindin and kidney injury molecule-1 (Kim-1) in mice treated with cisplatin. The results show that urinary concentrations of calbindin and Kim-1 increased after cisplatin treatment, with calbindin showing a greater elevation. In addition, there was a decrease in intrarenal calbindin protein levels and an upregulation of calbindin and KIM-1 messenger RNAs on Day 3. These findings suggest that calbindin can be a potential urinary biomarker for kidney damage and can be used in conjunction with Kim-1 to phenotype acute kidney injury caused by cisplatin administration.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Yu-Ping Hsiao, Hsiao-Ling Chen, Jen-Ning Tsai, Meei-Yn Lin, Jiunn-Wang Liao, Meng-Syuan Wei, Jiunn-Liang Ko, Chu-Chyn Ou
Summary: This study demonstrated that LCs probiotic can protect against cisplatin-induced nephrotoxicity by reconstructing and maintaining a healthy gut microbiota structure and diversity, suppressing inflammation, alleviating oxidative stress and fibrosis, reducing kidney damage and toxin production, increasing butyrate production, improving cisplatin-induced dysbiosis, maintaining intestinal barrier integrity, and mediating the gut-kidney axis.
Article
Biochemistry & Molecular Biology
Nada F. Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H. Eisa
Summary: The study demonstrates that quinacrine alleviates cisplatin-induced renal toxicity by upregulating SIRT-1, downregulating inflammatory markers (ICAM-1 and TNF-alpha), reducing oxidative stress, and inhibiting apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Tomohiro Shigematsu, Soichiro Tajima, Rao Fu, Mengyu Zhang, Yuuka Itoyama, Akihiro Tsuchimoto, Nobuaki Egashira, Ichiro Ieiri
Summary: Research shows that everolimus attenuates tacrolimus-induced renal interstitial fibrosis through the inhibition of mTOR signaling. This finding provides guidance for the concomitant use of everolimus and tacrolimus in clinical practice.
Article
Oncology
Rui M. Gil da Costa, Christine Levesque, Daniella Bianchi-Frias, Payel Chatterjee, Hung-Ming Lam, Carlos Santos, Ilsa M. Coleman, Pedro Ferreirinha, Manuel Vilanova, Nazare Pinto da Cunha, Hugo Carvalho, Alexandra Moreira-Pais, Ana Faustino-Rocha, Tiago Neto, Jose Batista da Costa, Jonathan L. Wright, Rita Ferreira, Paula A. Oliveira, Joaquim Mendes, Margarida M. S. M. Bastos, Bruno Colaco, Carlos Lopes, Peter C. Black, Christopher J. Sweeney, Peter S. Nelson
Summary: This study found that most patients with muscle-invasive bladder cancer (MIBC) are not cured by platinum chemotherapy. The up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-?B) is a major mechanism underlying chemoresistance, and its pharmacological inhibition may increase platinum efficacy. Both in vitro and in vivo experiments showed that the NF-?B inhibitor dimethylaminoparthenolide (DMAPT) significantly improved the efficacy of cisplatin, without aggravating immuno-hematological toxicity.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Anne-Marie Begin, Marie-Lawrence Monfette, Etienne Boudrias-Dalle, Emmie Lavallee, Vanessa Samouelian, Denis Soulieres, Miguel Chagnon, Marie-Andree Fournier, Nathalie Letarte, Jean-Philippe Adam
Summary: This retrospective study found that using mannitol in hydration protocols significantly reduces the risk of all grade cisplatin-associated AKI in cancer patients, especially in gynecologic, upper gastrointestinal, urinary tract malignancies, and lymphoma patients. The addition of mannitol did not show significant impact on AKI occurrence in head and neck, lung, germ cells, and other cancer types, however, head and neck cancer patients had fewer grade 2 and 3 AKI events.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Biochemistry & Molecular Biology
Dong-Uk Kim, Dong-Gu Kim, Ji-Won Choi, Joon Yeon Shin, Bitna Kweon, Ziqi Zhou, Ho-Sub Lee, Ho-Joon Song, Gi-Sang Bae, Sung-Joo Park
Summary: The study demonstrates that loganin can attenuate cisplatin-induced acute kidney injury through inhibiting renal damage, inflammatory cytokines release, and cell apoptosis, among other pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Emad H. M. Hassanein, Fares E. M. Ali, Magy R. Kozman, Omnia A. M. Abd El-Ghafar
Summary: This study demonstrates that umbelliferone has a protective effect against gentamicin-induced nephrotoxicity by improving kidney function and histological changes. Umbelliferone regulates multiple biomarkers and protein expressions to suppress inflammation pathways associated with nephrotoxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Yuzhen Li, Lang Shi, Fan Zhao, Yanwen Luo, Mingjiao Zhang, Xiongfei Wu, Jiefu Zhu
Summary: This study reveals the protective effect of PIM1 in cisplatin-induced AKI and suggests that the regulation of Drp1 activation might be the underlying mechanism.
CELLULAR SIGNALLING
(2024)
Review
Chemistry, Multidisciplinary
Chun-yan Fang, Da-yong Lou, Li-qin Zhou, Jin-cheng Wang, Bo Yang, Qiao-jun He, Jia-jia Wang, Qin-jie Weng
Summary: Cisplatin is a clinically advanced anticancer drug, but its severe nephrotoxic effects limit its clinical use. There are currently no effective drugs for cisplatin-induced kidney injury, but natural products may have potential therapeutic effects.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Immunology
Sarah Kroeller, Bianka Wissuwa, Sophie Dennhardt, Nadine Krieg, Christoph Thiemermann, Christoph Daniel, Kerstin Amann, Florian Gunzer, Sina M. Coldewey
Summary: Hemolytic-uremic syndrome (HUS) is a complication of Shiga-toxin (Stx)-producing Escherichia coli infection, presenting with acute kidney injury, hemolytic anemia, and thrombocytopenia. In this study, the researchers investigated the effects of BTK inhibitors (BTKi) on HUS in mice. They found that BTK inhibition attenuated disease progression and reduced renal immune cell invasion. Only ibrutinib treatment improved acute kidney injury and reduced hemolysis. This research suggests that BTK could be a potential target for HUS therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Jui-Yi Chen, Chia-Lin Tsai, Chiao-Yun Tseng, Pei-Rong Yu, Yu-Hsuan Chang, Yue-Ching Wong, Hui-Hsuan Lin, Jing-Hsien Chen
Summary: This study found that lotus seedpod extract (LSE) can alleviate cisplatin-induced nephrotoxicity by reducing oxidative stress and apoptosis in the kidneys.