期刊
BIORESOURCE TECHNOLOGY
卷 277, 期 -, 页码 221-224出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biortech.2019.01.046
关键词
Gluconobacter oxydans NL71; Sorbose; Sorbitol; Biomass; COS-SSB
资金
- Nanjing Forestry University for Scientific Research, People's Republic of China [163030127]
- Key Research and Development Program of Jiangsu, People's Republic of China [BE2015758]
- National Natural Science Foundation of People's Republic China [31370573]
High-efficiency cell proliferation of Gluconobacter oxydans was carried out in a compressed oxygen supply and sealed bioreactor to co-produce biomass and corresponding metabolite (sorbose). Higher cell density of Gluconobacter oxydans was achieved by implementing high-oxygen tension supply strategy resulting into high sorbose production from bio-oxidation of sorbitol. The highest biomass of 8.8 g/L and highest sorbose production of 432.8 g/L were simultaneously obtained after 72 h of fed-batch operation. Moreover, continuous co-production of biomass and sorbose was successfully conducted with retaining 10% sorbitol fermentation broth as the seed of next stage culture. The key features of this bioprocess application would enable cost-competitive Gluconobacter oxydans industrial applications.
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