Article
Multidisciplinary Sciences
Michael N. Trinh, Michael S. Brown, Joachim Seemann, Goncalo Vale, Jeffrey G. McDonald, Joseph L. Goldstein, Feiran Lu
Summary: Asters are involved in the transport of LDL cholesterol from the plasma membrane to the endoplasmic reticulum. Their action primarily depends on phosphatidylserine (PS).
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Cristina M. Ramirez, Marta Torrecilla-Parra, Virginia Pardo-Marques, Mario Fernandez de-Frutos, Ana Perez-Garcia, Carlos Tabraue, Juan Vladimir de la Rosa, Patricia Martin-Rodriguez, Mercedes Diaz-Sarmiento, Uxue Nunez, Marta C. Orizaola, Paqui G. Traves, Marta Camps, Lisardo Bosca, Antonio Castrillo
Summary: Macrophages are immune cells crucial for host defense, with the LXR-Cav-1 axis on the cell membrane playing a significant role in cholesterol efflux and inflammatory responses. Modulation of this axis could potentially control exacerbated inflammation and cholesterol overload in macrophages during lipid and immune disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hironobu Hojo, Toshiki Takei, Yuya Asahina, Nobuaki Okumura, Toshifumi Takao, Masatomo So, Isao Suetake, Takeshi Sato, Akihiro Kawamoto, Yoshio Hirabayashi
Summary: In this study, the essential protein Caveolin-1 for caveola formation was chemically synthesized and successfully inserted into the lipid bilayer to form a V-shaped structure. The solid-phase method was used to synthesize peptide segments, and O-acyl isopeptide structures were incorporated to improve solubility. After ligation by the thioester method and the introduction of palmitoyl groups, the obtained polypeptide was inserted into bicelles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Yong Zhou, Nicholas Ariotti, James Rae, Hong Liang, Vikas Tillu, Shern Tee, Michele Bastiani, Adekunle T. Bademosi, Brett M. Collins, Frederic A. Meunier, John F. Hancock, Robert G. Parton
Summary: Caveolae, specialized domains of the cell membrane, play crucial roles in lipid sorting and creating a unique lipid environment. Caveolin-1 (CAV1) and cavinl sort distinct plasma membrane lipids individually, while together they generate a unique lipid nano-environment. The selective lipid sorting by caveolae, regulated by lipid metabolism and acyl chain remodeling, may facilitate communication among lipid metabolism, vesicular trafficking, and signaling.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Vittoria Carmela Danese, Jessica Pepe, Federica Ferrone, Luciano Colangelo, Viviana De Martino, Luciano Nieddu, Giancarlo Ferrazza, Enrico Panzini, Roberto Pascone, Frank Blocki, Salvatore Minisola, Cristiana Cipriani
Summary: The study investigates the relationship between bone, glucose, and lipid metabolism. Hypovitaminosis D leads to worsening lipid profiles through PTH, while higher PTH levels are associated with elevated glucose and LDL-C levels.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Xinyan Zhang, Wenru Kong, Shuqi Wang
Summary: Researchers developed a highly reliable and reproducible method for the expression and purification of CAV1, demonstrating a caveolae-like membrane curvature in artificial lipid membranes. Solid-state nuclear magnetic resonance (ssNMR) structural characterization revealed that CAV1 is primarily alpha-helical in structure, with its scaffolding domain adopting an alpha-helical structure.
Article
Oncology
Christopher Godina, Vineesh Indira Chandran, Magdalena Barbachowska, Helga Tryggvadottir, Bjorn Nodin, Edward Visse, Signe Borgquist, Karin Jirstrom, Karolin Isaksson, Ana Bosch, Mattias Belting, Helena Jernstrom
Summary: CAV1 is associated with the progression and recurrence risk of breast cancer, particularly within the tumor microenvironment. Positive cytoplasmic CAV1 is associated with increased risk for contralateral disease, while strong stromal CAV1 is associated with increased risk for locoregional recurrence.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jason C. Porta, Bing Han, Alican Gulsevin, Jeong Min Chung, Yelena Peskova, Sarah Connolly, Hassane S. Mchaourab, Jens Meiler, Erkan Karakas, Anne K. Kenworthy, Melanie D. Ohi
Summary: This study reveals the structural characteristics of the human caveolin-1 complex using cryo-electron microscopy, providing new insights into its membrane remodeling activity and uncovering the roles of key regions of caveolin-1 in its function.
Article
Multidisciplinary Sciences
Joanna Lazniewska, Ka Lok Li, Ian R. D. Johnson, Alexandra Sorvina, Jessica M. Logan, Carmela Martini, Courtney Moore, Ben S. -Y. Ung, Litsa Karageorgos, Shane M. Hickey, Sarita Prabhakaran, Jessica K. Heatlie, Robert D. Brooks, Chelsea Huzzell, Nicholas I. Warnock, Mark P. Ward, Bashir Mohammed, Prerna Tewari, Cara Martin, Sharon O'Toole, Laura Bogue Edgerton, Mark Bates, Paul Moretti, Stuart M. Pitson, Stavros Selemidis, Lisa M. Butler, John J. O'Leary, Douglas A. Brooks
Summary: The development and progression of prostate cancer are closely related to the regulation of glucose and lipid metabolism, as well as alterations in androgen receptor expression and signaling. This study reveals a previously unrecognized molecular mechanism for prostate cancer, which involves the dynamic balance between sortilin and syndecan-1 and their impact on different metabolic phenotypes. In androgen-sensitive cells, sortilin enhances glucose metabolism while limiting lipid metabolism, whereas in androgen-insensitive cells, syndecan-1 promotes lipid metabolism. Additionally, androgen-deprived cells show decreased expression of sortilin and increased expression of syndecan-1, contributing to altered glucose and lipid metabolism. These findings have important implications for understanding disease progression and castration-resistant prostate cancer in the context of androgen-deprivation therapy.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Qingzhe Tan, Hanzhong Liu, Mojie Duan, Shuanghong Huo
Summary: The insertion of hIAPP affects lipid segregation and disrupts acyl chain packing near the polypeptide, while cholesterol modulates membrane mobility and the structure of hIAPP aggregates. The restoration of lipid domains occurs rapidly after perturbation, and hIAPP increases lipid fluidity and cholesterol diffusivity. These findings contribute to a better understanding of the mechanisms of amyloid cytotoxicity.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Chemistry, Multidisciplinary
Dariusz Lachowski, Carlos Matellan, Sahana Gopal, Ernesto Cortes, Benjamin K. Robinson, Alberto Saiani, Aline F. Miller, Molly M. Stevens, Armando E. del Rio Hernandez
Summary: Liver fibrosis is a common manifestation of chronic liver injury, and hepatic stellate cells (HSCs) play a crucial role in this process. This study reveals a mechanism by which matrix stiffness regulates plasma membrane tension, leading to increased secretion of TIMP-1. The expression of TIMP-1 and caveolin-1 is also found to be increased in cirrhosis and hepatocellular carcinoma.
Review
Immunology
Pamella Silva Lannes-Costa, Bruna Alves da Silva Pimentel, Prescilla Emy Nagao
Summary: This mini-review discusses the cellular pathogenesis and the role of Caveolin-1 (Cav-1) in sepsis. Cav-1 has been shown to play a significant role in sepsis through regulating membrane traffic and intracellular signaling pathways. Activation of apoptosis/autophagy is also considered relevant to the progression of sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Zhang, Taixing Cui, Xuejun Wang
Summary: Recent studies have revealed a complex interplay between autophagy and regulated necrosis, providing new insights into the pathophysiology of related diseases. Understanding the intricate relationship between these processes at the molecular level is crucial for further research and potential therapeutic implications in various pathological conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Physiology
Bojan Bozic, Sasa Svetina
Summary: This study reveals that the nonuniform distribution of the membrane nonspecific cation channel Piezo1 on red blood cell membrane could be explained by its curvature dependent interaction with the membrane. This result supports the role of Piezo1 in the regulation of red blood cell volume.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Houda Yasmine Ali Moussa, Kyung Chul Shin, Janarthanan Ponraj, Soo Jin Kim, Je-Kyung Ryu, Said Mansour, Yongsoo Park
Summary: Cholesterol is essential for neuronal activity and function, and its depletion impairs synaptic transmission. Through in vitro reconstitution experiments, it is shown that cholesterol is required for calcium-dependent vesicle fusion. Cholesterol strengthens synaptotagmin-1-induced membrane bending, lowering the energy barrier for fusion to occur.
Article
Chemistry, Physical
Anjali Krishna, Shikha Prakash, Durba Sengupta
JOURNAL OF PHYSICAL CHEMISTRY B
(2020)
Article
Chemistry, Physical
Shikha Prakash, Anjali Krishna, Durba Sengupta
Summary: The study investigates the interactions of caveolin-1 (cav-1) with complex membrane bilayers and reveals its role in inducing membrane curvature and forming cholesterol-rich domains. It shows direct interactions between specific lipid types and suggests an interplay between membrane topology and lipid species.
FARADAY DISCUSSIONS
(2021)
Review
Multidisciplinary Sciences
Shikha Prakash, Anjali Krishna, Durba Sengupta
PROCEEDINGS OF THE INDIAN NATIONAL SCIENCE ACADEMY
(2019)