Review
Pharmacology & Pharmacy
Jing-Ze Lu, Dan Ye, Bing-Liang Ma
Summary: Gegen-Qinlian decoction (GQD) is a classic traditional Chinese medicine formula that is effective in treating inflammatory intestinal diseases, metabolic diseases, and lung injury. The main constituents of GQD can be classified into eight groups, with parent constituents including puerarin, baicalin, berberine, and glycyrrhetinic acid. Issues such as effective constituents, interactions, pharmacokinetics, drug interactions, and pharmacological effects of GQD were discussed in this review, with prospects for future research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Li Deng, Yucong Shi, Pei Liu, Sizhi Wu, Yiwen Lv, Huachong Xu, Xiaoyin Chen
Summary: The study demonstrates that GeGen QinLian decoction may act through multiple targets and pathways to treat influenza, by regulating intestinal flora, reducing mortality and lung inflammation in infected mice. The treatment restores the intestinal flora, inhibits inflammatory signaling pathways, affects inflammatory cytokine expression, and provides systemic protection against influenza virus infectious pneumonia.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Integrative & Complementary Medicine
Xiaojun Wang, Xuanqi Liu, Qiushuang Gao, Xuchao Gu, Guannan Zhang, Zhiyuan Sheng, Tao Wu, Zheling Su, Wenhao Wang, Maoqing Ye
Summary: This study investigates the underlying mechanism of the Gegen Qinlian Decoction (GGQLD) in treating asymptomatic hyperuricemia. The results suggest that GGQLD may regulate immune-related pathways, ILC cell proportion, and clock gene expression to exert its therapeutic effects.
Article
Plant Sciences
Yihan Wu, Yanfen Cheng, Yuhan Yang, Di Wang, Xiaoqin Yang, Chaomei Fu, Jinming Zhang, Yichen Hu
Summary: This study investigates the beneficial effects of Gegen Qinlian Pill (GQP) in treating irinotecan (CPT-11)-induced gut toxicity and diarrhea. Through identifying 19 GQP-derived chemical compounds in murine serum samples and establishing an interaction network, it is found that GQP exerts curative effects on diarrhea through regulating inflammation, oxidative stress, and proliferation processes via different targets. This provides insights into the pharmacological effects and mechanisms underlying GQP's treatment of CPT-11-induced gut toxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu Xu, Jihan Huang, Ning Wang, Hor-Yue Tan, Cheng Zhang, Sha Li, Guoyi Tang, Yibin Feng
Summary: Research has shown that GQL can impact blood sugar levels, improve inflammatory symptoms, and alleviate liver and pancreas tissue damage in high-fat diet plus streptozotocin-induced diabetic mice. The antidiabetic effects of GQL are associated with modulation of the TNF and PI3K-AKT-MTOR pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Jiamei Chen, Min Li, Rong Chen, Ziyi Xu, Xiaoqin Yang, Huan Gu, Lele Zhang, Chaomei Fu, Jinming Zhang, Yihan Wu
Summary: This study investigated the active ingredients and mechanisms of a traditional Chinese medicine decoction, Gegen Qinlian formula, for the treatment of CPT-11-induced chemotherapy-induced diarrhea. The study identified 37 active compounds in the decoction and found that they exert their effects through the PI3K-AKT signaling pathway, protecting intestinal barrier function and alleviating diarrhea.
Article
Plant Sciences
Xiaojing Wang, Shaowei Huang, Meiling Zhang, Yulin Su, Zengfeng Pan, Junjie Liang, Xueqian Xie, Qing Wang, Jinyan Chen, Lian Zhou, Xia Luo
Summary: In this study, the protective effects of Gegen Qinlian decoction (GQD) on intestinal barrier damage in acute ulcerative colitis (UC) were investigated. The results showed that GQD treatment significantly alleviated the pathological symptoms and reduced bacterial infiltration in MLNs and colon tissues. GQD also repaired the structure of epithelial tight junctions, increased the expression of tight junction proteins, and regulated the diversity of gut microbiota and tryptophan metabolism.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiao-Jun Wang, Yi-Ding Qi, Hao-Chen Guan, Hua-Gang Lin, Pei-Qing He, Kang-Wei Guan, Lei Fu, Mao-Qing Ye, Jing Xiao, Tao Wu
Summary: Gegen Qinlian decoction (GGQLD) treats hyperuricemia (HUA) through anti-inflammatory and antiapoptotic pathways, reducing renal inflammation and promoting UA excretion. GGQLD inhibits GSDMD-dependent pyroptosis and reduces apoptosis, providing a novel therapeutic method for HUA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yifan Wang, Jiaqi Zhang, Lin Xu, Jing Ma, Mengxiong Lu, Jinxin Ma, Zhihong Liu, Fengyun Wang, Xudong Tang
Summary: MGQD administration significantly improved colonic inflammation in mice challenged by DSS, reducing weight loss, colon shortening, DAI score, histological score, and suppressing inflammatory response. By altering the diversity and community landscape of intestinal microbiota, MGQD boosted SCFA-producing gut microbiota, which are linked to promoting Treg cells and suppressing Th17 cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qinmei Li, Yao Cui, Baichang Xu, Yuhan Wang, Feifei Lv, Zheng Li, Huan Li, Xiaogang Chen, Xiaomin Peng, Yating Chen, Enyun Wu, Dongshuai Qu, Yichen Jian, Hongbin Si
Summary: The study found that PBM has the potential to exert anti-UC activity through gut microbiota dependence, possibly by increasing Akkermansia and Romboutsia while decreasing Escherichia-Shigella to regulate gut microbiota. Additionally, PBM was also able to increase the production of propionate and total short-chain fatty acids (SCFAs) in colitis rats, regulate medium and long chain fatty acids (M-LCFAs), maintain bile acids (BAs) homeostasis, and regulate amino acids (AAs) metabolism.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Wei Li, Zihe Ding, Ying Chen, Yi Wang, Mingming Peng, Chuanqiu Li, Han Zhang, Renxing Zhong, Tianyi Xia, Luyang Zhong, Mantong Zhao, Mengru Yang, Yimin Yue, Lanyuan Liang, Xia Cao, Zunpeng Shu
Summary: This study found that GQD can improve lung damage and inflammation in LPS-induced ALI rats through multiple pathways, and it can also regulate immune-related pathways and the balance of intestinal microbiota.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen
Summary: Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine, and dysbiosis of gut microbiota is one of its main pathogenic mechanisms. This study found that Gegen Qinlian decoction (GD) could inhibit the expansion of pathogenic Escherichia coli (E. coli) by activating PPAR-gamma signaling pathway, which contributes to the improvement of UC symptoms.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Integrative & Complementary Medicine
Xue Wang, Jianye Quan, Chengkui Xiu, Jiali Wang, Jiaqi Zhang
Summary: In this study, the role of ferroptosis-mediated IEC death in ulcerative colitis (UC) treated mice with Gegen Qinlian decoction (GQD) was evaluated using a colitis mouse model and intestinal organoids. The results showed that GQD administration could protect against colonic damage and intestinal epithelial barrier dysfunction by inhibiting ferroptosis, as evidenced by improvements in body weight, DAI scores, colon length, histological characteristics, and expression of ferroptosis-associated proteins.
Article
Pharmacology & Pharmacy
Jing-Ze Lu, Dan-Dan Hong, Dan Ye, Sheng Mu, Rong Shi, Yu Song, Chu Feng, Bing-Liang Ma
Summary: A liquid chromatography-tandem mass spectrometry method was developed and applied to analyze the distribution and pharmacokinetic properties of oral GQD in mice. The results showed that different constituents of GQD had different concentrations in the liver and colon, indicating their potential efficacy in treating liver and colon-related diseases. Furthermore, the study revealed the pharmacokinetic properties of GQD as a whole, including its accumulation in the colon.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Junzheng Yang, Qi He, Yunhan Wang, Zhaofeng Pan, Gangyu Zhang, Jianming Liang, Lijun Su, Ailin Wang, Chuning Zeng, Haoran Luo, Lingyun Liu, Jianliang Li, Qiuhong Rao, Baohua Wang, Haibin Wang, Peng Chen
Summary: Experimental studies have shown that GQD has a protective effect in managing T2DOP by upregulating IGFBP3 expression and downregulating the IGFBP3/MAPK/NFATc1 signaling pathway.
Article
Materials Science, Paper & Wood
Haoquan Zhong, Jinming Zhang, Yanzhu Guo, Lu Wang, Wenjiao Ge, Meiwan Chen, Runcang Sun, Xiaohui Wang
Article
Chemistry, Medicinal
Yuee Cai, Jinming Zhang, Nelson G. Chen, Zhi Shi, Jiange Qiu, Chengwei He, Meiwan Chen
MEDICINAL RESEARCH REVIEWS
(2017)
Correction
Pharmacology & Pharmacy
Zhang-Feng Zhong, Hai-Bing Yu, Chun-Ming Wang, Wen-An Qiang, Sheng-Peng Wang, Jin-Ming Zhang, Hua Yu, Liao Cui, Tie Wu, De-Qiang Li, Yi-Tao Wang
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Food Science & Technology
Zhejie Chen, Chen Zhang, Fei Gao, Qiang Fu, Chaomei Fu, Yao He, Jinming Zhang
FOOD AND CHEMICAL TOXICOLOGY
(2018)
Article
Nanoscience & Nanotechnology
Jinming Zhane, Xiaobin Fang, Zeyong Li, Hon Fai Chan, Zhixiu Lin, Yitao Wang, Meiwan Chen
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Agriculture, Multidisciplinary
Jinming Zhang, Di Wang, Yihan Wu, Wei Li, Yichen Hu, Gang Zhao, Chaomei Fu, Shu Fu, Liang Zou
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2018)
Article
Food Science & Technology
Guixing Ren, Yichen Hu, Jinming Zhang, Liang Zou, Gang Zhao
Article
Multidisciplinary Sciences
Jinming Zhang, Lu Wang, Hon Fai Chan, Wei Xie, Sheng Chen, Chengwei He, Yitao Wang, Meiwan Chen
SCIENTIFIC REPORTS
(2017)
Article
Biochemical Research Methods
Yao He, Tianhui Gao, Jie Li, Zhejie Chen, Lijuan Wang, Jinming Zhang, Fei Gao, Chaomei Fu
BIOMEDICAL CHROMATOGRAPHY
(2019)
Article
Pharmacology & Pharmacy
Liang Zou, Xiaowei Liu, Jingjing Li, Wei Li, Lele Zhang, Jian Li, Jinming Zhang
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Food Science & Technology
Chen Zhang, Fei Gao, Shuai Gan, Yanan He, Zhejie Chen, Xiaowei Liu, Chaomei Fu, Yan Qu, Jinming Zhang
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Jingjing Li, Yihan Wu, Di Wang, Liang Zou, Chaomei Fu, Jinming Zhang, George Pak-Heng Leung
PHARMACOLOGICAL RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Xuewei Ma, Yichen Hu, Xin Li, Xiaoting Zheng, Yitao Wang, Jinming Zhang, Chaomei Fu, Funeng Geng
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Shengpeng Wang, Min Shao, Zhangfeng Zhong, Anqi Wang, Jiliang Cao, Yucong Lu, Yitao Wang, Jinming Zhang
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)