Article
Plant Sciences
Mehmet Ali Temiz, Emine Okumus, Turan Yaman, Omer Faruk Keles
Summary: This study investigates the antidiabetic and hepato-pancreatic protective effects of Prunus spinosa leaves and flowers extract in streptozocin-induced diabetes mellitus. The extract showed efficient inhibition of alpha-amylase and alpha-glucosidase, regulated blood glucose levels, improved insulin levels, and enhanced antioxidant capacity in the liver, protecting against oxidative stress and damage in diabetes.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Biology
Abdulsamad Alsalahi, Zamri Chik, Zahurin Mohamed, Nelli Giribabu, Mohammed Abdullah Alshawsh
Summary: The study found that cathinone had a weaker in vitro inhibition on alpha-amylase and alpha-glucosidase compared to alpha-acarbose, and it significantly affected the blood sugar levels of diabetic rats, exacerbating their hyperglycemia.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Endocrinology & Metabolism
Dinesh Kumar Chellappan, Jestin Chellian, Nur Suraiza Nabila Rahmah, Wee Jin Gan, Priyanka Banerjee, Saptarshi Sanyal, Pradipta Banerjee, Nandini Ghosh, Tanner Guith, Amitava Das, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, Anil Philip Kunnath, Nur Azeyanti Norhashim, Kuan Hung Ong, Kishneth Palaniveloo
Summary: Diabetes mellitus (DM) is a global health problem due to defective insulin activity. Conventional therapies for DM are limited and often have adverse effects. Therefore, there is an increased focus on exploring potential therapeutic agents from natural resources. Marine organisms, including microorganisms, microalgae, macroalgae, corals, sponges, and fishes, have been evaluated for their anti-diabetic properties. The bioactive metabolites discovered show promising hypoglycaemic potential through various mechanisms of action and antioxidant activities. This review highlights marine-derived chemicals as potential treatments for DM.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Plant Sciences
Deeptimayee Rout, Umesh Chandra Dash, Satish Kanhar, Sandeep Kumar Swain, Atish Kumar Sahoo
Summary: The study focused on investigating the efficacy of using Homalium zeylanicum leaves to treat hyperglycemia, with results demonstrating its antioxidant activities and anti-inflammatory properties. The bioactive compounds in HAHZL showed significant glycemic response and improved markers of diabetes in experimental rats, providing potential benefits for managing type 2 diabetes.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Adekunle O. Ajiboye, Sidiqat A. Shodehinde
Summary: This study evaluated the ameliorating effect and antidiabetic properties of diets augmented with boiled unripe plantain in diabetic rats. The results showed that the boiled unripe plantain diet reversed the increase in blood glucose level and enzyme activities in the diabetic rats. This suggests that boiled unripe plantain could be a potential economic means of managing diabetes in developing countries.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biology
Amit Kumar Singh, Harvesh Kumar Rana, Vishal Singh, Tara Chand Yadav, Pritish Varadwaj, Abhay Kumar Pandey
Summary: Chlorogenic acid effectively inhibits glucose metabolising enzymes and decreases hyperglycemia, hyperlipidemia, and hepatorenal damage associated with diabetes in rats, making it a potential functional food ingredient and drug candidate for diabetes management.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Nikeherpianti Lolok, Sri Adi Sumiwi, Dwi Syah Fitra Ramadhan, Jutti Levita, I. Sahidin
Summary: The study found that stigmasterol and beta-sitosterol in Morinda citrifolia fruit can effectively inhibit the activity of a-amylase and a-glucosidase.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Imane Abdelli, Nabila Benariba, Sara Adjdir, Zohra Fekhikher, Ismail Daoud, Mohammed Terki, Hanane Benramdane, Said Ghalem
Summary: The study revealed that tannic acid is a functional inhibitor of alpha-glucosidase and alpha-amylase activities and can be used as an alternative for regulating post-prandial hyperglycaemia. Among the phenolic compounds tested, L1 showed the best docking scores and the lowest energy score in interaction with both enzymes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Ninon G. E. R. Etsassala, Jelili A. Badmus, Jeanine L. Marnewick, Samuel Egieyeh, Emmanuel. I. Iwuoha, Felix Nchu, Ahmed A. Hussein
Summary: This study found that compounds in the methanolic extract of Plectranthus ecklonii have moderate inhibitory activity against alpha-glucosidase and alpha-amylase, as well as strong antioxidant capacities. This provides potential candidate compounds for the development of antidiabetic drugs.
Article
Spectroscopy
Mohammad Ezati, Fahimeh Ghavamipour, Hadi Adibi, Khadijeh Pouraghajan, Seyed Shahriar Arab, Reza H. Sajedi, Reza Khodarahmi
Summary: Curcumin has an important role in preventing various diseases, including diabetes. In this study, curcumin-fused aldohexose derivatives were synthesized and found to inhibit two enzymes related to hyperglycemia. Spectral analysis confirmed the formation of the target compounds. In vivo studies showed that one of the compounds could lower blood glucose levels in rats.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Ganiyu Oboh, Taiwo Gbemisola Bello, Odunayo Michael Agunloye
Summary: This study produced biscuits from acha-sandpaper leaf composite flour and found that these biscuits could reduce fasting blood glucose and blood pressure in hypertensive-diabetic rats, as well as decrease the activity of related enzymes while improving antioxidant status. Moreover, biscuits with 3.75% sandpaper leaf showed better hypertensive-diabetic properties due to the bioactive compounds present.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Microbiology
Sujay S. Huligere, V. B. Chandana Kumari, Sudhanva M. Desai, Ling Shing Wong, Nagma Firdose, Ramith Ramu
Summary: This study evaluates the probiotic and antidiabetic properties of lactic acid bacteria (LAB) obtained from milk and dairy-based products. The strains were tested for their physiological, biochemical, and molecular characteristics. The results show that these LAB isolates inhibit carbohydrate hydrolysis enzymes, have antioxidant activity, exhibit high survival rate under gastrointestinal conditions, and show resistance to antibiotics. They also demonstrate good attachment properties and potential application in various sectors. Further in vivo testing is needed to confirm their probiotic potential.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Plant Sciences
Akanksha Bakshi, Nitika Sharma, Avinash Kaur Nagpal
Summary: This study compared the antioxidant and antidiabetic potential of leaf extracts from Azadirachta indica, Bauhinia variegata, Dalbergia sissoo, Psidium guajava, and Syzygium cumini. The extracts of B. variegata and S. cumini exhibited better antioxidant and antidiabetic activity compared to other plant species.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Review
Biochemistry & Molecular Biology
Maira Huerta-Reyes, Rosario Tavera-Hernandez, J. Javier Alvarado-Sansininea, Manuel Jimenez-Estrada
Summary: This study reviewed the most commonly used species of Cucurbitaceae in Mexico for the treatment of diabetes. The reviewed species showed various properties such as hypoglycemic, antioxidant, anti-inflammatory, anti-obesity, and protective effects on diverse organs and cells, which are essential in the complex pathogenesis of diabetes. These species could potentially be used as components in diets for diabetes control and may serve as a basis for novel clinical treatments.
Article
Biochemistry & Molecular Biology
Cinzia Sanna, Antonella Fais, Benedetta Era, Giovanna L. Delogu, Enrico Sanna, Laura Dazzi, Antonella Rosa, Arianna Marengo, Patrizia Rubiolo, Antonio De Agostini, Sonia Floris, Francesca Pintus
Summary: This study revealed the potential of Ptilostemon casabonae extract as a treatment for T2D, as it showed strong inhibitory activity against alpha-glucosidase and antioxidant effects. The complex polyphenolic fraction in the extract and the compounds 1,5-dicaffeoylquinic acid, apigenin, and rutin were identified as having good alpha-glucosidase inhibitory activity. Further research on the therapeutic potential of this extract is encouraged.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Karunanidhi Kaleshkumar, Rajendran Rajaram, Bilal Ahamad Paray, Sajad Ali
Summary: The nutritional composition and fatty and amino acids profiling of recently commercialized marine pufferfishes from the coast of Mandapam in the Gulf of Mannar were evaluated. The results provide baseline data for evaluating the nutritional profiles of various fishes in the future.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Chemistry, Analytical
Selvakumar Muruganantham, Venkateshwaran Krishnaswami, Shanmugarathinam Alagarsamy, Ruckmani Kandasamy
Summary: In recent decades, the rising human population has led to increased demand for food, prompting agricultural intensification. To protect crops from pests, farmers widely use pesticides, despite the health risks involved. Therefore, it is crucial to develop a specific and efficient method for detecting pesticides in various samples to safeguard human health.
CURRENT ANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Athira Pulickal Santhosh, Anisha Pyary, Anagha Biju, Emmanuel Charles Partheeban, Jebashalomi Vethanayaham, Rajaram Rajendran, Mohammad Khalid Al-Sadoon, Aneela Gulnaz
Summary: The spatiotemporal variations of five heavy metals in beach sediments along the Tamil Nadu coast were assessed, and pollution monitoring indices were computed to understand the metal pollution status. The concentrations of metals were higher in the summer season compared to the monsoon season. The study also found that Cd and Pb pose greater hazards compared to other metals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
Selvakumar Muruganantham, Venkateshwaran Krishnaswami, Ruckmani Kandasamy, Shanmugarathinam Alagarsamy
Summary: The aim of this study was to improve the solubility of zaltoprofen (ZLT) by formulating ZLT loaded polyvinyl pyrrolidone K30 (PVP K30) nanodispersions. Different formulations of ZLT nanodispersions were developed by varying the concentrations of PVP K30 and poloxamer 407. The effects of formulation variables on the properties of ZLT nanodispersions were investigated. The results showed that the developed ZLT nanodispersion (ZLTNDs-4) had small particle size, high drug content, and good anti-inflammatory activity compared to pure ZLT.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Elaiyappillai Elanthamilan, Arumugam Ganeshkumar, Sea-Fue Wang, Rajendran Rajaram
Summary: In this article, the synthesis of a cobalt-benzimidazole metal organic framework (Co-Bi-m MOF) and a cobalt-benzimidazole MOF@reduced graphene oxide (Co-Bi-m@rGO) composite for supercapacitor application is reported. Various physicochemical techniques confirm the structural and morphological features of the Co-Bi-m MOF and Co-Bi-m@rGO composite. The Co-Bi-m@rGO composite shows excellent supercapacitive performance, attributed to its mesoporous nature, improved surface area, multiple redox sites, and synergistic effect between the Co-Bi-m MOF and rGO moiety. It also exhibits good cyclic stability and biocompatibility. The effective energy storage ability of the Co-Bi-m@rGO composite suggests its potential as a candidate for supercapacitors in day-to-day applications.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Immunology
Krubha Athirathinam, Selvasudha Nandakumar, Shailendra Kumar Verma, Ruckmani Kandasamy
Summary: This study evaluates the use of the biocompatible polymer dextran to improve the shelf-life and biological activity of a thermally unstable plague vaccine protein called LcrV. Analytical techniques and in vivo evaluations demonstrate the structural stability of LcrV protein and its significantly higher immune response when formulated with dextran as compared to the native antigen. Dextran, along with sodium chloride, is proposed as a potential biopolymer to provide compactness and prevent protein unfolding at room temperature for up to three weeks.
Article
Pharmacology & Pharmacy
Gover Antoniraj Mariya, Mohankumar Ramar, Linda Jeeva Kumari Henry, Subramanian Natesan, Ruckmani Kandasamy
Summary: This study presents a novel synthesis method of redox-responsive copolymers using chitosan and methoxy poly-ethylene glycol (mPEG), as well as the formulation of prednisone-loaded nanoparticles (P-NPs) for glutathione (GSH)-responsive release. The specific ligand atrial natriuretic peptide (ANP) was conjugated to the P-NPs (ANP-P-NPs) for targeted drug delivery. Physiochemical characterizations showed that the nanoparticle sizes were below 200 nm, with an entrapment efficiency of 73.89 +/- 0.45% and a zeta potential of approximately -20 mV. The in vitro and in vivo studies demonstrated the potential of these redox-responsive nanoparticles as safe and efficient drug delivery vehicles.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Environmental Sciences
Vethanayaham Jebashalomi, Partheeban Emmanuel Charles, Rajendran Rajaram, Paramasivam Sadayan
Summary: Nanoplastics, the least-known type of marine litter, have attracted much interest due to their prevalence in the environment and potential harm to living organisms. This article focuses on understanding the sources, fate, absorption, potential toxin release, and degradation methods of nanoplastics in the marine environment. Thorough examination of nanoplastics' sources, fate, and effects is crucial to better mitigate and raise awareness about this emerging contaminant.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2023)
Article
Biochemistry & Molecular Biology
T. V. Dinesh, Beutline Malgija, Mano Ranjana Ponraj, Pavankumar Muralakar, Jesse Joel Thathapudi, Ruckmani Kandasamy, Jeyasankar Alagarmalai, Anna Benedict Balakrishnan, Perumal Samy Ramar, Jannet Vennila James, Jebasingh Bhagavathsingh
Summary: In response to the pandemic crisis caused by the corona virus, researchers have designed pyrimidine-based nucleotides to target the replication targets of SARS-CoV-2. Molecular docking studies indicated that these compounds have good binding affinity, with some outperforming the control drug remdesivir. Molecular dynamics simulation studies further confirmed their stability and non-covalent interactions. Ligand2-BzV_0Tyr showed promising results as it exhibited dual target specificity for both Mpro and RdRp.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
P. Emmanuel Charles, M. Sathya, R. Rajaram, M. K. Al-Sadoon, A. Gulnaz, B. A. Paray
Summary: Microplastic pollution is a global concern and has been found in the feces of Indian house crows with a detection rate of 92%. The majority of the microplastics were in the form of fibers and fragments, with an average length of 1727.16 μm and width of 27.07 μm. Further research is needed to understand the fate of microplastics in terrestrial ecosystems.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Review
Polymer Science
Jeseeta Suresh, Nirmal Aravindaraj, Venkateshwaran Krishnaswami, Ruckmani Kandasamy
Summary: The prerequisite for effective drug delivery has increased, leading to extensive exploration of oral film technology (OFT). Oral films dissolve rapidly in the buccal cavity and deliver therapeutic agents into the systemic circulation, enhancing efficacy and bioavailability with minimal toxicity. Their simpler administration mode increases patient compliance, even in non-cooperative and bedridden patients. This review provides an overview of the benefits and shortcomings of oral film technologies, oral cavity anatomy and physiology, drug transport and mucoadhesion mechanisms, as well as production methods and clinical trials.
MACROMOLECULAR RESEARCH
(2023)
Article
Polymer Science
Krubha Athirathinam, Selvasudha Nandakumar, Shanmugarathinam Alagarsamy, Ruckmani Kandasamy
Summary: This study evaluates the effectiveness of the Vi polysaccharide antigen of Salmonella Typhi in stabilizing the plague vaccine antigen, resulting in improved humoral immune response without an adjuvant. The use of taurine as a co-excipient and natural linker provides dynamic covalent bonding between the excipients, enhancing structural stability for 4 weeks at room temperature. The formulated antigen maintains its biological activity for up to 4 weeks, with significantly higher antibody response compared to the adjuvanted pure antigen stored at optimal temperature.
MACROMOLECULAR RESEARCH
(2023)
Review
Chemistry, Analytical
Huahong Shi, Joao Frias, Alaa El-Din H. Sayed, Gabriel Enrique De-la-Torre, Mui-Choo Jong, Sheikh Aftab Uddin, Rajendran Rajaram, Suchana Chavanich, Abolfazl Najii, Melisa Daiana Fernandez-Severini, Yusof Shuaib Ibrahim, Lei Su
Summary: Plastic pollution and research on micro- and nano-plastics have gained significant attention, but there are still challenges in analyzing small particles and assessing plastic debris. This study highlights the importance of investigating small plastic fragments to bridge the knowledge gap between large and micro- and nano-plastics.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Microbiology
Arumugam Ganeshkumar, Juliana Caparroz Goncale, Rajendran Rajaram, Juliana Campos Junqueira
Summary: This review discusses the significance of marine natural products in controlling the proliferation and metabolism of Candida species, including drug-resistant strains. It highlights the research value of sponges that produce compounds with inhibitory activity against Candida strains. Additionally, the review reveals the mechanisms and synergistic activity of marine products with conventional antifungals. Overall, the majority of compounds derived from the marine environment are capable of controlling specific functions of Candida microorganisms, providing insights into the design of new anti-candidal therapies.
Article
Environmental Sciences
Nandakumar Selvasudha, Joseph PushpaSweety, Thekkila-Veedu Saranya, Kandasamy Ruckmani, Loganathan Gayathri
Summary: This study aimed to adapt a simple protein estimation method for detecting nisin and to formulate and evaluate site-specific nanoformulation for therapeutic applications. Among the three nanoformulations prepared and characterized, the one with gellan gum showed the best characteristics. Interaction and stability patterns were confirmed using FT-IR and DSC, and CD demonstrated the stability of nisin in an alkaline environment. The formulated gellan gum-nisin colloidal nanoparticles showed significant effectiveness against colon cancer cells and antimicrobial activity against Staphylococcus aureus.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
