Article
Multidisciplinary Sciences
Marco D'Ario, Rafael Tavares, Katharina Schiessl, Benedicte Desvoyes, Crisanto Gutierrez, Martin Howard, Robert Sablowski
Summary: The study reveals that cell size variability in the Arabidopsis shoot stem cell niche is corrected by adjusting the growth period before DNA synthesis. KRP4 and FBL17 proteins play key roles in removing excess cell cycle regulators, ensuring daughter cells are born with comparable amounts of KRP4. This suggests a potential mechanism where a cell cycle regulator associated with mitotic chromosomes can read DNA content as a cell size-independent scale.
Article
Biotechnology & Applied Microbiology
Kai Wang, Baosong Li, Peng Fan, Xiang Ren, Hong Jiang
Summary: The study highlights the crucial roles of DDX21 and CDC5L in colorectal cancer progression. Upregulation of DDX21 promotes cell growth and tumor development in CRC, while CDC5L can reverse the inhibitory effects of DDX21. This provides a new direction for therapeutic strategies in colorectal cancer.
Article
Biochemistry & Molecular Biology
Zhirou Li, Jinge Mao, Daiyun Huang, Bowen Song, Jia Meng
Summary: 5-methyluridine (m5U) is a crucial base on RNA molecules influencing cancer development and immune diseases. The RNADSN neural network model shows superior performance in predicting mRNA m5U sites, even without experimental data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shangyu Gao, Yu Sun, Xiaoguang Chen, Changhua Zhu, Xiaoye Liu, Wenlei Wang, Lijun Gan, Yanwu Lu, Frank Schaarschmidt, Marco Herde, Claus-Peter Witte, Mingjia Chen
Summary: This study reveals that free 5-methylcytidine (5mC) and 5-methyl-2'-deoxycytidine are produced from nucleic acid turnover in Arabidopsis thaliana. The degradation process of these cytidines, which is unclear in eukaryotes, is elucidated. It is found that 5-methyluridine (5mU) is mainly generated from RNA, and most 5mU is directly released from RNA without a 5mC intermediate. The removal of 5mU is shown to be an important function of pyrimidine degradation in many organisms, protecting RNA from stochastic m(5)U modification in plants.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Microbiology
Lezheng Yu, Yonglin Zhang, Li Xue, Fengjuan Liu, Runyu Jing, Jiesi Luo
Summary: Post-transcriptionally RNA modifications, known as the epitranscriptome, are important for gene expression regulation during development. Deep learning has been used for RNA modification site prediction and has shown promising results. This study evaluates different deep learning models for pyrimidine modifications and designs an improved neural network, Deepm5U, for accurately predicting m(5)U sites. The study also demonstrates the use of interpretation techniques for deep neural networks in understanding model behavior and operation. Overall, this research provides practical guidance for the development, benchmarking, and analysis of deep learning models for RNA modifications.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tomoyuki Fukami, Atsushi Shiozaki, Toshiyuki Kosuga, Michihiro Kudou, Hiroki Shimizu, Takuma Ohashi, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Yukiko Morinaga, Eiichi Konishi, Eigo Otsuji
Summary: ANO5 is a key regulator in tumor progression and a potential prognostic biomarker for gastric cancer. Knockdown of ANO5 inhibits cell proliferation, induces apoptosis, and affects cell cycle progression, invasion, and migration. High expression of ANO5 is associated with poor prognosis in patients with GC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Endocrinology & Metabolism
Mengxue Jiang, Zhijian Kuang, Yaohui He, Yin Cao, Tingyan Yu, Jidong Cheng, Wen Liu, Wei Wang
Summary: This study reveals that SNAPIN plays a crucial role in regulating insulin secretion and beta cell proliferation, with its expression influenced by age and diabetes. The function of SNAPIN is achieved through its impact on cell cycle regulation, suggesting it might be a potential pharmacotherapeutic target for diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng, Longyu Jin
Summary: PTBP3 is overexpressed in LUSC tissues and its high expression is significantly correlated with poor prognosis. PTBP3 knockdown results in decreased cell proliferation rate. Bioinformatics analysis reveals that PTBP3 is involved in cell cycle regulation in LUSC.
CANCER CELL INTERNATIONAL
(2022)
Article
Spectroscopy
Jhonatam O. Carvalho, Joao G. Oliveira Neto, Jose G. Silva Filho, Francisco F. de Sousa, Paulo T. C. Freire, Adenilson O. Santos, Pedro F. Facanha Filho
Summary: The structural, vibrational, and thermal properties of 5-methyluridine hemihydrate crystals were investigated using experimental and computational methods. The study revealed the structural and vibrational changes caused by dehydration, as well as the significance of hydrogen bonds in the intermolecular interactions of the methylated nucleoside.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Oncology
Junneng Zhang, Huanzong Zhang, Yinghui Wang, Qingshui Wang
Summary: The study revealed that the MCM2-7 genes are overexpressed in ccRCC patients and associated with poor prognosis. MCM2-7 influences the progression of ccRCC by regulating the cell cycle. A two-gene risk score model including MCM4 and MCM6 can predict overall survival of ccRCC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Pengmian Feng, Wei Chen
Summary: In this study, a support vector machine based method called iRNA-m(5)U was developed to identify m(5)U sites in the yeast transcriptome. The accuracy of iRNA-m(5)U is promising, indicating its potential as a useful tool for identification of m(5)U sites.
Article
Biochemistry & Molecular Biology
Monika Witzenberger, Sandra Burczyk, David Settele, Wieland Mayer, Luisa M. Welp, Matthias Heiss, Mirko Wagner, Thomas Monecke, Robert Janowski, Thomas Carell, Henning Urlaub, Stefanie M. Hauck, Aaron Voigt, Dierk Niessing
Summary: 5-Methyluridine (m(5)U) is a common RNA modification in cytosolic tRNA, and tRNA methyltransferase 2 homolog A (hTRMT2A) is the enzyme responsible for m(5)U formation at position 54 of tRNA. Through structural and sequence analysis, it has been determined that hTRMT2A achieves specificity for tRNA modification through a combination of binding preference and the presence of a uridine at position 54. Additionally, hTRMT2A has been found to interact with proteins involved in RNA biogenesis and its knockdown has been shown to reduce translation fidelity.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Deshuai Ren, Xiaoyu Zhuang, Yanxin Lv, Yun Zhang, Jiazhi Xu, Fengquan Gao, Dagang Chen, Yu Wang
Summary: This study found that FAM84B is highly expressed in glioma tissues and inhibits the proliferation of glioma cells through regulating the cell cycle pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniella A. Gomes, Anna M. Joubert, Michelle H. Visagie
Summary: The study found that papaverine (PPV) exhibits dose- and time-dependent antiproliferative activity on MDA-MB-231, A549, and DU145 cell lines, while also increasing cellular protrusions and oxidative stress. Exposure to PPV resulted in alterations in cell cycle progression, with more cells entering the sub-G(1) phase and endoreduplication.
Review
Biochemistry & Molecular Biology
Hong-Li Li, Lu-Lu Dong, Min-Jie Jin, Qian-Yu Li, Xiao Wang, Mei-Qi Jia, Jian Song, Sai-Yang Zhang, Shuo Yuan
Summary: Neuroblastoma exhibits heterogeneity and can spontaneously degenerate into benign tumors. However, the prognosis for high-risk types remains unsatisfactory despite intensive treatments. Abnormal amplification and high-level expression of the MYCN gene are positively correlated with malignant progression, poor prognosis, and mortality of neuroblastoma. This article explores the role of N-Myc, the gene expression product of MYCN, on target genes related to the cell cycle and reveals its regulatory network in promoting tumor proliferation and malignant progression. It aims to provide ideas and direction for the research and development of drugs targeting N-Myc and its downstream target genes.
Article
Biochemistry & Molecular Biology
Koen van Wijk, Takeru Akabane, Tomohiro Kimura, Shinichi Saitoh, Satoshi Okano, Vincent P. Kelly, Michiaki Takagi, Ken Kodama, Kiwamu Takahashi, Tohru Tanaka, Motowo Nakajima, Osamu Nakajima
Summary: This study found an age-dependent reduction in free heme levels in the skeletal muscle and liver of ALAS1 heterozygous mice, while there was only a slight decrease in the liver of WT mice. Total heme levels did not show significant differences between young and aged mice. ALAS1 mRNA levels exhibited an age-dependent reduction similar to the free heme levels.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Claire Fergus, Mashael Al-Qasem, Michelle Cotter, Ciara M. McDonnell, Emiliano Sorrentino, Franciane Chevot, Karsten Hokamp, Mathias O. Senge, John M. Southern, Stephen J. Connon, Vincent P. Kelly
Summary: Base modification can occur throughout a transfer RNA molecule, with a particular emphasis on position 34 of the anticodon loop. Human enzymes can recognize a wide range of artificial derivatives for transfer RNA incorporation, while displaying strict specificity for decoding certain codons. Exploiting the queuosine incorporation pathway shows broad potential for intentionally engineering chemical diversity into transfer RNA anticodons.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Magda Ghanim, Nicola Relitti, Gavin McManus, Stefania Butini, Andrea Cappelli, Giuseppe Campiani, K. H. Mok, Vincent P. Kelly
Summary: CD44 as an important receptor biomarker for oral cancer, the water-soluble fluorescent probe compound 1 shows promising potential for real-time intraoperative imaging due to its reversible and non-toxic nature.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ciara G. Doran, Ryoichi Sugisawa, Michael Carty, Fiona Roche, Claire Fergus, Karsten Hokamp, Vincent P. Kelly, Andrew G. Bowie
Summary: Investigations into the gene expression of SARM1 in macrophages have revealed its roles in neuronal degeneration and immunity. The generation of Sarm1-/- mice and epitope-tagged SARM1 mice have provided further insights into the transcriptional regulation and functional aspects of SARM1 in macrophages and neurons.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Akihiro Kuno, Yoshihisa Ikeda, Shinya Ayabe, Kanako Kato, Kotaro Sakamoto, Sayaka R. Suzuki, Kento Morimoto, Arata Wakimoto, Natsuki Mikami, Miyuki Ishida, Natsumi Iki, Yuko Hamada, Megumi Takemura, Yoko Daitoku, Yoko Tanimoto, Tra Thi Huong Dinh, Kazuya Murata, Michito Hamada, Masafumi Muratani, Atsushi Yoshiki, Fumihiro Sugiyama, Satoru Takahashi, Seiya Mizuno
Summary: Genome editing can introduce designed mutations, but it can also lead to unintended variations. Existing genotyping methods are unable to comprehensively analyze diverse mutations. We developed a genotyping method with the software DAJIN, which can automatically identify and classify various mutations. This approach is highly adaptable and convenient, making DAJIN a potential new standard for validating genome editing outcomes.
Article
Chemistry, Medicinal
Ciara M. McDonnell, Magda Ghanim, J. Mike Southern, Vincent P. Kelly, Stephen J. Connon
Summary: This study investigates the impact of modified beta-lysines on the growth rates of eubacterial cells. The results indicate that the observed effects are due to the post translational modification of Elongation Factor P (EFP) catalyzed by PoxA. The promiscuity of PoxA allows for examination of a wide range of exogenous beta-lysines.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Giuseppe Campiani, Tuhina Khan, Cristina Ulivieri, Leopoldo Staiano, Chiara Papulino, Stefania Magnano, Seema Nathwani, Anna Ramunno, Daniel Lucena-Agell, Nicola Relitti, Stefano Federico, Luca Pozzetti, Gabriele Carullo, Alice Casagni, Simone Brogi, Francesca Vanni, Paola Galatello, Magda Ghanim, Niamh McCabe, Stefania Lamponi, Massimo Valoti, Ola Ibrahim, Jeffrey O'Sullivan, Richard Turkington, Vincent P. Kelly, Ruben VanWemmel, J. Fernando Diaz, Sandra Gemma, Daniela Zisterer, Lucia Altucci, Antonella De Matteis, Stefania Butini, Rosaria Benedetti
Summary: Autophagy, a crucial mechanism for maintaining organismal homeostasis, has become a focus in cancer therapy. In this study, new multifunctional agents with both pro-apoptotic and autophagy-inhibiting effects were designed and their therapeutic potential was demonstrated through experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Le Phuong Hoang Anh, Ken Nishimura, Akihiro Kuno, Nguyen Thuy Linh, Tetsuo Kato, Manami Ohtaka, Mahito Nakanishi, Eiji Sugihara, Taka-Aki Sato, Yohei Hayashi, Aya Fukuda, Koji Hisatake
Summary: Somatic cell reprogramming proceeds through a series of events to generate induced pluripotent stem cells (iPSCs). In this study, the researchers found that the downregulation of Osr2 is crucial for efficient reprogramming by using a cell-based model. Osr2 acts as a novel EMT regulator and its downregulation diminishes TGF-beta signaling and activates Wnt signaling, promoting MET and acquiring pluripotency.
Article
Pathology
Fumiya Teruyama, Akihiro Kuno, Yoshihiko Murata, Tomoki Nakagawa, Aya Shiba-Ishii, Shu Yuguchi, Masayuki Noguchi
Summary: This article reports a case of multiple breast angiosarcoma that underwent multiple resections and comprehensive genetic mutation analysis. The findings suggest that this case was likely a multiprimary angiosarcoma.
PATHOLOGY INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Johannes A. Sake, Mohammed Ali Selo, Lyubomyr Burtnyak, Henriette E. Dahnhardt, Camelia Helbet, Severin Mairinger, Oliver Langer, Vincent P. Kelly, Carsten Ehrhardt
Summary: Multidrug resistance-associated protein 1 (MRP1/ABCC1) is an efflux transporter responsible for the extrusion of endogenous substances as well as xenobiotics and their respective metabolites. The generation of an ABCC1-/- clone based on the human distal lung epithelial cell line NCI-H441 via a targeted CRISPR/Cas9 approach provides a useful tool to study MRP1 function in vitro. The ABCC1-/- NCI-H441 clone showed complete absence of mRNA and protein, and retained the ability to form electrically tight barriers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Arun Kumar Burramsetty, Ken Nishimura, Takumi Kishimoto, Muhammad Hamzah, Akihiro Kuno, Aya Fukuda, Koji Hisatake
Summary: This study identified and characterized proteins associated with the Nanog promoter in mouse embryonic stem cells (mESCs) using unbiased methods. The results revealed the importance of these proteins, including RNA-binding proteins (RBPs), in the maintenance of pluripotency and the reprogramming of somatic cells. The findings highlight the functional relevance of RBPs in ESC differentiation and somatic cell reprogramming.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shr-Hau Hung, Gregory Elliott, Thakku R. Ramkumar, Lyubomyr Burtnyak, Callum J. McGrenaghan, Sana Alkuzweny, Samia Quaiyum, Dirk Iwata-Reuyl, Xiaobei Pan, Brian D. Green, Vincent P. Kelly, Valerie De Crecy-Lagard, Manal A. Swairjo
Summary: Eukaryotic life relies on bacteria for the biosynthesis and supply of vitamins and micronutrients, including the micronutrient queuosine. The hydrolase enzyme QNG1 plays a crucial role in releasing queuine from queuosine-5'-monophosphate, which is essential for various physiological processes associated with queuine deficiency, such as metabolism, proliferation, differentiation, and cancer progression.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Mitsunori Fujino, Naoki Morito, Takuto Hayashi, Masami Ojima, Shun Ishibashi, Akihiro Kuno, Seizo Koshiba, Kunihiro Yamagata, Satoru Takahashi
Summary: The transcription factor c-Maf has been found to be important in embryonic kidney development, but its role in adult kidneys is unclear. This study investigated the effects of c-Maf deletion in adult mice and found that it caused changes in kidney morphology and function. In diabetic conditions, c-Maf deficiency promoted recovery from hyperglycemia and improved diabetic nephropathy. These findings suggest that c-Maf could be a potential therapeutic target for treating diabetic nephropathy.
Article
Gastroenterology & Hepatology
Jilei Zhang, Yongguo Zhang, Callum J. McGrenaghan, Vincent P. Kelly, Yinglin Xia, Jun Sun
Summary: This study found that the expression of QTRT1 was significantly downregulated in patients with inflammatory bowel disease (IBD). The 4 Q-tRNA-related tRNA synthetases were also decreased in IBD patients. These changes were associated with alterations in epithelial cell proliferation and junction formation. Further investigation revealed that queuine treatment enhanced cell proliferation and junction activity, and reduced inflammation in epithelial cells. These findings uncover a novel role for tRNA modifications in the pathogenesis of IBD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Meeting Abstract
Hematology
Aoife Yeow, Ciara Byrne, Heike Hawerkamp, Anne Chevalier, Laura Matarazzo, Jamie M. O'Sullivan, Vincent Kelly, Bagirath Gangadharan, BirgitM. Reipert, James O'Donnell, Peter Turecek, Padraic Fallon
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)