Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Rui-Ting Liu, Wei Li, Dong Guo, Chun-Lin Yang, Jie Ding, Jian-Xin Xu, Rui-Sheng Duan
Summary: The study found that NK cells in patients with myasthenia gravis have abnormal immune-regulation on CD4(+) T cells and Tfh cells, which may contribute to the immune-pathological mechanism of MG.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Emily R. Kansler, Saida Dadi, Chirag Krishna, Briana G. Nixon, Efstathios G. Stamatiades, Ming Liu, Fengshen Kuo, Jing Zhang, Xian Zhang, Kristelle Capistrano, Kyle A. Blum, Kate Weiss, Ross M. Kedl, Guangwei Cui, Koichi Ikuta, Timothy A. Chan, Christina S. Leslie, A. Ari Hakimi, Ming O. Li
Summary: This study reveals an innate immune surveillance response mediated by cytotoxic ILC1 sensing of cancer cell-expressed IL-15, which is associated with patient survival and contributes to tumor suppression.
Article
Immunology
Yongwei Qin, Liangqiong Chen, Qiuwen Fei, Xiaoyi Shao, Wenxuan Lv, Junling Yang, Feifan Xu, Jiahai Shi
Summary: In this study, CD226 immunoregulation functions were evaluated using peripheral blood from tuberculosis patients and healthy donors. The results showed that a subset of T cells and NK cells expressing CD226 exhibited a distinct phenotype in TB patients. CD226+ subsets produced more IFN-gamma and CD107a than CD226- subsets in tuberculosis patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Takahiro Uchida, Shuhji Seki, Takashi Oda
Summary: Natural killer T (NKT) cells and NK cells have important roles in antitumor and antimicrobial functions. They are involved in various renal diseases, including acute kidney injury (AKI). NKT cells in mice are activated by specific ligands, cytokines, and bacterial components, leading to AKI. Both renal vascular endothelial cell injury (via perforin-mediated pathway) and tubular epithelial cell injury (via tumor necrosis factor-alpha/Fas ligand pathway) are independently involved in the pathogenesis of AKI. NK cells complement the functions of NKT cells in the development of infection-associated AKI. Human CD56(+) T cells, which are functional counterparts of murine NKT cells, and a subpopulation of CD56(+) NK cells damage intrinsic renal cells in vitro upon activation, possibly through mechanisms similar to those in mice. These cells are also thought to be involved in the acute exacerbation of pre-existing glomerulonephritis triggered by infection in humans, and their roles in sepsis-associated AKI are currently under investigation. In this review, we provide an overview of recent advances in the understanding of the association among infections, NKT and NK cells, and kidney injury, which is much more profound than previously considered. The important role of liver macrophages in the activation of NKT cells is also introduced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Dandan Jiang, Tong Gao, Shuang Liang, Weiwei Mu, Shunli Fu, Yang Liu, Rui Yang, Zipeng Zhang, Yongjun Liu, Na Zhang
Summary: The study proposed a lymph node delivery strategy to modulate the immune response by activating CTLs and NK cells simultaneously, achieving significant antitumor efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Can M. Sungur, Qiankun Wang, Ayse N. Ozanturk, Hongbo Gao, Aaron J. Schmitz, Marina Cella, Wayne M. Yokoyama, Liang Shan
Summary: The role of NK cells in HIV-1 infections was investigated using a humanized mouse model. The study showed that NK cells directly provided anti-HIV-1 responses in nonlymphoid organs, but had limited functionality in lymphoid organs. Antiretroviral therapy and a broadly neutralizing antibody, PGT121, were found to enhance NK cell function and reduce viral load.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Tsong-Long Hwang, Chuan-Hsin Chang
Summary: This study aimed to determine whether oridonin enhances the anti-tumor activity of natural killer (NK) cells against lung cancer cells. The results showed that oridonin enhances NK cell cytotoxicity against A549 lung cancer cells by upregulating the expression of degranulation marker CD107a and IFN-γ, as well as activating NK cells and their ligand MICA/B. Oridonin also inhibits STAT3 phosphorylation in A549 cells and NK cells, and has a synergistic effect on the anti-tumor activity of NK cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Baochen Li, Rui Su, Huanhuan Yan, Juanjuan Liu, Chong Gao, Xiaofeng Li, Caihong Wang
Summary: The novel NAFLD nomogram demonstrated efficient in assessing the risk of NAFLD in PsA patients, while peripheral blood NK cell levels may be associated with dyslipidemia in patients with PsA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
David B. Rosen, Anne Mansson Kvarnhammar, Burkhardt Laufer, Thomas Knappe, Jens Jakob Karlsson, Enping Hong, Yu-Chi Lee, Dhruv Thakar, Luis Alejandro Zuniga, Kathy Bang, Simran Singh Sabharwal, Karan Uppal, Janne Damm Olling, Kristian Kjaergaard, Thomas Kurpiers, Meike Schnabel, Diana Reich, Philipp Glock, Joachim Zettler, Mathias Krusch, Ana Bernhard, Stefan Heinig, Valentino Konjik, Thomas Wegge, Yvonne Hehn, Steffen Killian, Laura Viet, Josefine Runz, Frank Faltinger, Mohammad Tabrizi, Kristin Laura Abel, Vibeke Miller Breinholt, Stina M. Singel, Kennett Sprogoe, Juha Punnonen
Summary: Recombinant interleukin-2 (IL-2) is an approved cancer immunotherapy, but it has severe toxicities and suboptimal pharmacokinetics. TransCon IL-2 beta/gamma is a novel prodrug designed to address these issues, showing sustained release of IL-2 and potential antitumor activity in animal models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Viraj Bhingardive, Guillaume Le Saux, Avishay Edri, Angel Porgador, Mark Schvartzman
Summary: The cytotoxic activity of natural killer cells is regulated by various chemical and physical cues, with a newly engineered platform based on nanowires revealing how spatial heterogeneity affects NK cell function. The platform demonstrates the tunability of NK cell cytotoxicity, offering insights into their immune function and potential applications in immunotherapy.
Article
Health Care Sciences & Services
Mengxuan Du, Yanqiu Li, Heng Gu, Mengge Gao, Hang Xu, Wenyao Zhong, Xiaohua Liu, Xingming Zhong
Summary: The proportion of NK cells, Th1 cells, and the Th1/Th2 ratio were significantly higher in patients with URSA compared to normal controls. There was a positive correlation between the percentage of NK cells and CD3+T cells, as well as CD3+CD4+T cells. NK cells and T cells, including their subgroups, are closely related.
TECHNOLOGY AND HEALTH CARE
(2023)
Review
Biochemistry & Molecular Biology
Cinzia Fionda, Gianluca Scarno, Helena Stabile, Rosa Molfetta, Chiara Di Censo, Angela Gismondi, Rossella Paolini, Silvano Sozzani, Angela Santoni, Giuseppe Sciume
Summary: Colorectal cancer is a common malignancy globally, with NK cells and ILC playing crucial roles in the disease prognosis and outcome. Their cytotoxic functions are key in controlling CRC metastasis, and understanding their molecular mechanisms holds significance for CRC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Oleksandr Kyrysyuk, Kai W. Wucherpfennig
Summary: T cells and NK cells have complementary roles in tumor immunity. Targeting immune evasion mechanisms and shared receptors between T cells and NK cells can enhance their immune response. Inhibitory and activating cytokines are also potential therapeutic strategies to impact lymphocyte function in tumors.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Review
Oncology
Julian Burks, Purevdorj B. Olkhanud, Jay A. Berzofsky
Summary: Gastrointestinal cancers are a group of complex cancers that affect the digestive system. NKT cells, with their immunoregulatory properties, play a crucial role in tumor immunity and can have either anti-tumor or pro-tumor effects depending on the cytokine profile expressed and the type of GI cancer.
Article
Obstetrics & Gynecology
Jia Liu, Peng Dong, Ningyi Jia, Xi Wen, Lanrong Luo, Shijun Wang, Jian Li
Summary: This study investigated the expression levels of TNF-alpha, IFN-gamma, IL-4, and IL-10 in dNK cells and found that the MAPK signal pathway is involved in the regulation of cytokine secretion by decidual NK cells at the maternal-fetal interface.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Jia Liu, Peng Dong, Liane Zhou, Shijun Wang
Summary: This study conducted a meta-analysis on the association between miRNA gene polymorphisms and cervical cancer risk. The results suggest a potential increased risk of cervical cancer associated with the miR-124 rs531564 polymorphism, but further large-scale studies are needed to confirm this finding.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)