Article
Environmental Sciences
Chen-Xi Li, Milton Talukder, Ya-Ru Xu, Shi-Yong Zhu, Ying-Xin Zhao, Jin- Long Li
Summary: Cadmium is a non-biodegradable environmental pollutant that can cross the blood-brain barrier and cause cerebral toxicity. However, its effect on the blood-brain barrier remains unclear.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Apor Veres-Szekely, Csenge Szasz, Domonkos Pap, Beata Szebeni, Peter Bokrossy, Adam Vannay
Summary: In the last 10 years, the relationship between dysbiosis and central nervous diseases has been proven. Microbial alterations lead to increased intestinal permeability, resulting in the penetration of bacterial fragments and toxins that induce local and systemic inflammatory processes, affecting distant organs including the brain. The integrity of the intestinal epithelial barrier plays a central role in the microbiota-gut-brain axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Maria Angeles Avila-Galvez, Daniela Marques, Ines Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Claudia Nunes dos Santos
Summary: Sesquiterpene lactones, such as those found in chicory, have shown potential as bioactive compounds with health benefits for brain disorders. In this study, researchers investigated the ability of six sesquiterpene lactones to cross the blood-brain barrier (BBB) and their effects on brain microvascular endothelial cells. They found that different lactones had varying capacities to be transported through the BBB, with costunolide showing the highest transport rate. Additionally, costunolide and parthenolide were found to improve barrier tightness by affecting the expression of specific proteins. These findings suggest that costunolide and parthenolide could be promising compounds for brain therapies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Biomedical
Li Yan, Cole W. Dwiggins, Rebecca A. Moriarty, Jae W. Jung, Udit Gupta, Ken D. Brandon, Kimberly M. Stroka
Summary: The blood-brain barrier (BBB) responds to mechanical cues and changes in substrate stiffness. The compromised function of the BBB is associated with neurological disorders and altered brain stiffness. Understanding the effects of matrix stiffness on BBB permeability could lead to new treatments for BBB dysfunction-related diseases.
ACTA BIOMATERIALIA
(2023)
Review
Immunology
Haoran Wang, Tingting Zhao, Zhenjiang Liu, Danzengquzhen, Cisangzhuoma, Jinying Ma, Xin Li, Xiaodan Huang, Bin Li
Summary: Recent investigations suggest that dietary consumption of flavonoids has neuroprotective effects by inhibiting neuroinflammatory and oxidative stress responses. Flavonoids may also shape gut microbiota composition and promote the growth of beneficial bacteria that produce neuroprotective metabolites. By influencing the microbiota-gut-brain axis, flavonoids indirectly improve brain health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Editorial Material
Immunology
Nathalie Stakenborg, Guy E. Boeckxstaens
Summary: Schiller et al. found that local sympathetic nerve activation can decrease the expression of the adhesion molecule MAdCAM-1 in endothelial cells, leading to reduced immune cell infiltration and inflammation. These findings suggest that local sympathetic stimulation plays a crucial role in regulating organ homeostasis.
Article
Immunology
Tingting Yang, Lin Li, Jiale Pang, Cai Heng, Chujing Wei, Xue Wang, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang
Summary: This study demonstrates that activating intestinal S1PR1 can improve cholestatic hepatitis by modulating intestinal barrier function. The results reveal the importance of intestinal tight junctions and the regulatory role of agonist SEW2871 in the gut-liver axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher, Dragos Andrei Chiran
Summary: This review examines the risk of SARS-CoV-2 infection and severe forms of COVID-19 in children diagnosed with celiac disease (CD) and emphasizes the importance of understanding the interaction and effects of the infection in CD. It also highlights the role of environmental and genetic factors, as well as the molecular mechanisms involved in modulating intestinal permeability and autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria Abou Diwan, Marwa Lahimer, Veronique Bach, Fabien Gosselet, Hafida Khorsi-Cauet, Pietra Candela
Summary: Accumulating evidence suggests that chronic exposure to low levels of pesticides in the diet affects the gut-microbiota-blood-brain barrier axis. This axis describes the connection between the microbiota, intestinal barrier, and blood-brain barrier. Preclinical observations have shown that pesticides cause gut microbiota alteration, or dysbiosis, which is associated with gastrointestinal disorders and diseases affecting distant organs like the blood-brain barrier. However, the interaction between pesticides, microbiota, intestinal barrier, and blood-brain barrier is not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Linghang Qu, Xiong Lin, Chunlian Liu, Chang Ke, Zhongshi Zhou, Kang Xu, Guosheng Cao, Yanju Liu
Summary: This study demonstrated that atractylodin has the potential to treat ulcerative colitis by inhibiting the MAPK pathway, protecting the intestinal barrier, and improving intestinal microecology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xingdao Zhang, Yuni Zhang, Yu He, Xingwang Zhu, Qing Ai, Yuan Shi
Summary: The study found that pretreatment with beta-glucan can improve intestinal injury in neonatal mice with necrotizing enterocolitis (NEC). This is achieved by suppressing the TLR4-NF-kappa B signaling pathway, improving intestinal barrier function, and regulating the composition of intestinal microbiota.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Weijun Wang, Nagore Marin-Ramos, Haiping He, Shan Zeng, Hee-Yeon Cho, Stephen D. Swenson, Long Zheng, Alan L. Epstein, Axel H. Schonthal, Florence M. Hofman, Ligang Chen, Thomas C. Chen
Summary: NEO100 was found to safely and reversibly open the BBB, allowing for increased brain entry of various therapeutics in both in vitro and in vivo models. Mechanistic studies revealed its effects on different BBB transport pathways and the translocation of tight junction proteins in brain endothelial cells. This approach has the potential to provide a safe and widely available method to enhance brain entry of therapeutics.
Review
Nutrition & Dietetics
Victoria Anthony Uyanga, Felix Kwame Amevor, Min Liu, Zhifu Cui, Xiaoling Zhao, Hai Lin
Summary: The text highlights the importance of gut health in animal welfare and wellbeing, as well as the role of dietary supplements such as citrulline and quercetin in promoting gut functions and homeostasis. These bioactive substances can influence gut health through anti-inflammatory and immunomodulatory effects.
Review
Immunology
Susana Lechuga, Manuel B. B. Braga-Neto, Nayden G. G. Naydenov, Florian Rieder, Andrei I. I. Ivanov
Summary: Disruption of the intestinal epithelial barrier is a common feature in mucosal inflammation, which leads to an inflammatory response. Previous studies on the breakdown of the gut barrier have mainly utilized colon cancer cell lines, which do not fully represent normal human intestinal epithelial cells. The development of human intestinal organoids provides a more physiologically-relevant platform to study the regulation and dysfunction of the intestinal barrier. This review discusses the use of human intestinal organoids to understand gut barrier disruption during mucosal inflammation, comparing them to conventional cell lines and identifying unique research questions that can be addressed using organoid platforms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Wei-Sheng Lin, Tai-Ling Chueh, Kalyanam Nagabhushanam, Chi -Tang Ho, Min-Hsiung Pan
Summary: This study evaluated the effects of Piceatannol (PIC) and 3'-hydroxypterostilbene (HPSB) on DSS-induced colitis in mice. The findings showed that both PIC and HPSB attenuated inflammation by inhibiting specific pathways and reducing inflammasome activation. PIC was also effective in modulating tight junctions. Additionally, both PIC and HPSB altered the composition of gut microbiota. These results suggest that PIC may be more effective in maintaining gut barrier integrity than HPSB and could be a promising ingredient for colitis prevention.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Helene David, Aurore Ughetto, Philippe Gaudard, Maelle Plawecki, Nitchawat Paiyabhroma, Emma Zub, Pascal Colson, Sylvain Richard, Nicola Marchi, Pierre Sicard
Summary: The study utilized in vivo photoacoustic imaging to track changes in vascular oxygen saturation in multiple organs and the brain post-myocardial infarction. Results showed a correlation between LV sO(2) and cardiac dysfunction, with global hypoxia observed in the brain, kidney, and liver shortly after MI, but returning to pre-MI levels after 7 days.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Environmental Sciences
Isabel Forner-Piquer, Adele Faucherre, Julia Byram, Marine Blaquiere, Frederic de Bock, Laurence Gamet-Payrastre, Sandrine Ellero-Simatos, Etienne Audinat, Chris Jopling, Nicola Marchi
Summary: In zebrafish larvae, exposure to high concentrations of glyphosate leads to behavioral and neurophysiological defects, while cellular and transcript signatures can be detected in response to low doses.
Article
Clinical Neurology
Damir Janigro, Damian M. Bailey, Sylvain Lehmann, Jerome Badaut, Robin O'Flynn, Christophe Hirtz, Nicola Marchi
Summary: The blood-brain barrier in the neurovascular unit plays a critical role in isolating the brain parenchyma from peripheral blood, and increased permeability of the barrier can contribute to the onset of CNS diseases. Biomarkers from glial, neuronal, and pericyte cells can exit the brain and appear in peripheral body fluids, such as saliva or urine, in various temporal trajectories under pathological conditions.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Damian M. Bailey, Anthony R. Bain, Ryan L. Hoiland, Otto F. Barak, Ivan Drvis, Christophe Hirtz, Sylvain Lehmann, Nicola Marchi, Damir Janigro, David B. MacLeod, Philip N. Ainslie, Zeljko Dujic
Summary: In this study, it was found that prolonged apnea duration during voluntary asphyxia leads to increased cerebral blood flow and blood-brain barrier permeability. The study highlights the critical role of hypoxemia and hypercapnia in BBB disruption.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Geoffrey Canet, Charleine Zussy, Celia Hernandez, Nathalie Chevallier, Nicola Marchi, Catherine Desrumaux, Laurent Givalois
Summary: This study reveals that chronic corticosterone (CORT) consumption is a main risk factor for Alzheimer's disease (AD) and suggests that glucocorticoid-based therapies should be prescribed with caution in populations with AD risk.
NEUROENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Erwin A. van Vliet, Nicola Marchi
Summary: The neurovascular unit (NVU) is a complex network involving different cells in the brain, including specialized brain endothelium, glial and mural cells, and neurons. Research suggests that dysfunction of the NVU is a common mechanism underlying late-onset seizures or epilepsy, neurological and neurodegenerative disorders associated with aging. Further studies also indicate that seizure activity may contribute to brain aging by causing regional NVU dysfunction, while cerebrovascular pathology may be linked to comorbidities. Diagnostic approaches tailored to seizure conditions in the elderly and disease-modifying strategies focusing on NVU restoration and control of inflammation are being explored. However, there are still knowledge gaps and clinical challenges in understanding seizure onset and conditions in an aging population.
Article
Clinical Neurology
Geoffrey Canet, Emma Zub, Charleine Zussy, Celia Hernandez, Marine Blaquiere, Valentin Garcia, Mathieu Vitalis, Frederic DeBock, Maria Moreno-Montano, Etienne Audinat, Catherine Desrumaux, Emmanuel Planel, Laurent Givalois, Nicola Marchi
Article
Critical Care Medicine
Charlotte Oris, Julie Durif, Marion Rouzaire, Bruno Pereira, Damien Bouvier, Samy Kahouadji, Mathieu Abbot, Marina Brailova, Sylvain Lehmann, Christophe Hirtz, Philippe Decq, Bernard Dusfour, Nicola Marchi, Vincent Sapin
Summary: This study evaluated the use of seven blood biomarkers for sport-related concussions. Only S100B and GFAP remained stable over the course of a season. The individual percentage change of S100B and NFL concentrations measured 36 hours after concussion was significantly different between non-resolutive and resolutive cases.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Pharmacology & Pharmacy
Nannan Gao, Fariba Rezaee
Summary: This review discusses the pathophysiological mechanisms by which microorganisms disrupt the airway epithelial barrier by targeting intercellular contacts between epithelial cells. It also presents recent progress in understanding signaling pathways involved in the formation and regulation of cell junctions. Potential chemical inhibitors and pharmacological approaches to restore the integrity of the airway epithelial barrier are summarized.
Article
Chemistry, Multidisciplinary
Mohammed Tanjimur Rahman, Youzhi Kaung, Logan Shannon, Charlie Androjna, Nima Sharifi, Vinod Labhasetwar
Summary: Bone metastasis at an advanced disease stage is common and untreatable. Overexpression of RANKL in tumor-bone marrow microenvironment drives tumor progression and bone resorption. Evaluation of biodegradable nanoparticles localized in tumor tissue showed that the combination treatment with docetaxel and Denosumab completely regressed the tumor, preventing bone resorption without causing mortality.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Clinical Neurology
N. Cresto, A. Janvier, N. Marchi
Summary: While seizures involve neuronal events, other brain cells also play a significant role in synaptic transmission. The blood-brain barrier and neuro-glio-vascular unit regulate the brain's homeostasis by maintaining the composition of the interstitial fluid. Damage to the blood-brain barrier and neuroinflammation are mechanisms that sustain abnormal neuronal discharges, which are associated with various pathological conditions. The understanding of the role of the blood-brain barrier and neuroinflammation in epilepsy could lead to the development of biomarkers for predicting disease progression and the discovery of new diagnostic and therapeutic approaches.
REVUE NEUROLOGIQUE
(2023)
Article
Environmental Sciences
Sophie Sakkaki, Noemie Cresto, Raphael Chancel, Emma Zub, Pierre Sicard, Tangui Maurice, Sandrine Ellero-Simatos, Laurence Gamet-Payrastre, Nicola Marchi, Julie Perroy
Summary: This study investigates the risk of continuous exposure to glyphosate from prenatal to adulthood and the impact of Shank3 synaptic gene mutation on neurological adaptations. The results show that prenatal exposure to glyphosate increases embryonic mortality rate and leads to neuroinflammation and behavioral adaptations in progenies of Shank3(Delta C/+) mice.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Neurosciences
Valentin Garcia, Marine Blaquiere, Alicia Janvier, Noemie Cresto, Carla Lana, Athenais Genin, Helene Hirbec, Etienne Audinat, Adele Faucherre, Emmanuel L. Barbier, Sophie Hamelin, Philippe Kahane, Chris Jopling, Nicola Marchi
Summary: This study reveals the association between mechanosensitive channel PIEZO1 and inflammatory responses in the central nervous system, particularly in the context of epilepsy. The expression of PIEZO1 is increased in epileptogenic regions of the brain and correlates with pro-inflammatory biomarkers. Additionally, TNF alpha is identified as a direct regulator of PIEZO1 expression. These findings highlight the potential significance of PIEZO1 in neuro-inflammatory processes.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Veronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common chronic liver disease, especially in obese individuals. This study suggests that the nuclear receptor CAR may play a role in the pathogenesis of NAFLD and could be a potential therapeutic target. In mice, deletion of CAR led to a NASH-like hepatic transcriptomic signature and astrogliosis in the hypothalamus of female mice.
Article
Immunology
Anais Virenque, Hennariikka Koivisto, Salli Antila, Emma Zub, Erin Jane Rooney, Diana Miszczuk, Adrian Mueller, Enija Stoka, Nicola Marchi, Kari Alitalo, Heikki Tanila, Francesco Mattia Noe
Summary: Understanding the pathological mechanisms of chronic traumatic brain injury (TBI) could lead to new therapeutic approaches. This study examined the role of meningeal lymphatic vessel dysfunction in modifying post-TBI pathology. The results showed that preexisting dysfunction of meningeal lymphatic vessels did not impact the structural brain damage and post-TBI behavior, but was associated with increased activation of microglia over time.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)