Article
Oncology
Jing Wang, Lucy K. Shewell, Christopher J. Day, Michael P. Jennings
Summary: One form of abnormal glycosylation in human tumors is the expression of Neu5Gc, a type of acid. The enzyme responsible for producing Neu5Gc in mammals is believed to be inactive in humans. However, low levels of Neu5Gc have been found in healthy humans, indicating its acquisition from diet, such as red meat. Elevated levels of Neu5Gc have been consistently detected in cancer tissues, cells, and serum samples, suggesting its potential as a biomarker for cancer. This review examines the use of Neu5Gc-containing tumor glycoconjugates as cancer biomarkers for detection, monitoring, prognosis, and therapeutic targets.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Lucy K. Shewell, Christopher J. Day, Jamie R. Kutasovic, Jodie L. Abrahams, Jing Wang, Jessica Poole, Colleen Niland, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Mark von Itzstein, James C. Paton, Adrienne W. Paton, Michael P. Jennings
Summary: The optimized SubB2M SPR assay revealed significantly elevated levels of Neu5Gc biomarkers in serum from breast cancer patients, allowing for differentiation of breast cancer patients from cancer-free individuals with 98.96% sensitivity and 100% specificity. Analysis of serum collected prospectively from breast cancer patients at high risk for disease recurrence showed a trend for a decrease in Neu5Gc levels immediately following treatment for those in remission, indicating the potential of Neu5Gc serum biomarkers as a promising tool for early detection and disease monitoring for breast cancer.
Article
Biochemistry & Molecular Biology
Lucy K. Shewell, Christopher J. Day, Tiana Hippolite, Xavier De Bisscop, James C. Paton, Adrienne W. Paton, Michael P. Jennings
Summary: Cutaneous melanoma is an aggressive and deadly type of skin cancer, and its prevalence is increasing worldwide. Currently, there are no serum biomarkers available for the early detection of cutaneous melanoma. However, researchers have developed a Neu5Gc-specific lectin called SubB2M, which can detect elevated levels of Neu5Gc-containing biomarkers in the serum of cancer patients. This discovery suggests that serum Neu5Gc-containing glycoconjugates can serve as novel biomarkers for cutaneous melanoma and contribute to its early diagnosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Marefa Jahan, Peter C. Thomson, Peter C. Wynn, Bing Wang
Summary: The study revealed that the concentration of Neu5Gc in red meat varies depending on tissue and species, with some animals lacking Neu5Gc in muscle and organ tissues. These findings provide consumers with guidance on animal meat preferences and shed light on the functionality of Neu5Gc.
Review
Obstetrics & Gynecology
Qianrun Chen, Jiayan Shi, Danhua Ruan, Ce Bian
Summary: This review provides a brief introduction to the biological characteristics of exosomes and the recent advances in isolating and detecting them. It also summarizes the various functions of exosomes in ovarian cancer, highlighting their potential as diagnostic biomarkers and therapeutic targets.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xu Cao, Song Yu, Wei Wang, Ruixiang Sun, Zepan Wu, Zhanfeng Gao, Yue Pang, Qingwei Li
Summary: Previous studies have shown that Neu5Gc is highly expressed in various types of cancer, but its role in bladder cancer has not been well studied. This study demonstrates that Neu5Gc is increased in bladder cancer and can be detected using the LIP from lamprey. The addition of Neu5Gc to cells also leads to increased gene expression of the Neu5Gc synthesis pathway. These findings provide a new tool for detecting bladder cancer and insights into the abnormal glycosylation process.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Genetics & Heredity
Fadian Ding, Yunfeng Lin, Guozhong Liu, Yuxin Liu, Feng Gao, Qicai Liu, Zhibo Zhang, Shangeng Weng
Summary: Organ (stem cell) transplantation is the most effective treatment for advanced organ failure. Neu5Gc, a pathogenic non-human sialic acid, hinders transplantation due to its immune disguise function. Gene knockout, such as CMAH, reduces donor antigenicity and enables xenotransplantation. Understanding immune disguise events is crucial for studying the mechanism of transplantation immune tolerance.
GENES AND IMMUNITY
(2022)
Article
Medicine, Research & Experimental
Hayato Iwase, Abhijit Jagdale, Takayuki Yamamoto, Mohamed H. Bikhet, Huy Q. Nguyen, Mohamed Ezzelarab, David Ayares, Douglas J. Anderson, Devin E. Eckhoff, Jeremy B. Foote, Huma Fatima, Hendrik Jan Schuurman, Hidetaka Hara, David K. C. Cooper
Summary: This study compared the survival of renal grafts from pigs expressing different Neu5Gc genes in baboon recipients. The absence of Neu5Gc expression on pig kidneys was found to impact graft survival when transplanted into baboons.
XENOTRANSPLANTATION
(2021)
Article
Biotechnology & Applied Microbiology
Hongying Li, Qiujin Zhu, Rui Chang, Ke Hu, Xuling Zhu, Aqi Xu, Shitao Xu, Pengyu Tang
Summary: This study successfully reduced the Neu5Gc content in 180-day-old Xiang pigs by adding 5'-CMP to their feed, while increasing umami amino acids. The inhibitory mechanism and effects of 5'-CMP varied in Xiang pigs of different ages, and there was no significant impact on the physicochemical parameters of the longissimus muscle.
JOURNAL OF FOOD PROTECTION
(2021)
Article
Oncology
Vivek Kumar, Sameer Gupta, Amrita Chaurasia, Manisha Sachan
Summary: Epithelial ovarian cancer (EOC) is a lethal gynecological malignancy, and early diagnosis is crucial for management. Aberrantly expressed miRNAs, particularly miR-205, miR-200c, and miR-141, show potential as minimally invasive biomarkers for early detection of EOC. The miRNA panel has high diagnostic potential with elevated AUC, sensitivity, and specificity, especially in early-stage serum samples.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucio Manzi, Nunzio Sepe, Walter Migliaccio, Ludovica Lanzoni, Luisa Iozzino, Fabrizia D'Angelo, Lucia Colarusso, Susana Montenegro, Angelo Palmese, Thomas D'Hooghe, Alfredo Ulloa-Aguirre, Yulia Koloda, Monica Lispi
Summary: This study compared the structural features of reference r-hFSH-alfa with five biosimilar preparations from different global regions. Differences were found in glycosylation, heterogeneity, post-translational modifications, and higher order structure between the reference and biosimilar preparations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thomas Senage, Anu Paul, Thierry Le Tourneau, Imen Fellah-Hebia, Marta Vadori, Salam Bashir, Manuel Galinanes, Tomaso Bottio, Gino Gerosa, Arturo Evangelista, Luigi P. Badano, Alberto Nassi, Cristina Costa, Galli Cesare, Rizwan A. Manji, Caroline Cueff de Monchy, Nicolas Piriou, Romain Capoulade, Jean-Michel Serfaty, Guillaume Guimbretiere, Etienne Dantan, Alejandro Ruiz-Majoral, Guenola Coste du Fou, Shani Leviatan Ben-Arye, Liana Govani, Sharon Yehuda, Shirley Bachar Abramovitch, Ron Amon, Eliran Moshe Reuven, Yafit Atiya-Nasagi, Hai Yu, Laura Iop, Kelly Casos, Sebastian G. Kuguel, Arnau Blasco-Lucas, Eduard Permanyer, Fabrizio Sbraga, Roger Llatjos, Gabriel Moreno-Gonzalez, Melchor Sanchez-Martinez, Michael E. Breimer, Jan Holgersson, Susann Teneberg, Marta Pascual-Gilabert, Alfons Nonell-Canals, Yasuhiro Takeuchi, Xi Chen, Rafael Manez, Jean-Christian Roussel, Jean-Paul Soulillou, Emanuele Cozzi, Vered Padler-Karavani
Summary: In a large cohort of patients who underwent aortic valve replacement, antibody responses to glycans present in bioprosthetic heart valves, notably galactose-alpha 1,3-galactose and N-glycolylneuraminic acid, were implicated in valve calcification and deterioration. It was found that antibodies against xenoantigens galactose-alpha 1,3-galactose and N-glycolylneuraminic acid could mediate the deterioration of bioprosthetic heart valves through calcification. Results suggest that BHVs manufactured using donor tissues deficient in these antigens may have improved durability.
Article
Medicine, Research & Experimental
Jeremy B. Foote, Abhijit Jagdale, Takayuki Yamamoto, Hidetaka Hara, Mohamed H. Bikhet, Henk-Jan Schuurman, Huy Q. Nguyen, Mohamed Ezzelarab, David Ayares, Douglas J. Anderson, Huma Fatima, Devin E. Eckhoff, David K. C. Cooper, Hayato Iwase
Summary: The study found that pig kidney grafts lacking Neu5Gc expression were associated with increased binding of baboon antibodies to pig endothelium and reduced graft survival when transplanted into baboons.
XENOTRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Wenqian Yang, Yuan Jiang, Qulian Guo, Zhixin Tian, Zhigang Cheng
Summary: Neu5Gc is an aberrant molecule in humans due to the lack of a converting enzyme. It has been observed in human cancer cells and tissues and can cause obstacles in clinical treatments. Therefore, studying Neu5Gc in humans is important for pathology and clinical relevance.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
Md. Khirul Islam, Misba Khan, Kamlesh Gidwani, Kenneth W. Witwer, Urpo Lamminmaeki, Janne Leivo
Summary: Extracellular vesicles (EVs) have potential as diagnostic, prognostic, and therapeutic agents for cancer. The glycosylation patterns on the EV surface can reveal their cell of origin and be used for targeted delivery. Lectins and other glycan recognizing entities can be powerful tools for discovering and detecting novel cancer biomarkers.
BIOMARKER RESEARCH
(2023)
Article
Microbiology
Lucy K. Shewell, Christopher J. Day, Xavier De Bisscop, Jennifer L. Edwards, Michael P. Jennings
Summary: Neisseria gonorrhoeae has developed resistance to previous antibiotics, necessitating the development of novel antimicrobials. Carbamazepine has been shown to block the interaction between gonococcal pili and human complement receptor 3, as well as effectively clear established gonococcal infections. Concentrations of carbamazepine in vaginal fluid from women taking the drug were found to be sufficient to significantly reduce the number of viable gonococci recovered from cervical cell infections. These findings support the further development of carbamazepine as a host-targeted therapy for gonococcal cervicitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Lucy K. Shewell, Christopher J. Day, Tiana Hippolite, Xavier De Bisscop, James C. Paton, Adrienne W. Paton, Michael P. Jennings
Summary: Cutaneous melanoma is an aggressive and deadly type of skin cancer, and its prevalence is increasing worldwide. Currently, there are no serum biomarkers available for the early detection of cutaneous melanoma. However, researchers have developed a Neu5Gc-specific lectin called SubB2M, which can detect elevated levels of Neu5Gc-containing biomarkers in the serum of cancer patients. This discovery suggests that serum Neu5Gc-containing glycoconjugates can serve as novel biomarkers for cutaneous melanoma and contribute to its early diagnosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Microbiology
Preeti Garai, John M. Atack, Brandon M. Wills, Michael P. Jennings, Lauren O. Bakaletz, Kenneth L. Brockman
Summary: This study investigated the role of ModA phasevarions in regulating the adherence of NTHi to specific host substrates in the respiratory tract. The findings suggest that NTHi adherence is substrate-specific and dependent on the ModA allele encoded, with adhesins Protein E and P4 playing a significant role. Understanding the substrate-specific regulation of NTHi adherence by ModA phasevarions can aid in the development of targeted vaccines and therapeutics against NTHi.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biochemistry & Molecular Biology
Nusrat Nahar, Greg Tram, Freda E-C Jen, Zachary N. Phillips, Lucy A. Weinert, Janine T. Bosse, Jafar S. Jabbari, Quentin Gouil, Mei R. M. Du, Matthew E. Ritchie, Rory Bowden, Paul R. Langford, Alexander W. Tucker, Michael P. Jennings, Conny Turni, Patrick J. Blackall, John M. Atack
Summary: Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, has been found to possess phase-variable regulons known as phasevarions, which lead to altered expression of multiple genes via epigenetic mechanisms. This variation is caused by the variable expression of DNA methyltransferases, resulting in methylation differences within the bacterial population. The identification of these phasevarions in A. pleuropneumoniae is important for the development of a subunit vaccine against this veterinary pathogen.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Jing Wang, Lucy K. Shewell, Christopher J. Day, Michael P. Jennings
Summary: One form of abnormal glycosylation in human tumors is the expression of Neu5Gc, a type of acid. The enzyme responsible for producing Neu5Gc in mammals is believed to be inactive in humans. However, low levels of Neu5Gc have been found in healthy humans, indicating its acquisition from diet, such as red meat. Elevated levels of Neu5Gc have been consistently detected in cancer tissues, cells, and serum samples, suggesting its potential as a biomarker for cancer. This review examines the use of Neu5Gc-containing tumor glycoconjugates as cancer biomarkers for detection, monitoring, prognosis, and therapeutic targets.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Microbiology
Joanna E. Musik, Jessica Poole, Christopher J. Day, Thomas Haselhorst, Freda E. -C. Jen, Thomas Ve, Veronika Masic, Michael P. Jennings, Yaramah M. Zalucki
Summary: This study designed 11 peptides to mimic signal peptides that are inefficiently cleaved by LepB. The binding affinity and inhibitory potential of these peptides against LepB were assessed. It was found that the tryptophan residue in the signal peptide inhibited the cleavage of the peptide by LepB, and replacing this residue with alanine improved the cleavage efficiency.
MICROBIOLOGY SPECTRUM
(2023)
Review
Biochemistry & Molecular Biology
Yuan Zhang, Freda E. -C. Jen, Kate L. Fox, Jennifer L. Edwards, Michael P. Jennings
Summary: Phosphorylcholine (ChoP) is present in all life forms, including bacteria. Recent research has shown that ChoP modification and phase variation play a role in bacterial pathogenesis. However, the mechanisms of ChoP synthesis in some bacteria are still unclear. This review examines the recent developments in ChoP-modified proteins and glycolipids, as well as ChoP biosynthetic pathways, and discusses the role of ChoP in bacterial pathobiology and immune response modulation.
TRENDS IN MICROBIOLOGY
(2023)
Article
Microbiology
Yuan Zhang, Freda E. -C. Jen, Jennifer L. L. Edwards, Michael P. P. Jennings
Summary: Phosphorylcholine (ChoP) modification on bacterial surface proteins and carbohydrates contributes to host mimicry and survival in the host. This study systematically analyzed bacterial genomes to identify the potential ChoP biosynthetic pathways, and found the association between specific pathways and the type of ChoP-modified surface factors.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Greg Tram, Freda E. -C. Jen, Zachary N. Phillips, John F. Lancashire, Jamie Timms, Jessica Poole, Michael P. Jennings, John M. Atack
Summary: This study characterized the ModA phasevarion in H. influenzae biogroup aegyptius, finding ModA13 in non-BPF causing strains and ModA16 unique to BPF causing isolates. Phase variation of ModA13 and ModA16 resulted in genome-wide changes to DNA methylation, leading to altered protein expression. However, these changes did not affect serum resistance in H. influenzae biogroup aegyptius strains.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
John M. Atack, Kenneth L. Brockman, Lauren O. Bakaletz, Michael P. Jennings
Summary: This study presents high-depth coverage RNA-Seq data from prototype NTHi strains 723 and R2866, which encode two of the most common phase-variable ModA alleles found in NTHi strains, ModA2 and ModA10.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
