Review
Biochemistry & Molecular Biology
Hideo Tsubouchi
Summary: Homologous recombination (HR) is crucial for meiosis and is induced during meiotic prophase. The Hop2-Mnd1 complex, originally identified in budding yeast, is conserved across species and plays an essential role in meiosis. Accumulating evidence suggests that Hop2-Mnd1 promotes RecA-like recombinases for homology search and strand exchange. This review summarizes studies on the mechanism of the Hop2-Mnd1 complex in promoting HR and beyond.
Article
Biochemistry & Molecular Biology
Kei Yamaya, Bin Wang, Nadin Memar, Arome Solomon Odiba, Alexander Woglar, Anton Gartner, Anne M. Villeneuve
Summary: RAD54 family DNA translocases, together with RAD51 recombinases, play a role in maintaining genome stability. Studying the functions of RAD54 paralogs RAD-54.L and RAD-54.B in Caenorhabditis elegans during meiotic prophase reveals their distinct contributions to the dynamics of RAD-51 association with DNA and meiotic double-strand break repair. RAD-54.L is essential for RAD-51 removal from meiotic double-strand break sites, while RAD-54.B prevents excessive accumulation of RAD-51 on unbroken DNA. This study provides insights into the division of labor among RAD-54 paralogs in promoting efficient homologous recombination and preventing deleterious effects of unproductive RAD-51 association.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Genetics & Heredity
Karen Voelkel-Meiman, Ashwini Oke, Arden Feil, Alexander Shames, Jennifer Fung, Amy J. MacQueen
Summary: The study reveals that while the SC proteins are not essential for recombination itself, they promote efficient mismatch repair at interhomolog recombination sites. Failure to repair mismatches leads to the formation of genotypically sectored colonies, with an increased frequency of unrepaired mismatches in cells lacking specific proteins.
Article
Biochemistry & Molecular Biology
Marina Marcet-Ortega, Andros Maldonado-Linares, Maria Lopez-Panades, Ignasi Roig
Summary: This study provides a detailed analysis of the role of p53 in meiotic prophase in mouse spermatocytes. The absence of p53 slows down prophase progression and affects crossover formation and localization. These findings contribute to a deeper understanding of the functions of p53 during meiotic prophase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Junchao Qin, Tao Huang, Jing Wang, Limei Xu, Qianli Dang, Xiuhua Xu, Hongbin Liu, Zhaojian Liu, Changshun Shao, Xiyu Zhang
Summary: This study reveals an essential role of Rad51 in the maintenance of spermatogonia and meiotic progression in mice.
CELL DEATH DISCOVERY
(2022)
Article
Genetics & Heredity
Lieke Koornneef, Johan A. Slotman, Esther Sleddens-Linkels, Wiggert A. Van Cappellen, Marco Barchi, Attila Toth, Joost Gribnau, Adriaan B. Houtsmuller, Willy M. Baarends
Summary: This study used three-color dSTORM microscopy and a mouse model to investigate the accumulation patterns of RAD51/DMC1 recombinases in meiosis, revealing the impact of HORMAD1 on recombinase formation and dynamics, as well as a previously unknown role of HORMAD1 in inhibiting coil formation in the synaptonemal complex.
Article
Multidisciplinary Sciences
Mara De Marco Zompit, Monica Torres Esteban, Clemence Mooser, Salome Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, Ann-Marie K. Shorrocks, Andrew N. Blackford, Daniel Durocher, Manuel Stucki
Summary: In this study, CIP2A is identified as a protein that interacts with TOPBP1 and specifically regulates its localization in mitosis. Cells lacking CIP2A show increased radio-sensitivity, micronuclei formation, and chromosomal instability.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Masaru Ito, Asako Furukohri, Kenichiro Matsuzaki, Yurika Fujita, Atsushi Toyoda, Akira Shinohara
Summary: This study demonstrates that FIGNL1 plays a positive role in homologous recombination by controlling the non-productive assembly of RAD51/DMC1 on single-stranded and double-stranded DNAs, and promoting chromosome synapsis and meiotic DSB repair.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Kazi Nazrul Islam, Maitri Mitesh Modi, Kellee Renee Siegfried
Summary: The SMC1β protein plays a crucial role in meiosis in vertebrates, primarily involved in meiosis in both fish and mammals. In zebrafish, Smc1b is essential for the leptotene to zygotene transition in spermatogenesis, with key differences in Smc1b requirement for meiosis observed among vertebrates.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Priyanka Sawant, Stephen Mwaniki, Yurika Fujita, Masaru Ito, Asako Furukohri, Akira Shinohara
Summary: In budding yeast, the meiosis-specific protein Mei5-Sae3 promotes the assembly of Dmc1 filaments by stimulating DNA strand exchanges by Rad51 and Dmc1. The YNEL residues in the Sae3 sequence play a critical role in Dmc1 assembly.
GENES & GENETIC SYSTEMS
(2023)
Article
Cell Biology
Laia Marin-Gual, Laura Gonzalez-Rodelas, Maria M. Garcias, Lukas Kratochvil, Nicole Valenzuela, Arthur Georges, Paul D. Waters, Aurora Ruiz-Herrera
Summary: This study compares the regulation of meiotic prophase I in reptiles by examining four species. The results show that meiosis progression is highly conserved in reptiles, with telomeres clustering forming the bouquet, promoting homologous pairing and synapsis. Low levels of meiotic double strand breaks were also detected in all taxa, providing new insights into reptile meiosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Genetics & Heredity
Ian R. Adams, Owen R. Davies
Summary: In meiosis, the synaptonemal complex (SC) plays a crucial role in facilitating the synapsis of homologous chromosomes. Mutations in SC genes have been linked to male and female infertility in humans. This article integrates structural information and genetics to explain how SC mutations can lead to human infertility, highlighting different susceptibility of SC proteins to disease mutations and the pathogenic effects of seemingly minor genetic variants.
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Jasvinder S. Ahuja, Catherine S. Harvey, David L. Wheeler, Michael Lichten
Summary: This study found that both noncrossover and crossover recombination in meiosis involve break repair through synthesis-dependent strand annealing. The formation of crossover-specific double Holliday junctions occurs through processes involving branch migration.
Review
Genetics & Heredity
Sarah N. Ur, Kevin D. Corbett
Summary: Meiotic cell division is a specialized process preparing for sexual reproduction, involving homologous chromosomes identifying each other and forming physical links through DNA recombination. The SMC family cohesin complexes and meiotic chromosome axis play crucial roles in organizing chromosomes and promoting recombination. The synaptonemal complex (SC) ensures high fidelity in meiotic recombination by assembling between homologs and providing feedback.
ANNUAL REVIEW OF GENETICS, VOL 55
(2021)
Article
Biochemistry & Molecular Biology
Meng Lin, Jinxing Lv, Dan Zhao, Siyu Liu, Jinfu Xu, Yangyang Wu, Fuxin Wang, Jun Zhang, Bo Zheng, Cong Shen, Xie Guan, Jun Yu, Xiaoyan Huang
Summary: Given the importance of the MRN complex in HR, this study identifies MRNIP as a novel HR factor crucial for the expression of the MRN complex and loading of recombinases, thus promoting meiotic progression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Ga-Young Jeong, Mi Kyung Park, Hee-Joo Choi, Hee Woon An, Young-Un Park, Hyung-Jun Choi, Jin Park, Hyung-Yong Kim, Taekwon Son, Ho Lee, Kyueng-Whan Min, Young-Ha Oh, Jeong-Yeon Lee, Gu Kong
Summary: NSD3 plays a critical epigenetic role in breast cancer progression by modulating NOTCH signaling pathway, promoting tumor development and metastasis. This study highlights NSD3 as a potential therapeutic target for metastatic breast cancer.
Article
Biochemistry & Molecular Biology
Ji Won Park, Ji Eun Kim, Yun Ju Choi, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Jin Tae Hong, Ho Lee, Dae Youn Hwang
Summary: Alterations in complement component 3 (C3) expression have been associated with various bowel diseases, and this study found that C3 deficiency can lead to constipation phenotypes in mice, characterized by reduced stool excretion, prolonged gastrointestinal transit, decreased intestine length, altered crypt structure, and suppressed mucin secretion.
Article
Immunology
Jin-Kwan Lee, Seo-Young Koo, Hye-Mi Nam, Jee-Boong Lee, Jiwon Ko, Kyung-Mo Kim, Eun-Ji Park, Tae Jin Kim, Ho Lee, Heounjeong Go, Chang-Woo Lee
Summary: The Ssu72 phosphatase plays a crucial role in T-cell differentiation and function by regulating Tregs development and cytokine response. Deletion of Ssu72 disrupts the balance between effector T cells and Tregs in the periphery, resulting in impaired mucosal tolerance in patients. Ssu72 interacts with PLCγ1 to modulate T-cell receptor signaling and Treg development.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Editorial Material
Genetics & Heredity
Marie-Christine Birling, Atsushi Yoshiki, David J. Adams, Shinya Ayabe, Arthur L. Beaudet, Joanna Bottomley, Allan Bradley, Steve D. M. Brown, Antje Buerger, Wendy Bushell, Francesco Chiani, Hsian-Jean Genie Chin, Skevoulla Christou, Gemma F. Codner, Francesco J. DeMayo, Mary E. Dickinson, Brendan Doe, Leah Rae Donahue, Martin D. Fray, Alessia Gambadoro, Xiang Gao, Marina Gertsenstein, Alba Gomez-Segura, Leslie O. Goodwin, Jason D. Heaney, Yann Herault, Martin Hrabe de Angelis, Si-Tse Jiang, Monica J. Justice, Petr Kasparek, Ruairidh E. King, Ralf Kuhn, Ho Lee, Young Jae Lee, Zhiwei Liu, K. C. Kent Lloyd, Isabel Lorenzo, Ann-Marie Mallon, Colin McKerlie, Terrence F. Meehan, Violeta Munoz Fuentes, Stuart Newman, Lauryl M. J. Nutter, Goo Taeg Oh, Guillaume Pavlovic, Ramiro Ramirez-Solis, Barry Rosen, Edward J. Ryder, Luis A. Santos, Joel Schick, John R. Seavitt, Radislav Sedlacek, Claudia Seisenberger, Je Kyung Seong, William C. Skarnes, Tania Sorg, Karen P. Steel, Masaru Tamura, Glauco P. Tocchini-Valentini, Chi-Kuang Leo Wang, Hannah Wardle-Jones, Marie Wattenhofer-Donze, Sara Wells, Michael V. Wiles, Brandon J. Willis, Joshua A. Wood, Wolfgang Wurst, Ying Xu, Lydia Teboul, Stephen A. Murray
Summary: The International Mouse Phenotyping Consortium has reported the generation of new mouse mutant strains for over 5,000 genes, including 2,850 new null mutations, 2,987 new conditional-ready strains, and 4,433 new reporter alleles.
Article
Oncology
Hee Eun Kang, Yoojeong Seo, Jun Seop Yun, Sang Hyun Song, Dawool Han, Eunae Sandra Cho, Sue Bean Cho, Yoon Jeon, Ho Lee, Hyun Sil Kim, Joyeon Kang, Jong In Yook, Nam Hee Kim, Tae Il Kim
Summary: This study revealed that Axin2, a downstream target of canonical Wnt, activates Hippo pathway in APC-mutated CRC, limiting the therapeutic potential of niclosamide. By combining niclosamide with metformin, Hippo pathway can be activated synergistically with suppression of canonical Wnt in APC-mutated CRC. This combinatory approach offers a novel therapeutic strategy for FAP and CRC patients by targeting both Wnt and Hippo pathways.
Article
Biochemistry & Molecular Biology
Won-Sik Shin, Mi-Kyung Park, Jae Hoon Kim, Si Won Oh, Ji-Yun Jang, Ho Lee, Seung-Taek Lee
Summary: In this study, we found that PTK7 plays an oncogenic role in esophageal squamous cell carcinoma (ESCC). Overexpression of PTK7 enhanced the proliferation, adhesion, wound healing, and migration of ESCC cells, and important signaling pathways were activated during this process. Furthermore, mouse models confirmed the importance of PTK7 in tumor formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Enkhmend Enkhtaivan, Hyun Ji Kim, Boram Kim, Hyung Jung Byun, Lu Yu, Tuan Minh Nguyen, Thi Ha Nguyen, Phuong Anh Do, Eun Ji Kim, Kyung Sung Kim, Hieu Phung Huy, Mostafizur Rahman, Ji Yun Jang, Seung Bae Rho, Ho Lee, Gyeoung Jin Kang, Mi Kyung Park, Nan-Hyung Kim, Chang Ick Choi, Kyeong Lee, Hyo Kyung Han, Jungsook Cho, Ai Young Lee, Chang Hoon Lee
Summary: This study investigates the role of EMP2 in melanogenesis and finds that it is involved in the process through the regulation of TRP-2 expression.
BIOMOLECULES & THERAPEUTICS
(2022)
Review
Cell Biology
Ho Lee
Summary: Obesity is closely linked to at least 13 different types of cancer, with potential mechanisms including hyperactivation of the IGF pathway, metabolic dysregulation, dysfunctional angiogenesis, chronic inflammation, and interaction between pro-inflammatory cytokines, endocrine hormones, and adipokines. Mouse models have been commonly used to study the link between obesity and cancer, and the experimental results obtained from these models provide strong evidence and suggest underlying mechanisms.
Article
Biochemistry & Molecular Biology
Gyeoung Jin Kang, Jung Ho Park, Hyun Ji Kim, Eun Ji Kim, Boram Kim, Hyun Jung Byun, Lu Yu, Tuan Minh Nguyen, Thi Ha Nguyen, Kyung Sung Kim, Hiu Phung Huy, Mostafizur Rahman, Ye Hyeon Kim, Ji Yun Jang, Mi Kyung Park, Ho Lee, Chang Ick Choi, Kyeong Lee, Hyo Kyung Han, Jungsook Cho, Seung Bae Rho, Chang Chang Hoon
Summary: Advanced or metastatic breast cancer is a major cause of cancer-related death. This study reveals the role of PRR16 and ABI2 in the epithelial-mesenchymal transition (EMT) process of breast cancer cells. PRR16 interacts with ABI2, interfering with its inhibition of ABL1 kinase and promoting cancer cell migration and invasion. ABL1 kinase inhibitors may be potential therapeutic agents for PRR16-related breast cancer.
BIOMOLECULES & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Mi Kyung Park, Ho Lee, Chang Hoon Lee
Summary: This review article provides an overview of the diverse functions of PTM in protein regulation and the pivotal role of ZEB family transcription factors in tumour progression and metastasis. The article also discusses the PTM of ZEBs and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lu Yu, Ho Lee, Seung Bae Rho, Mi Kyung Park, Chang Hoon Lee
Summary: This article introduces the research progress of ethacrynic acid (ECA) and its derivatives as potential anticancer agents. Despite limitations and side effects in its clinical application, ECA has been shown to impact multiple hallmark processes of cancer through various mechanisms. Additionally, the trend of synthesis research to improve the bioavailability of ECA is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Hong Thi Lam Phan, Kyoungmi Kim, Ho Lee, Je Kyung Seong
Summary: Programmable nucleases, such as ZFNs, TALENs, and CRISPR/Cas, have diverse applications and enormous potential for targeted genomic modifications. Advances in genome editing tools have accelerated the development of genetically modified animal models for studying human diseases. This review summarizes the progress in developing mouse models of human diseases based on programmable nucleases and discusses their therapeutic applications.
Article
Oncology
Na-Lee Ka, Mi Kyung Park, Seung-Su Kim, Yoon Jeon, Sewon Hwang, Sun Mi Kim, Ga Young Lim, Ho Lee, Mi-Ock Lee
Summary: NR1D1 enhances antitumor immunity and suppresses breast cancer progression and lung metastasis by activating the cGAS-STING pathway, suggesting potential immunotherapeutic strategies for breast cancer.
Article
Biochemistry & Molecular Biology
Mingyu Kang, Joon H. H. Kang, In A. Sim, Do Y. Seong, Suji Han, Hyonchol Jang, Ho Lee, Sang W. Kang, Soo-Youl Kim
Summary: Previous work has shown that cancer cells rely on fatty acid oxidation rather than glycolysis for ATP production. However, this study found that some cancer cells undergo cell death when deprived of glucose, resulting in a decrease in ATP production. The response to glucose deprivation was different between glucose insensitive cancer cells (GIC) and glucose sensitive cancer cells (GSC). Glucose deprivation induced cell death in GSC, but not GIC, indicating that GIC have a higher tolerance for decreased NADPH levels. The findings suggest that glucose deprivation-induced cancer cell death is independent of ATP depletion, but rather caused by a failure of ROS regulation by the antioxidant system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Thi Ha Nguyen, Tuan Minh Nguyen, Dinh Thi Minh Ngoc, Taesik You, Mi Kyung Park, Chang Hoon Lee
Summary: This review discusses the molecular mechanisms of autophagy and mitophagy in hepatocellular carcinoma (HCC) and highlights the dual role of autophagy in tumor initiation and progression. Additionally, a detailed analysis of autophagy- and mitophagy-related molecules reveals their specific functions during tumorigenesis and the progression of HCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)