Article
Medicine, Research & Experimental
Niuniu Zhong, Yi Yu, Jun Chen, Yuanyuan Shao, Zhiqiang Peng, Junhe Li
Summary: This study explored the clinicopathological characteristics, survival outcomes, and prognosis of very young gastric cancer (GC) patients. The results showed that very young GC patients were predominantly female, with diffuse and poorly differentiated types, and most patients were diagnosed at an advanced stage. The common sites of metastasis were the ovary and peritoneum. TNM stage and radical surgery were identified as independent prognostic factors for the overall survival of very young GC patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Oncology
Guo Zu, Jiacheng Gao, Tingting Zhou
Summary: The expression of SOX9 is associated with depth of tumor invasion, TNM stage, and poorer overall survival in gastric cancer patients. High expression of SOX9 is also correlated with shorter survival in GC patients. TCGA analysis indicates that SOX9 is upregulated in STAD patients compared to normal patients, and high expression of SOX9 is associated with poorer overall survival, although the statistical difference is not significant.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Juan He, Yali Zhuang, Chengyang Hu
Summary: This study aimed to explore the clinicopathological characteristics and prognostic risk factors of cervical cancer in patients aged <= 35 years. The results showed that patients in the <= 35-year-old group had higher rates of human papillomavirus (HPV) infection, contact vaginal bleeding, depth of cervical interstitial infiltration, parametrial metastasis, and vascular infiltration compared to the >35-year-old group. The 3-year cumulative disease-free survival (DFS) rates were significantly lower in the <= 35-year-old group. Depth of cervical interstitial infiltration >4 mm, parametrial metastasis, lymph node metastasis, and vascular infiltration were identified as independent risk factors for the prognosis of cervical cancer patients aged <= 35 years.
Article
Oncology
Guhyun Kang, Jung-Soo Pyo, Nae-Yu Kim, Dong-Wook Kang
Summary: This study revealed that in colorectal cancer, a low tumor-stroma ratio is associated with less invasion and distant metastasis, as well as better survival. The high stroma group has higher expressions of HIF-1 alpha and MVD, and CRC with mucinous components have a higher stroma-low rate.
Article
Oncology
Kenichi Nakamura, Kojiro Eto, Shiro Iwagami, Katsuhiro Ogawa, Hiroshi Sawayama, Takatsugu Ishimoto, Masaaki Iwatsuki, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
Summary: This study examined the concordance between preoperative clinical and postoperative histological diagnoses of different subtypes of gastric cancer. It found that poorly cohesive carcinoma subtypes have different biological characteristics and prognoses compared to other subtypes.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Chang-An Guo, Xiao-Lu Su, Wen-Jie Wang, Tian-Hong Xia, Xiao-Meng Cao, Shao-Bin Yuan, Wen-An Wang, An Zhang, Hong-Bin Liu
Summary: NPM1 plays an important role in the occurrence and development of leukemia and various solid tumors. This study investigated the expression of NPM1 in gastric cancer (GC) and its association with clinicopathological characteristics. The results showed that NPM1 was lowly expressed in the majority of GC tissues and high expression was associated with better overall survival and disease-free survival. These findings suggest that NPM1 may be a valuable tool for the diagnosis and prognosis assessment of GC.
Article
Pathology
Fang Li, Guiqing Meng, Bibo Tan, Zihao Chen, Qiang Ji, Xiaoxiao Wang, Chang Liu, Shuyao Niu, Yong Li, Yueping Liu
Summary: HER2 overexpression is closely related to gastric cancer neovascularization and is an independent predictor of gastric cancer prognosis. In clinical treatment, anti-HER2 targeted therapy and antiangiogenesis drugs can be adopted for effective treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Pathology
Nathalie Guedj, Lorraine Blaise, Francois Cauchy, Miguel Albuquerque, Olivier Soubrane, Valerie Paradis
Summary: In this study, the prognostic value of stromal compartment in iCC was evaluated using multiparametric morphological analysis. It was found that high proportionated stromal area was associated with better disease-free survival (DFS), while low activated stroma index was linked to a better DFS. On the other hand, high collagen reticulation index was associated with poorer overall survival, suggesting potential clinical relevance in evaluating collagen reticulation in patients with iCC.
Article
Oncology
Qing Wei, Yiding Gao, Changsong Qi, Xing Yuan, Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Wei Zhuo, Zhiyuan Xu, Jieer Ying
Summary: A total of 11,363 gastric cancer patients were enrolled, with SRC patients more likely to occur in female and young patients. Significant factors for prognosis included age, tumor site, tumor size, T classification, N classification, TNM stage, and primary site surgery, as identified through univariate and multivariate analyses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fengxian Fu, Xulan Ma, Yiyan Lu, Hongbin Xu, Ruiqing Ma
Summary: This study retrospectively reviewed the clinicopathological characteristics and prognostic factors of 22 patients with MOC-derived PMP, suggesting that histopathologic subtype and PCI may predict prognosis, and patients with high-grade disease may benefit from complete cytoreduction.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Min Wang, Bo Yuan, Zhen-huan Zhou, Wei-wei Han
Summary: Cervical adenocarcinoma patients present with early clinicopathological features and have 5-year and 10-year survival rates of 74.47% and 70.00% respectively. Married status, surgery, and chemotherapy are favorable prognostic indicators, while age, tumor grade, tumor size, FIGO stage, and pelvic lymph node metastasis are unfavorable prognostic factors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Keisuke Komori, Kazuki Kano, Shuji Ando, Hayato Watanabe, Kosuke Takahashi, Yukio Maezawa, Hirohito Fujikawa, Sho Sawazaki, Masakatsu Numata, Toru Aoyama, Takanobu Yamada, Hiroshi Tamagawa, Norio Yukawa, Yasushi Rino, Takashi Ogata, Takashi Oshima
Summary: This study compared the clinicopathological characteristics and prognosis of patients with mucinous gastric carcinoma (MGC) and non-mucinous gastric carcinoma (NMGC). Significant differences were observed in tumor location, tumor diameter, lymph node metastasis, venous invasion, and lymphatic invasion between the two groups. However, after propensity score matching, there were no significant differences in the 5-year overall survival and cancer-specific survival rates between MGC and NMGC patients.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Ying Ren, Shicheng Wang, Bo Wu, Zhan Wang
Summary: This study aims to uncover the clinicopathological features and identify prognostic risk factors among patients with pancreatic cancer bone metastasis (PCBM). The results show that age, pathological type, chemotherapy, liver metastasis, lung metastasis, and marital status are independent prognostic factors for PCBM patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yi-Tong Li, Xiang-Yu Wang, Bo Zhang, Bao-Rui Tao, Zhen-Mei Chen, Xiao-Chen Ma, Jia-Hao Han, Chong Zhang, Rui Zhang, Jin-Hong Chen
Summary: This study aimed to explore the prognostic significance of clinicopathological characteristics in early-onset versus late-onset colorectal liver metastases (CRLM). The data of CRLM patients who underwent hepatectomy from September 2010 to September 2020 were retrospectively analyzed. The results showed that preoperative CA19-9 level, RAS/BRAF status, bilobar involvement, and preoperative CEA level were predictive of early-onset CRLM patient prognosis, while the number of CRLM, preoperative CA19-9 level, and BRAF status were predictive of late-onset CRLM patient prognosis.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Zhu Hui Liu, Shi Yuan Lu, Xiao Bo Li, Hui Min Chen, Hao Yan Chen, Xiao Yu Chen, Jing-Yuan Fang, Yun Cui
Summary: This study aimed to clarify the endoscopic, clinicopathological, and growth characteristics of minute gastric cancer (MGC) and improve its detection rate. The majority of MGC lesions presented as type IIc and reddish appearance, with well-differentiated tubular adenocarcinoma. MGC showed a relatively slow growth rate, and if missed diagnosed, there was still a chance for curative resection.
JOURNAL OF DIGESTIVE DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)