Article
Food Science & Technology
Karolina Nowak, Ziga Jakopin
Summary: Due to concerns about endocrine disruption, bisphenol A (BPA) is being phased out and replaced with other substances. This study aimed to evaluate the endocrine-disrupting potential of 18 BPA analogues and their halogenated derivatives. The results showed that some BPA analogues displayed higher endocrine disruption potential than BPA itself. Halogenation was predicted to increase the binding affinity of bisphenols for certain nuclear receptors. Further in vitro experiments are needed to confirm these findings and evaluate the safety of BPA substitutes and their halogenated transformation products.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Physical
Claudia Carnimeo, Nicola Colatorti, Valeria D'Orazio, Pasquale Trotti, Elisabetta Loffredo
Summary: In this study, biochar obtained from poplar wood gasification was used to adsorb xenoestrogens and a herbicide from water. The surface micromorphology and functional groups composition of biochar were investigated using scanning electron microscopy and Fourier-transform infrared spectroscopy. The adsorption kinetics showed the formation of strong bonds between biochar and the compounds, and the adsorption isotherms were described by several mathematical models. Biochar exhibited strong adsorption ability at higher temperatures, and desorption was slow and scarce. This study highlights the excellent potential of biochar as a low-cost biosorbent for retaining organic compounds permanently.
Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Sana Ullah, Shahid Ahmad, Xinle Guo, Saleem Ullah, Ghulam Nabi, Kunyuan Wanghe
Summary: The vast expansion of plastic manufacturing has led to the increased environmental impact of microplastics and nanoplastics, posing a threat to marine and terrestrial life due to the presence of endocrine disrupting chemicals and other harmful compounds. These plastics can absorb and transport harmful chemicals commonly used in plastic production, which can easily leach into liquids and affect the endocrine system of mammals. The size-dependent bioaccumulation, distribution, and translocation of microplastics and nanoplastics can have deleterious effects on mammalian endocrine components, leading to various health issues such as oxidative stress, reproductive toxicity, neurotoxicity, developmental abnormalities, decreased sperm quality, and immunotoxicity. More research is needed to understand the direct effects of these plastics on the hypothalamus, pituitary, and adrenal glands.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
Alana Galvao Guimaraes, Vania Lima Coutinho, Armando Meyer, Patricia Cristina Lisboa, Egberto Gaspar de Moura
Summary: This systematic review investigated the literature on patient exposure to bisphenol A (BPA) through medical-hospital devices. The PICO framework was used to guide the review process. A total of 12 articles were included in the final analysis, and the findings suggest that there is an association between the use of medical-hospital devices and patients' exposure to BPA. Further research is needed to explore the clinical outcomes of patients exposed to medical-hospital materials containing BPA.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Environmental Sciences
John N. Hahladakis, Eleni Iacovidou, Spyridoula Gerassimidou
Summary: The investigation of human exposure to bisphenol-A (BPA) over the lifecycle of BPA-based plastic materials, components, and products is necessary. Current regulations and safety limits may underestimate the potential health implications of BPA exposure. Controversies regarding dose-response curves, sources and pathways of exposure, and the quality of toxicological studies hinder the regulation of BPA-based plastic materials. Further research and collaboration among stakeholders are needed to explore the long-term impacts of BPA and introduce restrictions to BPA-based products.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2023)
Article
Cell Biology
Jumpei Fujiki, Megumi Uchida, Sakurako Tsunoda, Naoyuki Maeda, Hiroki Inoue, Hiroshi Yokota, Hidetomo Iwano
Summary: Bisphenol A (BPA) may affect the growth and cell cycle of human placental cells through the sulfatase pathway, leading to adverse effects.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Engineering, Environmental
Md Saidur Rahman, Won-Ki Pang, Shehreen Amjad, Do-Yeal Ryu, Elikanah Olusayo Adegoke, Yoo-Jin Park, Myung-Geol Pang
Summary: This study evaluated the effects of exposure to mixtures containing bisphenol A and seven phthalates on liver functions and metabolic homeostasis. The results showed that exposure to EDCs at doses exceeding the human daily exposure limit had detrimental impacts on overall liver function, leading to metabolic abnormalities, steatohepatitis, and hepatic fibrosis. These findings have significant relevance for public health.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Public, Environmental & Occupational Health
Francesco Sessa, Rita Polito, Vincenzo Monda, Alessia Scarinci, Monica Salerno, Marco Carotenuto, Giuseppe Cibelli, Anna Valenzano, Angelo Campanozzi, Maria Pina Mollica, Marcellino Monda, Giovanni Messina
Summary: The study evaluated urinary BPA levels in an Italian pediatric cohort over a 6-month period, finding a reduction in BPA levels in a group following a plastic-free diet regimen in a school canteen setting. The results demonstrate a connection between BPA levels and food packaging, with significant reductions seen in the group with the altered diet plan.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Manuel S. Vidal, Ramkumar Menon, Gracia Fe B. Yu, Melissa D. Amosco
Summary: This article summarizes the possible mechanisms of action of bisphenols on preterm birth by conducting an integrative literature search. The results suggest that bisphenols may have adverse effects on the placenta, decidua, and fetal membranes, leading to failure of pregnancy maintenance and preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Aijing Li, Fengbang Wang, Le Tao, Chunyan Ma, Lei Bi, Maoyong Song, Guibin Jiang
Summary: In this study, a rapid and sensitive method using solid-phase extraction (SPE) tandem liquid-liquid extraction (LLE) was developed for the simultaneous determination of bisphenols, parabens, and their metabolites in complex biological samples. The method showed satisfactory recovery, precision, and detection limits, and allowed for the analysis of 24 endocrine-disrupting chemicals (EDCs) in one injection. It provides a new strategy for the identification of compounds with a wide range of polarities from complicated biological matrices.
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Review
Toxicology
Henrique Eloi Costa, Elisa Cairrao
Summary: Bisphenol A (BPA) is a widely produced synthetic compound that can disrupt the endocrine system and have detrimental effects on the neurological system. Exposure to BPA can lead to oxidative stress, changes in gene and protein expression, neuronal damage, and increased risk of neurologic diseases such as stroke, Alzheimer's, and Parkinson's. Epidemiological studies have also shown that BPA exposure during neurodevelopment can contribute to the emergence of disorders such as ADHD, ASD, depression, and cognitive disorders.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Environmental Sciences
Haiyang Yu, Wenlu Song, Xue Chen, Qiang Zhao, Xinxin Du
Summary: In this study, zebrafish embryo transcriptomic data were used to identify up-regulated genes or pathways in response to different BPA exposures. The systemic lupus erythematosus signaling pathway was found to be significantly enriched in all BPA exposure groups, with most up-regulated genes being histones. This suggests that autoimmunity signaling and histones may play a key role in the zebrafish embryo-larvae response to BPA exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Agnethe Mehlsen, Laerke Hollund, Henriette Boye, Hanne Frederiksen, Anna-Maria Andersson, Signe Bruun, Steffen Husby, Tina Kold Jensen, Clara Amalie Gade Timmermann
Summary: This study suggests that high BPA exposure during pregnancy is associated with shorter duration of breastfeeding. Although the results were not statistically significant, estimates indicate an increased risk of early termination of breastfeeding with high exposure. Future studies should consider measuring BPA more than once.
ENVIRONMENTAL RESEARCH
(2022)
Review
Immunology
Maria Giovanna Danieli, Mario Andrea Piga, Alberto Paladini, Eleonora Longhi, Cristina Mezzanotte, Gianluca Moroncini, Yehuda Shoenfeld
Summary: The coronavirus disease-19 (COVID-19) pandemic caused by SARS-CoV-2 presents challenges globally, with a small percentage of patients progressing to severe or fatal involvement of multiple organs. Intravenous immunoglobulin (IVIg) treatment has shown benefits in reducing ICU stays, lowering mortality rates, and improving pulmonary function in critically ill patients with COVID-19.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Maria Giovanna Danieli, Alessandro Tonacci, Alberto Paladini, Eleonora Longhi, Gianluca Moroncini, Alessandro Allegra, Francesco Sansone, Sebastiano Gangemi
Summary: This study evaluated the response to IVIg and 20%SCIg treatment using artificial intelligence in patients with IIM. AI techniques, such as machine learning and deep learning, were employed to analyze data and identify predictors for treatment response. The results showed that the presence of dysphagia and skin disorders, as well as the myositis activity index (MITAX) at the beginning of treatment, were associated with muscle strength as evaluated by MMT8 score at follow-up. The study suggests that Elastic Net and similar approaches are effective in predicting the clinical outcome in myositis.
AUTOIMMUNITY REVIEWS
(2022)