标题
Therapeutic implications of cancer epithelial-mesenchymal transition (EMT)
作者
关键词
Epithelial-mesenchymal transition, EMT, Therapeutic resistance, Oncogenes, Snail, Wnt
出版物
ARCHIVES OF PHARMACAL RESEARCH
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2019-01-16
DOI
10.1007/s12272-018-01108-7
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis
- (2018) Daniele V. F. Tauriello et al. NATURE
- TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
- (2018) Sanjeev Mariathasan et al. NATURE
- Results From the Phase III Randomized Trial of Onartuzumab Plus Erlotinib Versus Erlotinib in Previously Treated Stage IIIB or IV Non–Small-Cell Lung Cancer: METLung
- (2017) David R. Spigel et al. JOURNAL OF CLINICAL ONCOLOGY
- Snail and Axin2 expression predict the malignant transformation of oral leukoplakia
- (2017) Xianglan Zhang et al. ORAL ONCOLOGY
- Effect of Fluorouracil, Leucovorin, and Oxaliplatin With or Without Onartuzumab in HER2-Negative, MET-Positive Gastroesophageal Adenocarcinoma
- (2017) Manish A. Shah et al. JAMA Oncology
- Phase I study of PF-03446962, a fully human monoclonal antibody against activin receptor-like kinase-1, in patients with hepatocellular carcinoma
- (2016) M. Simonelli et al. ANNALS OF ONCOLOGY
- EMT: 2016
- (2016) M. Angela Nieto et al. CELL
- Immunological Consequences of Epithelial–Mesenchymal Transition in Tumor Progression
- (2016) Peter J. Chockley et al. JOURNAL OF IMMUNOLOGY
- A Phase II Study of PF-03446962 in Patients with Advanced Malignant Pleural Mesothelioma. CCTG Trial IND.207
- (2016) Paul Wheatley-Price et al. Journal of Thoracic Oncology
- Epithelial–mesenchymal transition: a new target in anticancer drug discovery
- (2016) Fabrizio Marcucci et al. NATURE REVIEWS DRUG DISCOVERY
- A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
- (2016) Alba A. Brandes et al. NEURO-ONCOLOGY
- Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability
- (2016) D. R. Pattabiraman et al. SCIENCE
- Cutaneous keratoacanthomas/squamous cell carcinomas associated with neutralization of transforming growth factor β by the monoclonal antibody fresolimumab (GC1008)
- (2015) Mario E. Lacouture et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma
- (2015) E. A. Kuczynski et al. CANCER RESEARCH
- Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study
- (2015) Lindsey M. Hoffman et al. CHILDS NERVOUS SYSTEM
- A Phase I Study of the Anti-Activin Receptor-Like Kinase 1 (ALK-1) Monoclonal Antibody PF-03446962 in Patients with Advanced Solid Tumors
- (2015) L. W. Goff et al. CLINICAL CANCER RESEARCH
- Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma
- (2015) Q. Yang et al. CLINICAL CANCER RESEARCH
- The discovery and development of sorafenib for the treatment of thyroid cancer
- (2015) Peter T White et al. Expert Opinion on Drug Discovery
- A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia
- (2015) Ivan Diaz-Padilla et al. GYNECOLOGIC ONCOLOGY
- Vismodegib in patients with advanced basal cell carcinoma (STEVIE): a pre-planned interim analysis of an international, open-label trial
- (2015) Nicole Basset-Seguin et al. LANCET ONCOLOGY
- RECIST progression patterns during EGFR tyrosine kinase inhibitor treatment of advanced non-small cell lung cancer patients harboring an EGFR mutation
- (2015) Tatsuya Yoshida et al. LUNG CANCER
- Nintedanib in non-small cell lung cancer: from preclinical to approval
- (2015) Christian Caglevic et al. Therapeutic Advances in Respiratory Disease
- Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933
- (2014) Sylvia M. Lee et al. CANCER
- An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial–mesenchymal transition
- (2014) Chul-Yong Park et al. CANCER LETTERS
- First-in-Human Dose Study of the Novel Transforming Growth Factor-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Patients with Advanced Cancer and Glioma
- (2014) Jordi Rodon et al. CLINICAL CANCER RESEARCH
- Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition
- (2014) Rik Derynck et al. CURRENT OPINION IN CELL BIOLOGY
- Inhibition of Wnt/β-catenin pathway by niclosamide: A therapeutic target for ovarian cancer
- (2014) Rebecca C. Arend et al. GYNECOLOGIC ONCOLOGY
- A phase II study of the gamma secretase inhibitor RO4929097 in patients with previously treated metastatic pancreatic adenocarcinoma
- (2014) Ana De Jesus-Acosta et al. INVESTIGATIONAL NEW DRUGS
- EW-7197, a Novel ALK-5 Kinase Inhibitor, Potently Inhibits Breast to Lung Metastasis
- (2014) J. Y. Son et al. MOLECULAR CANCER THERAPEUTICS
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Phase I Study of GC1008 (Fresolimumab): A Human Anti-Transforming Growth Factor-Beta (TGFβ) Monoclonal Antibody in Patients with Advanced Malignant Melanoma or Renal Cell Carcinoma
- (2014) John C. Morris et al. PLoS One
- Signaling mechanisms of the epithelial-mesenchymal transition
- (2014) D. M. Gonzalez et al. Science Signaling
- Treatment of HER2-positive breast cancer
- (2013) Maria Cristina Figueroa-Magalhães et al. BREAST
- Anticancer Effects of Niclosamide in Human Glioblastoma
- (2013) A. Wieland et al. CLINICAL CANCER RESEARCH
- TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer
- (2013) Neil E. Bhola et al. JOURNAL OF CLINICAL INVESTIGATION
- Randomized Phase II Trial of Onartuzumab in Combination With Erlotinib in Patients With Advanced Non–Small-Cell Lung Cancer
- (2013) David R. Spigel et al. JOURNAL OF CLINICAL ONCOLOGY
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer
- (2012) Alexandria M Haslehurst et al. BMC CANCER
- miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
- (2012) Helge Siemens et al. CELL CYCLE
- EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness
- (2012) Ester Sánchez-Tilló et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Vandetanib for the Treatment of Medullary Thyroid Cancer
- (2012) N. G. Chau et al. CLINICAL CANCER RESEARCH
- Vandetanib for the Treatment of Symptomatic or Progressive Medullary Thyroid Cancer in Patients with Unresectable Locally Advanced or Metastatic Disease: U.S. Food and Drug Administration Drug Approval Summary
- (2012) K. Thornton et al. CLINICAL CANCER RESEARCH
- Everolimus vs. Temsirolimus for Advanced Renal Cell Carcinoma: Use and Use of Resources in the US Oncology Network
- (2012) Nicholas J. Vogelzang et al. Clinical Genitourinary Cancer
- TGF-β signaling and epithelial–mesenchymal transition in cancer progression
- (2012) Yoko Katsuno et al. CURRENT OPINION IN ONCOLOGY
- A phase II study of RO4929097 in metastatic colorectal cancer
- (2012) Jonathan R. Strosberg et al. EUROPEAN JOURNAL OF CANCER
- Analysis of Snail-1, E-Cadherin and Claudin-1 Expression in Colorectal Adenomas and Carcinomas
- (2012) Michala Bezdekova et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- TGF- -induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion
- (2012) S. Lamouille et al. JOURNAL OF CELL SCIENCE
- Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors
- (2012) Ian Krop et al. JOURNAL OF CLINICAL ONCOLOGY
- Pharmacogenetics ofEGFRin lung cancer: perspectives and clinical applications
- (2012) Clara Mayo et al. PHARMACOGENOMICS
- Down-Regulation of CDH1 Is Associated with Expression of SNAI1 in Colorectal Adenomas
- (2012) Feride Kroepil et al. PLoS One
- Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression
- (2012) Z.-Q. Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chemoresistance to 5-fluorouracil induces epithelial–mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells
- (2011) Weijia Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- EW-7203, a novel small molecule inhibitor of transforming growth factor-β (TGF-β) type I receptor/activin receptor-like kinase-5, blocks TGF-β1-mediated epithelial-to-mesenchymal transition in mammary epithelial cells
- (2011) Chul-Yong Park et al. CANCER SCIENCE
- Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: A systematic review
- (2011) Mark Murphy et al. DRUG RESISTANCE UPDATES
- p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
- (2011) Taewan Kim et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
- (2011) Mark J. Anderton et al. TOXICOLOGIC PATHOLOGY
- Slug Confers Resistance to the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
- (2010) Tzu-Hua Chang et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Regulation of Excision Repair Cross-Complementation Group 1 by Snail Contributes to Cisplatin Resistance in Head and Neck Cancer
- (2010) D. S.-S. Hsu et al. CLINICAL CANCER RESEARCH
- The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness
- (2010) Zhiwei Wang et al. CURRENT DRUG TARGETS
- Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression
- (2009) Hanna Tuhkanen et al. BMC CANCER
- Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer
- (2009) T. Arumugam et al. CANCER RESEARCH
- Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
- (2009) Piyush B. Gupta et al. CELL
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition
- (2009) Theresa Vincent et al. NATURE CELL BIOLOGY
- Snail1 Protein in the Stroma as a New Putative Prognosis Marker for Colon Tumours
- (2009) Clara Francí et al. PLoS One
- New regulatory mechanisms of TGF-β receptor function
- (2009) Jong Seok Kang et al. TRENDS IN CELL BIOLOGY
- The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer
- (2008) S. Spaderna et al. CANCER RESEARCH
- A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition
- (2008) C. P. Bracken et al. CANCER RESEARCH
- Insulin-like Growth Factor-I-Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells
- (2008) T. R. Graham et al. CANCER RESEARCH
- The role of the ZEB family of transcription factors in development and disease
- (2008) C. Vandewalle et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
- (2008) E.A. Eisenhauer et al. EUROPEAN JOURNAL OF CANCER
- The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2
- (2008) Manav Korpal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
- (2008) Philip A. Gregory et al. NATURE CELL BIOLOGY
- Rational targeting of Notch signaling in cancer
- (2008) P Rizzo et al. ONCOGENE
- Notch signaling mediates hypoxia-induced tumor cell migration and invasion
- (2008) C. Sahlgren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More