Article
Fisheries
Zhibin Wu, Xiaozhou Qi, Shenye Qu, Fei Ling, Gaoxue Wang
Summary: This study successfully isolated a broad-spectrum antimicrobial strain Bacillus velezensis B8 from the gut of grass carp, which has the potential to replace antibiotics for disease control in aquaculture and be developed into a microecological preparation.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Yongtao Li, Nannan Jiang, Wenying Zhang, Zhengbing Lv, Jianxin Liu, Hengbo Shi
Summary: Marine-derived GB-9 and RT were found to significantly reduce the SCC in dairy goats and decrease the concentrations of certain immune parameters. Analysis of fecal samples revealed that GB-9 altered the bacterial community significantly, with feeding associated with changes in immunoglobulin and interleukin concentrations.
Article
Gastroenterology & Hepatology
Fereshteh Ghazisaeedi, Jochen Meens, Bianca Hansche, Sven Maurischat, Peter Schwerk, Ralph Goethe, Lothar H. Wieler, Marcus Fulde, Karsten Tedin
Summary: The probiotic bacterial strain Enterococcus faecium SF68 has been found to alleviate intestinal inflammation and modulate the immune response. The inhibitory effect on host cell signaling pathways is likely due to the presence of arginine deiminase, which is responsible for the anti-inflammatory effects observed in clinical trials.
Article
Plant Sciences
Yingxia Liang, David Y. W. Lee, Sherri Zhen, Haoqi Sun, Biyue Zhu, Jing Liu, Dan Lei, Chih-Chung Jerry Lin, Siyi Zhang, Nicholas A. Jacques, Luisa Quinti, Chongzhao Ran, Changning Wang, Ana Griciuc, Se Hoon Choi, Rong Hua Dai, Thomas Efferth, Rudolph E. Tanzi, Can Zhang
Summary: This study investigated the mechanisms of HLXL, a Chinese medicine containing multiple bioactive components, in attenuating AD neuropathology. The results showed that HLXL significantly reduced amyloid neuropathology by regulating phagocytosis and energy metabolism pathways. This study provides a new avenue for the development of AD therapeutics.
Article
Physiology
Denise R. Rodrigues, Kim M. Wilson, Lisa R. Bielke
Summary: This study investigated the impact of early intestinal colonizers on immune processes in chicks. The results showed that probiotic treatment facilitated the activation and balanced function of innate and adaptive immune systems, while exposure to Enterobacteriaceae may lead to dysregulated immunological mechanisms.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joanne Wayne, Teresa Brooks, Alexandra Landras, Andrew J. Massey
Summary: Activating stimulator of interferon genes to turn immunologically refractive cold tumor hot is an exciting therapeutic approach to increase the clinical responsiveness of some human cancers to immune checkpoint inhibitors. However, there are challenges in combining Chk1 or Wee1 inhibitors with immune checkpoint inhibitors that need further investigation.
Review
Immunology
Osamu Kanauchi, Zhao Xuan Low, Kenta Jounai, Ryohei Tsuji, Sazaly Abubakar
Summary: This comprehensive review examines the medical impact of probiotics on infectious diseases, particularly focusing on the periods before, during, and after the COVID-19 pandemic. It finds that certain probiotic strains have shown clinical effectiveness in treating gastrointestinal diseases, the common cold, and flu. However, the direct effectiveness of probiotics in treating or preventing COVID-19 is still uncertain. As we enter the post-COVID-19 era, the relationship between COVID-19 and the innate immune system is gradually being understood, offering potential for developing novel vaccines and treatments. Further research is needed to explore the interaction between probiotics and the immune system and their role in immunoregulatory therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Damariz Marin-Palma, Geysson Javier Fernandez, Julian Ruiz-Saenz, Natalia A. Taborda, Maria T. Rugeles, Juan C. Hernandez
Summary: Airborne particulate matter from industrial sources and automobiles has been shown to increase susceptibility to infectious diseases and is recognized by immune cells. However, the molecular mechanisms and gene expression changes induced by PM in immune cells are not fully understood. In this study, RNA-seq analysis of human peripheral blood mononuclear cells exposed to PM10 revealed that PM10 can reprogram the expression of 1,196 genes in immune cells, leading to an inflammatory state with increased cytokines and chemokines. The activation of IL-36 signaling pathway and upregulation of chemokines involved in neutrophil and monocyte recruitment suggest inflammation mechanisms upon PM exposure, while NK cell-recruiting chemokines are suppressed. PM exposure also affects transcription factors associated with inflammatory pathways and reduces expression of RNases and pathogen response genes. Overall, our findings suggest that PM plays a role in the dysregulation of immune cell functions relevant to antiviral responses and host defense against pathogens.
SCIENTIFIC REPORTS
(2023)
Review
Food Science & Technology
Cristina Valeria Bulgaru, Daniela Eliza Marin, Gina Cecilia Pistol, Ionelia Taranu
Summary: ZEA is an estrogenic fusariotoxin that affects reproductive health and immune response. It can cause reproductive disorders and impact immune response, with studies showing effects on different types of immune cells and immune organs. Despite the increasing research on the mechanisms of ZEA in modulating immune response, data are currently insufficient and further investigation is needed.
Review
Immunology
Yuhan Zhong, Xiao Zhong, Liangjun Qiao, Hong Wu, Chang Liu, Ting Zhang
Summary: The Z alpha domain is a compact α/β structure that specifically binds to nucleic acids with a left-handed helical conformation. It has been identified in several proteins, including ADAR1 and ZBP1, which play important roles in immune response regulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Jiali Zhu, Feng Chu, Meirong Zhang, Wenhuan Sun, Fangfang Zhou
Summary: Neddylation is a crucial protein modification process that plays important roles in the development of the central nervous system and various processes of the human immune system, including inflammation regulation, bacterial and viral infections, and T cell function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Miriam Angulo, Abel Ramos, Martha Reyes-Becerril, Kevyn Guerra, Elizabeth Monreal-Escalante, Carlos Angulo
Summary: This study investigated the effect of Debaryomyces hansenii CBS 8339 on innate immune responses in mice. The results showed that oral delivery of D. hansenii for 7 days enhanced phagocytosis, respiratory burst activity, and nitric oxide production in mice before and after bacterial challenge. It also upregulated the expression of pro-inflammatory cytokines on day 7, but downregulated them on day 15. Furthermore, D. hansenii increased serum IgG and IgA titers in mice. Overall, short-term oral delivery of D. hansenii improved immune innate response in mice.
Review
Fisheries
Mirja Kaizer Ahmmed, Shuva Bhowmik, Fatema Ahmmed, Stephen G. Giteru, Shikder Saiful Islam, Mayssa Hachem, Md. Ashraf Hussain, Osman N. Kanwugu, Dominic Agyei, Tom Defoirdt
Summary: This paper discusses the importance of using probiotics for disease control in the high-yielding prawn variety, Macrobrachium rosenbergii. Intensive culture systems can lead to disease outbreaks, and probiotics have emerged as a promising alternative for disease control by enhancing the prawns' immunity and antagonizing pathogenic microorganisms.
JOURNAL OF FISH DISEASES
(2023)
Review
Immunology
Jia-Rui Zheng, Zi-Long Wang, Bo Feng
Summary: Hepatitis B virus infection causes indirect damage to hepatocytes through the immune system. The exhaustion of virus-specific immune cells and immune suppression by virus antigens contribute to the chronicity of the infection. Functional cure can be achieved by restoring the specific immune function, providing a theoretical basis for complete cure of hepatitis B.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Jose Carlos Campos-Sanchez, Enrica Vitarelli, Francisco A. Guardiola, Diana Ceballos-Francisco, Jose Maria Garcia Beltran, Antonio Ieni, Maria Angeles Esteban
Summary: This study evaluated local inflammation mechanisms in the skin of gilthead seabream induced by carrageenin, finding an increase in skin mucus-secreting cells and acidophilic granulocytes after injection. Gene expression of various markers and proinflammatory genes was also up-regulated post-injection. Results indicate the chronological involvement of important immune cells in resolving inflammation in the fish skin.
JOURNAL OF FISH DISEASES
(2022)
Article
Immunology
Carlos Angulo, Veronica Sanchez, Karen Delgado, Elizabeth Monreal-Escalante, Luis Hernandez-Adame, Miriam Angulo, Marlene Tello-Olea, Martha Reyes-Becerril
Summary: Vaccines have been crucial in saving millions of humans and animals from fatal diseases. While subunit vaccines have several advantages, they lack strong immunogenicity. Nanotechnology offers a promising approach to vaccine development, utilizing nanoparticles as carriers and adjuvants, particularly for oral vaccines. This review provides an update on recent developments in oral organic nanovaccines, discussing suitable nanomaterials for oral vaccine design and advancements in fighting the major pathogens causing human and animal diseases over the past five years.
MICROBIAL PATHOGENESIS
(2022)
Review
Agriculture, Dairy & Animal Science
Cristian Machuca, Yuniel Mendez-Martinez, Martha Reyes-Becerril, Carlos Angulo
Summary: This review analyzes the immune and biological activities of yeast beta-glucans in fish, highlighting the inefficiency of commercially available beta-glucans in some fish species and the potential adverse effects of increased dosage. However, experimental beta-glucans from other yeast species show interesting activities such as antibacterial, antioxidant, and healing properties.
Review
Fisheries
Abir Bahi, Abel Ramos-Vega, Carlos Angulo, Elizabeth Monreal-Escalante, Francisco A. Guardiola
Summary: In recent years, microalgal biotechnology has been recognized as a valuable source of functional feed additives for fish species. Numerous microalgae have demonstrated immunostimulant properties and enhanced disease resistance in fish. This literature review aims to gather and present research on the immune modulation effects of microalgae and their compounds in farmed fish, highlighting their potential for aquaculture. Although the exact mechanisms remain unclear, the inclusion of different microalgal species in fish feed has proven to improve the immune response and increase survival under stress and infectious conditions.
REVIEWS IN AQUACULTURE
(2023)
Article
Biotechnology & Applied Microbiology
Miriam Angulo, Abel Ramos, Martha Reyes-Becerril, Kevyn Guerra, Elizabeth Monreal-Escalante, Carlos Angulo
Summary: This study investigated the effect of Debaryomyces hansenii CBS 8339 on innate immune responses in mice. The results showed that oral delivery of D. hansenii for 7 days enhanced phagocytosis, respiratory burst activity, and nitric oxide production in mice before and after bacterial challenge. It also upregulated the expression of pro-inflammatory cytokines on day 7, but downregulated them on day 15. Furthermore, D. hansenii increased serum IgG and IgA titers in mice. Overall, short-term oral delivery of D. hansenii improved immune innate response in mice.
Article
Biochemistry & Molecular Biology
Aurora Araiza-Campos, Guillermo Herrera-Perez, Joan S. Salas-Leiva, Margarita Chavez-Beltran de Rio, Alejandro Aguirre-Hernandez, Antonia Luna-Velasco, Dayana Salas-Leiva, Eduardo Campos-Chavez, Dariel Tovar-Ramirez, Alejandro Romo-Chacon, Erasmo Orrantia-Borunda, Francisco Paraguay-Delgado
Summary: The current study compares the antibacterial activity of zinc oxide nanostructures. The quasi-diamond platelet-shaped nanostructures showed enhanced antibacterial activity compared to the quasi-round agglomerated particles. The morphology plays a crucial role in the antimicrobial activity, while the enrichment of oxygen vacancies does not have a significant effect.
Article
Microbiology
Luis Daniel Moreno-Figueroa, Eduardo Quiroz-Guzman, Dariel Tovar-Ramirez, Gabriela Palestino, Candida A. Cisneros-Covarrubias, Luis Hernandez-Adame
Summary: Phage therapy is a promising alternative to control bacterial diseases. This research evaluated the viability of lyophilized vibrio phage vB_Pd_PDCC-1 using trehalose as a preservative excipient. The results showed that trehalose is beneficial in maintaining the viability of post-lyophilization phages, even at room temperature. The use of lyophilized phage PDCC-1 increased brine shrimp survival and reduced Vibrio concentrations.
CURRENT MICROBIOLOGY
(2023)
Article
Plant Sciences
Yuniel Mendez-Martinez, Rosa I. Narvaez-Narvaez, Carlos Angulo, Edilmar Cortes-Jacinto, Aroldo Botello-Leon, Danis M. Verdecia-Acosta, Yenny G. Torres-Navarrete
Summary: The development of alternative plant protein sources in aquaculture is a major challenge due to the high cost and continued shortage of animal protein sources. In this study, the effects of Tithonia diversifolia on the growth performance, feed efficiency, and metabolic biochemistry of Oreochromis mossambicus x Oreochromis niloticus juveniles were investigated. The results showed that T. diversifolia flour has an appropriate chemical composition and amino acid balance, without causing negative effects on the growth performance and metabolic biochemistry of the fish.
NOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCA
(2023)
Article
Agriculture, Dairy & Animal Science
Ignasi Sanahuja, Alberto Ruiz, Joana P. P. Firmino, Felipe E. E. Reyes-Lopez, Juan B. B. Ortiz-Delgado, Eva Vallejos-Vidal, Lluis Tort, Dariel Tovar-Ramirez, Isabel M. M. Cerezo, Miguel A. A. Morinigo, Carmen Sarasquete, Enric Gisbert
Summary: The supplementation of Debaryomyces hansenii in the diet of gilthead seabream improved growth and feed efficiency, while enhancing intestinal condition and modulating gut microbiota. Transcriptomic analysis revealed that this probiotic yeast promoted metabolic pathways, antioxidant mechanisms, and immune processes, contributing to the defensive capacity and homeostasis of the intestine.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Immunology
Ignasi Sanahuja, Laura Fernandez-Alacid, Silvia Torrecillas, Alberto Ruiz, Eva Vallejos-Vidal, Joana P. Firmino, Felipe E. Reyes-Lopez, Lluis Tort, Dariel Tovar-Ramirez, Antoni Ibarz, Enric Gisbert
Summary: This study examines the effects of supplementing Debaryomyces hansenii as a probiotic in a low fish meal-based diet on the skin mucosal tissue in Sparus aurata. The results show that the probiotic supplementation improves fish growth and feed conversion ratio, and modulates immune and metabolic processes in the skin.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Miriam Angulo, Kevyn Guerra, Paola Arevalo, Edgar Trujillo, Elizabeth Monreal-Escalante, Carlos Angulo
Summary: Bacillus sp. 62A has biosafe and immunomodulatory probiotic potential, as it improves immune system activity and induces an anti-inflammatory response in mice.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Chemistry, Multidisciplinary
Norma Flores-Holguin, Joan S. Salas-Leiva, Erick J. Nunez-Vazquez, Dariel Tovar-Ramirez, Daniel Glossman-Mitnik
Summary: Marine toxins pose significant risks to marine ecosystems and human health. Understanding their structures and properties is crucial for mitigating risks and exploring their potential as therapeutic agents. This study compares four marine toxins, examining their reactivity properties and bioavailability. By investigating their similarities, valuable insights for new drug development can be gained. Exploring the lipophilic and hydrophilic properties in drug design is important for drug distribution and interaction. By elucidating shared molecular properties, this research aims to guide future drug discovery efforts and contribute to the field of molecular toxinology. The findings expand knowledge on toxins, deepen understanding of their bioactivities, and unlock new therapeutic possibilities.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Colleen Guinle, Erick Julian Nunez-Vazquez, Leyberth Jose Fernandez-Herrera, Daniela Alejandra Corona-Rojas, Dariel Tovar-Ramirez
Summary: Harmful algal blooms can have noxious effects on marine organisms. This study found that saxitoxin had toxicological effects on the embryonic and early larval stages of Seriola rivoliana. The toxin reduced hatching percentage, increased enzyme activity, and induced overexpression of genes. The effects were more pronounced in young larvae than in embryos.
Article
Biochemistry & Molecular Biology
N. Perales-Garcia, D. Tovar-Ramirez, M. G. Martinez-Morales, B. P. Ceballos-Vazquez, D. A. Corona-Rojas, M. A. Salcedo-Meza, A. Garrido-Mora, F. Vega-Villasante, H. Nolasco-Soria
Summary: This study provides the first report on the digestive tract pH of the pygmy octopus. The pH of the digestive tract regions was found to be lower than 7.0 and did not differ significantly between wild and captive octopuses. The digestive gland had the lowest pH values, but they were still above 5.0.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)