期刊
APOPTOSIS
卷 24, 期 1-2, 页码 74-82出版社
SPRINGER
DOI: 10.1007/s10495-018-1499-y
关键词
Anti-lung cancer; Toxicity; Apoptosis; Pyroptosis; NF-kappa B
资金
- Zhejiang Province Natural Science Fund of China [LY15H280014, LY17H160059, LY19H130001]
- Technology Foundation for Medical Science of Zhejiang Province [2015KYA1506]
- National Natural Science Foundation of China [81272462]
- Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences
Pyroptosis is a novel manner of cell death that can be mediated by chemotherapy drugs. The awareness of pyroptosis is significantly increasing in the fields of anti-tumor research and chemotherapy drugs. Invoking the occurrence of pyroptosis is an attractive prospect for the treatment of lung cancer. Here, the compound L61H10 was obtained as a thiopyran derivative to compare its activity with curcumin. It was indicated that L61H10 exhibited good anti-tumor activity both in vitro and in vivo via the switch of apoptosis-to-pyroptosis, which was associated with the NF-B signaling pathway. In addition, L61H10 had no obvious side effects both in vitro and in vivo. In brief, L61H10 is shown to be a potential anti-lung cancer agent and research on its anti-tumor mechanism provides new information for chemotherapy drug research.
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