期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 63, 期 1, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01551-18
关键词
Klebsiella pneumoniae carbapenemase; carbapenem-resistant Enterobacteriaceae; carbapenemase-producing Klebsiella pneumoniae; ceftazidime-avibactam; meropenem-vaborbactam
资金
- bioMerieux Inc.
We report a case of a 24-year-old liver transplant recipient who developed hepatic artery thrombosis and graft failure, which was complicated by subphrenic abscess and persistent Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae bacteremia. Ceftazidime-avibactam treatment led to emergence of resistance, and alternative combination therapy failed due to persistent infection and toxicity. The infection resolved after initiation of meropenem-vaborbactam, which created a bridge to retransplantation. Treatment-emergent ceftazidime-avibactam resistance is increasingly recognized, suggesting a role for meropenem-vaborbactam.
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