REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)

Regulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β–mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps

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Immunometabolism in systemic lupus erythematosus

(2017) Laurence Morel   Nature Reviews Rheumatology

Netting Insights into Fibrosis

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Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation

(2016) Garyfalia Papadaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

(2016) Sung Hoon Cho et al.   NATURE

Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction

(2015) Dimitrios A. Stakos et al.   EUROPEAN HEART JOURNAL

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

(2015) Shuxi Qiao et al.   Nature Communications

Hypoxia Inducible Factor-1 Alpha Promotes Mesangial Cell Proliferation in Lupus Nephritis

(2014) Wei Deng et al.   AMERICAN JOURNAL OF NEPHROLOGY

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

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Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever

(2014) Eirini Apostolidou et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

(2014) Alexander J Clarke et al.   ANNALS OF THE RHEUMATIC DISEASES

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

(2014) Tomohiro Koga et al.   JOURNAL OF CLINICAL INVESTIGATION

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

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Neutrophil extracellular traps promote differentiation and function of fibroblasts

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Neutrophil Extracellular Trap-Derived Enzymes Oxidize High-Density Lipoprotein: An Additional Proatherogenic Mechanism in Systemic Lupus Erythematosus

(2014) Carolyne K. Smith et al.   Arthritis & Rheumatology

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE

(2013) Tiffany N Caza et al.   ANNALS OF THE RHEUMATIC DISEASES

Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

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Gene expression and regulation in systemic lupus erythematosus

(2013) Eleni A. Frangou et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Enhanced isolation of fibroblasts from human skin explants

(2012) Lily Huschtscha et al.   BIOTECHNIQUES

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1  

(2012) A. M. McInturff et al.   BLOOD

Type I IFN system in the development and manifestations of SLE

(2012) Keith B. Elkon et al.   CURRENT OPINION IN RHEUMATOLOGY

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Interleukin-17 Cytokines Are Critical in Development of Fatal Lupus Glomerulonephritis

(2012) Prapaporn Pisitkun et al.   IMMUNITY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

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Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

(2012) Konstantinos Kambas et al.   PLoS One

cAMP response element modulator   controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus

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Urinary Hypoxia-Inducible Factor-1alpha Levels Are Associated with Histologic Chronicity Changes and Renal Function in Patients with Lupus Nephritis

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Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis

(2012) Elena Gonzalo et al.   ARTHRITIS RESEARCH & THERAPY

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

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Glucocorticoid Elevation of Dexamethasone-induced Gene 2 (Dig2/RTP801/REDD1) Protein Mediates Autophagy in Lymphocytes

(2011) Jason K. Molitoris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways

(2011) Min Huan Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

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(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

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(2011) Xavier Bosch   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Gene Network Analysis of Bone Marrow Mononuclear Cells Reveals Activation of Multiple Kinase Pathways in Human Systemic Lupus Erythematosus

(2010) Magdalene Nakou et al.   PLoS One

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of correlations between selected endothelial cell activation markers, disease activity, and nailfold capillaroscopy microvascular changes in systemic lupus erythematosus patients

(2009) Mariusz Ciołkiewicz et al.   CLINICAL RHEUMATOLOGY

The Role of IL-23/IL-17 Axis in Lupus Nephritis

(2009) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Gene expression in systemic lupus erythematosus: Bone marrow analysis differentiates active from inactive disease and reveals apoptosis and granulopoiesis signatures

(2008) Magdalene Nakou et al.   ARTHRITIS AND RHEUMATISM

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS