期刊
ANNALS OF ONCOLOGY
卷 30, 期 2, 页码 211-218出版社
OXFORD UNIV PRESS
DOI: 10.1093/annonc/mdy544
关键词
cerebrospinal fluid; circulating cell-free tumour DNA; glioblastoma; brain metastasis; liquid biopsy; brain cancer
类别
资金
- Fondo de Investigacion Sanitaria (FIS) Instituto de Salud Carlos III grant [PI16/01278]
- FERO - EDM support
- H2020 grant [635342-2 MoTriColor]
- AIRC IG [17707]
- AIRC Special Program 5 per mille metastases project [21091]
Challenges in obtaining tissue specimens from patients with brain tumours limit the diagnosis and molecular characterisation and impair the development of better therapeutic approaches. The analysis of cell-free tumour DNA in plasma (considered a liquid biopsy) has facilitated the characterisation of extra-cranial tumours. However, cell-free tumour DNA in plasma is limited in quantity and may not reliably capture the landscape of genomic alterations of brain tumours. Here, we review recent work assessing the relevance of cell-free tumour DNA from cerebrospinal fluid in the characterisation of brain cancer. We focus on the advances in the use of the cerebrospinal fluid as a source of cell-free tumour DNA to facilitate diagnosis, reveal actionable genomic alterations, monitor responses to therapy, and capture tumour heterogeneity in patients with primary brain tumours and brain and leptomeningeal metastases. Profiling cerebrospinal fluid cell-free tumour DNA provides the opportunity to precisely acquire and monitor genomic information in real time and guide precision therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据