Article
Endocrinology & Metabolism
Svenia Schmid, Barbara Heim-Kupr, Joaquin Perez-Schindler, Shivani Mansingh, Markus Beer, Nitish Mittal, Nikolaus Ehrenfeuchter, Christoph Handschin
Summary: This study reveals the role of PGC-1β in the regulation of catabolic pathways in muscle-specific loss-of-function mouse models. PGC-1β plays a crucial role in protein breakdown, muscle mass preservation, and function.
MOLECULAR METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Lin Yin, Na Li, Weihua Jia, Nuoqi Wang, Meidai Liang, Xiuying Yang, Guanhua Du
Summary: Skeletal muscle is crucial for various bodily functions, but pathological issues can lead to muscle wasting and atrophy, characterized by weakness and reduced mass. While exercise is effective, it is not universally applicable, highlighting the need for further research into treatment options.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Yuko Ono, Masafumi Saito, Kazuho Sakamoto, Yuko Maejima, Shingen Misaka, Kenju Shimomura, Nobuto Nakanishi, Shigeaki Inoue, Joji Kotani
Summary: Burn injury is a major cause of death and disability worldwide, leading to a significant economic burden on society. The systemic inflammation caused by burn injuries can result in muscle wasting, which negatively affects the survival and functional outcomes of patients. Currently, there are no pharmacological interventions available for the treatment of burn-induced muscle wasting.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Yajing Pan, Ting Zhou, Xingtong Dong, Leiyun Wu, Peiwen Wang, Shiyuan Wang, Aihua Zhang
Summary: Skeletal muscle wasting and atrophy is common in chronic renal failure (CRF) and is associated with increased mortality risk. This study investigates the role of urotensin II (UII) in skeletal muscle atrophy by upregulating the ubiquitin-proteasome system (UPS) in CRF. The findings show that UII decreases myotube diameters and upregulates dephosphorylated Fxo03A protein. Additionally, UII receptor gene knockout downregulates the expression of muscle-specific E3 ubiquitin ligases (MuRF1, MAFbx) in CRF mice. UII also inhibits the differentiation of satellite cells in CRF mice. These results indicate that UII-induced skeletal muscle atrophy in CRF is associated with UPS upregulation and inhibition of satellite cell differentiation.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Engineering, Environmental
Apoorva H. Nagendra, Mohd Altaf Najar, Bipasha Bose, Shenoy P. Sudhee
Summary: Fluoride at high doses is known to be toxic to the musculoskeletal system, primarily affecting bone and cartilage cells. However, there is limited research on the toxicity of fluoride to skeletal muscle. This study found that during skeletal fluorosis, muscle is also affected. Short-term exposure to sodium fluoride (NaF) led to muscle hypertrophy through activation of the IGF1/PI3/Akt/mTOR signaling pathway, while long-term exposure resulted in muscle atrophy due to activation of the ubiquitin-proteasome pathway. Differentially expressed proteins were identified and characterized using proteomic analysis.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nutrition & Dietetics
Singareddy Sreenivasa Reddy, Utkarsh Reddy Addi, Raghu Pullakhandam, G. Bhanuprakash Reddy
Summary: The study found that zinc deficiency affects skeletal muscle proteostasis and mitochondrial biology in growing rats, leading to decreased cell size and increased cell death. It also activates the ubiquitin-proteasome system, declines autophagy, and affects mitochondrial fission, fusion, transcription, and oxidative phosphorylation components.
Article
Cell Biology
Yusuke Nishimura, Jitpisute Chunthorng-Orn, Samuel Lord, Ibrahim Musa, Peter Dawson, Lars Holm, Yu-Chiang Lai
Summary: In this study, the researchers showed that Atrogin-1 and MuRF1 protein contents are regulated by different mechanisms, specifically the downstream of Akt, and that Atrogin-1 protein content can be regulated by the rapamycin-sensitive mTOR-S6K1-dependent signaling pathway.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Tania Cid-Diaz, Saul Leal-Lopez, Fatima Fernandez-Barreiro, Jessica Gonzalez-Sanchez, Icia Santos-Zas, Luis J. Andrade-Bulos, Manuel E. Rodriguez-Fuentes, Carlos S. Mosteiro, Vincent Mouly, Xesus Casabiell, Jose Luis Relova, Yolanda Pazos, Jesus P. Camina
Summary: The obestatin/GPR39 system was found to protect against chronic glucocorticoid-induced muscle atrophy by regulating protein homeostasis and re-establishing protein synthesis balance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Yohei Ikeno, Maya Inomata, Yuka Tsukimura, Yuta Suzuki, Hiroto Takeuchi, Yui Harada, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Takeshi Yamada, Junzo Kamei, Hiroyasu Sakai
Summary: Cisplatin-induced muscle atrophy can be attenuated by EPA through down-regulation of up-regulated Ub gene expression.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Pandarinath Savitikadi, Ramesh Gogulothu, Ayesha Ismail, Geereddy Bhanuprakash Reddy, Vadde Sudhakar Reddy
Summary: This study investigated the effects of a maternal low-protein diet and postnatal rehabilitation on muscle protein degradation in adult offspring. The results showed that chronic protein restriction led to muscle atrophy and increased protein degradation, while postnatal rehabilitation had little effect on these processes.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mengqi Xiang, Xinmeng Yuan, Nianyun Zhang, Liumei Zhang, Yuting Liu, Jingjing Liu, Yaran Gao, Ye Xu, Wen Sun, Qiang Tang, Yuan Zhang, Jiao Lu
Summary: This study investigated the functional role of exercise, metformin, and combination treatment on type 2 diabetic mellitus-induced muscle atrophy. Exercise and metformin interventions can increase insulin sensitivity, but exercise alone is more effective in inhibiting the ubiquitin-proteasome system and alleviating skeletal muscle atrophy. However, the combination treatment exhibits no synergistic effect on muscle atrophy.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Rodrigo Zuloaga, Oscar Varas, Camila Ahrendt, Victor M. Pulgar, Juan A. Valdes, Alfredo Molina, Cristian Duarte, Angel Urzua, Fabian Guzman-Rivas, Marcela Aldana, Jose Pulgar
Summary: Upwelling oceanographic phenomenon affects food availability, seawater temperature and pH, which in turn significantly influence fish muscle growth. This study evaluated the muscle fibers size, protein content, and gene expression of growth and atrophy-related genes in fish from upwelling and downwelling zones. The results showed that fish from upwelling zones had larger muscle fibers and higher protein content, associated with lower protein ubiquitination and gene expression of F-box only protein 32. This study highlights how oceanographic conditions can modulate food quality and fish muscle physiology in an integrated way, with important implications for marine conservation and sustainable fisheries management.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Stefanie Haberecht-Mueller, Elke Krueger, Jens Fielitz
Summary: The majority of critically ill ICU patients with severe sepsis develop ICU-acquired weakness characterized by loss of muscle mass, reduction in myofiber size and decreased muscle strength. This phenotype results from dysregulated protein homeostasis, with UPS being the predominant protein-degrading system in muscle under various conditions causing muscle atrophy. The regulation and target-specificity of E3 ubiquitin ligases in muscle atrophy, as well as the function of standard and immunoproteasome in inflammation-induced muscle atrophy and the potential treatment strategies, are discussed in this review.
Review
Physiology
Xiangsheng Pang, Peng Zhang, Xiaoping Chen, Wenming Liu
Summary: This paper provides a comprehensive view of different types of muscle atrophy and emphasizes the role of the ubiquitin-proteasome pathway. By examining recent scholarly advancements, it explores the association between the ubiquitin-proteasome pathway and specific pathological conditions linked to muscle atrophy.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Dina Aweida, Shenhav Cohen
Summary: Protein degradation is essential for cellular integrity, with autophagy and the UPS being the main systems responsible for protein breakdown. Recent studies show that even complex protein structures can be efficiently degraded in vivo, with AAA-ATPases playing a crucial role in the disassembly process.