期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 4, 页码 1203-1207出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201811991
关键词
continuous-flow; cyclopropenation; diazoalkanes; photochemistry; rearrangement
资金
- RWTH Aachen University - Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [408033718]
- Chinese Scholarship Council (CSC) [201807040083]
Carbenes are very important reactive intermediates to access a variety of complex molecules and are applied widely in organic synthesis and drug discovery. Typically, their chemistry is accessed by the use of transition metal catalysts. Herein, we describe the application of low-energy blue light for the photochemical generation of carbenes from donor-acceptor diazoalkanes. This catalyst-free and operationally simple approach enables highly efficient cyclopropenation reactions with alkynes and the rearrangement of sulfides under mild reaction conditions, which can be utilized for both batch and continuous-flow processes.
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