期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 57, 期 48, 页码 15891-15895出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201808939
关键词
bromine catalysis; C-H bond amination; homogeneous catalysis; iodine(III) reagents; natural products
资金
- Spanish Ministry for Economy and Competitiveness
- FEDER [CTQ2017-88496R]
- CERCA Programme of the Government of Catalonia
- COST Action [CA15106]
A new homogeneous bromine(-I/I) redox catalysis is described, which is based on monomeric bromine(I) compounds containing transferable phthalimidato groups. These catalysts enable intermolecular C-H amination reactions at previously unaccessible aliphatic positions and thus enlarge the synthetic potential of direct C-N bond formation, including its application in the synthesis of alkaloid building blocks This aspect is demonstrated by a new synthetic approach to aspidospermidine. In addition to the development of the catalyst system, the structures of the involved bromine(I) key catalysts were fully elucidated, including by X-ray analyses.
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