期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 9, 页码 2884-2888出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900059
关键词
asymmetric catalysis; bicyclic compounds; desymmetrization; Heck reaction; palladium
资金
- National Natural Science Foundation of China [NSFC21572272, CPU2018GY04, CPU2018GY35]
- Foundation of the Open Project of State Key Laboratory of Natural Medicines [SKLNMZZCX201818]
A palladium-catalyzed asymmetric reductive Heck reaction of unactivated aliphatic alkenes, with eliminable beta-hydrogen atoms, has been realized for the first time. A series of optically active bicyclo[3.2.1]octanes bearing chiral quaternary and tertiary carbon stereocenters were obtained in good yields with excellent enantioselectivities, exhibiting good functional-group tolerance and scalability. Moreover, deuterated optically active bicyclo[3.2.1]octanes were also obtained in high efficiency.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据