期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 8, 页码 2382-2386出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201813490
关键词
asymmetric catalysis; borylation; copper; enantioconvergent synthesis; guanidines
资金
- Ministry of Education [MOE2016-T2-1-087]
- Singapore University of Technology and Design [T1MOE1706, IDG31800104]
- Nanyang Technological University [M4011633]
An enantioconvergent synthesis of chiral cyclic allylboronates from racemic allylic bromides was achieved by using a guanidine-copper catalyst. The allylboronates were obtained with high gamma/alpha regioselectivities (up to 99:1) and enantioselectivities (up to 99 % ee), and could be further transformed into diverse functionalized allylic compounds without erosion of optical purity. Experimental and DFT mechanistic studies support an S(N)2 ' borylation process catalyzed by a monodentate guanidine-copper(I) complex that proceeds through a special direct enantioconvergent transformation mechanism.
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