Article
Genetics & Heredity
Angelo B. Arrigo, Wenjuan Zhu, Kylia A. Williams, Carla Guzman-Moreno, Cecilia Lo, Jiuann-Huey I. Lin
Summary: The study investigates the association between genetic variants, specifically LRP1 mutations, with congenital heart disease (CHD) and its phenotypes. Through analysis of mouse models and human data, LRP1 mutations were found to be significantly associated with CHD, particularly atrioventricular septal defect and conotruncal defect. Additionally, rare damaging LRP1 mutations were observed to have a significant relationship with atrioventricular septal defect. This study provides important insights into the molecular mechanisms underlying CHD.
Article
Cardiac & Cardiovascular Systems
Marwa Mahmoud, Ian Evans, Laura Wisniewski, Yuen Tam, Claire Walsh, Simon Walker-Samuel, Paul Frankel, Peter Scambler, Ian Zachary
Summary: Research indicates a specific requirement for Bcar1 in neural crest cells, early myogenic and cardiac cells, essential for outflow tract septation, myocardialization, epithelial-to-mesenchymal transformation/cell cycle regulation, and differentiation into myogenic lineages. On the other hand, conditional knockouts of Bcar1 in differentiated smooth muscle, endothelial cells, and second heart field cells survived to term and were phenotypically normal at birth and postnatally.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Jill P. J. M. Hikspoors, Yolanda Macias, Justin T. Tretter, Robert H. Anderson, Wouter H. Lamers, Timothy J. Mohun, Damian Sanchez-Quintana, Jeronimo Farre, Eduardo Back Sternick
Summary: Despite years of research, many details of the formation of the atrioventricular conduction axis remain uncertain. This study aimed to clarify the situation by studying serial histological sections and datasets of human embryos. The findings revealed the origin and development of the conduction axis, shedding light on how it forms from the primary interventricular ring and undergoes subsequent remodelling processes.
Article
Cardiac & Cardiovascular Systems
Chikai Zhou, Timm Haeneke, Eduarde Rohner, Jesper Sohlmer, Polina Kameneva, Artem Artemov, Igor Adameyko, Makoto Sahara
Summary: This study investigates the mechanism by which mutations in the STRA6 gene could lead to cardiac malformations. By comparing gene expression in human and mouse embryonic hearts, it is found that STRA6 is mainly expressed in the OFT region-specific heart progenitors in human hearts. Further experiments show that STRA6 knockout in human embryonic stem cells leads to improper differentiation into smooth muscle cells derived from the mesoderm and neural crest. Additionally, an interaction between RA nuclear receptors RAR alpha/RXR alpha and the cardiogenic transcription factor TBX1 is identified.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chaohui Zhang, Yuxin Li, Jiaheng Cao, Beibei Yu, Kaiyue Zhang, Ke Li, Xinhui Xu, Zhikun Guo, Yinming Liang, Xiao Yang, Zhongzhou Yang, Yunfu Sun, Vesa Kaartinen, Keyue Ding, Jikui Wang
Summary: The study reveals that Smoothened-mediated hedgehog signaling controls posterior cardiac progenitor commitment, suggesting that Smoothened mutation may be involved in the etiology of congenital heart diseases related to the cardiac conduction system and heart valves.
Article
Cell Biology
Akihiro Fukushima, Naoya Kataoka, Kazuhiro Nakamura
Summary: Oxytocinergic neurons in the PVH region innervate sympathetic premotor neurons in the rMR region to regulate BAT thermogenesis and cardiovascular functions. Defects in this pathway may lead to obesity and impaired thermoregulation.
Article
Cardiac & Cardiovascular Systems
Ashwini Suresh Chandiramani, Vivian Bader, Emma Finlay, Stuart Lilley, Andrew McLean, Ed Peng
Summary: Despite having adequate z scores, patients with atrioventricular septal defect (AVSD) demonstrated abnormal left ventricular outflow tract (LVOT) morphometrics early postoperatively. Besides intrinsic morphology, repair techniques may have an impact on postoperative LVOT morphometrics and requires further evaluation.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Engineering, Biomedical
Stephanie E. Lindsey, Irene E. Vignon-Clementel, Jonathan T. Butcher
Summary: Mechanical forces play a crucial role in the growth and remodeling of primitive pharyngeal arch arteries into the heart's great vessels. However, the direct correlation between hemodynamics and PAA morphogenesis has been poorly understood. A study using minimally invasive occlusion experiments in avian embryos and 3D anatomical models revealed significant changes in morphology and hemodynamics following vessel occlusion, providing insights into the dynamic vessel adaptation process.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Biotechnology & Applied Microbiology
Chenggang Li, Bo Xie, Ruizhe Tan, Lijin Liang, Zhaoxiang Peng, Qi Chen
Summary: This review discusses the complications associated with bovine jugular vein conduit (BJVC) in right ventricular outflow tract (RVOT) reconstruction surgery and summarizes the current technological advancements. Novel crosslinking agents, decellularization techniques, conduit coatings, and physical reinforcement materials have improved the performance of BJVCs. The authors believe that breakthroughs in BJVC's clinical application may come from new genetic research findings and advanced characterization apparatuses and bioreactors, and they are optimistic about BJVC's potential in providing sophisticated therapies for next-generation RVOT reconstruction.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Joshua C. Peterson, Tim P. Kelder, Marie Jose T. H. Goumans, Monique R. M. Jongbloed, Marco C. DeRuiter
Summary: Although significant progress has been made in understanding the pathophysiology of congenital heart disease (CHDs) in recent years, the developmental processes affecting the cardiac outflow tract (OFT) remain poorly understood. There is a large variation in disease phenotypes among CHDs affecting the OFT, and relating cell lineage dynamics to morphologic variation in OFT pathologies remains challenging due to technical limitations. The lack of knowledge in this area is postulated to be related to underlying cell lineage dynamics, which are not well understood.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Yen-Yu Lu, Yao-Chang Chen, Yung-Kuo Lin, Shih-Ann Chen, Yi-Jen Chen
Summary: The right ventricular outflow tract (RVOT) is a major source of ventricular arrhythmias. Various cellular and molecular mechanisms, including calcium handling protein modulation, enhanced CaMKII activity, ryanodine receptor phosphorylation, and elevated cAMP levels, contribute to arrhythmogenesis in RVOT. Decreased expression of Cx43 and Scn5a may also lead to electrical uncoupling. This review aims to provide an updated understanding of these mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Xuguang Nie, Christopher L. Ricupero, Kai Jiao, Peixin Yang, Jeremy J. Mao
Summary: mTOR plays a crucial role in cardiac neural crest cell development, and its disruption can lead to a spectrum of cardiac defects, including various degrees of persistent truncus arteriosus, ventricular septal defect, and ventricular wall defect.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Naosumi Sekiya, Masaaki Ryomoto, Hiroe Tanaka, Mitsuhiro Yamamura, Keigo Yamashita, Shin Yajima, Hisashi Uemura, Ayaka Satoh, Daisuke Ueda, Taichi Sakaguchi
Summary: The 76-year-old female underwent graft replacement surgery for an ascending aortic aneurysm with LVOT obstruction and SAM. Echocardiography revealed improvements post-surgery, suggesting that graft traction may have alleviated compression on the aortic root and ventricular septum.
ANNALS OF THORACIC SURGERY
(2021)
Article
Surgery
Hui Guo, Zhongshi Wu, Tianli Zhao, Jinfu Yang, Shijun Hu, Can Huang, Yifeng Yang, Li Xie
Summary: This study aimed to assess the effect of RVOT stenting on pulmonary artery growth in patients with Tetralogy of Fallot (TOF). The results showed that compared to mBTS, RVOT stenting can better promote pulmonary artery growth, improve arterial oxygen saturation, and have fewer procedure complications.
FRONTIERS IN SURGERY
(2023)
Review
Ophthalmology
Mervyn G. Thomas, Eleni Papageorgiou, Helen J. Kuht, Irene Gottlob
Summary: Normal foveal development involves displacement of inner retinal layers and changes in outer retinal layers. Foveal hypoplasia is a characteristic feature of various developmental abnormalities and can be diagnosed and correlated with visual acuity based on morphology and grading.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jacquelyn Kukulski, Jacqueline Rausa, Julia Weld, Amina Jaji, Nobuyuki Ikeda, Brian Lee, Lisha Thomas, Robert H. Anderson, Rohit S. Loomba
Summary: This study demonstrates that a structured, interactive teaching session using heart specimens can effectively educate paediatric residents on cardiac anatomy. The residents showed a strong interest in this type of session and achieved significant learning outcomes.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Tyler Bendrick, Dillon Polito, Randy Richardson, Robert H. Anderson, Deepa Prasad
Summary: In this study, we present a case series of six children with ligamentous atresia of the left side of a double arch assessed using CT, highlighting the importance of CT in accurate diagnosis and surgical planning.
CARDIOLOGY IN THE YOUNG
(2023)
Letter
Cardiac & Cardiovascular Systems
Robert H. Anderson
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Weld, Brian Lee, Rohit S. Loomba, Saad Siddiqui, Amina Jaji, Luca Vricella, Narutoshi Hibino, Robert H. Anderson, Chawki Elzein
Summary: This article presents a rare case of tricuspid atresia with common arterial trunk, accompanied by interrupted aortic arch. The patient underwent surgical treatment and was discharged at the age of two months.
CARDIOLOGY IN THE YOUNG
(2023)
Review
Cardiac & Cardiovascular Systems
Robert H. Anderson, Madalina Garbi, Dasa Zugwitz, Steffen E. Petersen, Robin Nijveldt
Summary: It is widely accepted that the mitral valve functions through a complex combination of different components. However, controversies still exist in the understanding and description of these components. It is important to accurately describe the valvar complex using appropriate terms and to utilize three-dimensional techniques for clinical imaging.
Review
Anatomy & Morphology
Anthony Graham, Jill P. J. M. Hikspoors, Robert H. Anderson, Wouter H. Lamers, Simon D. Bamforth
Summary: The pharyngeal arches, bulges on the head of vertebrate embryos, have been traditionally labelled as 1, 2, 3, 4, and 6, with no fifth arch. Recent studies have shown that this labelling is problematic and causes confusion in understanding pharyngeal arch development. To address this, a new terminology is proposed, labelling the arches as mandibular, hyoid, carotid, aortic, and pulmonary.
JOURNAL OF ANATOMY
(2023)
Review
Cardiac & Cardiovascular Systems
Robert H. Anderson, Adrian Crucean, Diane E. Spicer
Summary: As yet, there is no agreed definition for the so-called hypoplastic left heart syndrome. Even its origin remains contentious. Our review summarizes the evidence supporting the notion that an intact ventricular septum should now be part of the definition of the hypoplastic left heart syndrome.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Madan M. Maddali, Hamood N. Al Kindi, Pranav Subbaraya Kandachar, Abdulla Al Farqani, Khalid S. Al Alawi, Faiza Al Kindi, Salim Nasser Al-Maskari, Diane E. Spicer, Robert Henry Anderson
Summary: This article discusses the anomalous systemic venous connections, specifically the connection of the systemic venous tributaries to the left atrium. Previous studies were compromised by the inclusion of individuals with isomeric atrial appendages, leading to inaccurate descriptions. In most cases, the anomalous connections are associated with a sinus venosus defect. Rarely, the primary atrial septum can be located in a way that directly connects the systemic venous sinus to the left atrium instead of the right atrium. The report includes a series of cases potentially falling into the category of anomalous systemic venous connections, with a spectrum of partially to totally anomalous connections. One case is an autopsy example of a totally anomalous systemic venous connection caused by an abnormal location of the primary atrial septum. The article discusses the potential morphogenesis of this finding and emphasizes the distinction between anomalous systemic venous connections and anomalous systemic venous drainage.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Ujjwal Kumar Chowdhury, Robert H. Anderson, Niraj Nirmal Pandey, Niwin George, Lakshmi Kumari Sankhyan, Maroof A. Khan, Shikha Goja, Sivasubramanian Ramakrishnan, Saurabh Kumar Gupta
Summary: This study compares the long-term outcomes of biventricular, univentricular, and one-and-one-half ventricular repairs in patients with left and right isomerism. The results show that surgical correction in patients with right isomerism had higher mortality rates, indicating the need for reassessment of management strategies.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Roman Sekelyk, Ibrahim B. Yusifli, Dmytro M. Kozhokar, Vsevolod V. Safonov, Robert H. Anderson, Illya M. Yemets
Summary: We successfully performed surgical repair on a rare variant of the common arterial trunk with unusual arrangement of the pulmonary arteries. This variant cannot be easily classified using popular classifications for the common arterial trunk. However, we provide a detailed account of cardiac development that offers an accurate explanation for its morphogenesis.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Ujjwal Kumar Chowdhury, Robert H. H. Anderson, Niraj Nirmal Pandey, Sundeep Mishra, Lakshmi Kumari Sankhyan, Niwin George, Maroof A. Khan, Shikha Goja
Summary: In this study, the indications, timing, and results of the one-and-a-half ventricle repair as an alternative surgical procedure to the Fontan circulation and high-risk biventricular repair were reviewed. The reported operative mortalities ranged from 3% to 20%, with a 10-year actuarial survival of 80% to 90%. The one-and-a-half ventricle repair reduces the surgical risk for biventricular repair and reverses the Fontan paradox.
CARDIOLOGY IN THE YOUNG
(2023)
Review
Cardiac & Cardiovascular Systems
Robert H. Anderson, Anthony Graham, Jill P. J. M. Hikspoors, Wouter H. Lamers, Simon D. Bamforth
Summary: There are ongoing controversies regarding the number of pharyngeal arches and their contained arteries in developing humans. Resolving these controversies is crucial for pediatric cardiologists as abnormalities in the extrapericardial arterial pathways are often interpreted based on the persistence of a fifth set of arteries. However, the evidence supporting this interpretation is questionable. In this review, the authors present the history of six such arteries, emphasizing that initial accounts of human development only provided evidence for the existence of five sets. They summarize the current evidence that supports these initial findings and suggest alternative explanations for lesions based on collateral channels or remodeling of the aortic sac.
CARDIOLOGY IN THE YOUNG
(2023)
Review
Cardiac & Cardiovascular Systems
Hussam Ali, Pierpaolo Lupo, Sara Foresti, Guido De Ambroggi, Robert H. Anderson, Carmine De Lucia, Dario Turturiello, Edoardo Maria Paganini, Riccardo Bessi, Igino Contrafatto, Ahmad Abdelrady Abdelsalam Farghaly, Ernesto Cristiano, Riccardo Cappato
Summary: Due to its endocardial course, the right bundle branch (RBB) is susceptible to traumatic block caused by bumping during right-heart catheterization. Catheter-induced RBB block (CI-RBBB) has become a common phenomenon in cardiac electrophysiology, but it is often overlooked by electrophysiologists. CI-RBBB can provide valuable diagnostic information, but may occasionally lead to diagnostic difficulties or undesired consequences. This article aims to provide a comprehensive practical review of CI-RBBB and its impact on the conduction system and various arrhythmic substrates.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Robert H. Anderson, Diane E. Spicer, Colin J. Mcmahon, R. Krishna Kumar, Justin T. Tretter
Summary: Surgical repair of ventricular channels is improved with precise placement of a patch or baffle. Communication between surgeons and cardiologists is important. Currently, the same term is used for different areas within the heart.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Anatomy & Morphology
Robert H. Anderson, Wouter H. Lamers, Jill P. J. M. Hikspoors, Timothy J. Mohun, Simon D. Bamforth, Bill Chaudhry, Lorraine Eley, Janet Kerwin, Moira Crosier, Deborah J. Henderson
Summary: The separation of the outflow tract of the developing heart into the systemic and pulmonary arterial channels is still controversial and not well understood. This study investigates the anatomical changes and developmental processes involved in the separation of the outflow channels, using histological and high-resolution imaging techniques. The findings provide insights into the development of the tripartite postnatal arrangement.
JOURNAL OF ANATOMY
(2023)