Article
Environmental Sciences
Meiru Wang, Martin Rucklin, Robert E. Poelmann, Carmen L. de Mooij, Marjolein Fokkema, Gerda E. M. Lamers, Merijn A. G. de Bakker, Ernest Chin, Lilla J. Bakos, Federica Marone, Bert J. Wisse, Marco C. de Ruiter, Shixiong Cheng, Luthfi Nurhidayat, Martina G. Vijver, Michael K. Richardson
Summary: In this study, the researchers investigated the effects of polystyrene nanoparticles on chicken embryos. They found that these nanoparticles could cross the gut wall and distribute to multiple organs in the embryo. The exposure to polystyrene nanoparticles resulted in severe malformations, including congenital heart defects, by selectively binding to neural crest cells.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Xuerong Wen, Nicholas Belviso, Emily Murray, Adam K. Lewkowitz, Kristina E. Ward, Kimford J. Meador
Summary: The study found a higher risk of minor congenital malformations associated with the use of prenatal prescription opioids in the third trimester, which appears to be dose-dependent. Further investigation is needed to establish causality and explore the physiologic plausibility of this association.
Article
Veterinary Sciences
Marina Vilela Estevam, Samara Beretta, Nathalia F. Smargiassi, Maricy Apparicio, Gilson Helio Toniollo, Gener T. Pereira
Summary: The popularity of brachycephalic dogs has increased due to their temperament and unique features. However, the inbreeding and lack of genetic diversity in these breeds have led to an increase in the occurrence of malformations. This study found a high incidence of malformations in brachycephalic dogs, with cleft palate and anasarca being the most common types. Older bitches were more likely to give birth to malformed puppies. Brachycephalic breeds were more prone to malformations compared to other breeds, especially modern brachycephalic. The presence of malformed puppies in a litter causes suffering, highlighting the importance of veterinarians in preventing and treating these conditions.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Genetics & Heredity
Jiachen Lin, Lina Zhao, Sen Zhao, Shengjie Li, Zhengye Zhao, Zefu Chen, Zhifa Zheng, Jiashen Shao, Yuchen Niu, Xiaoxin Li, Jianguo Terry Zhang, Zhihong Wu, Nan Wu
Summary: Genetic perturbations in NADSYN1 may predispose individuals to VCRL syndrome, and the study found that variants in NADSYN1 could impact protein levels and enzymatic activity, contributing to the complex genetic etiology of congenital vertebral malformations.
Article
Biochemistry & Molecular Biology
Julie A. Jurgens, Brenda J. Barry, Gabrielle Lemire, Wai-Man Chan, Mary C. Whitman, Sherin Shaaban, Caroline D. Robson, Sarah MacKinnon, Eleina M. England, Hugh J. McMillan, Christopher Kelly, Brandon M. Pratt, Anne O'Donnell-Luria, Daniel G. MacArthur, Kym M. Boycott, David G. Hunter, Elizabeth C. Engle
Summary: Variants in tubulin genes, specifically TUBA1A, have been linked to neurodevelopmental disorders such as CFEOM, with MRI findings showing oculomotor muscle abnormalities and brain structural anomalies. Certain mutated residues in tubulins are associated with tubulin dimerization or protofilament interactions, expanding our understanding of tubulinopathies.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Review
Veterinary Sciences
Aris Pourlis, Georgios I. Papakonstantinou, Dimitrios Doukas, Vasileios G. Papatsiros
Summary: This study investigated congenital malformations in pigs associated with anomalous twinning. The most common defect among the recorded conjoined twins was syncephalus thoracopagus or cephalothoracopagus. The pathogenetic mechanisms of this disease, which is common in veterinary practice, are discussed. The importance of embryonic conjoined twins is frequently associated with dystocia.
VETERINARY SCIENCES
(2023)
Article
Medicine, General & Internal
Beatrice Trabalza Marinucci, Cecilia Menna, Paolo Scanagatta, Silvia Fiorelli, Matteo Tiracorrendo, Giuseppe Naldi, Alessandro Inserra, Francesco Macchini, Erino Angelo Rendina, Mohsen Ibrahim
Summary: This study aimed to compare the effectiveness of lobectomy and sub-lobar resections in the treatment of congenital pulmonary malformations (CPMs) in adults and pediatrics. The results showed that lobectomy had a significant advantage in preventing symptom recurrence and reducing intraoperative complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Simona Di Pietro, Giuseppe Santi Rapisarda, Luca Cicero, Vito Angileri, Simona Morabito, Giovanni Cassata, Francesco Macri
Summary: The report describes unusual congenital limb defects in four dogs, including radial and ulnar malformations, ectrodactyly, and simple complete uncomplicated syndactyly. These anomalies are rare in companion animals and have been rarely documented. Postaxial terminal longitudinal ulnar hemimelia has not been reported in dogs previously.
Article
Surgery
Steven C. Mehl, Walker D. Short, Austin Kinley, Oluyinka O. Olutoye II, Timothy C. Lee, Sundeep G. Keswani, Alice King
Summary: This study evaluates the management of high-risk CLMs in our institution, specifically focusing on the use of multiple maternal steroid courses and maternal steroids in CLMs with pathologies other than CPAM. The results show that the majority of CLMs receiving steroids had a reduction or no change in CVR, suggesting the potential effectiveness of multiple steroid courses in refractory cases.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Kendall E. Martin, Joshua S. Waxman
Summary: This article discusses early developmental mechanisms that instruct appropriate formation of the venous pole in zebrafish embryos, focusing primarily on atrial chamber size and specialized pacemaker cells. It also explores the plasticity and maintenance of cardiomyocyte identity in embryonic zebrafish hearts.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Article
Pediatrics
Chenyu Liu, Xuejiao Yu, Kaisheng Cheng, Dengke Luo, Miao Yuan, Taozhen He, Chang Xu
Summary: This study found that a considerable proportion of asymptomatic patients with congenital lung malformations had hidden infections, which could increase the difficulty and risks of surgery. Therefore, early surgery may be a more appropriate choice for the management of these patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Surgery
Shaun M. Kunisaki, Jacqueline M. Saito, Mary E. Fallat, Shawn D. St Peter, Dave R. Lal, Monita Karmakar, Katherine J. Deans, Samir K. Gadepalli, Ronald B. Hirschl, Peter C. Minneci, Michael A. Helmrath
Summary: This study evaluated the clinical outcomes in children with prenatally diagnosed congenital lung malformations and found that an initial CVR <= 1.4 identifies fetuses at very low risk for hydrops, and a maximum CVR < 0.9 is associated with asymptomatic disease at birth.
Article
Cardiac & Cardiovascular Systems
Ahmed M. Al-Kaisey, Ramanathan Parameswaran, Robert Anderson, Joshua Hawson, Michael Nam, Hariharan Sugumar, David Chieng, Troy Watts, Alex McLellan, Peter M. Kistler, Geoffrey Lee, Jonathan M. Kalman
Summary: This study demonstrated complete wave front dissociation between the left and right interatrial septum in patients with persistent atrial fibrillation. The findings suggest that the two sides of the septum function as electrically discrete structures and may have implications for mapping and ablation of persistent atrial fibrillation.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Pediatrics
Arash Bordbar, Mandana Kashaki, Maryam Vafapour, Amir A. Sepehri
Summary: Screening for critical congenital heart defects should be performed early to save lives and reduce the incidence of undetected adult congenital heart diseases. Using a certified and internationally patented digital intelligent phonocardiography machine, accurate screening for congenital heart malformations is possible. This study aimed to assess the incidence of heart defects in neonates and evaluate the prevalence of unrecognized severe and critical congenital heart defects.
FRONTIERS IN PEDIATRICS
(2023)
Article
Oncology
Sara Patrizi, Federica Pederiva, Adamo Pio D'Adamo
Summary: The study found methylation anomalies shared by lung tumors and PPB in congenital lung malformations, regardless of histology. This suggests a potential correlation between congenital lung malformations and some step of malignant transformation.
FRONTIERS IN ONCOLOGY
(2021)
Review
Physiology
William Joyce, Tobias Wang
Summary: Acute exposure to low oxygen leads to conflicting demands on the heart, resulting in tachycardia or bradycardia. While mammals and fishes show different mechanisms in heart rate regulation during hypoxia, there are similarities in the underlying mechanisms. Bradycardia may primarily serve to protect the heart.
Editorial Material
Physiology
Steve F. Perry, Tobias Wang
Article
Anatomy & Morphology
Bjarke Jensen, Henrik Lauridsen, Grahame J. W. Webb, Tobias Wang
Summary: Non-crocodylian reptiles have hearts with a single ventricle, but the hearts of monitor lizards and pythons have functional division resembling mammals and birds. The hearts of leatherback turtles may have similar adaptations due to their extensive migrations and elevated body temperatures. This study provides detailed anatomical information on the hearts of leatherback turtles and suggests that their relatively large ventricles may meet exceptional circulation needs.
JOURNAL OF ANATOMY
(2022)
Article
Multidisciplinary Sciences
Jaeike W. Faber, Rob C. I. Wust, Inge Dierx, Janneke A. Hummelink, Diederik W. D. Kuster, Edgar Nollet, Antoon F. M. Moorman, Damian Sanchez-Quintana, Allard C. van der Wal, Vincent M. Christoffels, Bjarke Jensen
Summary: The morphology of the ventricular wall is determined by the differential growth rates of the trabecular and compact layers, rather than a process of compaction. Trabecular and compact myocardium have an equal capacity for force production.
Article
Physiology
Vibeke S. S. Elbrond, Morten B. B. Thomsen, Jonas L. L. Isaksen, Ester D. D. Lunde, Stefano Vincenti, Tobias Wang, Jorgen Tranum-Jensen, Kirstine Calloe
Summary: The purpose of this study was to investigate and evaluate the relationship between the unique electrical axis pattern in the horse heart and the distribution and histology of the conduction system. The results showed that the direction of the electrical axis in the equine heart is determined by the structure of the intramural Purkinje fiber network, rather than being related to ventricular mass.
Review
Cardiac & Cardiovascular Systems
Bjarke Jensen, Steffen E. Petersen, Bram F. Coolen
Summary: The development of coronary circulation in gestation is initially in the compact layer and extends to the trabeculations in fetal development. Conflicting results have been reported regarding the perfusion of the trabecular layer compared to the compact wall after birth. This study reviewed different imaging techniques and histology to evaluate myocardial perfusion in normal and excessively trabeculated hearts, suggesting that trabecular and compact muscle are likely equally perfused in normal hearts and most cases of excessive trabeculation.
JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sophie Meyer, Henrik Lauridsen, Kathrine Pedersen, Sofie Amalie Andersson, Pim van Ooij, Tineke Willems, Rolf M. F. Berger, Tjark Ebels, Bjarke Jensen
Summary: The heart of the axolotl salamander can serve as a model system for studying rare congenital heart diseases. Both the axolotl and human DILV hearts can separate blood flows of disparate oxygen saturation in a single ventricle. The axolotls have lower heart rate, lower ejection fraction, and higher resting oxygen consumption compared to DILV.
SCIENTIFIC REPORTS
(2022)
Article
Ecology
Martina Gregorovicova, Martin Bartos, Bjarke Jensen, Jiri Janacek, Bryan Minne, Jiri Moravec, David Sedmera
Summary: This study focused on the group Anguimorpha and found a correlation between heart morphology, ecological niche, and phylogenetic position.
ECOLOGY AND EVOLUTION
(2022)
Correction
Cardiac & Cardiovascular Systems
Jaeike W. Faber, Marieke F. J. Buijtendijk, Hugo Klarenberg, Arja Suzanne Vink, Bram Coolen, Antoon F. M. Moorman, Vincent M. Christoffels, Sally-Ann Clur, Bjarke Jensen
PEDIATRIC CARDIOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Bjarke Jensen, Antoon Fransiscus Maria Moorman, Tobias Wang, Peter Rask Moller, Jose Manuel Icardo, Henrik Lauridsen
Editorial Material
Cardiac & Cardiovascular Systems
Steffen E. Petersen, Bjarke Jensen, Nay Aung, Matthias G. Friedrich, Colin J. McMahon, Saidi A. Mohiddin, Ricardo H. Pignatelli, Fabrizio Ricci, Robert H. Anderson, David A. Bluemke
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Simone K. A. Videsen, Malene Simon, Fredrik Christiansen, Ari Friedlaender, Jeremy Goldbogen, Hans Malte, Paolo Segre, Tobias Wang, Mark Johnson, Peter T. Madsen
Summary: Giant rorqual whales have a massive food turnover driven by a high-intake lunge feeding style, which is considered the largest biomechanical action. This feeding behavior, although high-drag, is energetically cheap, allowing rorquals to be flexible in exploiting different prey patches and resilient to environmental fluctuations and disturbance. As a result, the ecological role and food turnover of these marine giants are likely overestimated.
Article
Anatomy & Morphology
Myrte M. Huijskes, Jose M. Icardo, Bram F. Coolen, Bjarke Jensen
Summary: Dextrocardia, a rare congenital malformation, can occur in both farmed and wild non-teleost fish. It is characterized by the heart mass being positioned in the right hemithorax instead of the left. This anomaly has been observed in spiny dogfish and Adriatic sturgeon, providing further insights into the atypical positions of cardiac chambers in fish.
JOURNAL OF ANATOMY
(2023)
Article
Mycology
Bjarke Jensen
Summary: In Polyporales, the pore field behind the basidiocarp margin may determine the hymenophore configuration, but its importance is not exclusive. Through observations and experiments on oak mazegill basidiocarps, it was found that the pore field is not necessary for basidiocarp growth and the ability to configure the hymenophore may exist broadly in the basidiocarp.