Article
Surgery
David S. Wheeler, Keizo Misumi, Natalie M. Walker, Ragini Vittal, Michael P. Combs, Yoshiro Aoki, Russell R. Braeuer, Vibha N. Lama
Summary: Histopathologic examination of lungs afflicted by chronic lung allograft dysfunction consistently shows both mononuclear cell inflammation and mesenchymal cell fibroproliferation, with interleukin 6 (IL-6) potentially playing a critical role in mediating the communication between these cells and contributing to the pathogenesis of CLAD.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Wai Wong, Brandy Johnson, Pi Chun Cheng, Maureen B. Josephson, Katsuhide Maeda, Robert A. Berg, Steven M. Kawut, Michael O. Harhay, Samuel B. Goldfarb, Nadir Yehya, Adam S. Himebauch
Summary: This study aimed to investigate the impact of grade 3 PGD within 48 or 72 hours on CLAD-free survival following pediatric lung transplantation. The study found that the occurrence of grade 3 PGD within 48 or 72 hours was associated with shorter CLAD-free survival, and gender may be a modifier of this association.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Christophe Pison, Adrien Tissot, Eric Bernasconi, Pierre-Joseph Royer, Antoine Roux, Angela Koutsokera, Benjamin Coiffard, Benjamin Renaud-Picard, Jerome Le Pavec, Pierre Mordant, Xavier Demant, Thomas Villeneuve, Jean-Francois Mornex, Simona Nemska, Nelly Frossard, Olivier Brugiere, Valerie J. Siroux, Benjamin Marsland, Aurore Foureau, Karine Botturi, Eugenie Durand, Johann Pellet, Richard Danger, Charles Auffray, Sophie Brouard, Laurent Nicod, Antoine Magnan
Summary: SysCLAD is a research aiming to predict chronic lung allograft dysfunction (CLAD), which involves investigating various factors including clinical data, assessment of airway microbiota, air pollution studies, activation of immune cells, secretion of matrix metalloproteinase-9 by T cells, subpopulations of T and B cells, genome polymorphisms, blood transcriptome, plasma proteome studies, and MSK1 expression to develop predictors of CLAD.
FRONTIERS IN MEDICINE
(2023)
Article
Hematology
Yifan Pang, Ananth Charya, Michael B. Keller, Arlene Sirajuddin, Yi-Ping Fu, Noa G. Holtzman, Steven Z. Pavletic, Sean Agbor-Enoh
Summary: This study adapted the 2019 International Society for Heart and Lung Transplantation criteria to define novel phenotypes of pulmonary chronic graft-versus-host disease (PcGVHD) and compared its performance with the NIH criteria in identifying high-risk PcGVHD patients. The adapted criteria were found to be effective in identifying high-risk PcGVHD patients that were missed by the NIH criteria.
Article
Medicine, Research & Experimental
Aaditya Khatri, Jamie L. . Todd, Fran L. . Kelly, Andrew Nagler, Zhicheng Ji, Vaibhav Jain, Simon G. Gregory, Kent J. Weinhold, Scott M. Palmer
Summary: Chronic lung allograft dysfunction (CLAD), characterized by decline in pulmonary function and bronchiolitis obliterans, lacks approved therapies. Single-cell RNA-Seq and spatial transcriptomic analysis identified the important role of JAK-STAT signaling in airway epithelial cells in CLAD. Activation of JAK-STAT signaling leads to upregulation of MHC-I in airway basal cells, resulting in cytotoxic T cell-mediated basal cell death. This study provides mechanistic insight and potential therapeutic strategy for CLAD.
Article
Surgery
Katrina Bazemore, Nitipong Permpalung, Joby Mathew, Merte Lemma, Betelihim Haile, Robin Avery, Hyesik Kong, Moon Kyoo Jang, Temesgen Andargie, Shilpa Gopinath, Steven D. Nathan, Shambhu Aryal, Jonathan Orens, Hannah Valantine, Sean Agbor-Enoh, Pali Shah
Summary: This study suggests that the donor-derived cell-free DNA percentage at the time of respiratory viral infection could be a predictor of chronic lung allograft dysfunction progression in lung transplant recipients. The recipients with higher levels of %ddcfDNA experienced greater decline in lung function and had a higher risk of progression and failure within one year.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Michael D. Parkes, Kieran Halloran, Alim Hirji, Shane Pon, Justin Weinkauf, Irina L. Timofte, Greg I. Snell, Glen P. Westall, Jan Havlin, Robert Lischke, Andrea Zajacova, Ramsey Hachem, Daniel Kreisel, Deborah Levine, Bartosz Kubisa, Maria Piotrowska, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Philip F. Halloran
Summary: The study revealed that CLAD primarily reflects severe parenchymal injury-induced changes and dedifferentiation rather than inflammation. Fibrillar collagen genes were increased in CLAD, indicating matrix changes, and normal transcripts were decreased.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Surgery
Rickey A. Evans, Krysta S. Walter, Leonard Jason Lobo, Raymond Coakley, Christina T. Doligalski
Summary: Chronic lung allograft dysfunction (CLAD) remains the leading cause of death in lung transplant recipients (LTRs) despite improvements in immunosuppression management. Treatments for CLAD are usually ineffective and there are currently no evidence-based guidelines.
CLINICAL TRANSPLANTATION
(2022)
Article
Immunology
Juan Margallo Iribarnegaray, Alicia De Pablo Gafas, Rodrigo Alonso Moralejo, Carlos Andres Quezada Loaiza, Fernando Revuelta Salgado, Isabel Pina Maiquez, Virginia Luz Perez Gonzalez
Summary: Among 13 CLAD patients treated with ATG, half of them showed a favorable positive response, with most responders being in CLAD stage 1 to 2. Lung function improved after treatment. The study also found a trend toward better survival in early CLAD patients.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Surgery
Daniel T. Dugger, Monica Fung, Steven R. Hays, Jonathan P. Singer, Mary E. Kleinhenz, Lorriana E. Leard, Jeffrey A. Golden, Rupal J. Shah, Joyce S. Lee, Fred Deiter, Nancy Y. Greenland, Kirk D. Jones, Chaz R. Langelier, John R. Greenland
Summary: In patients with chronic lung allograft dysfunction (CLAD) following lung transplantation, research indicated that small airway gene expression changes were associated with CLAD, and molecular analysis conducted on airway brushings showed potential for diagnosing CLAD.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Respiratory System
Saskia Bos, Laurens J. De Sadeleer, Arno Vanstapel, Hanne Beeckmans, Annelore Sacreas, Jonas Yserbyt, Wim A. Wuyts, Robin Vos
Summary: Pre-transplant antifibrotic therapy may have potential benefits for lung transplant recipients with chronic lung allograft dysfunction, but the impact on peri-transplant complications and wound healing should be considered. Further research is needed to evaluate the effects of antifibrotics in lung transplant recipients.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Surgery
Mohammad Rahman, Ranjithkumar Ravichandran, Sandhya Bansal, Kristina Sanborn, Sara Bowen, Jennifer Eschbacher, Angara Sureshbabu, Timothy Fleming, Ankit Bharat, Rajat Walia, Ramsey Hachem, Ross M. Bremner, Michael A. Smith, Thalachallour Mohanakumar
Summary: The study investigates the role of LKB1 in the development of CLAD following lung transplantation, revealing that downregulation of LKB1 is associated with EMT occurrence. Exosomes from lungs undergoing chronic rejection are linked to inactivation of LKB1, leading to EMT and the pathogenesis of CLAD.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Critical Care Medicine
Jarrod E. Dalton, Carli J. Lehr, Paul R. Gunsalus, Lyla Mourany, Maryam Valapour
Summary: This study examined the performance of models predicting waitlist and posttransplant survival in lung transplant allocation. The results showed that different models had similar performance in predicting waitlist and posttransplant survival, and using alternative modeling strategies and contemporary cohorts did not improve the models' performance in determining access to lung transplant.
Article
Respiratory System
Auke E. S. de Zwart, Annelies Riezebos-Brilman, Gerton A. Lunter, Ewald C. U. Neerken, Coretta C. van Leer-Buter, Jan-Willem C. Alffenaar, Anna P. van Gemert, Michiel E. Erasmus, Christiaan T. Gan, Huib A. M. Kerstjens, Judith M. Vonk, Erik A. M. Verschuuren
Summary: The social distancing measures during COVID-19 led to a reduction in respiratory virus infection rates, which correlated with less decline in lung function, fewer episodes of TDLF, and possibly lower incidence of CLAD in lung transplant recipients.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cell Biology
Laura Bergantini, Miriana d'Alessandro, Elda De Vita, Felice Perillo, Antonella Fossi, Luca Luzzi, Piero Paladini, Anna Perrone, Paola Rottoli, Piersante Sestini, Elena Bargagli, David Bennett
Summary: In acute rejection (AR) and chronic lung allograft dysfunction, the balance between immune cells is different, with a predominance of Th17 cells subtypes and depletion of Tregs observed in AR patients. Understanding the balance between regulatory and effector cells can effectively discriminate patients' immunological status.
Article
Cardiac & Cardiovascular Systems
Ananth Charya, Ileana L. Ponor, Adam Cochrane, Deborah Levine, Mary Philogene, Yi-Ping Fu, Moon K. Jang, Hyesik Kong, Pali Shah, Ann Mary Bon, Aravind Krishnan, Joby Mathew, Helen Luikart, Kiran K. Khush, Gerald Berry, Charles Marboe, Aldo Iacono, Jonathan B. Orens, Steven D. Nathan, Sean Agbor-Enoh
Summary: This study aims to define the clinical features and associated outcomes of recently defined antibody-mediated rejection (AMR) categories in lung transplant recipients. Clinical AMR showed a higher risk of allograft failure compared to subclinical or no AMR.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
John Kenneth Peel, Shaf Keshavjee, David Naimark, Mingyao Liu, Lorenzo Del Sorbo, Marcelo Cypel, Kali Barrett, Eleanor M. Pullenayegum, Beate Sander
Summary: This study compared the institutional costs of lung transplantation before and after the availability of EVLP and determined the health-economic impact of EVLP. The study found that EVLP availability was associated with faster progression to transplantation without significant marginal cost increase.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Rayoun Ramendra, Andrew T. Sage, Jonathan Yeung, Juan C. Fernandez-Castillo, Marcelo Cuesta, Meghan Aversa, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee, Tereza Martinu
Summary: This study investigates the utility of measuring total bile acids (TBA) in donor large airway bronchial wash (LABW) to predict the performance of donor lungs and recipient outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
P. Riddell, S. C. Juvet
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Letter
Surgery
Andrea Mariscal, Jussi Tikkanen, Lindsay Calderone, Olivia Hough, Manyin Chen, Tereza Martinu, Stephen Juvet, Marcelo Cypel, Mingyao Liu, Shaf Keshavjee
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Pharmacology & Pharmacy
Leeann Yao, Dejan Bojic, Mingyao Liu
Summary: The use of gold nanoparticles in medicine has vast clinical implications and exciting therapeutic potential. Current studies suggest that there are no major safety concerns with the use of gold nanoparticles, but more research and clinical trials are needed to further understand their safety and efficacy in clinical settings.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Cell Biology
Shozo Ohtsuki, Chenyao Wang, Ryu Watanabe, Hui Zhang, Mitsuhiro Akiyama, Melanie C. Bois, Joseph J. Maleszewski, Kenneth J. Warrington, Gerald J. Berry, Jorg J. Goronzy, Cornelia M. Weyand
Summary: Loss of function of inhibitory immune checkpoints can lead to autoimmune disease, such as giant cell arteritis (GCA). In this study, a defective CD155-CD96 immune checkpoint was found in GCA patients, resulting in the retention of CD155 in the endoplasmic reticulum (ER) of macrophages. Antigen-presenting cells with low CD155 expression induced the expansion of tissue invasive CD4+CD96+ T cells that released interleukin-9 (IL-9). The dysregulated immune response caused vessel wall destruction, which could be suppressed by anti-IL-9 antibodies in a GCA mouse model.
CELL REPORTS MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Michael J. Paulsen, Edgar C. Aranda-Michel, Gerald J. Berry, Y. Joseph Woo
Article
Biochemistry & Molecular Biology
Lei Huang, Ravi N. Vellanki, Zhiyuan Zhu, Bradly G. Wouters, Shaf Keshavjee, Mingyao Liu
Summary: Ex vivo lung perfusion (EVLP) has improved lung transplant success by evaluating marginal lungs before transplantation. To develop EVLP as a platform for donor lung reconditioning, a prolonged EVLP and new perfusates providing sufficient nutritional support are necessary. A combination of DMEM and a current EVLP perfusate (Steen solution) enhanced cell function and reduced apoptosis. A new EVLP perfusate, D05D7A solution, based on DMEM was designed and tested, showing improved cell function and higher levels of GSH and HSP70 compared to Steen solution. DMEM-based nutrient-rich perfusate could prolong EVLP and improve donor lung quality for transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jamie E. Jeon, Lei Huang, Zhiyuan Zhu, Aaron Wong, Shaf Keshavjee, Mingyao Liu
Summary: This study investigated the effects of ischemia-reperfusion and ex vivo lung perfusion (EVLP) on gene expression in human pulmonary microvascular endothelial cells and epithelial cells. The results showed that both cell types exhibited changes in gene expressions after ischemia-reperfusion or EVLP, with the former showing upregulated pro-inflammatory genes and downregulated cell metabolism pathways, while the latter showed downregulation of cell metabolism without any inflammatory signals.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Cell Biology
Yajin Zhao, Kimberly Main, Tanroop Aujla, Shaf Keshavjee, Mingyao Liu
Summary: Organ transplantation is the only treatment option for end-stage organ dysfunction, but it faces various limitations. This study reveals the mechanisms of necroptosis in organ transplantation and identifies potential targeted drugs.
Article
Gastroenterology & Hepatology
Meghan Marmor, Gerald Berry, Rishi Raj
ACG CASE REPORTS JOURNAL
(2023)