Article
Cardiac & Cardiovascular Systems
Roxy Senior, Harmony R. Reynolds, James K. Min, Daniel S. Berman, Michael H. Picard, Bernard R. Chaitman, Leslee J. Shaw, Courtney B. Page, Sajeev C. Govindan, Jose Lopez-Sendon, Jesus Peteiro, Gurpreet S. Wander, Jaroslaw Drozdz, Jose Marin-Neto, Joseph B. Selvanayagam, Jonathan D. Newman, Christophe Thuaire, Johann Christopher, James J. Jang, Raymond Y. Kwong, Sripal Bangalore, Gregg W. Stone, Sean M. Brien, William E. Boden, David J. Maron, Judith S. Hochman
Summary: In patients with moderate or severe ischemia, it was found that clinical and stress testing parameters were not strongly predictive of left main coronary artery disease (LMD) on coronary computed tomography angiography (CTA). Anatomical imaging is necessary to rule out LMD in most patients with moderate or severe ischemia.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jonas Persson, Jacinth Yan, Oskar Angeras, Dimitrios Venetsanos, Anders Jeppsson, Iwar Sjogren, Rikard Linder, David Erlinge, Torbjorn Ivert, Elmir Omerovic
Summary: This observational study aimed to analyze outcomes after coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) in patients with unprotected left main coronary artery (LMCA) disease. The study found that CABG was associated with lower mortality and fewer major adverse cardiovascular and cerebrovascular events (MACCE) compared to PCI in LMCA disease patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Milan Vecsey-Nagy, Balint Szilveszter, Marton Kolossvary, Melinda Boussoussou, Borbala Vattay, Xenia Gonda, Zoltan Rihmer, Bela Merkely, Pal Maurovich-Horvat, Janos Nemcsik
Summary: The study found that elevated hyperthymic affective temperament scores significantly decreased the odds of severe CAD, while dyslipidemia and cyclothymic affective temperament scores were positively associated with CAD. Ideal cutoff values for hyperthymic, cyclothymic, and irritable temperament scores were independently linked to severe CAD based on ROC analysis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas Martinsson, Susanne J. Nielsen, Erik Bjorklund, Aldina Pivodic, Carl Johan Malm, Emma C. Hansson, Anders Jeppsson
Summary: RAS inhibitors are underutilized after coronary artery bypass grafting (CABG), despite being recommended for patients with reduced left ventricular function, diabetes, hypertension, or previous myocardial infarction. The study showed that the use of RAS inhibitors was associated with a reduction in major adverse cardiovascular events (MACE) in all CABG patients, regardless of indication for treatment. Randomized controlled trials are needed to confirm the benefits of RAS inhibition for all CABG patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Peripheral Vascular Disease
Preeti Gahlan, Deebanshu Gupta, Samkit Mutha, Sanjay Shah, Tejas Patel
Summary: This study aimed to determine the prevalence and clinical predictors of coronary artery ectasia (CAE). The results showed that the prevalence of CAE was 7% and it was frequently associated with atherosclerotic coronary disease. Smoking was a significant predisposing factor for CAE.
Article
Cardiac & Cardiovascular Systems
Zsofia D. Drobni, Marton Kolossvary, Julia Karady, Adam L. Jermendy, Adam D. Tarnoki, David L. Tarnoki, Judit Simon, Balint Szilveszter, Levente Littvay, Szilard Voros, Gyorgy Jermendy, Bela Merkely, Pal Maurovich-Horvat
Summary: This study found that noncalcified plaque volume is mainly influenced by environmental factors, while coronary artery calcification score and calcified plaque volume are more determined by genetics. This emphasizes the importance of early lifestyle interventions in preventing coronary plaque formation.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
David Feldman, Jacqueline Latina, Jana Lovell, Roger S. Blumenthal, Armin Arbab-Zadeh
Summary: The treatment of coronary artery disease focuses on managing symptoms and preventing cardiovascular events. Coronary CTA has emerged as the first line noninvasive imaging modality for evaluating coronary atherosclerosis, improving diagnostic accuracy and patient outcomes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Gemma A. Figtree, Philip D. Adamson, Charalambos Antoniades, Roger S. Blumenthal, Michael Blaha, Matthew Budoff, David S. Celermajer, Mark Y. Chan, Clara K. Chow, Damini Dey, Girish Dwivedi, Nicola Giannotti, Stuart M. Grieve, Christian Hamilton-Craig, Bronwyn A. Kingwell, Jason C. Kovacic, James K. Min, David E. Newby, Sanjay Patel, Karlheinz Peter, Peter J. Psaltis, Stephen T. Vernon, Dennis T. Wong, Stephen J. Nicholls
Summary: Coronary artery disease (CAD) is the leading cause of adult mortality globally. Improvements in imaging techniques have provided a better understanding of different phenotypes of coronary atherosclerosis, which are associated with different risks for acute ischemic events. Noninvasive coronary imaging techniques have the potential to accelerate cardiovascular drug development and reduce costs and timelines.
Article
Cardiac & Cardiovascular Systems
Goran Bergstrom, Margaretha Persson, Martin Adiels, Elias Bjornson, Carl Bonander, Hakan Ahlstrom, Joakim Alfredsson, Oskar Angeras, Goran Berglund, Anders Blomberg, John Brandberg, Mats Borjesson, Kerstin Cederlund, Ulf de Faire, Olov Duvernoy, Orjan Ekblom, Gunnar Engstrom, Jan E. Engvall, Erika Fagman, Mats Eriksson, David Erlinge, Bjorn Fagerberg, Agneta Flinck, Isabel Goncalves, Emil Hagstrom, Ola Hjelmgren, Lars Lind, Eva Lindberg, Per Lindqvist, Johan Ljungberg, Martin Magnusson, Maria Mannila, Hanna Markstad, Moman A. Mohammad, Fredrik H. Nystrom, Ellen Ostenfeld, Anders Persson, Annika Rosengren, Anette Sandstrom, Anders Sjalander, Magnus C. Skold, Johan Sundstrom, Eva Swahn, Stefan Soderberg, Kjell Toren, Carl Johan Ostgren, Tomas Jernberg
Summary: Through conducting a study using CCTA on a random sample of individuals aged 50 to 64, we found that silent coronary atherosclerosis is common in this population, particularly in individuals with higher CAC scores.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiming Li, Yu Wu, Jingjing He, Weili Jiang, Jianyong Wang, Yong Peng, Yuheng Jia, Tianyuan Xiong, Kaiyu Jia, Zhang Yi, Mao Chen
Summary: In this study, a deep learning algorithm was used to achieve rapid classification and diagnosis of coronary artery disease from CCTA images. The deep learning model can automatically segment the coronary artery quickly and accurately, delivering a diagnosis of >= 50% coronary artery stenosis. Artificial intelligence methods such as deep learning have the potential to significantly improve efficiency in CCTA image analysis.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Hiyam Mahmoud, Eliza Cinteza, Cristiana Voicu, Irina Margarint, Iulian Rotaru, Amelia Aria, Tammam Youssef, Alin Nicolescu
Summary: Anomalous origin of the right coronary artery from the pulmonary artery is an extremely rare congenital heart disease. Although patients can be asymptomatic, early corrective intervention is generally recommended.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shi-hai Zhao, Wei-feng Guo, Zhi-feng Yao, Shan Yang, Hong Yun, Yin-yin Chen, Tong-tong Han, Xiao-yue Zhou, Cai-xia Fu, Meng-su Zeng, Chen-guang Li, Cui-zhen Pan, Hang Jin
Summary: In this study, a fully automated pixel-wise post-processing framework was used to evaluate quantitative cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI). The study aimed to assess the additional value of coronary magnetic resonance angiography (CMRA) in the diagnostic performance of fully automated pixel-wise quantitative CMR-MPI for detecting hemodynamically significant coronary artery disease (CAD). The results showed that the fully automated pixel-wise quantitative CMR-MPI can accurately detect hemodynamically significant CAD, but the integration of CMRA did not provide significantly additive value.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liang Jin, Yiyi Gao, An'qi Jiang, Zhenlin Li, Peijun Wang, Ming Li
Summary: The study aimed to investigate whether using coronary artery calcium score scan (CACS) could reduce radiation dose for coronary computed tomography angiography (CCTA) scanning and overall radiation exposure (ORE). The results showed that CACS led to shorter scan lengths and lower dose-length product (DLP) in CCTA scanning, but its effectiveness in reducing overall radiation exposure was weak.
ACADEMIC RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Philip Sarajlic, Moa Simonsson, Tomas Jernberg, Magnus Back, Robin Hofmann
Summary: This study aimed to determine the incidence, associated outcomes, and predictors of upper gastrointestinal bleeding (UGIB) following acute myocardial infarction (MI). The study found that UGIB was significantly associated with increased risk of all-cause death and stroke, but not recurrent MI. Important predictors of UGIB included haemoglobin, age, systolic blood pressure, blood glucose, smoking status, previous upper gastrointestinal bleeding, and antithrombotic and gastroprotective treatment.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Harmony R. Reynolds, C. Noel Bairey Merz, Colin Berry, Rohit Samuel, Jacqueline Saw, Nathaniel R. Smilowitz, Ana Carolina do A. H. de Souza, Robert Sykes, Viviany R. Taqueti, Janet Wei
Summary: Ischemic heart disease is the leading cause of mortality in women and requires gender-specific risk stratification for prevention, diagnosis, and treatment. Recent research has improved understanding of cardiovascular disease in women, including mechanisms of ischemia with no obstructive coronary arteries and myocardial infarction with no obstructive coronary arteries. Despite progress, sex differences in ischemic heart disease outcomes persist.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Sripal Bangalore, John A. Spertus, Susanna R. Stevens, Philip G. Jones, G. B. John Mancini, Jonathon Leipsic, Harmony R. Reynolds, Matthew J. Budoff, Cameron J. Hague, James K. Min, William E. Boden, Sean M. O'Brien, Robert A. Harrington, Jeffrey S. Berger, Roxy Senior, Jesus Peteiro, Neeraj Pandit, Leonid Bershtein, Mark A. de Belder, Hanna Szwed, Rolf Doerr, Lorenzo Monti, Khaled Alfakih, Judith S. Hochman, David J. Maron
Summary: The study found that intermediate left main disease (LMD) was associated with cardiovascular events. An invasive strategy can reduce nonprocedural MI and improve angina-related quality of life.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Health Care Sciences & Services
S. Raquel Ramos, Constance Johnson, Gail Melkus, Trace Kershaw, Marya Gwadz, Harmony Reynolds, Allison Vorderstrasse
Summary: This study proposes the first technology-based virtual environment intervention for addressing behavioral risk factors associated with cardiovascular and metabolic comorbidities in sexual-minority men of color with HIV. The study has been approved by institutional review boards and data collection is ongoing, with expectations of positive outcomes for CVD prevention education and peer social support.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Cardiac & Cardiovascular Systems
Faizan Mazhar, Paul Hjemdahl, Catherine M. Clase, Kristina Johnell, Tomas Jernberg, Arvid Sjolander, Juan Jesus Carrero
Summary: This study evaluated the associations of lipid-lowering therapy (LLT) intensity, adherence, and their combination with the risk of major adverse cardiovascular events (MACE) in patients with coronary heart disease. The results showed that higher LLT adherence and intensity were associated with a lower risk of MACE and higher odds of achieving low-density lipoprotein cholesterol goals. Strategies to improve adherence and use of intensive therapies could significantly reduce cardiovascular risk in these patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Moman A. Mohammad, Gregg W. Stone, Sasha Koul, Goran K. Olivecrona, Sofia Bergman, Jonas Persson, Thomas Engstrom, Ole Frobert, Tomas Jernberg, Elmir Omerovic, Stefan James, Goran Bergstrom, David Erlinge
Summary: Coronary atherosclerosis progresses slowly but more frequently in the left coronary artery in men and in the presence of traditional risk factors. The relative impact of risk factors appears to be of greater importance in younger patients and women. Coronary artery segments without risk factors have little or no risk of stenosis progression.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Judith S. Hochman, Rebecca Anthopolos, Harmony. R. Reynolds, Sripal Bangalore, Yifan Xu, Sean M. O'Brien, Stavroula Mavromichalis, Michelle Chang, Aira Contreras, Yves Rosenberg, Ruth Kirby, Balram Bhargava, Roxy Senior, Ann Banfield, Shaun G. Goodman, Renato D. Lopes, Radoslaw Pracon, Jose Lopez-Sendon, Aldo Pietro Maggioni, Jonathan D. Newman, Jeffrey S. Berger, Mandeep S. Sidhu, Harvey D. White, Andrea B. Troxel, Robert A. Harrington, William E. Boden, Gregg W. Stone, Daniel B. Mark, John A. Spertus, David J. Maron
Summary: The ISCHEMIA trial compared the outcomes of initial invasive strategy versus initial conservative strategy in patients with chronic coronary disease and moderate or severe ischemia. The trial found no major difference in most outcomes, but there was lower risk of cardiovascular mortality and higher risk of noncardiovascular mortality with the invasive strategy.
Article
Cardiac & Cardiovascular Systems
Troels Yndigegn, Bertil Lindahl, Joakim Alfredsson, Jocelyne Benatar, Lisa Brandin, David Erlinge, Urban Haaga, Claes Held, Pelle Johansson, Patric Karlstrom, Thomas Kellerth, Toomas Marandi, Katarina Mars, Annica Ravn-Fischer, Johan Sundstrom, Ollie Ostlund, Robin Hofmann, Tomas Jernberg
Summary: This article introduces a trial called REDUCE-AMI, which aims to evaluate the effect of long-term beta-blocker treatment on death and recurrent myocardial infarction in patients with acute MI. The study will involve 5000 patients and observe both primary and secondary endpoints. The results will have important implications for guidelines and clinical practice.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Nina Talmor, Michael Gurin, Nathaniel Smilowitz, Dana Gossett, Bruria Eisner, Mitchell Pleasure, Harmony R. Reynolds
Summary: This case report describes a 37-year-old woman with recurrent non-ST elevation myocardial infarction (NSTEMI) during her menstrual periods. Intracoronary acetylcholine provocation testing revealed coronary spasm in the left anterior descending artery (LAD) that was relieved with nitroglycerine. Initiating calcium channel blockade and suppressing cyclical variation in sex hormones improved her symptoms and prevented monthly NSTEMI events caused by coronary spasm.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Priya Panday, Anais Hausvater, Mitchell Pleasure, Nathaniel R. Smilowitz, Harmony R. Reynolds
Summary: Women with myocardial infarction (MI) are more likely to have nonobstructive coronary artery disease (MINOCA), spontaneous coronary artery dissection (SCAD), and takotsubo syndrome (TS) than men. This study aims to determine the prevalence of cancer in women with MI and investigate its association with the mechanism of MI presentation.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Tjerkaski, Tomas Jernberg, Joakim Alfredsson, David Erlinge, Stefan James, Bertil Lindahl, Moman Aladdin Mohammad, Elmir Omerovic, Dimitrios Venetsanos, Karolina Szummer
Summary: This study compared the effectiveness of Ticagrelor and Clopidogrel in myocardial infarction patients with high bleeding risk. It found that Ticagrelor can reduce the risk of myocardial infarction, stroke, and major adverse cardiovascular events compared to Clopidogrel, but it increases the risk of bleeding.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Scott D. J. Solomon, Charles J. S. Lowenstein, Ankeet S. Bhatt, Alexander Peikert, Orly N. Vardeny, Mikhail N. S. Kosiborod, Jeffrey S. R. Berger, Harmony R. Reynolds, Stephanie Mavromichalis, Anya D. Barytol, Andrew D. F. Althouse, James F. S. Luther, Eric S. L. Leifer, Andrei L. Kindzelski, Mary N. Cushman, Michelle N. Z. Gong, Lucy Z. Kornblith, Pooja S. Khatri, Keri S. Kim, Lisa Baumann Kreuziger, Lana Wahid, Bridget-Anne W. Kirwan, Mark W. D. Geraci, Matthew D. S. Neal, Judith S. Hochman
Summary: This study aimed to evaluate the efficacy of using the P-selectin inhibitor crizanlizumab in reducing mortality and disease progression in COVID-19 patients. However, the results showed that the drug did not improve organ support-free days in patients hospitalized with COVID-19.
Editorial Material
Cardiac & Cardiovascular Systems
Sunil V. Rao, Harmony R. Reynolds, Judith S. Hochman
Letter
Cardiac & Cardiovascular Systems
J. Tjerkaski, T. Jernberg, K. Szummer
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Surgery
Erik Stenberg, Yang Cao, Tomas Jernberg, Erik Naslund
Summary: Patients with both severe obesity and heart disease have a higher risk of postoperative cardiovascular complications after metabolic surgery compared to patients without heart disease. However, careful preoperative cardiovascular evaluation is necessary, and patients with both severe obesity and heart disease should not be excluded from undergoing metabolic surgery.