Article
Cardiac & Cardiovascular Systems
Michael J. Blaha, Seamus P. Whelton, Mahmoud Al Rifai, Zeina Dardari, Leslee J. Shaw, Mouaz H. Al-Mallah, Kunihiro Matsushita, Alan Rozanski, John A. Rumberger, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Miguel Cainzos-Achirica
Summary: This study compared the risk discrimination for predicting CHD and CVD deaths between the Pooled Cohort Equations (PCE), the MESA Risk Score (with and without CAC), and the addition of CAC to the PCE. The results showed that adding CAC to the PCE improved risk discrimination, and the MESA Risk Score with CAC, as well as the PCE plus CAC, performed best among patients with 5% to 20% estimated risk. Additionally, CAC also modestly improved discrimination in low- and high-risk groups.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander C. Razavi, S. M. Iftekhar Uddin, Zeina A. Dardari, Daniel S. Berman, Matthew J. Budoff, Michael D. Miedema, Albert D. Osei, Olufunmilayo H. Obisesan, Khurram Nasir, Alan Rozanski, John A. Rumberger, Leslee J. Shaw, Laurence S. Sperling, Seamus P. Whelton, Martin Bodtker Mortensen, Michael J. Blaha, Omar Dzaye
Summary: Coronary artery calcium (CAC) is associated with the risk of incident sudden cardiac death (SCD), particularly among primary prevention patients with low-intermediate risk. Stratification of SCD risk through CAC measurement can identify patients who are most likely to benefit from further downstream testing in the early stages of coronary heart disease (CHD).
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Robert J. H. Miller, Donghee Han, Ananya Singh, Konrad Pieszko, Piotr J. Slomka, Heidi Gransar, Rebekah Park, Yuka Otaki, John D. Friedman, Sean Hayes, Louise Thomson, Alan Rozanski, Daniel S. Berman
Summary: This study evaluated the independent prognostic value of myocardial perfusion and coronary artery calcium (CAC) in PET examination for major adverse cardiovascular events (MACE). The findings showed that ischemic total perfusion deficit (TPD) and CAC were associated with increased MACE risk. Combining the assessment of atherosclerosis extent and functional measures improved the prediction of MACE risk.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nan Zhang, Guang Yang, Weiwei Zhang, Wenjing Wang, Zhen Zhou, Heye Zhang, Lei Xu, Yundai Chen
Summary: A fully automatic multiview shape constraint framework was developed for comprehensive coronary artery calcium scores quantification via deep learning on nonenhanced cardiac CT images. The framework showed no significant differences between automatic and manual CACS quantification results at both total and vessel-specific levels, indicating reliable and comprehensive quantification for calcified extent and distribution indicators.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Thosaphol Limpijankit, Sutipong Jongjirasiri, Nattawut Unwanatham, Sasivimol Rattanasiri, Ammarin Thakkinstian, Jiraporn Laothamatas
Summary: This study found that coronary artery calcium score (CACS) is associated with the development of future myocardial infarction (MI). Antiplatelet therapy showed a clear preventive effect in patients with CACS of 100 or above, but this benefit was partially offset by an increased risk of bleeding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Omar Dzaye, Alexander C. Razavi, Erin D. Michos, Martin Bodtker Mortensen, Zeina A. Dardari, Khurram Nasir, Albert D. Osei, Allison W. Peng, Ron Blankstein, John H. Page, Michael J. Blaha
Summary: This study aimed to determine the relationship between coronary artery calcium (CAC) scores and atherosclerotic cardiovascular disease (ASCVD) mortality rates. The study found that primary prevention individuals with increased CAC burden may have ASCVD mortality rates equivalent to persons with stable secondary prevention-level risk.
Article
Cardiac & Cardiovascular Systems
Nischal N. Hegde, Navin Mathew, Rajesh Thachathodiyl, Jaideep C. Menon
Summary: A single daily dose of 75 mg acetylsalicylic acid can effectively inhibit thromboxane-B2 synthesis, but some patients may benefit from a twice-daily dose. Patients with lower thromboxane-B2 levels at 4 hours and higher levels at 24 hours may consider switching to a twice-daily regimen for better anti-platelet effect.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Georges Chedid, Abdulaziz Malik, Ralph Daher, Francine K. Welty
Summary: This study examined the relationship between exercise capacity and coronary artery calcium (CAC) and found that higher METs levels were associated with lower CAC scores in both women and men. This suggests that recommending exercise to improve cardiorespiratory fitness may reduce CAC scores and decrease the risk of cardiovascular events. METs independently predicted baseline and 30-month CAC in women.
Article
Cardiac & Cardiovascular Systems
Lohendran Baskaran, Jing Kai Lee, Michelle Shi Min Ko, Subhi J. Al'Aref, Yu Pei Neo, Jien Sze Ho, Weiting Huang, Yeonyee Elizabeth Yoon, Donghee Han, Rine Nakanishi, Swee Yaw Tan, Mouaz Al-Mallah, Matthew J. Budoff, Leslee J. Shaw
Summary: This study compared the abilities of pooled cohort equations (PCE) and coronary artery calcium (CAC) assessment in predicting major adverse cardiovascular events (MACE) in an Asian population. Age, presence of CAC, and ln(Volume) were significantly associated with MACE in the overall subgroup, while age and PCE score were significantly associated with MACE in the CAC = 0 subgroup. No risk factors were associated with MACE in the CAC > 0 subgroup. The performance of PCE deteriorated in statin versus non-statin users, while the Agatston score performed consistently in both groups.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Kyle Wang, Hayley E. Malkin, Nicholas D. Patchett, Kevin A. Pearlstein, Hillary M. Heiling, Sean D. McCabe, Allison M. Deal, Panayiotis Mavroidis, Mary Oakey, Jeffrey Fenoli, Carrie B. Lee, J. Larry Klein, Brian C. Jensen, Thomas E. Stinchcombe, Lawrence B. Marks, Ashley A. Weiner
Summary: This study found that computed tomography (CT) coronary calcifications are associated with cardiac toxicity and can help ascertain baseline heart disease. The presence of coronary calcifications can identify high-risk patients and guide clinicians in taking measures before potentially cardiotoxic cancer treatments.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Emergency Medicine
Joochan Kim, Yong Soo Cho, Byung Kook Lee, Dong Hun Lee, Eujene Jung, Jeong Mi Moon, Byeong Jo Chun
Summary: RWMAs on TTE was independently associated with significant stenosis. The combination of RWMA and STE had better predictive performance for significant stenosis compared to using only STE on ECG.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Medicine, General & Internal
Frances M. Wang, Alan Rozanski, Yoav Arnson, Matthew J. Budoff, Michael D. Miedema, Khurram Nasir, Leslee J. Shaw, John A. Rumberger, Roger S. Blumenthal, Kunihiro Matsushita, Michael J. Blaha, Daniel S. Berman
Summary: Among older adults, coronary artery calcium scores and percentiles are strongly predictive of cardiovascular and all-cause mortality, with greater risk-stratification in females than males. Older adults with low coronary artery calcium scores define relatively lower risk individuals.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert J. H. Miller, Konrad Pieszko, Aakash Shanbhag, Attila Feher, Mark Lemley, Aditya Killekar, Paul B. Kavanagh, Serge D. Van Kriekinge, Joanna X. Liang, Cathleen Huang, Edward J. Miller, Timothy Bateman, Daniel S. Berman, Damini Dey, Piotr J. Slomka
Summary: Deep learning (DL) can automatically quantify coronary artery calcium (CAC) from low-dose ungated CT attenuation correction (CTAC) scans obtained with SPECT/CT myocardial perfusion imaging. DL CAC scores show good agreement with expert annotations and provide similar risk stratification. They can be obtained automatically and improve the classification of patients compared with SPECT myocardial perfusion alone.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ahmed A. Harhash, Teresa L. May, Chiu-Hsieh Hsu, Sachin Agarwal, David B. Seder, Michael R. Mooney, Nainesh Patel, John McPherson, Paul McMullan, Richard Riker, Eldar Soreide, Karen G. Hirsch, Pascal Stammet, Alison Dupont, Sten Rubertsson, Hans Friberg, Niklas Nielsen, Tanveer Rab, Karl B. Kern
Summary: This study analyzed the impact of each proposed unfavorable feature on survival to hospital discharge in successfully resuscitated cardiac arrest patients. Patients with 6 or more unfavorable features have a poor long-term prognosis, with <40% predicted survival if they have 3 or more unfavorable features.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Xiaolan Xu, Peng Xu, Xiaoyan Wu, Hua Lin, Yinhua Chen, Xiaohua Hu, Jiangquan Yu, Ruiqiang Zheng
Summary: This study presents a case of anomalous origin of the left coronary artery arising from the right coronary sinus. The successful treatment of the patient was attributed to the immediate use of VA ECMO and IABP, with a clear diagnosis established through echocardiography and cardiac CTA.
FRONTIERS IN MEDICINE
(2022)
Article
Sport Sciences
Eduardo Bodnariuc Fontes, Henrique Bortolotti, Kell Grandjean da Costa, Brunno Machado de Campos, Gabriela K. Castanho, Rodrigo Hohl, Timothy Noakes, Li Li Min
BRITISH JOURNAL OF SPORTS MEDICINE
(2020)
Article
Endocrinology & Metabolism
Christopher C. Webster, Tamzyn E. Murphy, Kate M. Larmuth, Timothy D. Noakes, James A. Smith
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2019)
Editorial Material
Medicine, General & Internal
Arthur J. Siegel
AMERICAN JOURNAL OF MEDICINE
(2020)
Editorial Material
Medicine, General & Internal
Arthur J. Siegel, Richard B. Patti, Agustin G. Yip
AMERICAN JOURNAL OF MEDICINE
(2021)
Letter
Medicine, General & Internal
Arthur J. Siegel
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Nutrition & Dietetics
Timothy David Noakes
Summary: The introduction of the needle muscle biopsy technique in the 1960s revolutionized the study of muscle tissue in exercising humans. The role of muscle glycogen content and blood glucose concentration in fatigue during prolonged exercise is still a matter of debate.
Review
Social Sciences, Interdisciplinary
Travis M. Noakes, David Bell, Timothy D. Noakes
Summary: The World Health Organization (WHO) has established a public research agenda to address the issue of infodemics, especially during the COVID-19 pandemic. They aim to flag illegitimate narratives and prevent the spread of misinformation that can have negative health and societal impacts. Researchers analyze the division of knowledge labor to understand the emergence of "post-truth" moments.
TD-THE JOURNAL FOR TRANSDISCIPLINARY RESEARCH IN SOUTHERN AFRICA
(2022)
Editorial Material
Medicine, General & Internal
Arthur J. Siegel
AMERICAN JOURNAL OF MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Arthur J. Siegel
EUROPEAN HEART JOURNAL
(2023)
Article
Sport Sciences
Habib Noorbhai, Timothy Noakes
BMJ OPEN SPORT & EXERCISE MEDICINE
(2019)
Article
Sport Sciences
Christian Froyd, Fernando G. Beltrami, Timothy D. Noakes
Article
Sport Sciences
Andreas Venhorst, Dominic Micklewright, Timothy D. Noakes
BRITISH JOURNAL OF SPORTS MEDICINE
(2018)
Letter
Sport Sciences
Timothy David Noakes
BMJ OPEN SPORT & EXERCISE MEDICINE
(2018)