Article
Cell Biology
Cristina Gonzalez-Ravina, Esther Santamaria-Lopez, Alberto Pacheco, Julia Ramos, Francisco Carranza, Lucia Murria, Ana Ortiz-Vallecillo, Manuel Fernandez-Sanchez
Summary: This study analyzed the clinical outcomes of magnetic-activated cell sorting (MACS) on donor intrauterine insemination (D-IUI) cycles. The results showed no significant differences in gestation, live birth, or miscarriage rates between the MACS group and the control group. Further studies with a larger sample size are needed to evaluate the application of MACS in fertility clinics.
Article
Obstetrics & Gynecology
Manar Hozyen, Eman Hasanen, Khaled Elqusi, Salma ElTanbouly, Samar Gamal, Abdul Ghafar Hussin, Hanaa AlKhader, Hosam Zaki
Summary: In patients with abnormal SDF undergoing ICSI treatment, the PICSI group showed the highest pregnancy rate while the DGC group had the lowest. The PICSI group also had a significantly higher implantation rate than the other groups, with the MACS and DGC groups performing better in terms of high-quality blastocyst rates.
REPRODUCTIVE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Usha Punjabi, Ilse Goovaerts, Kris Peeters, Diane De Neubourg
Summary: Antioxidant therapy should only be used for infertile patients showing signs of oxidative stress. However, there is no consensus on the measurement of the primary endpoint and the assay to be used. This study analyzed the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an early marker of sperm DNA oxidation (SDO), in male infertility patients. The results showed that SDO was associated with semen volume, sperm concentration, leucocytes and round cells, but not with age, body mass index, sperm DNA fragmentation or oxidative stress. Further validation and optimization of the methodology for SDO is needed before it can be used to monitor antioxidant therapy in male infertility.
Article
Endocrinology & Metabolism
Hongyi Yang, Yan Liu, Wenbin Niu, Zilan Yang, Yang Wang, Haixia Jin, Gang Li
Summary: This study aimed to evaluate the influence of abnormal semen parameters on embryo aneuploidy using a single nucleotide polymorphism microarray (SNP array). The results showed that abnormal semen parameters may affect embryo quality and increase the rate of aneuploidy in blastocyst chromosomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yanpeng Dai, Junjie Liu, Enwu Yuan, Yushan Li, Ying Shi, Linlin Zhang
Summary: This meta-analysis explores the relationship among traditional semen parameters, SDF, and unexplained RM. The results show that couples with unexplained RM have significantly increased levels of SDF and significantly decreased levels of total motility and progressive motility. Therefore, SDF assay may be important in the evaluation of couples with unexplained RM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Jennifer F. Knudtson, Fangbai Sun, R. Matthew Coward, Karl R. Hansen, Kurt T. Barnhart, James Smith, Richard S. Legro, Michael P. Diamond, Stephen A. Krawetz, Heping Zhang, Rebecca Usadi, Valerie L. Baker, Nanette Santoro, Anne Z. Steiner
Summary: In the USA, among men attending fertility centers with sufficient plasma antioxidant levels of zinc, selenium, or vitamin E, no association was observed between vitamins and semen parameters or clinical outcomes in couples with male infertility. Higher levels of antioxidants among men with circulating antioxidants in the normal range do not appear to confer benefit on semen parameters or male fertility.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Public, Environmental & Occupational Health
Jiri Rubes, Jaroslav Sipek, Vera Kopecka, Petra Musilova, Miluse Vozdova
Summary: The study investigated sperm quality in city policemen in Ostrava during high and low levels of air pollution. It found that exposure to high air pollution increased sperm chromatin damage and immature sperm, correlating with decreased sperm vitality, normal morphology, and acrosome-intact sperm.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Obstetrics & Gynecology
Sandro C. Esteves, Carmen Lopez-Fernandez, Mercedes Gonzalez Martinez, Ellen A. Silva, Jaime Gosalvez
Summary: The study indicates a substantial intraindividual agreement of sperm chromatin dispersion (SCD) assay results in classifying men with infertility into three SDF categories: normal, intermediate, and high. The reliability of SCD assay exceeded 0.80 using two ejaculates analyzed within a 3-month interval under similar conditions.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Luca Boeri, Gianpaolo Lucignani, Letizia Maria Ippolita Jannello, Matteo Turetti, Irene Fulgheri, Carlo Silvani, Franco Gadda, Paola Vigano, Edgardo Somigliana, Emanuele Montanari
Summary: Superoxide-dismutase-based treatment has been shown to significantly improve sperm DNA fragmentation (SDF), as well as sperm progressive motility and normal morphology, in men with idiopathic infertility. This treatment is more effective compared to antioxidants without superoxide-dismutase.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Jiangman Gao, Renpei Yuan, Siwei Yang, Yuanyuan Wang, Ying Huang, Liying Yan, Hui Jiang, Jie Qiao
Summary: The study analyzed the correlations between male age, traditional semen parameters, sperm DNA fragmentation index (DFI), and high DNA stainability (HDS) in a large sample size. The results showed that age negatively impacted semen volume, total sperm count, motility, and HDS, while positively affecting sperm concentration and DFI. The study concluded that aging affects sperm quantity and quality, and there are significant correlations between routine sperm parameters and sperm DNA/chromatin integrity.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Endocrinology & Metabolism
Giulia Traini, Lara Tamburrino, Linda Vignozzi, Elisabetta Baldi, Sara Marchiani
Summary: This study evaluated the association between oxidized viable spermatozoa and sperm functions using two probes. The results showed a positive correlation between oxidized viable spermatozoa and sperm basal parameters, and a negative correlation with sperm DNA fragmentation. In addition, viable oxidized spermatozoa did not exhibit apoptotic features.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ahmed T. Alahmar
Summary: This study explores the effects of selenium therapy on semen parameters, antioxidant capacity, and sperm DNA fragmentation in infertile patients with idiopathic oligoasthenoteratospermia. Results showed that selenium therapy significantly improved sperm concentration, motility, and antioxidant capacity, while reducing sperm DNA fragmentation. Therefore, selenium could be a promising therapy for male infertility.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Obstetrics & Gynecology
Cihan Kabukcu, Nazli Cil, Umit Cabus, Erkan Alatas
Summary: This study aimed to evaluate the effect of ejaculatory abstinence period on sperm DNA fragmentation and pregnancy rates in IUI cycles. The results showed that there was no significant difference in pregnancy rates among couples with unexplained infertility undergoing ovarian stimulation and IUI, regardless of whether the abstinence period was 1 day or 3 days.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Review
Andrology
Ashok Agarwal, Rossella Cannarella, Ramadan Saleh, Ahmed M. Harraz, Hussein Kandil, Gianmaria Salvio, Florence Boitrelle, Shinnosuke Kuroda, Ala'a Farkouh, Amarnath Rambhatla, Armand Zini, Giovanni Colpi, Murat Gul, Parviz Kavoussi, Taha Abo-Almagd Abdel-Meguid Hamoda, Edmund Ko, Gokhan Calik, Tuncay Toprak, Germar-Michael Pinggera, Hyun Jun Park, Ramy Abou Ghayda, Suks Minhas, Gian Maria Busetto, Mustafa Emre Bakircioglu, Ates Kadioglu, Eric Chung, Giorgio Ivan Russo, Aldo E. Calogero, Rafael F. Ambar, Channa N. Jayasena, Rupin Shah
Summary: The meta-analysis found that antioxidant therapy can significantly improve the spontaneous pregnancy rate and conventional sperm parameters in male infertile patients. However, the impact of antioxidant therapy on live-birth rate is still controversial, as there are very few randomized controlled trials specifically evaluating this outcome.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Agriculture, Dairy & Animal Science
Julian Valencia, Edgar Andres Alzate, German Gomez, Marc Yeste, Francisco Javier Henao
Summary: This study investigated the impact of temperature humidity index (THI) in different intertropical zones on the retention of cytoplasmic droplets (CDs), sperm function, and DNA integrity in boars. The results showed that boars from high THI farms had higher proportions of moderate and persistent CD incidence, and the presence of proximal CDs (PCDs) was negatively correlated with sperm DNA integrity. Joint analysis of both PCDs and distal CDs (DCDs) is necessary for routine sperm quality analyses.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Environmental Sciences
Silvia Garcia, Cristina Bouzas, David Mateos, Rosario Pastor, Laura Alvarez, Maria Rubin, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Albert Goday, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majem, Blanca Riquelme-Gallego, Xavier Pinto, Jose J. Gaforio, Pilar Matia, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emilio Ros, Maira Bes-Rastrollo, Patricia Guillem-Saiz, Stephanie Nishi, Robert Cabanes, Itziar Abete, Leire Goicolea-Guemez, Enrique Gomez-Gracia, Antonio Jose Signes-Pastor, Antoni Colom, Antonio Garcia-Rios, Sara Castro-Barquero, Jose C. Fernandez-Garcia, Jose Manuel Santos-Lozano, Zenaida Vazquez, Jose Sorli, Maria Pascual, Olga Castaner, Maria Angeles Zulet, Jessica Vaquero-Luna, F. Javier Basterra-Gortari, Nancy Babio, Ramon Ciurana, Vicente Martin-Sanchez, Josep A. Tur
Summary: This study examined the association between adherence to an energy-restricted Mediterranean diet and the amount of CO2 emissions in an older adult population. The findings suggest that the Mediterranean diet can contribute to lower total dietary CO2 emissions, indicating its potential environmental benefits.
ENVIRONMENTAL HEALTH
(2023)
Review
Environmental Sciences
Maria Angeles Martinez, Montse Marques, Albert Salas-Huetos, Nancy Babio, Jose L. Domingo, Jordi Salas-Salvado
Summary: The incidence of infertility currently affects about 15% of the world's population, with male factors accounting for 40-50% of the cases. Exposure to endocrine disrupting chemicals (EDCs) is suspected to be involved in these reproductive disorders. This systematic review and meta-analysis aimed to explore the association between male exposure to EDCs and male fertility through clinical and observational studies. The results showed high heterogeneity among studies and no significant association between EDC exposure and sperm parameters, except for a positive association between PCB153 exposure and sperm concentration that was not clinically relevant. Further investigations are needed to understand the potential harmful effects of EDCs on male fertility.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Morgane Fialon, Nancy Babio, Jordi Salas-Salvado, Pilar Galan, Emmanuelle Kesse-Guyot, Mathilde Touvier, Melanie Deschasaux-Tanguy, Barthelemy Sarda, Serge Hercberg, Nadine Khoury, Lydiane Nabec, Chantal Julia
Summary: This study analyzed Spanish consumers' preference and objective understanding of Nutri-Score and NutrInform, two front-of-pack labels currently under debate in the EU. The results showed that Nutri-Score was better understood and more liked by Spanish consumers compared to NutrInform, providing new evidence to support Nutri-Score's application in Spain.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Letter
Obstetrics & Gynecology
Marc Llavanera, Ariadna Delgado -Bermudez, Jordi Ribas-Maynou, Albert Salas-Huetos, Marc Yeste
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Jordi Ribas-Maynou, Sergi Novo, Albert Salas-Huetos, Sergi Rovira, Marta Antich, Marc Yeste
Summary: This study found that defects in sperm chromatin protamination and condensation can have an impact on ICSI outcomes. Sperm protamination is related to fertilization rates and the in vitro capacity of sperm to condense their chromatin is linked to blastocyst rates, with these associations being more apparent in women.
HUMAN REPRODUCTION
(2023)
Letter
Cardiac & Cardiovascular Systems
Stephanie K. Nishi, Emilio Ros, Joan Sabate, Jordi Salas-Salvado
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Jose L. Santos, Miguel Ruiz-Canela, Cristina Razquin, Clary B. Clish, Marta Guasch-Ferre, Nancy Babio, Dolores Corella, Enrique Gomez-Gracia, Miquel Fiol, Ramon Estruch, Jose Lapetra, Montserrat Fito, Fernando Aros, Lluis Serra-Majem, Liming Liang, Maria Angeles Martinez, Estefania Toledo, Jordi Salas-Salvado, Frank B. Hu, Miguel A. Martinez-Gonzalez
Summary: This study aimed to evaluate the association between baseline and 1-year levels of plasma citric acid cycle (CAC) metabolites and cardiovascular disease (CVD) incidence, and their interaction with Mediterranean diet interventions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Medicine, Research & Experimental
Cristina Bouzas, Rosario Pastor, Silvia Garcia, Margalida Monserrat-Mesquida, Miguel Angel Martinez-Gonzalez., Jordi Salas-Salvado, Dolores Corella, Albert Goday, J. Alfredo Martinez, Angel M. Alonso-Gomez, Olga Fernandez-Barcelo, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Lluis Serra-Majema, Blanca Riquelme-Gallegop, Vicente Martin-Sanchez, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia, Josep Vidal, Jersy-Jair Cardenas-Salas, Lidia Daimiel, Emilio Ros, Estefania Toledo, Josep M. Manzanares, Inmaculada Gonzalez-Monge, Miguel-Angel Munoz, Diego Martinez-Urbistondo, Lucas Tojal-Sierra, Carlos Munoz-Bravoaf, Salvador Miralles-Gisbert, Marian Martin, Antonio Garcia-Rios, Sara Castro-Barquero, Jose Carlos Fernandez-Garcia, Jose Manuel Santos-Lozano, F. Javier Basterra-Gortari, Liliana Gutierrez-Carrasquilla, Patricia Guillem-Saiz, Alba Satorres, Itziar Abete, Carolina Sorto-Sanchez, Javier Diez-Espino, Nancy Babio, Montse Fito, Josep A. Tur
Summary: In a one-year study involving 6881 patients with MetS, it was found that those treated with GLP-1RA and DPP-4I had better glycemic profiles, but improvements in weight and waist circumference were modest.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Nutrition & Dietetics
Linda Tapsell, Joan Sabate, Raquel Martinez, Marc Llavanera, Elizabeth Neale, Albert Salas-Huetos
Summary: Nuts are integral in dietary patterns associated with lower chronic disease risk, and their consumption is essential for human health. With the current focus on plant-based diets due to climate change, nuts provide a sustainable and minimally processed source of protein. Research in this area aims to improve production methods and investigate the environmental and human health impacts of nut consumption.
Article
Nutrition & Dietetics
Nil Novau-Ferre, Melina Rojas, Laia Gutierrez-Tordera, Pierre Arcelin, Jaume Folch, Christopher Papandreou, Monica Bullo
Summary: This study found associations between lipoprotein subfractions and telomere length, TERT, and WRAP53 expression. Medium and small-sized HDL particles were negatively associated with telomere length, TERT, and WRAP53 expression, while large HDL particles were only negatively associated with WRAP53 expression. These results suggest the importance of considering lipoprotein profiles in assessing the risk of chronic diseases.
Article
Geriatrics & Gerontology
Marti Llaurador-Coll, Santiago Rios, Jesus F. Garcia-Gavilan, Nancy Babio, Elisabet Vilella, Jordi Salas-Salvado
Summary: Plasma proteins related to cognitive function were identified in older adults with obesity and metabolic syndrome. Six proteins were found to potentially contribute to cognitive performance, with higher levels in the low cognitive function group compared to the high cognitive function group. Further research is needed to replicate these results and explore their predictive potential.
Article
Psychology, Clinical
Indira Paz-Graniel, Nancy Babio, Stephanie K. Nishi, Miguel angel Martinez-Gonzalez, Dolores Corella, Montserrat Fito, Alfredo Martinez, angel M. Alonso-Gomez, Julia Waernberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Manuel Santos-Lozano, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Miguel Delgado-Rodriguez, Pilar Matia-Martin, Josep Vidal, Cristina Calderon-Sanchez, Lidia Daimiel, Emili Ros, Fernando Fernandez-Aranda, Estefania Toledo, Cristina Valle-Hita, Jose V. Sorli, Camille Lassale, Antonio Garcia-Rios, Alejandro Oncina-Canovas, Francisco Javier Baron-Lopez, M. Angeles Zulet, Elena Rayo, Rosa Casas, Esther Thomas-Carazo, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Miguel Ruiz-Canela, Sara de las Heras-delgado, Rebeca Fernandez-Carrion, Olga Castaner, Patricia J. Pena-Orihuela, Sandra Gonzalez-Palacios, Pilar Buil-Cosiales, Albert Goday, Jordi Salas-Salvado
Summary: This study aimed to assess the impact of mobility and social restrictions during the COVID-19 lockdown on depressive symptoms in older adults with metabolic syndrome in Spain. The results showed that the severity of lockdown was not associated with depressive symptoms.
DEPRESSION AND ANXIETY
(2023)
Letter
Endocrinology & Metabolism
Andrew N. N. Reynolds, Hana Kahleova, Matti Uusitupa, Kjeld Hermansen, Anne-Marie Aas, Ursula Schwab, Michael E. J. Lean, Andreas Pfeiffer, Jordi Salas-Salvado, Jim I. I. Mann
Meeting Abstract
Cardiac & Cardiovascular Systems
Linzi Li, Estefania A. Toledo, Dora Romaguera, Angel M. Alonso-Gomez, Cristina Razquin, Lucas Tojal-Sierra, Miquel Fiol, Miguel A. Martinez-Gonzalez, Jordi Salas-Salvado, Montserrat Fito, Alvaro Alonso
Review
Nutrition & Dietetics
Stephanie K. Nishi, Nadine Khoury, Cristina Valle Hita, Andreea Zurbau, Jordi Salas-Salvado, Nancy Babio
Summary: This systematic review and meta-analysis of observational studies found that greater variety in vegetable and fruit consumption may reduce all-cause mortality, but no significant associations were observed with cardiovascular-related mortality or morbidity. The certainty of the evidence was graded as low or very low. Additional high-quality studies are needed to better understand the role of variety in vegetable and fruit consumption in cardiovascular health.