Tight junction, mucin, and inflammasome-related molecules are differentially expressed in eosinophilic, mixed, and neutrophilic experimental asthma in mice

Childhood Asthma Clusters Reveal Neutrophil-Predominant Phenotype with Distinct Gene Expression

(2018) Ming-Wei Su et al.   ALLERGY

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma

(2018) Christos Rossios et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients

(2018) Kazunari Sugita et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Addressing unmet needs in understanding asthma mechanisms

(2017) Michael R. Edwards et al.   EUROPEAN RESPIRATORY JOURNAL

Dysregulation of lipidomic profile and antiviral immunity in response to hyaluronan in patients with severe asthma

(2017) Milena Sokolowska et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma

(2017) Kelly Sweerus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of bronchial epithelial barrier integrity by type 2 cytokines and histone deacetylases in asthmatic patients

(2017) Paulina Wawrzyniak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients

(2017) Matthew Loxham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Viruses and bacteria in Th2-biased allergic airway disease

(2016) F. Lan et al.   ALLERGY

IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models

(2016) M. Yokota et al.   ALLERGY

Asthma phenotypes in childhood: conceptual thoughts on stability and transition

(2016) Ben Daniel Spycher et al.   EUROPEAN RESPIRATORY JOURNAL

Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis—PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

(2016) Antonella Muraro et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the NLRP3 inflammasome

(2016) Chiara Cipollina et al.   Scientific Reports

Endotypes of allergic diseases and asthma: An important step in building blocks for the future of precision medicine

(2016) Ioana Agache et al.   ALLERGOLOGY INTERNATIONAL

Prostaglandin E2Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages

(2015) Milena Sokolowska et al.   JOURNAL OF IMMUNOLOGY

Claudin-18 Deficiency Results in Alveolar Barrier Dysfunction and Impaired Alveologenesis in Mice

(2014) Michael J. LaFemina et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Farm-derived Gram-positive bacteriumStaphylococcus sciuriW620 prevents asthma phenotype in HDM- and OVA-exposed mice

(2013) S. Hagner et al.   ALLERGY

Elevated expression of the NLRP3 inflammasome in neutrophilic asthma

(2013) J. L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages

(2013) Milena Sokolowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1

(2013) L. S. Rodgers et al.   JOURNAL OF CELL SCIENCE

IL-22 Mediates Goblet Cell Hyperplasia and Worm Expulsion in Intestinal Helminth Infection

(2013) Jan-Eric Turner et al.   PLoS Pathogens

The multi-faceted role of allergen exposure to the local airway mucosa

(2012) K. Golebski et al.   ALLERGY

Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4

(2012) Michael B. Soyka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice

(2012) I. C. Allen et al.   JOURNAL OF IMMUNOLOGY

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Hydrogen peroxide and nitrite reduction in exhaled breath condensate of COPD patients

(2012) J. Stefanska et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Claudin-4 Levels Are Associated with Intact Alveolar Fluid Clearance in Human Lungs

(2011) Deepti Rokkam et al.   AMERICAN JOURNAL OF PATHOLOGY

Defective epithelial barrier function in asthma

(2011) Chang Xiao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice

(2011) J. L. Ather et al.   JOURNAL OF IMMUNOLOGY

Expression of the T Helper 17-Associated Cytokines IL-17A and IL-17F in Asthma and COPD

(2010) Camille Doe et al.   CHEST

Cytosolic phospholipase A2 group IVA is overexpressed in patients with persistent asthma and regulated by the promoter microsatellites

(2010) Milena Sokolowska et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury

(2009) Charlie Wray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Airway MUC5AC Expression by IL-1  and IL-17A; the NF- B Paradigm

(2009) T. Fujisawa et al.   JOURNAL OF IMMUNOLOGY

IL-9 Promotes IL-13-Dependent Paneth Cell Hyperplasia and Up-Regulation of Innate Immunity Mediators in Intestinal Mucosa

(2009) V. Steenwinckel et al.   JOURNAL OF IMMUNOLOGY