期刊
AGING-US
卷 11, 期 1, 页码 73-88出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101719
关键词
estrogen; menopause; sex-dependent; aging; ceramides; liquid chromatography/mass spectrometry
资金
- Italian Ministry of Health [RF-2013-02359074]
- National Center for Advancing Translational Sciences, National Institutes of Health (NIH), through the Biostatistics, Epidemiology and Research Design Unit [UL1 TR001414]
Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease. Nevertheless, the potential impact of age on plasma ceramide levels has not yet been systematically examined. In the present study, we quantified a focused panel of plasma ceramides and dihydroceramides in a cohort of 164 subjects (84 women) 19 to 80 years of age. After adjusting for potential confounders, multivariable linear regression analysis revealed a positive association between age and ceramide (d18: 1/24: 0) (beta (SE) = 5.67 (2.38); p = .0198) and ceramide (d18: 1/24: 1) (beta (SE) = 2.88 (.61); p <.0001) in women, and between age and ceramide (d18: 1/24: 1) in men (beta (SE) = 1.86 (.77); p = .0179). In women of all ages, but not men, plasma ceramide (d18: 1/24: 1) was negatively correlated with plasma estradiol (r = 0.294; p = .007). Finally, in vitro experiments in human cancer cells expressing estrogen receptors showed that incubation with estradiol (10 nM, 24 h) significantly decreased ceramide accumulation. Together, the results suggest that aging is associated with an increase in circulating ceramide levels, which in post-menopausal women is at least partially associated with lower estradiol levels.
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