Article
Multidisciplinary Sciences
Dayeon Shin, Kyung Won Lee
Summary: This study revealed a higher risk of developing type 2 diabetes in Korean women who were overweight or obese before pregnancy with a history of GDM compared to those without GDM history. Additionally, high pre-pregnancy BMI or high current BMI increased the likelihood of developing type 2 diabetes in Korean women, regardless of GDM history. This highlights the importance of maintaining a healthy weight status both before and after pregnancy to prevent future risk of type 2 diabetes.
Article
Endocrinology & Metabolism
Maria B. Nielsen, Yunus Colak, Marianne Benn, Borge G. Nordestgaard
Summary: The study found that low plasma adiponectin is associated with an increased risk of type 2 diabetes, and this association may be causal. Observational analysis and genetic Mendelian randomization were used to confirm the relationship between plasma adiponectin levels and type 2 diabetes risk.
Review
Endocrinology & Metabolism
Min Jeong Park, Kyung Mook Choi
Summary: Sarcopenic obesity, caused by the rising older population, has become a global health concern, leading to cardiometabolic morbidity and mortality. Excessive adiposity creates a pro-inflammatory environment, disrupting metabolic homeostasis and impeding muscle tissue regeneration. The interaction between adipokines and myokines plays a crucial role in the pathophysiology of sarcopenia and obesity, but its complexity makes it challenging to understand.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Review
Endocrinology & Metabolism
Emma K. Rautenberg, Yassin Hamzaoui, Dawn K. Coletta
Summary: Type 2 diabetes (T2D) and obesity present major challenges in public health. Understanding the molecular mechanisms contributing to these metabolic disorders, particularly insulin resistance, is crucial. Impaired mitochondria structure and function are common features in insulin-resistant individuals with T2D or obesity, potentially due to epigenetic regulation of mitochondrial and nuclear-encoded genes. Investigating mitochondrial abnormalities is important for gaining insights into the pathogenesis of diabetes and obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Article
Biochemistry & Molecular Biology
Yeo Jin Lee, Joeng Ju Kim, Jongmin Kim, Dong-Woo Cho, Jae Yon Won
Summary: Central obesity is a major risk factor for type 2 diabetes mellitus (DM), with diabetic retinopathy (DR) being the most common complication. The exact relationship between obesity and DR is unknown. This study evaluated the impact of obesity on DR by comparing adipokines in the aqueous humor. The concentrations of adipokines were significantly higher in the DR group, indicating a positive correlation with central obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Dae-Seok Kim, Philipp E. Scherer
Summary: High rates of obesity and diabetes are associated with increased risk of multiple types of cancers, influenced by various factors. Metabolic abnormalities caused by obesity and diabetes may significantly contribute to the development and progression of cancer through the regulation of distinct signaling pathways.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Endocrinology & Metabolism
Asmaa A. El Sehmawy, Fatma Elzhraa Ahmed Diab, Donia Ahmed Hassan, Doaa Sayed Mohammed, Mona Gamal El Din Al Anany, Noha A. Eldesoky, Reham Yousri Elamir
Summary: The study found that obese children had higher weight Z scores, waist-to-height ratios, serum cholesterol, LDL, and TG levels, as well as lower HDL levels. Higher levels of serum lipocalin-2 and adipsin and lower IL-10 levels were observed in the obese group. The results suggest that measuring general and central adiposity markers as well as serum lipocalin-2 can predict insulin resistance in obese children.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Frederique Van de Velde, D. Margriet Ouwens, Arsene-Helene Batens, Yves Van Nieuwenhove, Bruno Lapauw
Summary: Systemic improvements in inflammation and insulin resistance are observed after gastric bypass surgery, but changes in adipokine and myokine expression patterns only partially reflect these improvements. Expression of markers of inflammation and insulin/glucose metabolism in other tissues may be inconsistent and divergent.
Review
Endocrinology & Metabolism
David Aguilar-Recarte, Emma Barroso, Xavier Palomer, Walter Wahli, Manuel Vazquez-Carrera
Summary: Although many drugs are available for treating type 2 diabetes, some patients still do not achieve adequate disease control. Recent findings suggest that modulating the stress-induced cytokine GDF15 may be a promising approach for treating diabetes. GDF15 can suppress appetite, reduce inflammation, increase thermogenesis and lipid catabolism, and improve insulin resistance and hepatic steatosis.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Emanuel Fryk, Vagner R. R. Silva, Per-Anders Jansson
Summary: Galectin-1 plays a crucial role in obesity and insulin resistance, and may be associated with the development and progression of type 2 diabetes and its complications.
Review
Endocrinology & Metabolism
Jia-Xue Cheng, Ke Yu
Summary: This review summarizes several adipokines that have potential functions in obesity and type 2 diabetes, and suggests that some of them may have pathogenic or protective roles.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Yuan Wei, Chaoqun Liu, Fangfang Lai, Shan Dong, Haiyan Chen, Li Chen, Liping Shi, Fengfeng Zhu, Chuangbiao Zhang, Xiuxiu Lv, Shuang Peng, Guang Hao
Summary: The study found that individuals with lower serum total bilirubin levels had a significantly higher risk of type 2 diabetes compared to those with moderate or high levels. Additionally, it was discovered that body mass index (BMI) may moderate the association between bilirubin and type 2 diabetes, with a stronger effect observed in obese individuals. This study suggests that serum total bilirubin is associated with an increased risk of type 2 diabetes and that this association may be influenced by obesity.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Review
Endocrinology & Metabolism
Christina Christoffersen
Summary: The apoM/S1P complex is important for inflammation and cholesterol metabolism, as well as for maintaining a healthy endothelial barrier and reducing cholesterol accumulation in vessel walls. Recent studies have also explored the role of apoM and S1P in the development of diabetes and obesity, but limited evidence and conflicting results are available.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Giovanni De Pergola, Fabio Castellana, Roberta Zupo, Sara De Nucci, Francesco Panza, Marco Castellana, Luisa Lampignano, Martina Di Chito, Vincenzo Triggiani, Rodolfo Sardone, Gianluigi Giannelli
Summary: Family history of type 2 diabetes (FHT2D) was found to be an independent determinant of NAFLD, regardless of age group, in overweight individuals. The presence of FHT2D led to a twofold higher probability of NAFLD, even after adjusting for major confounders.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Shehab Mahmoud Abd El-Kader, Mohammed H. Saiem Al-Dahr
AFRICAN HEALTH SCIENCES
(2016)
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Medicine, General & Internal
Shehab M. Abd El-Kader, Osama H. Al-Jiffri, Fadwa M. Al-Shreef
AFRICAN HEALTH SCIENCES
(2016)
Article
Medicine, General & Internal
Shehab Mahmoud Abd El-Kader, Mohammed H. Saiem Al-Dahr
AFRICAN HEALTH SCIENCES
(2016)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Osama H. Al-Jiffri, Eman M. Ashmawy, Riziq Allah M. Gaowgzeh
AFRICAN HEALTH SCIENCES
(2016)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Fadwa M. Al-Shreef, Osama H. Al-Jiffri
AFRICAN HEALTH SCIENCES
(2016)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Mohammed H. Saiem Al-Dahr
AFRICAN HEALTH SCIENCES
(2016)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Fadwa M. Al-Shreef
AFRICAN HEALTH SCIENCES
(2018)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Fadwa M. Al-Shreef
AFRICAN HEALTH SCIENCES
(2018)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Osama H. Al-Jiffri
AFRICAN HEALTH SCIENCES
(2018)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Mohammed H. Saiem Al-Dahr
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2018)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Osama H. Al-Jiffri
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2018)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2018)
Article
Medicine, General & Internal
Fadwa M. Al-Shreef, Shehab M. Abd El-Kader
EUROPEAN JOURNAL OF GENERAL MEDICINE
(2017)
Article
Medicine, General & Internal
Shehab M. Abd El-Kader, Mohammed H. Saiem-Aldahr, Osama H. Al-Jiffri
EUROPEAN JOURNAL OF GENERAL MEDICINE
(2017)