期刊
ADVANCES IN COLLOID AND INTERFACE SCIENCE
卷 262, 期 -, 页码 21-38出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cis.2018.11.001
关键词
Layered double hydroxides; Modified electrodes; Electrochemical biosensor; Biomarker determination; In vitro diagnostics
资金
- National Key Research and Development Program of China [2018YFF0215002]
- National Natural Science Foundation of China [51475177, 51572094]
- Independent Innovation
The development of layered double hydroxides (LDHs), also known as anionic clays with uniform distribution of metal ions and facile exchangeability of intercalated anions, are now appealing an immense deal of attention in synthesis of multifunctional materials. In electrochemical biosensors, LDHs provide stable environment for immobilization of enzymes or other sensing materials and play crucial roles in development of clinical chemistry, point-of-care devices through analysis of various small molecule metabolites excreted by biological processes which in turn serve as molecular biomarkers for medical diagnostics. In this review, we summarize the recent development in fabrication of LDH based nanoarchitectures and their electrocatalytic applications in ultrasensitive in vitro determination of conventional biomarkers, i.e., H2O2, glucose, dopamine and other biomolecules. Moreover, detailed discussion has been compiled to differentiate electrochemical enzymatic and nonenzymatic biosensors, to evaluate useful concentration ranges of H2O2 and glucose for analytical circumstances and to distinguish tumorigenic and normal cells via quantifying the released H2O2 efflux from living cells. Here, we envision that electrochemical sensing platform based on structurally integrated LDH nanohybrids with highly conducting substrates will assist as diseases diagnostic probe further enhancing diagnosis as well as therapeutic window for chronic diseases. Finally, the perspective for fabrication and assembly of LDH electrode is proposed for the future innovation of electrochemical biosensors with high performance making them more reliable for in vitro diagnostics. (C) 2018 Elsevier B.V. All rights reserved.
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