期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 360, 期 24, 页码 4699-4704出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201801457
关键词
flow chemistry; reductive amination; heterogeneous catalysis; C-N bond formation; flow fine synthesis
资金
- Japan Society for the Promotion of Science (JSPS)
- Global COE Program
- University of Tokyo
- MEXT, Japan
- Japan Science and Technology Agency (JST)
- Japan Agency for Medical Research and Development (AMED)
A general continuous-flow procedure for direct reductive amination of secondary and primary amines with aromatic and aliphatic aldehydes as well as ketones is reported. The use of hydrogen gas and commercially available Pt/C as a heterogeneous catalyst is a key. In addition to exhibiting an excellent functional group tolerance, this method allows the fast formation of C-N bonds without production of any hazardous chemical waste. Applications to the synthesis of key intermediates toward active pharmaceutical ingredients (Donepezil and Arformoterol/Tamsulosin) are also described.
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