Review
Behavioral Sciences
Jacob R. Bumgarner, William H. Walker, Randy J. Nelson
Summary: The circadian rhythms of pain are not produced by a single locus, but are a complex result of distributed rhythms throughout the pain system and interacting systems, including the opioid, endocrine, and immune systems.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Frank A. J. L. Scheer, Michael F. Hilton, Heather L. Evoniuk, Sally A. Shiels, Atul Malhotra, Rena Sugarbaker, R. Timothy Ayers, Elliot Israel, Anthony F. Massaro, Steven A. Shea
Summary: The study found that asthma patients experience worsened lung function and exacerbation of symptoms at night, often masked by sleep. Asthma patients exhibit significant circadian rhythms throughout the day and are more likely to use bronchodilators during the night.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Paula M. Wagner, Cesar G. Prucca, Beatriz L. Caputto, Mario E. Guido
Summary: Gliomas are solid tumors of the central nervous system classified into four groups by malignancy, with GBM being the most common and aggressive type. Current therapies for GBM have limited efficacy, prompting exploration of the potential role of the circadian clock in tumor cell modulation as a new target for novel treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Fuyuki Asano, Staci J. Kim, Tomoyuki Fujiyama, Chika Miyoshi, Noriko Hotta-Hirashima, Nodoka Asama, Kanako Iwasaki, Miyo Kakizaki, Seiya Mizuno, Michihiro Mieda, Fumihiro Sugiyama, Satoru Takahashi, Shoi Shi, Arisa Hirano, Hiromasa Funato, Masashi Yanagisawa
Summary: Deficiency of SIK3 in GABAergic neurons or NMS-producing neurons delays the arousal peak phase, while a gain-of-function mutant allele of Sik3 in GABAergic neurons advances the activity onset. Furthermore, HDAC4 deficiency shortens the circadian cycle.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Soo Ji Kim, Chris Chi, Gopal Pattanayak, Aaron R. Dinner, Michael J. Rust
Summary: By studying the cyanobacterial clock, a new protein called KidA was discovered to interact with the clock and shorten its period. It was also found that KidA alters the clock's ability to entrain to light-dark cycles. These findings reveal that the period and amplitude of the clock can be modulated by regulating the access of KaiB to the fold-switched form.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Plant Sciences
Elaine Tobin
Summary: The author, a successful woman in the field of science, was motivated by her family background to pursue education and adventure, which led to strong support and accomplishments in her career. She not only had an interest in science, but also a strong interest and involvement in politics.
ANNUAL REVIEW OF PLANT BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Noboru Imai
Summary: Migraine, a type of primary headache, exhibits circadian and circannual rhythms in attack onset, which involve the hypothalamus and melatonin. The prophylactic effect of melatonin in migraines is still controversial. Meanwhile, calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) play important roles in the pathophysiology and treatment of migraines by regulating circadian entrainment to light and could be potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Shuhui Jia, Xuantong Guo, Zuxin Chen, Shupeng Li, Xin-an Liu
Summary: Given the devastating social and health consequences of drug addiction and the limitations of current treatments, a new strategy involving correcting abnormal circadian rhythms and improving sleep quality may be beneficial in the treatment of drug addiction. Melatonin, a circadian hormone with various neuroprotective and pharmacological effects, has shown potential as an intervention for substance use disorders. This review discusses the roles of melatonin at different levels and its potential applications in drug addiction.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Julie C. Lim, Haruna Suzuki-Kerr, Tai X. Nguyen, Christopher J. J. Lim, Raewyn C. Poulsen
Summary: Accumulating evidence suggests an interconnection between circadian clocks and redox regulation. With advancing age, the depletion of the antioxidant glutathione (GSH) in the lens leads to the development of age-related cataracts. Understanding the mechanisms involved in regulating GSH levels may lead to the future development of approaches to protect the lens.
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Zoha Akbar, Zumin Shi
Summary: This study aimed to evaluate the associations between dietary patterns and circadian syndrome (CircS). Two major dietary patterns were identified, with the Western pattern positively associated with CircS and the prudent pattern inversely associated with CircS.
Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Melissa A. St Hilaire, Maria L. Amundadottir, Shadab A. Rahman, Shantha M. W. Rajaratnam, Melanie Ruger, George C. Brainard, Charles A. Czeisler, Marilyne Andersen, Joshua J. Gooley, Steven W. Lockley
Summary: This study investigates the contributions of different wavelengths of monochromatic light to human melatonin suppression and circadian resetting responses. The results show that, initially, short-wavelength (S) cones and long- and medium-wavelength (L+M) cones have a significant contribution, while the contribution of melanopsin-containing intrinsically-photosensitive retinal ganglion cells (ipRGCs) becomes dominant over time. The first few minutes of light exposure play a crucial role in the phase resetting response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Physiology
Siska Wilantri, Hanna Grasshoff, Tanja Lange, Timo Gaber, Luciana Besedovsky, Frank Buttgereit
Summary: Research on 24-h rhythms over the past four decades has revealed their significance for immunity and various diseases through genetic, molecular, and physiological findings. Disruption and misalignment of circadian rhythms have been linked to diseases and abnormal physiological functioning, highlighting their fundamental importance to mammals. This article provides an overview of the molecular regulation of 24-h rhythms, their impact on immunity, the detrimental effects of misalignment, the association between pathological rhythms and rheumatoid arthritis (RA), and the potential use of chronobiological rhythms for chronotherapy in inflammatory autoimmune diseases like RA.
Article
Physiology
Suhan Zhou, Jie Guo, Xinxin Liao, Qin Zhou, Xingyu Qiu, Shan Jiang, Nan Xu, Xiaohua Wang, Liang Zhao, Weipeng Hu, Lanyu Xie, Peng Xie, Yu Cui, Yi Yang, Andreas Patzak, Pontus B. Persson, Jianhua Mao, En Yin Lai
Summary: ADAMTS13 shows promise as a new treatment option for acute kidney injury, as it reduces oxidative stress and inflammation in renal ischemia/reperfusion injury.
Editorial Material
Physiology
Pontus B. Persson, Anja B. Persson
Editorial Material
Physiology
Pontus B. Persson, Anja B. Persson
Editorial Material
Physiology
Pontus B. Persson
Editorial Material
Physiology
Boye L. Jensen, Pontus B. Persson
Article
Biochemistry & Molecular Biology
Fang Dong, Shan Jiang, Chun Tang, Xiaohua Wang, Xiaoqiu Ren, Qichun Wei, Jiong Tian, Weipeng Hu, Jie Guo, Xiaodong Fu, Linlin Liu, Andreas Patzak, Pontus B. Persson, Fei Gao, En Yin Lai, Liang Zhao
Summary: TMAO aggravates hyperoxaluria-induced kidney injury by triggering the PERK/ROS pathway, which enhances autophagy, apoptosis, and inflammation, and facilitates CaOx crystal deposition in renal tubular cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Editorial Material
Physiology
Pontus B. Persson, Anja B. Persson
Article
Urology & Nephrology
Robert Labes, Lennart Brinkmann, Vera A. Kulow, Kameliya Roegner, Susanne Mathia, Bjorn Balcerek, Pontus B. Persson, Christian Rosenberger, Michael Fahling
Summary: This study demonstrates that the hypoxia inducible factor activator daprodustat can prevent the protein phosphorylation changes caused by Cyclosporine-A, and has a protective effect on microcirculation, hemoglobin concentration, and kidney capillary density.
KIDNEY INTERNATIONAL
(2022)
Review
Physiology
Qing Ye, Bing Lan, Huihui Liu, Pontus B. Persson, En Yin Lai, Jianhua Mao
Summary: This article discusses the mechanism of selective glomerular filtration, with a focus on the role of podocytes and the regulation of actin cytoskeleton in maintaining the integrity of the filtration barrier. The study found the presence of autoimmune podocytopathies in children with idiopathic nephrotic syndrome, revealing a new subgroup of the disease.
Editorial Material
Physiology
Pontus B. Persson
Article
Biochemistry & Molecular Biology
Minze Xu, Falk-Bach Lichtenberger, Cem Erdogan, Enyin Lai, Pontus B. Persson, Andreas Patzak, Pratik H. Khedkar
Summary: Reduced renal medullary oxygen supply is a key factor in the pathogenesis of acute kidney injury. Dilating the microvessels of the descending vasa recta may help in renoprotection by restoring renal medullary blood flow. PDE5 inhibitors may protect the pre-constricted microvessels, while sGC activators may be more effective in restoring renal medullary blood flow.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Physiology
Pontus B. Persson
Article
Peripheral Vascular Disease
Xiaohua Wang, Shan Jiang, Lingyan Fei, Fang Dong, Lanyu Xie, Xingyu Qiu, Yan Lei, Jie Guo, Ming Zhong, Xiaoqiu Ren, Yi Yang, Liang Zhao, Gensheng Zhang, Honghong Wang, Chun Tang, Luyang Yu, Ruisheng Liu, Andreas Patzak, Pontus B. Persson, Michael Hultstrom, Qichun Wei, En Yin Lai, Zhihua Zheng
Summary: This study found that the RhoA/ROCK pathway may play an important role in tacrolimus-induced hypertension by enhancing the vasoconstrictive effect of Ang II. Reactive oxygen species may participate in this process by activating the RhoA/ROCK pathway.
Editorial Material
Physiology
Pontus B. Persson, Anja Bondke Persson
Editorial Material
Physiology
Pontus B. Persson, Philipp Hillmeister, Anja B. Persson
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.
