Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

Fitting TDP-43 into the APOE ε4 and neurodegeneration story

(2018) Keith A Josephs   LANCET NEUROLOGY

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study

(2018) Hyun-Sik Yang et al.   LANCET NEUROLOGY

Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

(2018) Alexandra M. Wennberg et al.   JAMA Neurology

Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study

(2017) Keith A Josephs et al.   LANCET NEUROLOGY

Updated TDP-43 in Alzheimer’s disease staging scheme

(2016) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing

(2016) Kirsty E. McAleese et al.   BRAIN PATHOLOGY

TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features

(2015) Keith A. Josephs et al.   ANNALS OF NEUROLOGY

Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease

(2015) Sukriti Nag et al.   ANNALS OF NEUROLOGY

TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes

(2015) Rachel H. Tan et al.   BRAIN

Unlocking the mysteries of TDP-43

(2015) K. A. Josephs et al.   NEUROLOGY

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia

(2014) Marka van Blitterswijk et al.   ACTA NEUROPATHOLOGICA

TDP-43 in Alzheimer’s disease is not associated with clinical FTLD or Parkinsonism

(2014) Youngsin Jung et al.   JOURNAL OF NEUROLOGY

Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72

(2013) Melissa E. Murray et al.   ACTA NEUROPATHOLOGICA

TDP-43 deposition in prospectively followed, cognitively normal elderly individuals: correlation with argyrophilic grains but not other concomitant pathologies

(2013) Stacy J. Arnold et al.   ACTA NEUROPATHOLOGICA

Staging TDP-43 pathology in Alzheimer’s disease

(2013) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Consensus Recommendations on Pathologic Changes in the Hippocampus: A Postmortem Multicenter Inter-Rater Study

(2013) Tuomas Rauramaa et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TDP-43 Pathology, Cognitive Decline, and Dementia in Old Age

(2013) Robert S. Wilson et al.   JAMA Neurology

TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease

(2012) N. J. Rutherford et al.   NEUROLOGY

Neuropathological background of phenotypical variability in frontotemporal dementia

(2011) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

TDP-43 pathological changes in early onset familial and sporadic Alzheimer’s disease, late onset Alzheimer’s disease and Down’s Syndrome: association with age, hippocampal sclerosis and clinical phenotype

(2011) Yvonne S. Davidson et al.   ACTA NEUROPATHOLOGICA

A harmonized classification system for FTLD-TDP pathology

(2011) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Pathological 43-kDa Transactivation Response DNA-Binding Protein in Older Adults With and Without Severe Mental Illness

(2010) Felix Geser et al.   ARCHIVES OF NEUROLOGY

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

(2010) Vivianna M Van Deerlin et al.   NATURE GENETICS

TDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia

(2010) J. D. Rohrer et al.   NEUROLOGY

Does TDP-43 type confer a distinct pattern of atrophy in frontotemporal lobar degeneration?

(2010) J. L. Whitwell et al.   NEUROLOGY

Evaluation of subcortical pathology and clinical correlations in FTLD-U subtypes

(2009) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Phosphorylated TDP-43 in Alzheimer’s disease and dementia with Lewy bodies

(2009) Tetsuaki Arai et al.   ACTA NEUROPATHOLOGICA

Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity

(2009) Y.-J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal lobar predominance of TDP-43 neuronal cytoplasmic inclusions in Alzheimer disease

(2008) William T. Hu et al.   ACTA NEUROPATHOLOGICA

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

(2008) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Abnormal TDP-43 immunoreactivity in AD modifies clinicopathologic and radiologic phenotype

(2008) K. A. Josephs et al.   NEUROLOGY